1. Rainer A. Leitgeb

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    1. Mentioned In 100 Articles

    2. En face optical coherence tomography: a technology review [Invited]

      En face optical coherence tomography: a technology review [Invited]
      A review on the technological development of en face optical coherence tomography (OCT) and optical coherence microscopy (OCM) is provided. The terminology originally referred to time domain OCT, where the preferential scanning was performed in the en face plane. Potentially the fastest realization of en face image recording is full-field OCT, where the full en face plane is illuminated and recorded simultaneously. The term has nowadays been adopted for high-speed ...
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    3. Synthetic subaperture-based angle-independent Doppler flow measurements using single-beam line field optical coherence tomography in vivo

      Synthetic subaperture-based angle-independent Doppler flow measurements using single-beam line field optical coherence tomography in vivo
      We demonstrate a synthetic subaperture-based angle-independent Doppler flow calculation, using a line field spectral domain optical coherence tomography system. The high speed of the system features a high phase stability over the volume, which is necessary to apply synthetic subapertures in the aperture plane. Thus, the flow component for each subaperture can be reconstructed in postprocessing. Capillary phantom and in vivo retinal imaging experiments were performed to validate and demonstrate ...
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    4. Numerically focused full-field swept-source optical coherence microscopy with structured illumination

      Numerically focused full-field swept-source optical coherence microscopy with structured illumination
      This paper presents an experimental investigation of the possibility of transverse resolution improvement combined with effective numerically focused 3D imaging in full-field swept-source optical coherence microscopy (OCM) by using structured illumination and specific numerical post-processing. The possibility of transverse resolution improvement of the OCM coherence signal combined with the possibility of numerical focusing is demonstrated by imaging a resolution test target in the optical focus and defocus regions. The possibility ...
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    5. Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

      Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer
      We present a combination of optical coherence tomography (OCT) and Raman spectroscopy (RS) for improved diagnosis and discrimination of different stages and grades of bladder cancer ex vivo by linking the complementary information provided by these two techniques. Bladder samples were obtained from biopsies dissected via transurethral resection of the bladder tumor (TURBT). As OCT provides structural information rapidly, it was used as a red-flag technology to scan the bladder ...
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    6. Multimodal Optical Medical Imaging Concepts based on Optical Coherence Tomography

      Multimodal Optical Medical Imaging Concepts based on Optical Coherence Tomography
      Optical medical imaging techniques in general exhibit outstanding resolution and molecule-specific contrast. They come however with a limited penetration in depth and small field of view. Multimodal concepts help to combine complementary strengths of different imaging technologies. The present article reviews the advantages of optical multimodal imaging concepts using optical coherence tomography (OCT) as core technology. In particular we first discuss polarization sensitive OCT, Doppler OCT and OCT angiography, OCT ...
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    7. Feature Of The Week 07/01/2018: Endoscopic Optical Coherence Tomography with a Flexible Fiber Bundle

      Feature Of The Week 07/01/2018: Endoscopic Optical Coherence Tomography with a Flexible Fiber Bundle
      We demonstrate in vivo endoscopic optical coherence tomography (OCT) imaging in the forward direction using a flexible fiber bundle (FB). In comparison to current conventional forward-looking probe schemes, our approach simplifies the endoscope design by avoiding the integration of any beam steering components in the distal probe end due to two-dimensional scanning of a focused light beam over the proximal FB surface. We describe the challenges that arise when OCT ...
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    8. Endoscopic optical coherence tomography with a flexible fiber bundle

      Endoscopic optical coherence tomography with a flexible fiber bundle
      We demonstrate in vivo endoscopic optical coherence tomography (OCT) imaging in the forward direction using a flexible fiber bundle (FB). In comparison to current conventional forward-looking probe schemes, our approach simplifies the endoscope design by avoiding the integration of any beam steering components in the distal probe end due to two-dimensional scanning of a focused light beam over the proximal FB surface. We describe the challenges that arise when OCT ...
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    9. Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye

      Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye
      Imaging of the human retina with high resolution is an essential step towards improved diagnosis and treatment control. In this paper, we introduce a compact, clinically user-friendly instrument based on swept source optical coherence tomography (SS-OCT). A key feature of the system is the realization of two different operation modes. The first operation mode is similar to conventional OCT imaging and provides large field of view (FoV) images (up to ...
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    10. Endoscopic optical coherence tomography with a flexible fiber bundle

