1. Pierre M. Lane

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    1. Mentioned In 16 Articles

    2. Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components

      Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components
      Polarization Sensitive Optical Coherence Tomography (PSOCT) is a functional extension of Optical Coherence Tomography (OCT) that is sensitive to well-structured, birefringent tissue such as scars, smooth muscle and cartilage. In this work, we present a novel completely fiber based swept source PSOCT system using a fiber-optic rotary pullback catheter. This PSOCT implementation uses only passive optical components and requires no calibration while adding minimal additional cost to a standard structural ...
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    3. Optical coherence tomography and autofluorescence imaging of human tonsil

      Optical coherence tomography and autofluorescence imaging of human tonsil
      For the first time, we present co-registered autofluorescence imaging and optical coherence tomography (AF/OCT) of excised human palatine tonsils to evaluate the capabilities of OCT to visualize tonsil tissue components. Despite limited penetration depth, OCT can provide detailed structural information about tonsil tissue with much higher resolution than that of computed tomography, magnetic resonance imaging, and Ultrasound. Different tonsil tissue components such as epithelium, dense connective tissue, lymphoid nodules ...
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    4. Fiber-Based Polarization Diversity Detection for Polarization-Sensitive Optical Coherence Tomography

      Fiber-Based Polarization Diversity Detection for  Polarization-Sensitive Optical Coherence Tomography
      We present a new fiber-based polarization diversity detection (PDD) scheme for polarization sensitive optical coherence tomography (PSOCT). This implementation uses a new custom miniaturized polarization-maintaining fiber coupler with single mode (SM) fiber inputs and polarization maintaining (PM) fiber outputs. The SM fiber inputs obviate matching the optical lengths of the two orthogonal OCT polarization channels prior to interference while the PM fiber outputs ensure defined orthogonal axes after interference. Advantages ...
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    5. A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography

      A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography
      We present a power-efficient fiber-based imaging system capable of co-registered autofluorescence imaging and optical coherence tomography (AF/OCT). The system employs a custom fiber optic rotary joint (FORJ) with an embedded dichroic mirror to efficiently combine the OCT and AF pathways. This three-port wavelength multiplexing FORJ setup has a throughput of more than 83% for collected AF emission, significantly more efficient compared to previously reported fiber-based methods. A custom 900 ...
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    6. Validation of Airway Wall Measurements by Optical Coherence Tomography in Porcine Airways

      Validation of Airway Wall Measurements by Optical Coherence Tomography in Porcine Airways
      Examining and quantifying changes in airway morphology is critical for studying longitudinal pathogenesis and interventions in diseases such as chronic obstructive pulmonary disease and asthma. Here we present fiber-optic optical coherence tomography (OCT) as a nondestructive technique to precisely and accurately measure the 2-dimensional cross-sectional areas of airway wall substructure divided into the mucosa (WA muc ), submucosa (WA sub ), cartilage (WA cart ), and the airway total wall area (WAt). Porcine ...
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    7. Fiber-optic polarization diversity detection for rotary probe optical coherence tomography

      Fiber-optic polarization diversity detection for rotary probe optical coherence tomography
      We report a polarization diversity detection scheme for optical coherence tomography with a new, custom, miniaturized fiber coupler with single mode (SM) fiber inputs and polarization maintaining (PM) fiber outputs. The SM fiber inputs obviate matching the optical lengths of the X and Y OCT polarization channels prior to interference and the PM fiber outputs ensure defined X and Y axes after interference. Advantages for this scheme include easier alignment ...
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    8. High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes

      High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes
      We report a technique for blood flow detection using split spectrum Doppler optical coherence tomography (ssDOCT) that shows improved sensitivity over existing Doppler OCT methods. In ssDOCT, the Doppler signal is averaged over multiple sub-bands of the interferogram, increasing the SNR of the Doppler signal. We explore the parameterization of this technique in terms of number of sub-band windows, width and overlap of the windows, and their effect on the ...
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    9. Automated segmentation of porcine airway wall layers using optical coherence tomography: comparison with manual segmentation and histology

