1. Randy H. Kardon

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    1. Mentioned In 34 Articles

    2. Optical Coherence Tomography Neuro-Toolbox for the Diagnosis and Management of Papilledema, Optic Disc Edema, and Pseudopapilledema

      Optical Coherence Tomography Neuro-Toolbox for the Diagnosis and Management of Papilledema, Optic Disc Edema, and Pseudopapilledema
      Background: Distinguishing optic disc edema from pseudopapilledema is a common, sometimes challenging clinical problem. Advances in spectral-domain optical coherence tomography (SD-OCT) of the optic nerve head (ONH) has proven to be a cost effective, noninvasive, outpatient procedure that may help. At its core are tools that quantify the thickness of the retinal nerve fiber layer (RNFL) and ganglion cellinner plexiform layer (GC-IPL). The SD-OCT also provides a set of tools ...
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      Mentions: Randy H. Kardon
    3. Diagnosis and Grading Of Papilledema Using Optical Coherence Tomography Compared To Clinical Staging By Frise´n Scale

      Diagnosis and Grading Of Papilledema Using Optical Coherence Tomography Compared To Clinical Staging By Frise´n Scale
      Objectives To compare and contrast 2 methods of quantitating papilledema, namely, optical coherence tomography (OCT) and Modified Frisn Scale (MFS). Methods Digital optic disc photographs and OCT fast retinal nerve fiber layer (RNFL) thickness, fast RNFL map, total retinal thickness, and fast disc images were obtained in 36 patients with papilledema. Digital optic disc photographs were randomized and graded by 4 masked expert reviewers using the MFS. We performed Spearman ...
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    4. A Deep-Learning Approach for Automated OCT En-Face Retinal Vessel Segmentation in Cases of Optic Disc Swelling Using Multiple En-Face Images as Input

      A Deep-Learning Approach for Automated OCT En-Face Retinal Vessel Segmentation in Cases of Optic Disc Swelling Using Multiple En-Face Images as Input
      Purpose : In cases of optic disc swelling, segmentation of projected retinal blood vessels from optical coherence tomography (OCT) volumes is challenging due to swelling-based shadowing artifacts. Based on our hypothesis that simultaneously considering vessel information from multiple projected retinal layers can substantially increase vessel visibility, in this work, we propose a deep-learning-based approach to segment vessels involving the simultaneous use of three OCT en-face images as input. Methods : A human ...
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    5. Region-Based Segmentation of Capillary Density in Optical Coherence Tomography Angiography

      Region-Based Segmentation of Capillary Density in Optical Coherence Tomography Angiography
      Microvascular changes are one of the early symptoms of retinal diseases. Recently developed optical coherence tomography angiography (OCTA) technology allows visualization and analysis of the retinal microvascular network in a non-invasive way. However, automated analysis of microvascular changes in OCTA is not a trivial task. Current approaches often attempt to directly segment the microvasculature. These approaches generally have problems in cases of poor image quality and limited visibility of the ...
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    6. Optical coherence tomography is highly sensitive in detecting prior optic neuritis

      Optical coherence tomography is highly sensitive in detecting prior optic neuritis
      Objective To explore sensitivity of optical coherence tomography (OCT) in detecting prior unilateral optic neuritis. Methods This is a retrospective, observational clinical study of all patients who presented from January 1, 2014, to January 6, 2017, with unilateral optic neuritis and OCT available at least 3 months after the attack. We compared OCT retinal nerve fiber layer (RNFL) and ganglion cell inner plexiform layer (GCIPL) thicknesses between affected and unaffected ...
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      Mentions: Randy H. Kardon
    7. Optical Coherence Angiographic Demonstration of Retinal Changes From Chronic Optic Neuropathies

      Optical Coherence Angiographic Demonstration of Retinal Changes From Chronic Optic Neuropathies
      Glaucoma causes a decrease in peripapillary perfused capillary density on optical coherence tomography (OCT) angiography. However, other chronic optic neuropathies have not been explored with OCT angiography to see if these changes were specific to glaucoma. The authors evaluated OCT angiography in 10 patients who suffered various kinds of chronic optic neuropathies, including optic neuritis and ischaemic optic neuropathy, and found that all optic neuropathies showed a decrease in peripapillary ...
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    8. Avoiding Clinical Misinterpretation and Artifacts of Optical Coherence Tomography Analysis of the Optic Nerve, Retinal Nerve Fiber Layer, and Ganglion Cell Layer

      Avoiding Clinical Misinterpretation and Artifacts of Optical Coherence Tomography Analysis of the Optic Nerve, Retinal Nerve Fiber Layer, and Ganglion Cell Layer
      Background: Optical coherence tomography (OCT) has become an important tool for diagnosing optic nerve disease. The structural details and reproducibility of OCT continues to improve with further advances in technology. However, artifacts and misinterpretation of OCT can lead to clinical misdiagnosis of diseases if they go unrecognized. Evidence Acquisition: A literature review using PubMed combined with clinical and research experience. Results: We describe the most common artifacts and errors in ...
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    9. The Pattern of Visual Fixation Eccentricity and Instability in Optic Neuropathy and Its Spatial Relationship to Retinal Ganglion Cell Layer Thickness

