Articles that mention Rainer A. Leitgeb -Optical Coherence Tomography News

Rainer A. Leitgeb

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1. Mentioned In 111 Articles
2. Towards ultrahigh resolution OCT based endoscopical pituitary gland and adenoma screening: a performance parameter evaluation
  
  Explore OSA | OSA Publishing Jan 9 2021
  
  Ultrahigh resolution optical coherence tomography (UHR-OCT) for differentiating pituitary gland versus adenoma tissue has been investigated for the first time, indicating more than 80% accuracy. For biomarker identification, OCT images of paraffin embedded tissue are correlated to histopathological slices. The identified biomarkers are verified on fresh biopsies. Additionally, an approach, based on resolution modified UHR-OCT ex vivo data, investigating optical performance parameters for the realization in an in vivo endoscope ...
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  Mentions: Rainer A. Leitgeb Wolfgang Drexler Medical University of Vienna
3. Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings
  
  Explore Nature Publishing Group Jan 6 2021 Ophthalmology
  
  In this work, we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated chip. The diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide grating. Two arrayed waveguide grating designs with 256 channels were tested, which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal measurements. Design ...
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  Mentions: Rainer A. Leitgeb Wolfgang Drexler Medical University of Vienna
4. Ultra-high-resolution 3D optical coherence tomography reveals inner structures of human placenta-derived trophoblast organoids
  
  Explore IEEE Xplore Nov 19 2020
  
  Objective: 3D optical coherence tomography (OCT) is used for analyses of human placenta organoids in situ without sample preparation. Methods: The trophoblast organoids analyzed were derived from primary human trophoblast. In this study a custom made ultra-high-resolution spectral domain OCT system with uniform spatial and axial resolution of 2.48 m in organoid tissue was used. The obtained OCT results align to differentiation status tested via quantitative polymerase chain reaction ...
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  Mentions: Rainer A. Leitgeb Wolfgang Drexler Medical University of Vienna
5. Ex-vivo Alzheimer’s disease brain tissue investigation: a multiscale approach using 1060-nm swept source optical coherence tomography for a direct correlation to histology
  
  Explore SPIE Digital Library Aug 29 2020 Neurology
  
  Significance: Amyloid-beta (A-) plaques are pathological protein deposits formed in the brain of Alzheimers disease (AD) patients upon disease progression. Further research is needed to elucidate the complex underlying mechanisms involved in their formation using label-free, tissue preserving, and volumetric techniques. Aim: The aim is to achieve a one-to-one correlation of optical coherence tomography (OCT) data to histological micrographs of brain tissue using 1060-nm swept source OCT. Approach: A- plaques ...
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  Mentions: Rainer A. Leitgeb Wolfgang Drexler Medical University of Vienna
6. Ultra-high-resolution SD-OCM imaging with a compact polarization-aligned 840 nm broadband combined-SLED source
  
  Explore OSA | OSA Publishing Jun 5 2020
  
  We analyze the influence of intrinsic polarization alignment on image quality and axial resolution employing a broadband 840nm light source with an optical bandwidth of 160nm and an output power of 12mW tailored for spectral-domain optical coherence microscopy (SD-OCM) applications. Three superluminescent diodes (SLEDs) are integrated into a 14-pin butterfly module using a free-space micro-optical bench architecture, maintaining a constant polarization state across the full spectral output. We demonstrate superior ...
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  Mentions: Rainer A. Leitgeb Wolfgang Drexler Exalos
7. Taking the Pulse of the Eyes: OCT Measures the Mechanics of Eyes in Response to Heartbeats
  
  Explore Home: SPIE.org May 7 2020 Ophthalmology
  
  Life is measured in heartbeats, so they sayand heartbeats may soon help measure the health of our eyes. If doctors can measure pulse in the eye to diagnose corneal pathologies, the results may save vision and may also save lives. Every heartbeat sends a pulse wave of blood, inducing very small yet measurable changes in the eye volume, with a resultant momentary increase in intraocular pressure. Working from the postulate ...
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  Mentions: Rainer A. Leitgeb Kirill V. Larin Medical University of Vienna
8. Functional optical coherence tomography and photoacoustic microscopy imaging for zebrafish larvae
  
  Explore OSA | OSA Publishing Mar 28 2020 Developmental Biology
  
  We present a dual modality functional optical coherence tomography and photoacoustic microscopy (OCT-PAM) system. The photoacoustic modality employs an akinetic optical sensor with a large imaging window. This imaging window enables direct reflection mode operation, and a seamless integration of optical coherence tomography (OCT) as a second imaging modality. Functional extensions to the OCT-PAM system include Doppler OCT (DOCT) and spectroscopic PAM (sPAM). This functional and non-invasive imaging system is ...
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  Mentions: Rainer A. Leitgeb Wolfgang Drexler Medical University of Vienna
9. Changes in Retinal Blood Flow in Response to an Experimental Increase in IOP in Healthy Participants as Assessed With Doppler Optical Coherence Tomography
  