      Automated segmentation of porcine airway wall layers using optical coherence tomography: comparison with manual segmentation and histology
      The objective was to develop an automated optical coherence tomography (OCT) segmentation method. We evaluated three ex-vivo porcine airway specimens; six non-sequential OCT images were selected from each airway specimen. Histology was also performed for each airway and histology images were co-registered to OCT images for comparison. Manual segmentation of the airway luminal area, mucosa area, submucosa area and the outer airway wall area were performed for histology and OCT ...
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    10. Multimodal tissue imaging: using coregistered optical tomography data to estimate tissue autofluorescence intensity change due to scattering and absorption by neoplastic epithelial cells

      Multimodal tissue imaging: using coregistered optical tomography data to estimate tissue autofluorescence intensity change due to scattering and absorption by neoplastic epithelial cells
      Autofluorescence (AF) imaging provides valuable information about the structural and chemical states of tissue that can be used for early cancer detection. Optical scattering and absorption of excitation and emission light by the epithelium can significantly affect observed tissue AF intensity. Determining the effect of epithelial attenuation on the AF intensity could lead to a more accurate interpretation of AF intensity. We propose to use optical coherence tomography coregistered with ...
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    11. In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography

      In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography
      For the first time, the use of fiber-optic color Doppler optical coherence tomography (CDOCT) to map in vivo the three-dimensional (3-D) vascular network of airway segments in human lungs is demonstrated. Visualizing the 3-D vascular network in the lungs may provide new opportunities for detecting and monitoring lung diseases such as asthma, chronic obstructive pulmonary disease, and lung cancer. Our CDOCT instrument employs a rotary fiber-optic probe that provides simultaneous ...
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    12. Lung vasculature imaging using speckle variance optical coherence tomography

      Lung vasculature imaging using speckle variance optical coherence tomography
      Architectural changes in and remodeling of the bronchial and pulmonary vasculature are important pathways in diseases such as asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. However, there is a lack of methods that can find and examine small bronchial vasculature in vivo. Structural lung airway imaging using optical coherence tomography (OCT) has previously been shown to be of great utility in examining bronchial lesions during lung cancer screening ...
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    13. Research Assistant OCT Engineer at The Integrative Oncology Imaging Unit at the British Columbia Cancer

      Research Assistant OCT Engineer at The Integrative Oncology Imaging Unit at the British Columbia Cancer
      The Integrative Oncology Imaging Unit at the British Columbia Cancer Agency (Vancouver, BC) has an opening for a Research Assistant. The Integrative Oncology department develops optical instrumentation and software tools for the early detection of cancer. Our research includes all aspects of optical imaging and spectroscopy for the in vivo, ex vivo, and in silico analysis of tissues from the lung, cervix, oral cavity, skin and colon. Many of the ...
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    14. Postdoctoral Fellowship in the Integrative Oncolog Department at The Integrative Oncology Department at the British Columbia Cancer Agency

      Postdoctoral Fellowship in the Integrative Oncolog Department at The Integrative Oncology Department at the British Columbia Cancer Agency
      The Integrative Oncology Department at the British Columbia Cancer Agency (Vancouver, BC) has an immediate opening for a Post-doctoral fellow. The Integrative Oncology Department develops optical instrumentation and software tools for the early detection of cancer. Our research includes all aspects of optical imaging and spectroscopy for the in vivo, ex vivo, and in silica evaluation of tissues from different organ sites including lung, cervix, oral cavity, skin and colon ...
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    15. Optical coherence tomography imaging of preneoplastic lung lesion

      Although autofluorescence bronchoscopy improves the detection rate of high grade dysplasia and carcinoma in-situ compares to white-light examination, the natural history of preneoplastic bronchial lesions is still poorly understood because the biopsy procedure for histological confirmation can mechanically remove these small lesions. The lack of accurate information regarding the spontaneous progression and regression rates of preneoplastic lesions make if difficult to assess the effect of chemoprevention agents. It is therefore ...
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  2. About Pierre M. Lane

    Pierre M. Lane

    Pierre M. Lane is at the British Columbia Cancer Agency Research Center in Canada.