1. Physical Sciences Incorporated

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    1. Mentioned In 71 Articles

    2. Physical Sciences, Incorporated Receives NIH Grant for Multimodal Microscope for Interaoperative Assessment of Breast Surgical Margins

      Explore Optical Coherence Tomography News Oncology , Funding
      Physical Sciences, Incorporated Receives NIH Grant for Multimodal Microscope for Interaoperative Assessment of Breast Surgical Margins
      Physical Sciences, Incorporated Receives a 2017 NIH Grant for $525,207 for Multimodal Microscope for Interaoperative Assessment of Breast Surgical Margins. The principal investigator is Nicusor Iftima. The program began in 2014 and end sin 2019. Below is a summary of the proposed work. Physical Sciences, Inc. (PSI), in collaboration with MD Anderson Cancer Center (MDACC) and Caliber ID, Rochester, NY proposes to develop a novel technology for real-time assessment ...
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      Mentions: National Institutes of Health Physical Sciences Incorporated Nicusor Iftimia

    3. Handheld optical coherence tomography–reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins

      Explore SPIE | Journal Dermatology
      Handheld optical coherence tomography–reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins
      We present a hand-held implementation and preliminary evaluation of a combined optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) probe for detecting and delineating the margins of basal cell carcinomas (BCCs) in human skin in vivo . A standard OCT approach (spectrometer-based) with a central wavelength of 1310 nm and 0.11 numerical aperture (NA) was combined with a standard RCM approach (830-nm wavelength and 0.9 NA) into a ...
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      Mentions: Physical Sciences Incorporated Nicusor Iftimia

    4. Integrating optical coherence tomography with laryngeal videostroboscopy

      Explore asa.scitation.org Otolaryngology
      Integrating optical coherence tomography with laryngeal videostroboscopy
      During clinical voice assessment, laryngologists and speech-language pathologists rely heavily on laryngeal endoscopy with videostroboscopy to evaluate pathology and dysfunction of the vocal folds. The cost effectiveness, ease of use, and synchronized audio and visual feedback provided by videostroboscopic assessment serve to maintain its predominant clinical role in laryngeal imaging. However, significant drawbacks include only two-dimensional spatial imaging and the lack of subsurface morphological information. A novel endoscope will be ...
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      Mentions: Massachusetts General Hospital Harvard University Physical Sciences Incorporated

    5. Combined reflectance confocal microscopy-optical coherence tomography system for imaging of biological tissue

      Explore uspto.gov Patents
      Combined reflectance confocal microscopy-optical coherence tomography system for imaging of biological tissue
      A dual-modality apparatus for imaging of biological tissue includes a reflectance confocal microscopy (RCM) imaging apparatus and an optical coherence tomography (OCT) imaging apparatus. A first optical component reflects a first beam of light provided by a RCM imaging apparatus towards a sample and passes a second beam of light provided by an OCT imaging apparatus towards the sample, such that the first and second beam of lights share at ...
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      Mentions: Physical Sciences Incorporated R. Daniel Ferguson Nicusor Iftimia

    6. Physical Sciences ReceivesNIH Grant for Measurement of Retinal Nerves and Blood Vessels as Markers for Type 1 Diabetes

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      Physical Sciences ReceivesNIH Grant for Measurement of Retinal Nerves and Blood Vessels as Markers for Type 1 Diabetes
      ...ion research and subsequently on the clinical diagnosis and management of DR.

      Physical Sciences Incorporated Receives a 2017 NIH Grant for $230,823 for Measurement of Retinal Nerves and Bl...

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      Mentions: National Institutes of Health Physical Sciences Incorporated Mircea Mujat

    7. Airway compliance measured by anatomic optical coherence tomography

      Explore OSA | OSA Publishing Pulmonology
      Airway compliance measured by anatomic optical coherence tomography
      Quantification of airway compliance can aid in the diagnosis and treatment of obstructive airway disorders by detecting regions vulnerable to collapse. Here we evaluate the ability of a swept-source anatomic optical coherence tomography (SSaOCT) system to quantify airway cross-sectional compliance (CC) by measuring changes in the luminal cross-sectional area (CSA) under physiologically relevant pressures of 1040 cmH 2 O. The accuracy and precision of CC measurements are determined using simulations ...
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      Mentions: Amy L. Oldenburg University of North Carolina Physical Sciences Incorporated

    8. Physical Sciences Incorporated Receives NIH Grant for Hand-Held RCM/OCT Probe for Skin Cancer Laser Therapy Guidance

      Explore Optical Coherence Tomography News Dermatology , Funding
      Physical Sciences Incorporated Receives NIH Grant for Hand-Held RCM/OCT Probe for Skin Cancer Laser Therapy Guidance
      ...d perform its clinical evaluation for guiding laser ablation therapy of BCCs.

      Physical Sciences Incorporated Receives a 2016 NIH Grant for $475,423 for Hand-Held RCM/OCT Probe for Skin Can...

