1. Pradeep K. Gupta

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    1. Mentioned In 18 Articles

    2. Feasibility of speckle variance OCT for imaging cutaneous microvasculature regeneration during healing of wounds in diabetic mice

      Feasibility of speckle variance OCT for imaging cutaneous microvasculature regeneration during healing of wounds in diabetic mice
      We report on a study to assess the feasibility of a swept source-based speckle variance optical coherence tomography setup for monitoring cutaneous microvasculature. Punch wounds created in the ear pinnae of diabetic mice were monitored at different times post wounding to assess the structural and vascular changes. It was observed that the epithelium thickness increases post wounding and continues to be thick even after healing. Also, the wound size assessed ...
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    3. Absolute velocity measurement using three-beam spectral-domain Doppler optical coherence tomography

      Absolute velocity measurement using three-beam spectral-domain Doppler optical coherence tomography
      We report the development of a three-beam spectral-domain Doppler optical coherence tomography setup that allows single interferometer-based measurement of absolute flow velocity. The setup makes use of galvo-based phase shifting to remove complex conjugate mirror artifact and a beam displacer in the sample arm to avoid cross talk image. The results show that the developed approach allows efficient utilization of the imaging range of the spectral-domain optical coherence tomography setup ...
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    4. Effect of Intraocular Pressure and Anisotropy on the Optical Properties of the Cornea: A Study Using Polarization Sensitive Optical Coherence Tomography

      Effect of Intraocular Pressure and Anisotropy on the Optical Properties of the Cornea: A Study Using Polarization Sensitive Optical Coherence Tomography
      Purpose: We hypothesize that because of the anisotropic properties of the cornea, there should be a nonuniform change in birefringence with an increase in intraocular pressure (IOP). In this in vitro study, anisotropic properties, stress distribution within the cornea, and the effect of IOP on changes in stress level were investigated. Design: Button inflation tests for deformation with polarization sensitive optical coherence tomography were used to demonstrate optical and material ...
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    5. Single detector-based absolute velocity measurement using spectral domain Doppler optical coherence tomography

      Single detector-based absolute velocity measurement using spectral domain Doppler optical coherence tomography
      We propose an approach for absolute velocity measurement where the use of a beam displacer provides two orthogonal linearly polarized beams to probe the sample simultaneously at two different incidence angles. The approach helps remove the cross talk image and facilitates single detector-based Fourier domain Doppler velocity measurement. The system has been characterized by quantifying absolute flow velocity in a flow phantom.
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    6. Backscattering Mueller matrix measurement scheme using the same polarizing–analyzing optics

      Backscattering Mueller matrix measurement scheme using the same polarizing–analyzing optics
      Mueller matrix measurements are most commonly performed using a set of polarization state generating (PSG) optics and an independent set of polarization state analyzing (PSA) optics. However, for polarized confocal microscopy and polarization sensitive optical coherence tomography it would be advantageous if the same set of polarization optics could be used for both PSG as well as PSA. This has not been possible because, in this configuration, a complete set ...
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    7. Depth-sensitive Raman spectroscopy combined with optical coherence tomography for layered tissue analysis

      Depth-sensitive Raman spectroscopy combined with optical coherence tomography for layered tissue analysis
      Complete characterization of a layered tissue requires probing both the biochemical and the morphological information from its different layers at various depths. We report the development of a combined Raman spectroscopy (RS) and optical coherence tomography (OCT) system that is capable of measuring depth-sensitive Raman signal from the tissue layers imaged by the OCT. The sample arm of a real-time time-domain OCT system was modified to allow for co-alignment of ...
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    8. Feature Of The Week 11/13/11: OCT Used for Analysis of Developmental Defects in Zebrafish Embryos

      Feature Of The Week 11/13/11: OCT Used for Analysis of Developmental Defects in Zebrafish Embryos
      It is known that consumption of alcohol during pregnancy can lead to several disorders ranging from Fetal Alcohol Syndrome (FAS), alcohol related birth defects, and neuro developmental defects. Zebrafish is a popular model to understand the mechanisms of embryonic ethanol exposure generated disorders. To track these developmental defects, a noninvasive imaging technique like OCT could be useful, as it provides high-resolution cross-sectional images of tissues. Further, current high-speed OCT technology ...
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    9. Single mode fiber based polarization sensitive optical coherence tomography using a swept laser source

