1. Rainer A. Leitgeb

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    1. Mentioned In 109 Articles

    2. Ultra-high-resolution 3D optical coherence tomography reveals inner structures of human placenta-derived trophoblast organoids

      Explore IEEE Xplore
      Ultra-high-resolution 3D optical coherence tomography reveals inner structures of human placenta-derived trophoblast organoids
      Objective: 3D optical coherence tomography (OCT) is used for analyses of human placenta organoids in situ without sample preparation. Methods: The trophoblast organoids analyzed were derived from primary human trophoblast. In this study a custom made ultra-high-resolution spectral domain OCT system with uniform spatial and axial resolution of 2.48 m in organoid tissue was used. The obtained OCT results align to differentiation status tested via quantitative polymerase chain reaction ...
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      Mentions: Rainer A. Leitgeb Wolfgang Drexler Medical University of Vienna

    3. Ex-vivo Alzheimer’s disease brain tissue investigation: a multiscale approach using 1060-nm swept source optical coherence tomography for a direct correlation to histology

      Explore SPIE Digital Library Neurology
      Ex-vivo Alzheimer’s disease brain tissue investigation: a multiscale approach using 1060-nm swept source optical coherence tomography for a direct correlation to histology
      Significance: Amyloid-beta (A-) plaques are pathological protein deposits formed in the brain of Alzheimers disease (AD) patients upon disease progression. Further research is needed to elucidate the complex underlying mechanisms involved in their formation using label-free, tissue preserving, and volumetric techniques. Aim: The aim is to achieve a one-to-one correlation of optical coherence tomography (OCT) data to histological micrographs of brain tissue using 1060-nm swept source OCT. Approach: A- plaques ...
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      Mentions: Rainer A. Leitgeb Wolfgang Drexler Medical University of Vienna

    4. Ultra-high-resolution SD-OCM imaging with a compact polarization-aligned 840 nm broadband combined-SLED source

      Explore OSA | OSA Publishing
      Ultra-high-resolution SD-OCM imaging with a compact polarization-aligned 840 nm broadband combined-SLED source
      We analyze the influence of intrinsic polarization alignment on image quality and axial resolution employing a broadband 840nm light source with an optical bandwidth of 160nm and an output power of 12mW tailored for spectral-domain optical coherence microscopy (SD-OCM) applications. Three superluminescent diodes (SLEDs) are integrated into a 14-pin butterfly module using a free-space micro-optical bench architecture, maintaining a constant polarization state across the full spectral output. We demonstrate superior ...
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      Mentions: Rainer A. Leitgeb Wolfgang Drexler Exalos

    5. Taking the Pulse of the Eyes: OCT Measures the Mechanics of Eyes in Response to Heartbeats

      Explore Home: SPIE.org Ophthalmology
      Taking the Pulse of the Eyes: OCT Measures the Mechanics of Eyes in Response to Heartbeats
      Life is measured in heartbeats, so they sayand heartbeats may soon help measure the health of our eyes. If doctors can measure pulse in the eye to diagnose corneal pathologies, the results may save vision and may also save lives. Every heartbeat sends a pulse wave of blood, inducing very small yet measurable changes in the eye volume, with a resultant momentary increase in intraocular pressure. Working from the postulate ...
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      Mentions: Rainer A. Leitgeb Kirill V. Larin Medical University of Vienna

    6. Functional optical coherence tomography and photoacoustic microscopy imaging for zebrafish larvae

      Explore OSA | OSA Publishing Developmental Biology
      Functional optical coherence tomography and photoacoustic microscopy imaging for zebrafish larvae
      We present a dual modality functional optical coherence tomography and photoacoustic microscopy (OCT-PAM) system. The photoacoustic modality employs an akinetic optical sensor with a large imaging window. This imaging window enables direct reflection mode operation, and a seamless integration of optical coherence tomography (OCT) as a second imaging modality. Functional extensions to the OCT-PAM system include Doppler OCT (DOCT) and spectroscopic PAM (sPAM). This functional and non-invasive imaging system is ...
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      Mentions: Rainer A. Leitgeb Wolfgang Drexler Medical University of Vienna

