1. Rainer A. Leitgeb

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    1. Mentioned In 89 Articles

    2. Noniterative digital aberration correction for cellular resolution retinal optical coherence tomography in vivo

      Noniterative digital aberration correction for cellular resolution retinal optical coherence tomography in vivo
      .... Visual Sci. 52, 3908–3913 (2011). [Crossref] L. Ginner, C. Blatter, D. Fechtig, T. Schmoll, M. Gröschl, and R. A. Leitgeb, “Wide-field OCT angiography at 400 KHz utilizing spectral splitting,” Photonics 1, 369–379 (201...
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    3. Twenty-five years of optical coherence tomography: the paradigm shift in sensitivity and speed provided by Fourier domain OCT

      Twenty-five years of optical coherence tomography: the paradigm shift in sensitivity and speed provided by Fourier domain OCT
      Optical coherence tomography (OCT) has become one of the most successful optical technologies implemented in medicine and clinical practice mostly due to the possibility of non-invasive and non-contact imaging by detecting back-scattered light. OCT has gone through a tremendous development over the past 25 years. From its initial inception in 1991 [Science 254 , 1178 (1991)] it has become an indispensable medical imaging technology in ophthalmology. Also in fields like cardiology ...
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    4. Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics

      Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics
      The purpose of this work is to investigate the benefits of adaptive optics (AO) technology for optical coherence tomography angiography (OCTA). OCTA has shown great potential in non-invasively enhancing the contrast of vessels and small capillaries. Especially the capability of the technique to visualize capillaries with a lateral extension that is below the transverse resolution of the system opens unique opportunities in diagnosing retinal vascular diseases. However, there are some ...
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    5. Comparative study between a spectral domain and a high-speed single-beam swept source OCTA system for identifying choroidal neovascularization in AMD

      Comparative study between a spectral domain and a high-speed single-beam swept source OCTA system for identifying choroidal neovascularization in AMD
      This comparative study between a SD- and SS-OCTA system for visualizing neovascular patterns in AMD, also assessed the influence of cataract on OCTA imaging. 25 eyes with active CNV (AMD) were documented by FA, ICGA and SD-OCT. Two OCTA devices were used: A custom built SS-OCTA (1050nm, 400,000 A-scans/s, 55mm, no image segmentation); AngioVue (OptoVue, CA, USA) SD-OCTA (840nm, 70.000 A-scans/s, 33mm, SSADA technology). Two retina ...
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    6. Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography

      Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography
      Studies have proven the relationship between cutaneous vasculature abnormalities and dermatological disorders, but to image vasculature noninvasively in vivo , advanced optical imaging techniques are required. In this study, we imaged a palm of a healthy volunteer and three subjects with cutaneous abnormalities with photoacoustic tomography (PAT) and optical coherence tomography with angiography extension (OCTA). Capillaries in the papillary dermis that are too small to be discerned with PAT are visualized ...
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    7. Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging

      Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging
      Cutaneous blood flow accounts for approximately 5% of cardiac output in human and plays a key role in a number of a physiological and pathological processes. We show for the first time a multi-modal photoacoustic tomography (PAT), optical coherence tomography (OCT) and OCT angiography system with an articulated probe to extract human cutaneous vasculature in vivo in various skin regions. OCT angiography supplements the microvasculature which PAT alone is unable ...
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    8. Key Developments for Partial Coherence Biometry and Optical Coherence Tomography in the Human Eye Made in Vienna

      Key Developments for Partial Coherence Biometry and Optical Coherence Tomography in the Human Eye Made in Vienna
      Purpose : To describe key developments of optical biometry and optical coherence tomography (OCT) for ophthalmic applications made by one of the pioneering research groups. Methods : Partial coherence interferometry (PCI) as the basic ranging technology for modern optical biometry and for OCT was introduced for biomedical applications in the 1980s. Later, Fourier domain (FD) OCT was introduced and demonstrated to provide superior sensitivity as compared to time domain OCT. Further developments ...
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    9. Systems and methods for sub-aperture based aberration measurement and correction in interferometric imaging

      Systems and methods for sub-aperture based aberration measurement and correction in interferometric imaging
      Systems and methods for sub-aperture correlation based wavefront measurement in a thick sample and correction as a post processing technique for interferometric imaging to achieve near diffraction limited resolution are described. Theory, simulation and experimental results are presented for the case of full field interference microscopy. The inventive technique can be applied to any coherent interferometric imaging technique and does not require knowledge of any system parameters. In one embodiment ...
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    10. Line-field parallel swept source interferometric imaging at up to 1  MHz

      Line-field parallel swept source interferometric imaging at up to 1  MHz
      We present a novel medical imaging modality based on optical coherence tomography (OCT) that enables in vivo 3D tomography at acquisition rates up to 1 MHz. Line field parallel swept source interferometric imaging (LPSI) combines line-field swept source OCT with modulation of the interferometric signal in spatial direction for full range imaging. This method enables high speed imaging with cost-effective and commercially available technology. We explain the realization of the ...
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    11. Systems and methods for bidirectional functional optical coherence tomography

      Systems and methods for bidirectional functional optical coherence tomography
      Methods for determining improving quantitative and qualitative motion contrast information collected with optical coherence tomography (OCT) data are presented. In one embodiment, flow within a cross-sectional area of a sample is calculated independent of the Doppler and en face angles using a bidirectional OCT system. In another embodiment, motion contrast images are improved by averaging motion contrast information collected from a bidirectional OCT system.
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    12. 1-15 of 89 1 2 3 4 5 6 »
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  2. About Rainer A. Leitgeb

    Rainer A. Leitgeb

    Rainer Andreas Leitgeb is at the Center of Biomedical Engineering and Physics at the Medical University of Vienna, Vienna, Austria. Dr. Leitgeb is a physicist specializing in coherent imaging techniques and advanced microscopy. He researches modern techniques of Doppler tomography and is actively working in the functional imaging of tissue physiology.

  3. Quotes

    1. The condition of the vascular network carries important information on tissue health and its nutrition...Currently, the value of this information is not utilized to its full extent.
      In Tissues Tell the Tale: Non-Invasive Optical Technique Detects Cancer By Looking Under the Skin