1. Polytechnique Montreal

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    1. Mentioned In 39 Articles

    2. Imaging whole mouse brains with a dual resolution serial swept-source optical coherence tomography scanner

      Imaging whole mouse brains with a dual resolution serial swept-source optical coherence tomography scanner
      High resolution imaging of whole rodent brains using serial OCT scanners is a promising method to investigate microstructural changes in tissue related to the evolution of neuropathologies. Although micron to sub-micron sampling resolution can be obtained by using high numerical aperture objectives and dynamic focusing, such an imaging system is not adapted to whole brain imaging. This is due to the large amount of data it generates and the significant ...
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    3. Radiometric model for coaxial single- and multimode optical emission from double-clad fiber

      Radiometric model for coaxial single- and multimode optical emission from double-clad fiber
      Double-clad fibers (DCFs) are versatile waveguides supporting a single-mode core surrounded by a multimode inner cladding. DCFs are increasingly used for multimodal biomedical applications, such as imaging or therapy, for which the core is typically used for coherent illumination and the inner cladding, to support a concurrent modality. Proper optimization is, however, critical to ensure high optical performance and requires accurate modeling of coaxial single- and multimode output beams. In ...
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    4. Comparing three-dimensional serial optical coherence tomography histology to MRI imaging in the entire mouse brain

      Comparing three-dimensional serial optical coherence tomography histology to MRI imaging in the entire mouse brain
      An automated serial histology setup combining optical coherence tomography (OCT) imaging with vibratome sectioning was used to image eight wild type mouse brains. The datasets resulted in thousands of volumetric tiles resolved at a voxel size of ( 4.9 4.9 6.5 ) m 3 (4.94.96.5)m3 stitched back together to give a three-dimensional map of the brain from which a template OCT brain was obtained. To ...
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    5. Serial optical coherence scanning reveals an association between cardiac function and the heart architecture in the aging rodent heart

      Serial optical coherence scanning reveals an association between cardiac function and the heart architecture in the aging rodent heart
      Normal aging is accompanied by structural changes in the heart architecture. To explore this remodeling, we used a serial optical coherence tomography scanner to image entire mouse hearts at micron scale resolution. Ex vivo hearts of 7 young (4 months) and 5 old (24 months) C57BL/6 mice were acquired with the imaging platform. OCT of the myocardium revealed myofiber orientation changing linearly from the endocardium to the epicardium. In ...
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    6. Whole mouse brain imaging using optical coherence tomography: reconstruction, normalization, segmentation, and comparison with diffusion MRI

      Whole mouse brain imaging using optical coherence tomography: reconstruction, normalization, segmentation, and comparison with diffusion MRI
      An automated massive histology setup combined with an optical coherence tomography (OCT) microscope was used to image a total of n = 5 n=5 whole mouse brains. Each acquisition generated a dataset of thousands of OCT volumetric tiles at a sampling resolution of 4.9 4.9 6.5 m 4.94.96.5m . This paper describes techniques for reconstruction and segmentation of the sliced brains. In addition to the ...
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    7. White matter segmentation by estimating tissue optical attenuation from volumetric OCT massive histology of whole rodent brains

      White matter segmentation by estimating tissue optical attenuation from volumetric OCT massive histology of whole rodent brains
      A whole rodent brain was imaged using an automated massive histology setup and an Optical Coherence Tomography (OCT) microscope. Thousands of OCT volumetric tiles were acquired, each covering a size of about 2.5x2.5x0.8 mm3 with a sampling resolution of 4.9x4.9x6.5 microns. This paper shows the techniques for reconstruction, attenuation compensation and segmentation of the sliced brains. The tile positions within the mosaic were evaluated ...
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    8. Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

      Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography
      Scanning laser ophthalmoscopy (SLO) benefits diagnostic imaging and therapeutic guidance by allowing for high-speeden faceimaging of retinal structures. When combined with optical coherence tomography (OCT), SLO enables real-time aiming and retinal tracking and provides complementary information for post-acquisition volumetric co-registration, bulk motion compensation, and averaging. However, multimodality SLO-OCT systems generally require dedicated light sources, scanners, relay optics, detectors, and additional digitization and synchronization electronics, which increase system complexity. Here, we ...
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    9. Validating Intravascular Imaging with Serial Optical Coherence Tomography and Confocal Fluorescence Microscopy

      Validating Intravascular Imaging with Serial Optical Coherence Tomography and Confocal Fluorescence Microscopy
      Atherosclerotic cardiovascular diseases are characterized by the formation of a plaque in the arterial wall. Intravascular ultrasound (IVUS) provides high-resolution images allowing delineation of atherosclerotic plaques. When combined with near infrared fluorescence (NIRF), the plaque can also be studied at a molecular level with a large variety of biomarkers. In this work, we present a system enabling automated volumetric histology imaging of excised aortas that can spatially correlate results with ...
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    10. Combined optical coherence tomography and hyperspectral imaging using a double-clad fiber coupler