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      Mentions: National Institutes of Health Physical Sciences Incorporated Nicusor Iftimia

    9. Beyond Better Clinical Care: Optical Coherence Tomography's Economic Impact

      Explore BioOptics World
      Beyond Better Clinical Care: Optical Coherence Tomography's Economic Impact
      The optical coherence tomography (OCT) industry has grown dramatically in its first 25 years, and while the positive effects on patient clinical care are the most important measure of OCT's success, its contributions to the economy in jobs, tax receipts, and healthcare savings are also noteworthy. The field of optical coherence tomography (OCT) has grown dramatically since its discovery in the early 1990s. The commercialization and growth of OCT ...
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      Mentions: Tomophase Corporation Heliotis AG Imalux

    10. Feature of the Week 03/20/2016: Closed Loop Tracked Doppler OCT Based Heart Monitor for the Drosophila Melanogaster Larvae

      Explore Optical Coherence Tomography News Developmental Biology
      Feature of the Week 03/20/2016: Closed Loop Tracked Doppler OCT Based Heart Monitor for the Drosophila Melanogaster Larvae
      A fruit fly larva (top) was continuously tracked for continuous remote monitoring. A heartbeat trace of freely moving larva (bottom) was obtained by a low coherence interferometry based doppler sensing technique. This paper presents a novel instrument for biosciences, useful for studies of moving embryos. A dual sequential imaging/measurement channel is assembled via a closed-loop tracking architecture. The dual channel system can operate in two regimes: (i) single-point Doppler ...
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      Mentions: Adrian G. Podoleanu University of Kent Daniel X. Hammer

    11. Investigation of middle ear anatomy and function with combined video otoscopy-phase sensitive OCT

      Explore OSA | OSA Publishing Otolaryngology
      Investigation of middle ear anatomy and function with combined video otoscopy-phase sensitive OCT
      We report the development of a novel otoscopy probe for assessing middle ear anatomy and function. Video imaging and phase-sensitive optical coherence tomography are combined within the same optical path. A sound stimuli channel is incorporated as well to study middle ear function. Thus, besides visualizing the morphology of the middle ear, the vibration amplitude and frequency of the eardrum and ossicles are retrieved as well. Preliminary testing on cadaveric ...
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      Mentions: Harvard University Physical Sciences Incorporated Massachusetts Eye and Ear Infirmary

    13. Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study

      Explore SPIE | Journal Dermatology
      Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study
      We present a combined reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) approach, integrated within a single optical layout, for diagnosis of basal cell carcinomas (BCCs) and delineation of margins. While RCM imaging detects BCC presence (diagnoses) and its lateral spreading (margins) with measured resolution of 1 m 1m , OCT imaging delineates BCC depth spreading (margins) with resolution of 7 m 7m . When delineating margins in 20 specimens of ...
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      Mentions: Physical Sciences Incorporated Ernest W. Chang Nicusor Iftimia

    14. IMAGING WITH MULTIMODAL ADAPTIVE-OPTICS OPTICAL COHERENCE TOMOGRAPHY IN MULTIPLE EVANESCENT WHITE DOT SYNDROME: THE STRUCTURE AND FUNCTIONAL RELATIONSHIP

      Explore LWW Online Ophthalmology
      IMAGING WITH MULTIMODAL ADAPTIVE-OPTICS OPTICAL COHERENCE TOMOGRAPHY IN MULTIPLE EVANESCENT WHITE DOT SYNDROME: THE STRUCTURE AND FUNCTIONAL RELATIONSHIP
      Purpose: To elucidate the location of pathological changes in multiple evanescent white dot syndrome (MEWDS) with the use of multimodal adaptive optics (AO) imaging . Methods: A 5-year observational case study of a 24-year-old female with recurrent MEWDS. Full examination included history, Snellen chart visual acuity, pupil assessment, intraocular pressures, slit lamp evaluation, dilated fundoscopic exam, imaging with Fourier-domain optical coherence tomography (FD-OCT), blue-light fundus autofluorescence (FAF), fundus photography, fluorescein angiography ...
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      Mentions: University of Pittsburgh Joel S. Schuman Daniel X. Hammer

    15. Closed loop tracked Doppler optical coherence tomography based heart monitor for the Drosophila melanogaster larvae

      Explore Wiley Online Library Developmental Biology
      Closed loop tracked Doppler optical coherence tomography based heart monitor for the Drosophila melanogaster larvae
      A fruit fly larva (top) was continuously tracked for continuous remote monitoring. A heartbeat trace of freely moving larva (bottom) was obtained by a low coherence interferometry based doppler sensing technique. This paper presents a novel instrument for biosciences, useful for studies of moving embryos. A dual sequential imaging/measurement channel is assembled via a closed-loop tracking architecture. The dual channel system can operate in two regimes: (i) single-point Doppler ...
      Read Full Article
      Mentions: Adrian G. Podoleanu University of Kent Daniel X. Hammer

    16. Hand scanning optical coherence tomography imaging using encoder feedback

      Explore opticsinfobase.org Probes
      Hand scanning optical coherence tomography imaging using encoder feedback
      We present a new method for generating micron-scale OCT images of interstitial tissue with a hand scanning probe and a linear optical encoder that senses probe movement relative to a fixed reference point, i.e., tissue surface. Based on this approach, we demonstrate high resolution optical imaging of biological tissues through a very long biopsy needle. Minor artifacts caused by tissue noncompliance are corrected using a software algorithm which detects ...
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      Mentions: Massachusetts General Hospital Harvard University Physical Sciences Incorporated
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  4. About Physical Sciences Incorporated

    Physical Sciences Incorporated

    Physical Sciences Incorporated focuses on providing contract research and development services in a variety of technical areas to both government and commercial customers. Our interests range from basic research to technology development, with an emphasis on applied research.  Specifically, we develop advanced technologies for aerospace, energy, environmental, manufacturing and medical applications. The company's core technologies have been developed with more than $250 million of federal and industrial funding over three decades of operations, a period in which PSI has acquired an international reputation for technical excellence and innovation.

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