      Endoscopic optical coherence tomography with a flexible fiber bundle
      We demonstrate in vivo endoscopic optical coherence tomography (OCT) imaging in the forward direction using a flexible fiber bundle. In comparison to current conventional forward looking probe schemes, our approach simplifies the endoscope design by avoiding the integration of any beam steering components in the distal probe end due to 2D scanning of a focused light beam over the proximal fiber bundle surface. We describe the challenges that arise when ...
      Read Full Article
    11. Holographic line field en-face OCT with digital adaptive optics in the retina in vivo

      Holographic line field en-face OCT with digital adaptive optics in the retina in vivo
      We demonstrate a high-resolution line field en-face time domain optical coherence tomography (OCT) system using an off-axis holography configuration. Line field en-face OCT produces high speed en-face images at rates of up to 100 Hz. The high frame rate favors good phase stability across the lateral field-of-view which is indispensable for digital adaptive optics (DAO). Human retinal structures are acquired in-vivo with a broadband light source at 840 nm, and ...
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    12. Non-invasive multimodal optical coherence and photoacoustic tomography for human skin imaging

      Non-invasive multimodal optical coherence and photoacoustic tomography for human skin imaging
      The cutaneous vasculature is involved in many diseases. Current clinical examination techniques, however, cannot resolve the human vasculature with all plexus in a non-invasive manner. By combining an optical coherence tomography system with angiography extension and an all optical photoacoustic tomography system, we can resolve in 3D the blood vessels in human skin for all plexus non-invasively. With a customized imaging unit that permits access to various parts of patients ...
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    13. Noniterative digital aberration correction for cellular resolution retinal optical coherence tomography in vivo

      Noniterative digital aberration correction for cellular resolution retinal optical coherence tomography in vivo
      .... Visual Sci. 52, 3908–3913 (2011). [Crossref] L. Ginner, C. Blatter, D. Fechtig, T. Schmoll, M. Gröschl, and R. A. Leitgeb, “Wide-field OCT angiography at 400 KHz utilizing spectral splitting,” Photonics 1, 369–379 (201...
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    14. Twenty-five years of optical coherence tomography: the paradigm shift in sensitivity and speed provided by Fourier domain OCT

      Twenty-five years of optical coherence tomography: the paradigm shift in sensitivity and speed provided by Fourier domain OCT
      Optical coherence tomography (OCT) has become one of the most successful optical technologies implemented in medicine and clinical practice mostly due to the possibility of non-invasive and non-contact imaging by detecting back-scattered light. OCT has gone through a tremendous development over the past 25 years. From its initial inception in 1991 [Science 254 , 1178 (1991)] it has become an indispensable medical imaging technology in ophthalmology. Also in fields like cardiology ...
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    15. Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics

      Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics
      The purpose of this work is to investigate the benefits of adaptive optics (AO) technology for optical coherence tomography angiography (OCTA). OCTA has shown great potential in non-invasively enhancing the contrast of vessels and small capillaries. Especially the capability of the technique to visualize capillaries with a lateral extension that is below the transverse resolution of the system opens unique opportunities in diagnosing retinal vascular diseases. However, there are some ...
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    16. Comparative study between a spectral domain and a high-speed single-beam swept source OCTA system for identifying choroidal neovascularization in AMD

      Comparative study between a spectral domain and a high-speed single-beam swept source OCTA system for identifying choroidal neovascularization in AMD
      This comparative study between a SD- and SS-OCTA system for visualizing neovascular patterns in AMD, also assessed the influence of cataract on OCTA imaging. 25 eyes with active CNV (AMD) were documented by FA, ICGA and SD-OCT. Two OCTA devices were used: A custom built SS-OCTA (1050nm, 400,000 A-scans/s, 55mm, no image segmentation); AngioVue (OptoVue, CA, USA) SD-OCTA (840nm, 70.000 A-scans/s, 33mm, SSADA technology). Two retina ...
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  2. About Rainer A. Leitgeb

    Rainer A. Leitgeb

    Rainer Andreas Leitgeb is at the Center of Biomedical Engineering and Physics at the Medical University of Vienna, Vienna, Austria. Dr. Leitgeb is a physicist specializing in coherent imaging techniques and advanced microscopy. He researches modern techniques of Doppler tomography and is actively working in the functional imaging of tissue physiology.

  3. Quotes

    1. The condition of the vascular network carries important information on tissue health and its nutrition...Currently, the value of this information is not utilized to its full extent.
      In Tissues Tell the Tale: Non-Invasive Optical Technique Detects Cancer By Looking Under the Skin