      Combined optical coherence tomography and hyperspectral imaging using a double-clad fiber coupler
      This work demonstrates the combination of optical coherence tomography (OCT) and hyperspectral imaging (HSI) using a double-clad optical fiber coupler. The single-mode core of the fiber is used for OCT imaging, while the inner cladding of the double-clad fiber provides an efficient way to capture the reflectance spectrum of the sample. The combination of both methods enables three-dimensional acquisition of the sample morphology with OCT, enhanced with complementary molecular information ...
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    11. Collagen Content Limits Optical Coherence Tomography Image Depth in Porcine Vocal Fold Tissue

      Collagen Content Limits Optical Coherence Tomography Image Depth in Porcine Vocal Fold Tissue
      Objective Vocal fold scarring, a condition defined by increased collagen content, is challenging to treat without a method of noninvasively assessing vocal fold structure in vivo. The goal of this study was to observe the effects of vocal fold collagen content on optical coherence tomography imaging to develop a quantifiable marker of disease. Study Design Excised specimen study. Setting Massachusetts Eye and Ear Infirmary. Subjects and Methods Porcine vocal folds ...
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    12. Combined optical coherence tomography and hyper-spectral imaging using a double clad fiber coupler

      Combined optical coherence tomography and hyper-spectral imaging using a double clad fiber coupler
      This proceedings shows the combination of Optical Coherence Tomography (OCT) and Hyper-Spectral Imaging (HSI) using a double-clad optical fiber. The single mode core of the fiber is used to transmit OCT signals, while the cladding, with its large collection area, provides an efficient way to capture the reflectance spectrum of the sample. The combination of both methods enables three-dimensional acquisition of sample morphology with OCT, enhanced by the molecular information ...
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    13. Multimodal ophthalmic imaging using swept source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

      Multimodal ophthalmic imaging using swept source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography
      Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) benefit clinical diagnostic imaging in ophthalmology by enabling in vivo noninvasive en face and volumetric visualization of retinal structures, respectively. Spectrally encoding methods enable confocal imaging through fiber optics and reduces system complexity. Previous applications in ophthalmic imaging include spectrally encoded confocal scanning laser ophthalmoscopy (SECSLO) and a combined SECSLO-OCT system for image guidance, tracking, and registration. However, spectrally encoded imaging ...
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    14. Intraoperative imaging of pediatric vocal fold lesions using optical coherence tomography

      Intraoperative imaging of pediatric vocal fold lesions using optical coherence tomography
      Optical coherence tomography (OCT) has been previously identified as a promising tool for exploring laryngeal pathologies in adults. Here, we present an OCT handheld probe dedicated to imaging the unique geometry involved in pediatric laryngoscopy. A vertical cavity surface emitting laser-based wavelength-swept OCT system operating at 60 frames per second was coupled to the probe to acquire three-dimensional (3-D) volumes in vivo . In order to evaluate the performance of the ...
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    15. Toward an automated method for optical coherence tomography characterization

      Toward an automated method for optical coherence tomography characterization
      With the increasing use of optical coherence tomography (OCT) in biomedical applications, robust yet simple methods for calibrating and benchmarking a system are needed. We present here a procedure based on a calibration object complemented with an algorithm that analyzes three-dimensional OCT datasets to retrieve key characteristics of an OCT system. The calibration object combines state-of-the-art tissue phantom material with a diamond-turned aluminum multisegment mirror. This method is capable of ...
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    16. Using attenuation coefficients from optical coherence tomography as markers of vocal fold maturation

      Using attenuation coefficients from optical coherence tomography as markers of vocal fold maturation
      Objectives/Hypothesis Optical coherence tomography (OCT) is a promising technology to noninvasively assess vocal fold microanatomy. The goal of this study was to develop a methodology using OCT to identify quantifiable markers of vocal fold development. Study Design In vivo study. Methods A two-step process was developed to reproducibly image the midmembranous vocal fold edge of 10 patients younger than 2 years and 10 patients between 11 and 16 years ...
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    17. 1-15 of 39 1 2 3 »
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  2. About Polytechnique Montreal

    Polytechnique Montreal

    Polytechnique Montréal is one of Canada’s leading engineering schools and is the largest in Québec in terms of its student population and the scope of its research budgets.  The Optoelectronics Laboratory at the Polytechnique Montrealis active in the field of optical coherence tomography and high-performance photonic device research with special emphasis on active semiconductor devices. The research is both theoretical and experimental. The Laboratory of Optical Diagnoses and Imagery was created during the summer of 2008 by Professor Caroline Boudoux. The laboratory is affiliated to the departments of physical and biomedical engineering.