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    1. Mentioned In 34 Articles

    2. Quantitative and qualitative characterization of retinal dystrophies in canine models of inherited retinal diseases using spectral domain optical coherence tomography (SD-OCT)

      Explore ScienceDirect Ophthalmology
      Quantitative and qualitative characterization of retinal dystrophies in canine models of inherited retinal diseases using spectral domain optical coherence tomography (SD-OCT)
      The purpose of this study was to establish spectral domain optical coherence tomography (SD-OCT) assessment data in well-established canine models of inherited retinal dystrophies: PDE6B-rod-cone dysplasia 1 (RCD1: early onset retinitis pigmentosa), PRCD-progressive rod-cone degeneration (PRCD: late onset retinitis pigmentosa), CNGB3-achromatopsia, and RPE65-Leber congenital amaurosis (LCA). High resolution SD-OCT images of the retina were acquired from both eyes in 5 planes: temporal; superotemporal; superior; nasal; and inferior in adult dogs ...
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      Mentions: University of Pennsylvania Purdue University Michigan State University

    3. Common-path interferometer for digital holographic Doppler spectroscopy of living biological tissues

      Explore SPIE Digital Library
      Common-path interferometer for digital holographic Doppler spectroscopy of living biological tissues
      Significance: Common-path interferometers have the advantage of producing ultrastable interferometric fringes compared with conventional interferometers, such as Michelson or MachZehnder that are sensitive to environmental instabilities. Isolating interferometric measurements from mechanical disturbances is important in biodynamic imaging because Doppler spectroscopy of intracellular dynamics requires extreme stability for phase-sensitive interferometric detection to capture fluctuation frequencies down to 10 mHz. Aim: The aim of this study was to demonstrate that Doppler spectra ...
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      Mentions: Purdue University

    4. Multi-reference global registration of individual A-lines in adaptive optics optical coherence tomography retinal images

      Explore SPIE Digital Library Ophthalmology
      Multi-reference global registration of individual A-lines in adaptive optics optical coherence tomography retinal images
      Significance: Adaptive optics optical coherence tomography (AO-OCT) technology enables non-invasive, high-resolution three-dimensional (3D) imaging of the retina and promises earlier detection of ocular disease. However, AO-OCT data are corrupted by eye-movement artifacts that must be removed in post-processing, a process rendered time-consuming by the immense quantity of data. Aim: To efficiently remove eye-movement artifacts at the level of individual A-lines, including those present in any individual reference volume. Approach: We ...
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      Mentions: Purdue University Indiana University

    5. Multimodality Imaging-Based Characterization of Regional Material Properties in a Murine Model of Aortic Dissection

      Explore Nature Publishing Group Cardiology
      Multimodality Imaging-Based Characterization of Regional Material Properties in a Murine Model of Aortic Dissection
      hronic infusion of angiotensin-II in atheroprone ( ApoE / ) mice provides a reproducible model of dissection in the suprarenal abdominal aorta, often with a false lumen and intramural thrombus that thickens the wall. Such lesions exhibit complex morphologies, with different regions characterized by localized changes in wall composition, microstructure, and properties. We sought to quantify the multiaxial mechanical properties of murine dissecting aneurysm samples by combining in vitro extension-distension data with full-field ...
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      Mentions: Yale University Vanderbilt University Purdue University

    6. Method and apparatus for motility contrast imaging

      Explore uspto.gov Patents
      Method and apparatus for motility contrast imaging
      A system for motility contrast imaging a biological target within tissue comprising a CCD array; an illumination source for generating an incoming beam; a first beam splitter for receiving the incoming beam and producing an object beam and a reference beam; a second beam splitter for illuminating a multitude of biological targets with the object beam and for directing backscattered object beams towards the CCD array; a computer-controlled delay stage ...
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      Mentions: Purdue University

    7. Imaging and quantifying ganglion cells and other transparent neurons in the living human retina [Engineering]

      Explore pnas.org Ophthalmology
      Imaging and quantifying ganglion cells and other transparent neurons in the living human retina [Engineering]
      Ganglion cells (GCs) are fundamental to retinal neural circuitry, processing photoreceptor signals for transmission to the brain via their axons. However, much remains unknown about their role in vision and their vulnerability to disease leading to blindness. A major bottleneck has been our inability to observe GCs and their degeneration in the living human eye. Despite two decades of development of optical technologies to image cells in the living human ...
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      Mentions: Purdue University Indiana University