      Single mode fiber based polarization sensitive optical coherence tomography using a swept laser source
      We report the development of a near real time single mode fiber-optic based polarization sensitive optical coherence tomography (PSOCT) setup utilizing a swept source. The setup has a polarization modulator (PM) and polarizer in a sample arm to serve as a polarization state generator and analyzer. Since only intensity information is used to retrieve the polarization parameters of the sample, the problem of phase jitters present in the swept source ...
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    10. Noninvasive imaging of ethanol-induced developmental defects in zebrafish embryos using optical coherence tomography

      Noninvasive imaging of ethanol-induced developmental defects in zebrafish embryos using optical coherence tomography
      In this article, we report the use of optical coherence tomography for noninvasive cross-sectional real-time imaging of ethanol-induced developmental defects in zebrafish embryos larvae. For ethanol concentration of over 300 mM, developmental defects of eye (shrinkage and retinal abnormalities), malformation of the notochord and ataxia arising due to the toxic effects of ethanol were observed in OCT images from 3 days post fertilization onwards. The results suggest that OCT could ...
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    11. Use of common path phase sensitive spectral domain optical coherence tomography for refractive index measurements

      Use of common path phase sensitive spectral domain optical coherence tomography for refractive index measurements
      We report the use of a common path phase sensitive spectral domain optical coherence tomography setup for the measurement of the refractive index (RI) of a biomimetic material (glucose solution in water having intralipid as the scattering medium) and a single biological cell (keratinocyte). The RI of glucose solutions could be measured with a precision of ∼0.00015, which corresponds to a precision of ∼2 nm in the optical path ...
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    12. Differentiating Glaucomatous from Non-Glaucomatous Optic Nerve Cupping by Optical Coherence Tomography

      Differentiating Glaucomatous from Non-Glaucomatous Optic Nerve Cupping by Optical Coherence Tomography
      Abstract: Background: In clinical practice, the differentiation of glaucomatous from non-glaucomatous cupping can be difficult, even for experienced observers. The purpose of this study was to evaluate the role of optical coherence tomography (OCT) in differentiating glaucomatous from non-glaucomatous optic nerve cupping in a cross-sectional pilot study. Methods: Eleven consecutive patients presenting to the Duke Eye Center from September 2007 to July 2008 with nonglaucomatous optic nerve cupping and 12 ...
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    13. Feature Of The Week 4/11/10: Noninvasive Assessment of Healing of Bacteria Infected and Uninfected Wounds using Optical Coherence Tomography

      Feature Of The Week 4/11/10: Noninvasive Assessment of Healing of Bacteria Infected and Uninfected Wounds using Optical Coherence Tomography
      Feature Of The Week 4/11/10: Microbial infection is one of the major factors for the impairment of wound healing as the microbial toxins have a detrimental effect on collagen in the wounded tissue. Infected wounds can cause increased trauma, could severely compromise the overall health of an individual as well as increase the cost of treatment. To facilitate a faster healing of wounds it will be desirable if ...
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    14. Non-invasive assessment of healing of bacteria infected and uninfected wounds using optical coherence tomography

      Non-invasive assessment of healing of bacteria infected and uninfected wounds using optical coherence tomography
      Bacterial infection is one of the main predisposing factors for the delay in wound healing. To facilitate a timely decision for correct therapy, it is important to accurately monitor the morphological changes in the infected wounds using noninvasive tools. In the present study, we have explored the use of optical coherence tomography (OCT) for monitoring the healing of superficial wounds infected with Staphylococcus aureus in mice under in vitro and ...
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    15. Real-time in vivo imaging of adult Zebrafish brain using optical coherence tomography

      Real-time in vivo imaging of adult Zebrafish brain using optical coherence tomography
      We report noninvasive imaging of the brain of adult Zebrafish (Danio rerio) using real time optical coherence tomography (OCT) capable of acquiring cross sectional 2D OCT images @ 8 frames/sec. Anatomic features such as telencephalon, tectum opticum, eminentia Granularis and cerebellum were clearly resolved in the OCT images. A 3D model of Zebrafish brain was reconstructed, for the first time to our knowledge, using these 2D OCT images.
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    16. 1-15 of 18 1 2 »
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  2. About Pradeep K. Gupta

    Pradeep K. Gupta, Ph.D. is at Raja Ramanna Centre for Advanced Technology, India and heads its Laser Biomedical Applications and Instrumentation Division as well as Laser Materials Development and Devices Division. His research interests include biomedical applications of laser.