1. Pierre M. Lane

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    1. Mentioned In 29 Articles

    2. A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography

      A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography
      We present a power-efficient fiber-based imaging system capable of co-registered autofluorescence imaging and optical coherence tomography (AF/OCT). The system employs a custom fiber optic rotary joint (FORJ) with an embedded dichroic mirror to efficiently combine the OCT and AF pathways. This three-port wavelength multiplexing FORJ setup has a throughput of more than 83% for collected AF emission, significantly more efficient compared to previously reported fiber-based methods. A custom 900 ...
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    3. Validation of Airway Wall Measurements by Optical Coherence Tomography in Porcine Airways

      Validation of Airway Wall Measurements by Optical Coherence Tomography in Porcine Airways
      Examining and quantifying changes in airway morphology is critical for studying longitudinal pathogenesis and interventions in diseases such as chronic obstructive pulmonary disease and asthma. Here we present fiber-optic optical coherence tomography (OCT) as a nondestructive technique to precisely and accurately measure the 2-dimensional cross-sectional areas of airway wall substructure divided into the mucosa (WA muc ), submucosa (WA sub ), cartilage (WA cart ), and the airway total wall area (WAt). Porcine ...
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    4. High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes

      High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes
      ... »View Author Affiliations Barry Vuong,^1 Anthony M.D. Lee,^2 Timothy W.H. Luk,^1 Cuiru Sun,^1 Stephen Lam,^2 Pierre Lane,^2 and Victor X.D. Yang^1,^3,^4,^* ^1Biophotonics and Bioengineering Laboratory, Dept. Electrica...
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    5. Automated segmentation of porcine airway wall layers using optical coherence tomography: comparison with manual segmentation and histology

      Automated segmentation of porcine airway wall layers using optical coherence tomography: comparison with manual segmentation and histology
      ...n with manual segmentation and histology Miranda Kirby ; Anthony M. D. Lee ; Tara Candido ; Calum MacAulay ; Pierre Lane ; Stephen Lam ; Harvey O. Coxson; Automated segmentation of porcine airway wall layers using optic...
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    6. Multimodal tissue imaging: using coregistered optical tomography data to estimate tissue autofluorescence intensity change due to scattering and absorption by neoplastic epithelial cells

      Multimodal tissue imaging: using coregistered optical tomography data to estimate tissue autofluorescence intensity change due to scattering and absorption by neoplastic epithelial cells
      Autofluorescence (AF) imaging provides valuable information about the structural and chemical states of tissue that can be used for early cancer detection. Optical scattering and absorption of excitation and emission light by the epithelium can significantly affect observed tissue AF intensity. Determining the effect of epithelial attenuation on the AF intensity could lead to a more accurate interpretation of AF intensity. We propose to use optical coherence tomography coregistered with ...
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    7. In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography

      In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography
      For the first time, the use of fiber-optic color Doppler optical coherence tomography (CDOCT) to map in vivo the three-dimensional (3-D) vascular network of airway segments in human lungs is demonstrated. Visualizing the 3-D vascular network in the lungs may provide new opportunities for detecting and monitoring lung diseases such as asthma, chronic obstructive pulmonary disease, and lung cancer. Our CDOCT instrument employs a rotary fiber-optic probe that provides simultaneous ...
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    8. Lung vasculature imaging using speckle variance optical coherence tomography

      Lung vasculature imaging using speckle variance optical coherence tomography
      Architectural changes in and remodeling of the bronchial and pulmonary vasculature are important pathways in diseases such as asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. However, there is a lack of methods that can find and examine small bronchial vasculature in vivo. Structural lung airway imaging using optical coherence tomography (OCT) has previously been shown to be of great utility in examining bronchial lesions during lung cancer screening ...
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    9. Research Assistant OCT Engineer at The Integrative Oncology Imaging Unit at the British Columbia Cancer

      Research Assistant OCT Engineer at The Integrative Oncology Imaging Unit at the British Columbia Cancer
      The Integrative Oncology Imaging Unit at the British Columbia Cancer Agency (Vancouver, BC) has an opening for a Research Assistant. The Integrative Oncology department develops optical instrumentation and software tools for the early detection of cancer. Our research includes all aspects of optical imaging and spectroscopy for the in vivo, ex vivo, and in silico analysis of tissues from the lung, cervix, oral cavity, skin and colon. Many of the ...
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    10. Postdoctoral Fellowship in the Integrative Oncolog Department at The Integrative Oncology Department at the British Columbia Cancer Agency

      Postdoctoral Fellowship in the Integrative Oncolog Department at The Integrative Oncology Department at the British Columbia Cancer Agency
      The Integrative Oncology Department at the British Columbia Cancer Agency (Vancouver, BC) has an immediate opening for a Post-doctoral fellow. The Integrative Oncology Department develops optical instrumentation and software tools for the early detection of cancer. Our research includes all aspects of optical imaging and spectroscopy for the in vivo, ex vivo, and in silica evaluation of tissues from different organ sites including lung, cervix, oral cavity, skin and colon ...
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    11. B.C. Cancer Research Center Receives CIHR Grant To Investigate High-Resolution OCT Imaging of Bronchial Epithelium

      B.C. Cancer Research Center Receives CIHR Grant To Investigate High-Resolution OCT Imaging of Bronchial Epithelium
      ...an Dollars) to investigate high-resolution OCT Imaging of Bronchial Epithelium. The principal investigator is Pierre Lane. Below is a summary of that work. Lung cancer is the most common cause of cancer death world-wide...
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  2. About Pierre M. Lane

    Pierre M. Lane

    Pierre Lane is a Senior Scientist at the British Columbia Cancer Research Center and Associate Professor of Professional Practice, Simon Fraser University and  Associate Member in Biomedical Engineering at the University of British Columbia.