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    1. Mentioned In 18 Articles

    2. Calibration-free in-line monitoring of pellet coating processes via optical coherence tomography

      Calibration-free in-line monitoring of pellet coating processes via optical coherence tomography

      The paper presents a new in-line measurement technique for determining the coating thickness and uniformity of pharmaceutical pellets during film-coating in a fluid-bed apparatus. Non-destructive and contact-free process monitoring was performed via an optical coherence tomography (OCT) sensor providing cross-section images. Through the OCT measurements, the coating thickness could be determined directly, without a chemometric calibration model required for the quantification. The direct integration of the OCT sensor head into the fluid-bed systems allowed continuous monitoring of the coating growth. Moreover, the in-line investigation of the intra- and inter-pellet coating uniformity was possible due to OCT's high acquisition rate ...

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    3. Real-time data processing for in-line monitoring of a pharmaceutical coating process by optical coherence tomography

      Real-time data processing for in-line monitoring of a pharmaceutical coating process by optical coherence tomography

      Coating of tablets is a widely applied unit operation in the pharmaceutical industry. Thickness and uniformity of the coating layer are crucial for efficacy as well as for compliance. Not only due to different initiatives it is thus essential to monitor and control the coating process in-line. Optical coherence tomography (OCT) was already shown in previous works to be a suitable candidate for in-line monitoring of coating processes. However, to utilize the full potential of the OCT technology an automatic evaluation of the OCT measurements is essential. The automatic evaluation is currently implemented in MATLAB and includes several steps: (1 ...

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    4. Feature Of The Week 9/8/13: Austrian Researchers Investigate OCT for Analysis of Coatings in Pharmaceutical Tablets

      Feature Of The Week 9/8/13: Austrian Researchers Investigate OCT for Analysis of Coatings in Pharmaceutical Tablets
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    5. Optical coherence tomography for non-destructive analysis of coatings in pharmaceutical tablets

      Optical coherence tomography for non-destructive analysis of coatings in pharmaceutical tablets

      Tablet coating is a common pharmaceutical technique to apply a thin continuous layer of solid on the top of a tablet or a granule containing active pharmaceutical ingredients (APIs). Coating thickness and homogeneity are critical parameters regarding the drug release rate, and consequently a direct or indirect monitoring strategy of these critical process parameters is essential. With the aid of Optical Coherence Tomography (OCT) it is not only possible to measure the absolute coating thickness, but also to detect inhomogeneities in the coating or substrate material. In this work the possible application of OCT as in-line method for monitoring pharmaceutical ...

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    6. Announcing The First International Symposium on Optical Coherence Tomography for Non-Destructive Testing (OCT4NDT) February 13-14, 2013 Linz Austria

      Announcing The First International Symposium on Optical Coherence Tomography for Non-Destructive Testing (OCT4NDT) February 13-14, 2013 Linz Austria

      Optical coherence tomography (OCT) applications in the field of non-destructive testing (NDT) have grown immensely over the past few years. In order to pave the ground for a new OCT for NDT community we are pleased to announce the First International Symposium on OCT4NDT! The symposium is intended as a get-together for people working in this field and aims at initiating new ideas and projects. . For more information please click Here .

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    7. Evaluation of structural change and local strain distribution in polymers comparatively imaged by FFSA and OCT techniques

      Evaluation of structural change and local strain distribution in polymers comparatively imaged by FFSA and OCT techniques

      Mechanical material testing combined with optical coherence tomography (OCT) allows for the first time the immediate detection of inner structural changes along with a qualitative observation of the local strain distribution in surface near bulk regions of semitransparent and translucent specimens. In addition to a 3D full field strain analysis (FFSA) system based on digital image correlation (DIC), a customized spectral domain OCT system operating at 1550 nm was applied for investigation. Exemplified by tensile testing of elastomer particle filled polypropylene specimens, local dissimilarity evaluation of the OCT images was performed. The results show the high potential of OCT to ...

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    8. Non-destructive analysis of tablet coatings with optical coherence tomography

      Non-destructive analysis of tablet coatings with optical coherence tomography

      Optical coherence tomography (OCT) is a non-invasive analysis technique allowing fast and high-quality cross-sectional imaging of scattering media. OCT is based on the physical phenomenon of low coherence interferometry and is thus well suited to image layered structures. In this paper, high-speed spectral domain OCT was used for the characterization of pharmaceutical tablet coatings, sampled at different stages of an industrial drum spray coating process, comprising tablets with a coating thickness ranging from uncoated to a target coating thickness of about 70 μm. In addition to the OCT investigation of layer thickness and homogeneity, tablet weight gain and tablet diameters ...

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    9. 1-15 of 18 1 2 »
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      2. About RECENDT

        RECENDT

        RECENDT (Research Center for Non Destructive Testing) GmbH is based in Linz / Upper Austria and is an internationally well recognized Research Center for Non Destructive Testing and material characterization. The company is a 2009 – spin-off from the Upper Austrian Research (UAR) where the technological expertise has been built up since the year 2000. Shareholders are still the UAR, the Johannes Kepler University Linz (JKU) and the Upper Austrian University of Applied Science (FH OOE).