1. Raja Ramanna Centre for Advanced Technology

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    1. Mentioned In 18 Articles

    2. Feasibility of speckle variance OCT for imaging cutaneous microvasculature regeneration during healing of wounds in diabetic mice

      Feasibility of speckle variance OCT for imaging cutaneous microvasculature regeneration during healing of wounds in diabetic mice
      We report on a study to assess the feasibility of a swept source-based speckle variance optical coherence tomography setup for monitoring cutaneous microvasculature. Punch wounds created in the ear pinnae of diabetic mice were monitored at different times post wounding to assess the structural and vascular changes. It was observed that the epithelium thickness increases post wounding and continues to be thick even after healing. Also, the wound size assessed ...
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    3. Human ex-vivo oral tissue imaging using spectral domain polarization sensitive optical coherence tomography

      Human ex-vivo oral tissue imaging using spectral domain polarization sensitive optical coherence tomography
      We report the use of spectral domain polarization sensitive optical coherence tomography for ex-vivo imaging of human oral mandibular tissue samples. Our results show that compared to the changes observed in the epithelium thickness and the decay constant of A-scan intensity profile, a much larger degree of change was observed in the phase retardation for tissue sites progressing from normal to the malignant state. These results suggest that monitoring of ...
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    4. A dual-modal optical system combining depth-sensitive laser induced fluorescence (LIF) spectroscopy and optical coherence tomography (OCT) for analyzing layered biological tissue

      A dual-modal optical system combining depth-sensitive laser induced fluorescence (LIF) spectroscopy and optical coherence tomography (OCT) for analyzing layered biological tissue
      Background:There is a significant current interest in combining multiple modalities in a single optical system for a more complete characterization of tissue for improved diagnosis. Objective:We report development of a dual-modal optical system combing the depth-sensitive laser induced fluorescence (LIF) spectroscopy and optical coherence tomography (OCT) for analysis of layered biological tissues. Methods:A time-domain, real-time OCT system, assembled in-house, was used as the platform for developing the ...
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    5. Absolute velocity measurement using three-beam spectral-domain Doppler optical coherence tomography

      Absolute velocity measurement using three-beam spectral-domain Doppler optical coherence tomography
      We report the development of a three-beam spectral-domain Doppler optical coherence tomography setup that allows single interferometer-based measurement of absolute flow velocity. The setup makes use of galvo-based phase shifting to remove complex conjugate mirror artifact and a beam displacer in the sample arm to avoid cross talk image. The results show that the developed approach allows efficient utilization of the imaging range of the spectral-domain optical coherence tomography setup ...
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    6. Effect of Intraocular Pressure and Anisotropy on the Optical Properties of the Cornea: A Study Using Polarization Sensitive Optical Coherence Tomography

      Effect of Intraocular Pressure and Anisotropy on the Optical Properties of the Cornea: A Study Using Polarization Sensitive Optical Coherence Tomography
      Purpose: We hypothesize that because of the anisotropic properties of the cornea, there should be a nonuniform change in birefringence with an increase in intraocular pressure (IOP). In this in vitro study, anisotropic properties, stress distribution within the cornea, and the effect of IOP on changes in stress level were investigated. Design: Button inflation tests for deformation with polarization sensitive optical coherence tomography were used to demonstrate optical and material ...
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    7. Imaging of human breast tissue using polarization sensitive optical coherence tomography

      Imaging of human breast tissue using polarization sensitive optical coherence tomography
      Abstract  We report a study on the use of polarization sensitive optical coherence tomography (PSOCT) for discriminating malignant (invasive ductal carcinoma), benign (fibroadenoma) and normal (adipocytes) breast tissue sites. The results show that while conventional OCT, that utilizes only the intensity of light back-scattered from tissue microstructures, is able to discriminate breast tissues as normal (adipocytes) and abnormal (malignant and benign) tissues, PS-OCT helps in discriminating between malignant and benign ...
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    8. Noninvasive imaging of ethanol-induced developmental defects in zebrafish embryos using optical coherence tomography

      Noninvasive imaging of ethanol-induced developmental defects in zebrafish embryos using optical coherence tomography
      In this article, we report the use of optical coherence tomography for noninvasive cross-sectional real-time imaging of ethanol-induced developmental defects in zebrafish embryos larvae. For ethanol concentration of over 300 mM, developmental defects of eye (shrinkage and retinal abnormalities), malformation of the notochord and ataxia arising due to the toxic effects of ethanol were observed in OCT images from 3 days post fertilization onwards. The results suggest that OCT could ...
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    9. Use of common path phase sensitive spectral domain optical coherence tomography for refractive index measurements

      Use of common path phase sensitive spectral domain optical coherence tomography for refractive index measurements
      We report the use of a common path phase sensitive spectral domain optical coherence tomography setup for the measurement of the refractive index (RI) of a biomimetic material (glucose solution in water having intralipid as the scattering medium) and a single biological cell (keratinocyte). The RI of glucose solutions could be measured with a precision of ∼0.00015, which corresponds to a precision of ∼2 nm in the optical path ...
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    10. Feature Of The Week 4/11/10: Noninvasive Assessment of Healing of Bacteria Infected and Uninfected Wounds using Optical Coherence Tomography

      Feature Of The Week 4/11/10: Noninvasive Assessment of Healing of Bacteria Infected and Uninfected Wounds using Optical Coherence Tomography
      ...-resolution cross-sectional images of tissues with considerable penetration depth (1-2 mm). Researchers at Raja Ramanna Centre for Advanced Technology, Indore, India, have recently used Polarization-sensitive OCT to m...
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    11. Non-invasive assessment of healing of bacteria infected and uninfected wounds using optical coherence tomography

      Non-invasive assessment of healing of bacteria infected and uninfected wounds using optical coherence tomography
      Bacterial infection is one of the main predisposing factors for the delay in wound healing. To facilitate a timely decision for correct therapy, it is important to accurately monitor the morphological changes in the infected wounds using noninvasive tools. In the present study, we have explored the use of optical coherence tomography (OCT) for monitoring the healing of superficial wounds infected with Staphylococcus aureus in mice under in vitro and ...
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    12. Real-time in vivo imaging of adult Zebrafish brain using optical coherence tomography

      Real-time in vivo imaging of adult Zebrafish brain using optical coherence tomography
      We report noninvasive imaging of the brain of adult Zebrafish (Danio rerio) using real time optical coherence tomography (OCT) capable of acquiring cross sectional 2D OCT images @ 8 frames/sec. Anatomic features such as telencephalon, tectum opticum, eminentia Granularis and cerebellum were clearly resolved in the OCT images. A 3D model of Zebrafish brain was reconstructed, for the first time to our knowledge, using these 2D OCT images.
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    13. 1-15 of 18 1 2 »
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  2. About Raja Ramanna Centre for Advanced Technology

    Raja Ramanna Centre for Advanced Technology

    Raja Ramanna Centre for Advanced Technology is a unit of Department of Atomic Energy, Government of India, engaged in R & D in non-nuclear front line research areas of Lasers, Particle Accelerators & related technologies