      The Pattern of Visual Fixation Eccentricity and Instability in Optic Neuropathy and Its Spatial Relationship to Retinal Ganglion Cell Layer Thickness
      Purpose : The purpose of this study was to assess whether clinically useful measures of fixation instability and eccentricity can be derived from retinal tracking data obtained during optical coherence tomography (OCT) in patients with optic neuropathy (ON) and to develop a method for relating fixation to the retinal ganglion cell complex (GCC) thickness. Methods : Twenty-nine patients with ON underwent macular volume OCT with 30 seconds of confocal scanning laser ophthalmoscope ...
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    10. Combined use of high-density and volumetric optical coherence tomography for the segmentation of neural canal opening in cases of optic nerve edema

      Combined use of high-density and volumetric optical coherence tomography for the segmentation of neural canal opening in cases of optic nerve edema
      ...rumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only. Jui-Kai Wang ; Randy H. Kardon ; Mona K. Garvin; Combined use of high-density and volumetric optical coherence tomography for...
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    11. Homonymous Ganglion Cell Layer Thinning After Isolated Occipital Lesion: Macular OCT Demonstrates Transsynaptic Retrograde Retinal Degeneration

      Homonymous Ganglion Cell Layer Thinning After Isolated Occipital Lesion: Macular OCT Demonstrates Transsynaptic Retrograde Retinal Degeneration
      A 48-year-old man was examined 24 months after medial and surgical treatment of an isolated well-circumscribed right occipital lobe abscess. An asymptomatic residual left homonymous inferior scotoma was present. Fundus examination revealed temporal pallor of both optic discs, and optical coherence tomography (OCT) revealed mild temporal loss of retinal nerve fiber layer in both eyes. No relative afferent pupillary defect was present. Assessment of the retinal ganglion cell layer demonstrated ...
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      Mentions: Randy H. Kardon
    12. Optical Coherence Tomography in Papilledema: What Am I Missing?

      Optical Coherence Tomography in Papilledema: What Am I Missing?
      Background: Grading of papilledema severity is subjective and based on monocular fundus features of the optic nerve. Interobserver agreement on grading the severity of papilledema is poor among expert observers, even using well-defined criteria such as the Frisen scale, which is a non-continuous ordinal scale of grading. Furthermore, non-expert clinicians often find it difficult to properly view and interpret features of the optic nerve using ophthalmoscopy, which can lead to ...
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    13. Diagnostic Features of Retinal Nerve Fiber Layer Rotation in Skew Deviation Using Optical Coherence Tomography

      Diagnostic Features of Retinal Nerve Fiber Layer Rotation in Skew Deviation Using Optical Coherence Tomography
      A 41-year-old woman with skew deviation had cyclotorsion of both eyes. This resulted in a falsely low probability plot of retinal nerve fiber layer thickness in adjacent clock hours on optical coherence tomography (OCT) due to displacement of the retinal nerve fiber layer peaks. Ocular cyclotorsion may cause misinterpretation of OCT probability plots. OCT retinal nerve fiber layer plots also may be used to objectively quantify the degree of ocular ...
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      Mentions: Randy H. Kardon
    14. Scanning Laser Polarimetry, but Not Optical Coherence Tomography Predicts Permanent Visual Field Loss in Acute Nonarteritic Anterior Ischemic Optic Neuropathy

      Scanning Laser Polarimetry, but Not Optical Coherence Tomography Predicts Permanent Visual Field Loss in Acute Nonarteritic Anterior Ischemic Optic Neuropathy
      ...c Anterior Ischemic Optic Neuropathy 1. Mark J. Kupersmith^1⇑, 2. Susan Anderson^2, 3. Mary Durbin^3 and 4. Randy Kardon^2 1. ^1New York Eye and Ear Infirmary and INN at Roosevelt Hospital, New York, New York 2. ...
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    15. Scanning Laser Polarimetry, but not Optical Coherence Tomography Predicts Permanent Visual Field Loss in Acute Non-Arteritic Anterior Ischemic Optic Neuropathy

      Scanning Laser Polarimetry, but not Optical Coherence Tomography Predicts Permanent Visual Field Loss in Acute Non-Arteritic Anterior Ischemic Optic Neuropathy
      Purpose Scanning laser polarimetry (SLP) reveals abnormal retardance of birefringence in locations of the edematous peripapillary retinal nerve fiber layer (RNFL), which appear thickened by OCT, in non-arteritic anterior ischemic optic neuropathy (NAION). We hypothesize initial sector SLP RNFL abnormalities will correlate with long-term regional visual field loss due to ischemic injury. Methods We prospectively performed automated perimetry, SLP and HD- OCT of the RNFL in 25 eyes with acute ...
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  2. About Randy H. Kardon

    Randy H. Kardon

    Randy Kardon is a professor of ophthalmology and director of the Neuro-Ophthalmology Service in the Carver College of Medicine at the University of Iowa Hospitals and Clinics and Department of Veterans Affiars.

  3. Quotes

    1. It's very user friendly. It gives information that's hard to see on a regular exam because it gives a cross-section of the ocular structures, especially the retina....Different disorders affect different layers of the retina, so it's very useful, not only for making the right diagnosis, but also for following the course of treatment
      In Eye imaging technology catches problems earlier