1. Physical Sciences Incorporated

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    1. Mentioned In 86 Articles

    2. Fiber-based hand-held RCM-OCT probe for noninvasive assessment of skin lesions and therapy guidance

      Fiber-based hand-held RCM-OCT probe for noninvasive assessment of skin lesions and therapy guidance
      Noninvasive assessment of skin lesions, especially of basal cell carcinoma (BCC), has benefited more recently from the use of optical imaging techniques such as optical coherence tomography (OCT) and reflectance confocal microscopy (RCM). While RCM provides submicron scale resolution and thus enables identification of skin morphological changes of the skin, with the downside of limited penetration depth, OCT imaging of the same lesion brings the benefit of better resolving its ...
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    3. Noninvasive, in vivo, characterization of cutaneous metastases using a novel multimodal RCM-OCT imaging device: A case-series

      Noninvasive, in vivo, characterization of cutaneous metastases using a novel multimodal RCM-OCT imaging device: A case-series
      Background: Cutaneous metastases (CM) are clinically challenging, requiring an invasive biopsy for confirmation. A novel, RCM-OCT device combines the advantage of high-resolution reflectance confocal microscopy (RCM) images and deeper optical coherence tomography (OCT) images to aid in non-invasive diagnosis. Objective: Characterize CM using RCM-OCT device. Methods: Seven patients with suspicious CM were consented and imaged with RCM-OCT device. CM features were defined by comparing with histopathology. Tumor depths were measured ...
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    4. Raman microspectroscopy/micro-optical coherence tomography approach for chairside diagnosis of periodontal diseases - A pilot study

      Raman microspectroscopy/micro-optical coherence tomography approach for chairside diagnosis of periodontal diseases - A pilot study
      Background: Our objective was to develop and test a combined Raman microspectroscopy (RMS) and micro-optical coherence tomography (OCT) approach for chairside quantification of gingival collagen, DNA, epithelium and connective tissue. We hypothesized that a high-resolution RMS/OCT can characterize healthy and inflamed periodontal tissues for diagnosis and disease activity monitoring. Methods: A prototype instrument was developed, tested ex-vivo on gingival specimens and optimized for in-vivo intraoral use. The primary outcome ...
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    5. A Study on Radiation Therapy Guided by the Reflectance Confocal Microscopy (RCM)/Optimal Coherence Tomography (OCT) Device in People With Basal Cell Carcinoma

      A Study on Radiation Therapy Guided by the Reflectance Confocal Microscopy (RCM)/Optimal Coherence Tomography (OCT) Device in People With Basal Cell Carcinoma
      The purpose of this study is to find out if radiation therapy (RT) guided by the new reflectance confocal microscopy (RCM)/optimal coherence tomography (OCT) device is an effective treatment for basal cell carcinoma (BCC). The researchers will also look at the side effects from RT guided by the RCM/OCT device. In addition, will determine the quality of life before and after treatment by having the participant fill out ...
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    6. Apparatus and method for assessment of interstitial tissue

      Apparatus and method for assessment of interstitial tissue
      A handheld optical coherence tomography imaging and tissue sampling system and method of imaging and sampling a tissue is disclosed. The method includes inserting a catheter probe into a biopsy needle. The biopsy needle can be attached to a hand-held scanning and sampling device. The biopsy needle is maneuvered to an investigation site. A three-dimensional image of the tissue at the investigation site is captured with the catheter probe.
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    7. Physical Sciences, Inc Receives NIH Grant for Multimodal Optical Prove for Skin Cancer Detection and Therapy Guidance

      Physical Sciences, Inc Receives NIH Grant for Multimodal Optical Prove for Skin Cancer Detection and Therapy Guidance
      Physical Sciences, Inc Receives a 2021 NIH Grant for $742,473 for Multimodal Optical Prove for Skin Cancer Detection and Therapy Guidance. The principal investigator is Nicusor Iftima. Below is a summary of the proposed work. The primary goal of this research project is to develop and translate to clinical use a novel optical imaging technology based on combined Optical Coherence Tomography (OCT) and Confocal Microscopy (CM) for non- invasive ...
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    8. Assessment of breast cancer surgical margins with multimodal optical microscopy: A feasibility clinical study