    8. Ex vivo motility contrast imaging

      Explore uspto.gov Patents
      Ex vivo motility contrast imaging
      In a method for ex vivo evaluation of tissue response, a target biological sample is placed in a chamber of a sample holder. Biodynamic imaging (BDI) is performed on the sample to extract BDI data of the entire sample, optical coherence imaging (OCI) data is generated from the BDI data; and then motility contrast imaging (MCI) data is generated from the OCI data. The MCI data is used to select ...
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      Mentions: Purdue University

    9. Multi-Modality Imaging Enables Detailed Hemodynamic Simulations in Dissecting Aneurysms in Mice

      Explore IEEE Xplore Cardiology
      Multi-Modality Imaging Enables Detailed Hemodynamic Simulations in Dissecting Aneurysms in Mice
      A multi-modality imaging-based modeling approach was used to study complex unsteady hemodynamics and lesion growth in a dissecting abdominal aortic aneurysm model. We combined in vivo ultrasound (geometry and flow) and in vitro optical coherence tomography (OCT) (geometry) to obtain the high resolution needed to construct detailed hemodynamic simulations over large portions of the murine vasculature, which include fine geometric complexities. We illustrate this approach for a spectrum of dissecting ...
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      Mentions: Vanderbilt University Purdue University

    10. Microstructural characterization of myocardial infarction with optical coherence tractography and two‐photon microscopy

      Explore Home | Physiological Reports Cardiology
      Microstructural characterization of myocardial infarction with optical coherence tractography and two‐photon microscopy
      Myocardial infarction leads to complex changes in the fiber architecture of the heart. Here, we present a novel optical approach to characterize these changes in intact hearts in three dimensions. Optical coherence tomography (OCT) was used to derive a depth‐resolved field of orientation on which tractography was performed. Tractography of healthy myocardium revealed a smooth linear transition in fiber inclination or helix angle from the epicardium to endocardium. Conversely ...
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      Mentions: Purdue University

    11. Fingerprint Matching with Optical Coherence Tomography

      Explore Home - Springer Dermatology , Other Non-Medical
      Fingerprint Matching with Optical Coherence Tomography
      Fingerprint recognition is an important security technique with a steadily growing usage for the identification and verification of individuals. However, current fingerprint acquisition systems have certain disadvantages, which include the requirements of physical contact with the acquisition device, and the presence of undesirable artefacts, such as scars, on the surface of the fingerprint. This paper evaluates the accuracy of a complete framework for the capturing of undamaged, undistorted fingerprints from ...
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      Mentions: University of Houston Purdue University Texas A&M University

    13. Adaptive-optics optical coherence tomography processing using a graphics processing unit

      Explore IEEE Xplore
      Adaptive-optics optical coherence tomography processing using a graphics processing unit
      Graphics processing units are increasingly being used for scientific computing for their powerful parallel processing abilities, and moderate price compared to super computers and computing grids. In this paper we have used a general purpose graphics processing unit to process adaptive-optics optical coherence tomography (AOOCT) images in real time. Increasing the processing speed of AOOCT is an essential step in moving the super high resolution technology closer to clinical viability.
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      Mentions: Purdue University Indiana University

    16. Live tissue viability and chemosensitivity assays using digital holographic motility contrast imaging

      Explore opticsinfobase.org
      Live tissue viability and chemosensitivity assays using digital holographic motility contrast imaging
      Holographic optical coherence imaging is an en face form of optical coherence tomography that uses low-coherence digital holography as a coherence gate to select light from a chosen depth inside scattering tissue. By acquiring successive holograms at a high camera frame rate at a fixed depth, dynamic speckle provides information concerning dynamic light scattering from intracellular motility. Motility contrast imaging (MCI) uses living motion as a label-free and functional biomarker ...
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      Mentions: Purdue University Indiana University
    17. 1-15 of 34 1 2 3 »
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