1. Raghav K. Chhetri

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    1. Mentioned In 9 Articles

    2. Motility-, autocorrelation-, and polarization-sensitive optical coherence tomography discriminates cells and gold nanorods within 3D tissue cultures

      Motility-, autocorrelation-, and polarization-sensitive optical coherence tomography discriminates cells and gold nanorods within 3D tissue cultures
      ...lular activity) imaging using standard PS-OCT hardware. © 2013 Optical Society of America Amy L. Oldenburg, Raghav K. Chhetri, Jason M. Cooper, Wei-Chen Wu, Melissa A. Troester, and Joseph B. Tracy, "Motility-, autocor...
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    3. Polarization-Sensitive Optical Coherence Tomography to Study Diffusion of Plasmonic Gold Nanorods—a Novel Tool for Optical Bioimaging (Thesis)

      Polarization-Sensitive Optical Coherence Tomography to Study Diffusion of Plasmonic Gold Nanorods—a Novel Tool for Optical Bioimaging (Thesis)
      Optical Coherence Tomography (OCT) is an imaging tool that performs micronresolution, non-invasive, cross-sectional imaging by measuring the echoes of backscattered light. In this thesis, a custom-designed polarization-sensitive OCT (PS-OCT) system is discussed, which is implemented in using plasmonic gold nanorods (GNRs) as diffusion probes. PS-OCT imaging is undertaken in Newtonian fluids and validation of rotational and translational diffusion of GNRs with the Stokes-Einstein relation is presented via analysis of the ...
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    4. Longitudinal Study of Mammary Epithelial and Fibroblast Co-Cultures Using Optical Coherence Tomography Reveals Morphological Hallmarks of Pre-Malignancy

      Longitudinal Study of Mammary Epithelial and Fibroblast Co-Cultures Using Optical Coherence Tomography Reveals Morphological Hallmarks of Pre-Malignancy
      The human mammary gland is a complex and heterogeneous organ, where the interactions between mammary epithelial cells (MEC) and stromal fibroblasts are known to regulate normal biology and tumorigenesis. We aimed to longitudinally evaluate morphology and size of organoids in 3D co-cultures of normal (MCF10A) or pre-malignant (MCF10DCIS.com) MEC and hTERT-immortalized fibroblasts from reduction mammoplasty (RMF). This co-culture model, based on an isogenic panel of cell lines, can yield ...
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    5. Imaging three-dimensional rotational diffusion of plasmon resonant gold nanorods using polarization-sensitive optical coherence tomography

      Imaging three-dimensional rotational diffusion of plasmon resonant gold nanorods using polarization-sensitive optical coherence tomography
      We demonstrate depth-resolved viscosity measurements within a single object using polarized optical scattering from ensembles of freely tumbling plasmon resonant gold nanorods (GNRs) monitored with polarization-sensitive optical coherence tomography. The rotational diffusion coefficient of the GNRs is shown to correlate with viscosity in molecular fluids according to the Stokes-Einstein relation. The plasmon resonant and highly anisotropic properties of GNRs are favorable for microrheological studies of nanoscale properties.
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    6. Feature Of The Week 11/27/10: Contrast to Labeled Platelets with Magnetomotive OCT for Detecting Vascular Damage

      Feature Of The Week 11/27/10: Contrast to Labeled Platelets with Magnetomotive OCT for Detecting Vascular Damage
      Recently researchers from the University of North Carolina, Chapel Hill, published on an interesting OCT functional imaging modality that uses a magnetic field to induce small displacement of blood platelets to detect potential sites of bleeding and vascular damage. Below is an excerpt of this work. We introduce a new functional imaging paradigm that uses optical coherence tomography (OCT) to detect rehydrated, lyophilized platelets (RL platelets, StasixTM, Entegrion, Inc.) that ...
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    7. Magnetic and Contrast Properties of Labeled Platelets for Magnetomotive Optical Coherence Tomography

      Magnetic and Contrast Properties of Labeled Platelets for Magnetomotive Optical Coherence Tomography
      This article introduces a new functional imaging paradigm that uses optical coherence tomography (OCT) to detect rehydrated, lyophilized platelets (RL platelets) that are in the preclinical trial stage and contain superparamagnetic iron oxides (SPIOs) approved by the U.S. Food and Drug Administration. Platelets are highly functional blood cells that detect and adhere to sites of vascular endothelial damage by forming primary hemostatic plugs. By applying magnetic gradient forces, induced ...
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  2. About Raghav K. Chhetri

    Raghav K. Chhetri

    Raghav K. Chhetri is a graduate student working with Professor Amy L. Oldenburg in the Department of Physics and Astronomy at the University of North Carolina, Chapel Hill. Raghav completed his Masters in 2010 from the University of North Carolina, Chapel Hill and received his dual degrees in Physics and Mathematics from Truman State University in 2006. His current research work encompasses using Magnetomotive Optical Coherence Elastography (MMOCE) to study lung airway degradations in Cystic Fibrosis, and the study of Brownian dynamics of plasmon resonant nanoparticles using Optical Coherence Tomography.