    7. Changes in Retinal Blood Flow in Response to an Experimental Increase in IOP in Healthy Participants as Assessed With Doppler Optical Coherence Tomography

      Explore IOVS Journal Ophthalmology
      Changes in Retinal Blood Flow in Response to an Experimental Increase in IOP in Healthy Participants as Assessed With Doppler Optical Coherence Tomography
      Purpose : Blood flow autoregulation is an intrinsic mechanism of the healthy retinal vasculature to keep blood flow constant when ocular perfusion pressure (OPP) is changed. In the present study, we set out to investigate retinal blood flow in response to an experimental decrease in OPP in healthy participants using Doppler optical coherence tomography. Methods : Fifteen healthy participants aged between 22 and 31 years (mean, 27 3 years) were included in ...
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      Mentions: Rainer A. Leitgeb Medical University of Vienna Singapore Eye Research Institute

    8. Post Doc Position for Optical Coherence Tomography at the Medical University Vienna

      Explore Optical Coherence Tomography News Jobs & Studentships
      Post Doc Position for Optical Coherence Tomography at the Medical University Vienna
      A PostDoc position is available from March 1, 2020 at the Center for Medical Physics and Biomedical Engineering, Medical University of Vienna. We offer a research position in the field of biomedical imaging with strong interdisciplinary collaboration. Our research group is developing novel coherent biomedical imaging methods based on parallel OCT and digital adaptive optics to overcome the conventional resolution limits and to pave the way from pure structural to ...
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      Mentions: Rainer A. Leitgeb Medical University of Vienna

    9. Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscop

      Explore RSC Publishing Home Urology
      Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscop
      Non-muscle-invasive bladder cancer affects millions of people worldwide, resulting in significant discomfort to the patient and potential death. Today, cystoscopy is the gold standard for bladder cancer assessment, using white light endoscopy to detect tumor suspected lesion areas, followed by resection of these areas and subsequent histopathological evaluation. Not only does the pathological examination take days, but due to the invasive nature, the performed biopsy can result in significant harm ...
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      Mentions: Rainer A. Leitgeb Wolfgang Drexler Peter E. Andersen

    10. Comparison of optical coherence tomography angiography and narrow-band imaging using a bimodal endoscope

      Explore SPIE Digital Library Gastroenterology , Probes
      Comparison of optical coherence tomography angiography and narrow-band imaging using a bimodal endoscope
      We present coregistered images of tissue vasculature that allow a direct comparison between the performance of narrow-band imaging (NBI) and optical coherence tomography angiography (OCTA). Images were generated with a bimodal endomicroscope having a size of 152.43.3mm 3 ( l , w , h ) that combines two imaging channels. The white light imaging channel was used to perform NBI, the current gold standard for endoscopic visualization of vessels. The second channel ...
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      Mentions: Rainer A. Leitgeb Wolfgang Drexler Medical University of Vienna

    11. En face optical coherence tomography: a technology review [Invited]

      Explore OSA | OSA Publishing Microscopy
      En face optical coherence tomography: a technology review [Invited]
      A review on the technological development of en face optical coherence tomography (OCT) and optical coherence microscopy (OCM) is provided. The terminology originally referred to time domain OCT, where the preferential scanning was performed in the en face plane. Potentially the fastest realization of en face image recording is full-field OCT, where the full en face plane is illuminated and recorded simultaneously. The term has nowadays been adopted for high-speed ...
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      Mentions: Rainer A. Leitgeb Medical University of Vienna

    12. Synthetic subaperture-based angle-independent Doppler flow measurements using single-beam line field optical coherence tomography in vivo