      Assessment of breast cancer surgical margins with multimodal optical microscopy: A feasibility clinical study
      Providing surgical margin information during breast cancer surgery is crucial for the success of the procedure. The margin is defined as the distance from the tumor to the cut surface of the resection specimen. The consensus among surgeons and radiation oncologists is that there should be no tumor left within 1 to maximum 2 mm from the surface of the surgical specimen. If a positive margin remains, there is substantial ...
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    9. The potential utility of integrated reflectance confocal microscopy-optical coherence tomography for guiding triage and therapy of basal cell carcinomas

      The potential utility of integrated reflectance confocal microscopy-optical coherence tomography for guiding triage and therapy of basal cell carcinomas
      The increasing rate of incidence and prevalence of basal cell carcinomas (BCCs) worldwide, combined with the morbidity associated with conventional surgical treatment has led to the development and use of alternative minimally invasive non-surgical treatments. Biopsy and pathology are used to guide BCC diagnosis and assess margins and subtypes, which then guide the decision and choice of surgical or non-surgical treatment. However, alternatively, a noninvasive optical approach based on combined ...
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    10. Physical Sciences Incorporated Receives NIH Grant for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance

      Physical Sciences Incorporated Receives NIH Grant for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance
      ...Physical Sciences Incorporated Receives a 2020 NIH Grant for $672,2387 for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance. The principal investigator is Nicusor Iftimia. Below is a summ...
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    11. Synchronized, concurrent optical coherence tomography and videostroboscopy for monitoring vocal fold morphology and kinematics

      Synchronized, concurrent optical coherence tomography and videostroboscopy for monitoring vocal fold morphology and kinematics
      Voice disorders affect a large number of adults in the United States, and their clinical evaluation heavily relies on laryngeal videostroboscopy, which captures the medial-lateral and anterior-posterior motion of the vocal folds using stroboscopic sampling. However, videostroboscopy does not provide direct visualization of the superior-inferior movement of the vocal folds, which yields important clinical insight. In this paper, we present a novel technology that complements videostroboscopic findings by adding the ...
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    12. Physical Sciences Inc Receives NIH Grant for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance

      Physical Sciences Inc Receives NIH Grant for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance
      Physical Sciences Inc Receives a 2019 NIH Grant for $300,000 for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance. The principal investigator is Nicusor Iftimia. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. The primary goal of this research project is to develop and translate to clinical use a novel optical imaging technology based on combined Optical Coherence ...
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    13. Physical Sciences Incorporated Receives NIH Grant for Multimodal Endoscopic Probe for Inner Ear Hearing Loss Diagnosis and Therapy Guidance

      Physical Sciences Incorporated Receives NIH Grant for Multimodal Endoscopic Probe for Inner Ear Hearing Loss Diagnosis and Therapy Guidance
      ...al planning during hearing preservation approaches for cochlear implantation.

      Physical Sciences Incorporated Receives a 2019 NIH Grant for $ 505,632 for Multimodal Endoscopic Probe for Inn...

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    14. Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway

      Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway
      It is hypothesized that the local, viscoelastic (time-dependent) properties of the airway are important to accurately model and ultimately predict dynamic airway collapse in airway obstruction. Toward this end, we present a portable, endoscopic, swept-source anatomical optical coherence tomography (aOCT) system combined with a pressure catheter to capture local airway dynamics in vivo during respiration. aOCT scans were performed in the airways of a mechanically ventilated pig under paralysis with ...
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    15. Investigation of tissue cellularity at the tip of the core biopsy needle with optical coherence tomography

      Investigation of tissue cellularity at the tip of the core biopsy needle with optical coherence tomography
      We report the development and the pre-clinical testing of a new technology based on optical coherence tomography (OCT) for investigating tissue composition at the tip of the core biopsy needle. While ultrasound, computed tomography, and magnetic resonance imaging are routinely used to guide needle placement within a tumor, they still do not provide the resolution needed to investigate tissue cellularity (ratio between viable tumor and benign stroma) at the needle ...
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  2. About Physical Sciences Incorporated

    Physical Sciences Incorporated

    Physical Sciences Incorporated focuses on providing contract research and development services in a variety of technical areas to both government and commercial customers. Our interests range from basic research to technology development, with an emphasis on applied research.  Specifically, we develop advanced technologies for aerospace, energy, environmental, manufacturing and medical applications. The company's core technologies have been developed with more than $250 million of federal and industrial funding over three decades of operations, a period in which PSI has acquired an international reputation for technical excellence and innovation.