  Explore IOVS Journal Feb 26 2020 Ophthalmology
  
  Purpose : Blood flow autoregulation is an intrinsic mechanism of the healthy retinal vasculature to keep blood flow constant when ocular perfusion pressure (OPP) is changed. In the present study, we set out to investigate retinal blood flow in response to an experimental decrease in OPP in healthy participants using Doppler optical coherence tomography. Methods : Fifteen healthy participants aged between 22 and 31 years (mean, 27 3 years) were included in ...
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  Mentions: Rainer A. Leitgeb Medical University of Vienna Singapore Eye Research Institute
10. Post Doc Position for Optical Coherence Tomography at the Medical University Vienna
  
  Explore Optical Coherence Tomography News Feb 16 2020 Jobs & Studentships
  
  A PostDoc position is available from March 1, 2020 at the Center for Medical Physics and Biomedical Engineering, Medical University of Vienna. We offer a research position in the field of biomedical imaging with strong interdisciplinary collaboration. Our research group is developing novel coherent biomedical imaging methods based on parallel OCT and digital adaptive optics to overcome the conventional resolution limits and to pave the way from pure structural to ...
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  Mentions: Rainer A. Leitgeb Medical University of Vienna
11. Morpho-molecular ex vivo detection and grading of non-muscle-invasive bladder cancer using forward imaging probe based multimodal optical coherence tomography and Raman spectroscop
  
  Explore RSC Publishing Home Feb 6 2020 Urology
  
  Non-muscle-invasive bladder cancer affects millions of people worldwide, resulting in significant discomfort to the patient and potential death. Today, cystoscopy is the gold standard for bladder cancer assessment, using white light endoscopy to detect tumor suspected lesion areas, followed by resection of these areas and subsequent histopathological evaluation. Not only does the pathological examination take days, but due to the invasive nature, the performed biopsy can result in significant harm ...
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  Mentions: Rainer A. Leitgeb Wolfgang Drexler Peter E. Andersen
12. Comparison of optical coherence tomography angiography and narrow-band imaging using a bimodal endoscope
  
  Explore SPIE Digital Library Oct 1 2019 Gastroenterology , Probes
  
  We present coregistered images of tissue vasculature that allow a direct comparison between the performance of narrow-band imaging (NBI) and optical coherence tomography angiography (OCTA). Images were generated with a bimodal endomicroscope having a size of 152.43.3mm 3 ( l , w , h ) that combines two imaging channels. The white light imaging channel was used to perform NBI, the current gold standard for endoscopic visualization of vessels. The second channel ...
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  Mentions: Rainer A. Leitgeb Wolfgang Drexler Medical University of Vienna
13. En face optical coherence tomography: a technology review [Invited]
  
  Explore OSA | OSA Publishing Apr 9 2019 Microscopy
  
  A review on the technological development of en face optical coherence tomography (OCT) and optical coherence microscopy (OCM) is provided. The terminology originally referred to time domain OCT, where the preferential scanning was performed in the en face plane. Potentially the fastest realization of en face image recording is full-field OCT, where the full en face plane is illuminated and recorded simultaneously. The term has nowadays been adopted for high-speed ...
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  Mentions: Rainer A. Leitgeb Medical University of Vienna
14. Synthetic subaperture-based angle-independent Doppler flow measurements using single-beam line field optical coherence tomography in vivo
  
  Explore OSA | OSA Publishing Feb 13 2019
  
  We demonstrate a synthetic subaperture-based angle-independent Doppler flow calculation, using a line field spectral domain optical coherence tomography system. The high speed of the system features a high phase stability over the volume, which is necessary to apply synthetic subapertures in the aperture plane. Thus, the flow component for each subaperture can be reconstructed in postprocessing. Capillary phantom and in vivo retinal imaging experiments were performed to validate and demonstrate ...
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  Mentions: Rainer A. Leitgeb Medical University of Vienna Lara M. Wurster
15. Numerically focused full-field swept-source optical coherence microscopy with structured illumination
  
  Explore OSA | OSA Publishing Dec 19 2018
  
  This paper presents an experimental investigation of the possibility of transverse resolution improvement combined with effective numerically focused 3D imaging in full-field swept-source optical coherence microscopy (OCM) by using structured illumination and specific numerical post-processing. The possibility of transverse resolution improvement of the OCM coherence signal combined with the possibility of numerical focusing is demonstrated by imaging a resolution test target in the optical focus and defocus regions. The possibility ...
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  Mentions: Rainer A. Leitgeb Medical University of Vienna
16. Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer
  
  Explore MDPI Open Access Journals Platform Nov 23 2018 Oncology , Urology
  
  We present a combination of optical coherence tomography (OCT) and Raman spectroscopy (RS) for improved diagnosis and discrimination of different stages and grades of bladder cancer ex vivo by linking the complementary information provided by these two techniques. Bladder samples were obtained from biopsies dissected via transurethral resection of the bladder tumor (TURBT). As OCT provides structural information rapidly, it was used as a red-flag technology to scan the bladder ...
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  Mentions: Rainer A. Leitgeb Wolfgang Drexler Medical University of Vienna
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