      Explore OSA | OSA Publishing
      Synthetic subaperture-based angle-independent Doppler flow measurements using single-beam line field optical coherence tomography in vivo
      We demonstrate a synthetic subaperture-based angle-independent Doppler flow calculation, using a line field spectral domain optical coherence tomography system. The high speed of the system features a high phase stability over the volume, which is necessary to apply synthetic subapertures in the aperture plane. Thus, the flow component for each subaperture can be reconstructed in postprocessing. Capillary phantom and in vivo retinal imaging experiments were performed to validate and demonstrate ...
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      Mentions: Rainer A. Leitgeb Medical University of Vienna Lara M. Wurster

    13. Numerically focused full-field swept-source optical coherence microscopy with structured illumination

      Explore OSA | OSA Publishing
      Numerically focused full-field swept-source optical coherence microscopy with structured illumination
      This paper presents an experimental investigation of the possibility of transverse resolution improvement combined with effective numerically focused 3D imaging in full-field swept-source optical coherence microscopy (OCM) by using structured illumination and specific numerical post-processing. The possibility of transverse resolution improvement of the OCM coherence signal combined with the possibility of numerical focusing is demonstrated by imaging a resolution test target in the optical focus and defocus regions. The possibility ...
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      Mentions: Rainer A. Leitgeb Medical University of Vienna

    14. Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

      Explore MDPI Open Access Journals Platform Oncology , Urology
      Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer
      We present a combination of optical coherence tomography (OCT) and Raman spectroscopy (RS) for improved diagnosis and discrimination of different stages and grades of bladder cancer ex vivo by linking the complementary information provided by these two techniques. Bladder samples were obtained from biopsies dissected via transurethral resection of the bladder tumor (TURBT). As OCT provides structural information rapidly, it was used as a red-flag technology to scan the bladder ...
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      Mentions: Rainer A. Leitgeb Wolfgang Drexler Medical University of Vienna

    15. Multimodal Optical Medical Imaging Concepts based on Optical Coherence Tomography

      Explore Frontiers
      Multimodal Optical Medical Imaging Concepts based on Optical Coherence Tomography
      Optical medical imaging techniques in general exhibit outstanding resolution and molecule-specific contrast. They come however with a limited penetration in depth and small field of view. Multimodal concepts help to combine complementary strengths of different imaging technologies. The present article reviews the advantages of optical multimodal imaging concepts using optical coherence tomography (OCT) as core technology. In particular we first discuss polarization sensitive OCT, Doppler OCT and OCT angiography, OCT ...
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      Mentions: Rainer A. Leitgeb Medical University of Vienna Bernhard Baumann

    16. Feature Of The Week 07/01/2018: Endoscopic Optical Coherence Tomography with a Flexible Fiber Bundle

      Explore Optical Coherence Tomography News
      Feature Of The Week 07/01/2018: Endoscopic Optical Coherence Tomography with a Flexible Fiber Bundle
      We demonstrate in vivo endoscopic optical coherence tomography (OCT) imaging in the forward direction using a flexible fiber bundle (FB). In comparison to current conventional forward-looking probe schemes, our approach simplifies the endoscope design by avoiding the integration of any beam steering components in the distal probe end due to two-dimensional scanning of a focused light beam over the proximal FB surface. We describe the challenges that arise when OCT ...
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      Mentions: Rainer A. Leitgeb Medical University of Vienna Abhishek Kumar
    17. 1-15 of 109 1 2 3 4 5 6 7 8 »
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  4. About Rainer A. Leitgeb

    Rainer A. Leitgeb

    Rainer Andreas Leitgeb is at the Center of Biomedical Engineering and Physics at the Medical University of Vienna, Vienna, Austria. Dr. Leitgeb is a physicist specializing in coherent imaging techniques and advanced microscopy. He researches modern techniques of Doppler tomography and is actively working in the functional imaging of tissue physiology.

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  6. Quotes

    1. The condition of the vascular network carries important information on tissue health and its nutrition...Currently, the value of this information is not utilized to its full extent.
      In Tissues Tell the Tale: Non-Invasive Optical Technique Detects Cancer By Looking Under the Skin