1. Photini F. S. Rice

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    1. Mentioned In 15 Articles

    2. Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue

      Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue
      Ovarian cancer has the lowest survival rate among all gynecologic cancers predominantly due to late diagnosis. Early detection of ovarian cancer can increase 5-year survival rates from 40% up to 92%, yet no reliable early detection techniques exist. Optical coherence tomography (OCT) is an emerging technique that provides depth-resolved, high-resolution images of biological tissue in real-time and demonstrates great potential for imaging of ovarian tissue. Mouse models are crucial to ...
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    3. Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue

      Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue
      Ovarian cancer has the lowest survival rate among all gynecologic cancers due to predominantly late diagnosis. Early detection of ovarian cancer can increase 5-year survival rates from 40% up to 92%, yet no reliable early detection techniques exist. Optical coherence tomography (OCT) is an emerging technique that provides depthresolved, high-resolution images of biological tissue in real time and demonstrates great potential for imaging of ovarian tissue. Mouse models are crucial ...
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    4. Imaging colon cancer development in mice: IL-6 deficiency prevents adenoma in azoxymethane-treated Smad3 knockouts

      Imaging colon cancer development in mice: IL-6 deficiency prevents adenoma in azoxymethane-treated Smad3 knockouts
      The development of colorectal cancer in the azoxymethane-induced mouse model can be observed by using a miniaturized optical coherence tomography (OCT) imaging system. This system is uniquely capable of tracking disease development over time, allowing for the monitoring of morphological changes in the distal colon due to tumor development and the presence of lymphoid aggregates. By using genetically engineered mouse models deficient in Interleukin 6 (IL-6) and Smad family member ...
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    5. Time-serial Assessment of Drug Combination Interventions in a Mouse Model of Colorectal Carcinogenesis Using Optical Coherence Tomography

      Time-serial Assessment of Drug Combination Interventions in a Mouse Model of Colorectal Carcinogenesis Using Optical Coherence Tomography
      Optical coherence tomography (OCT) is a high-resolution, nondestructive imaging modality that enables time-serial assessment of adenoma development in the mouse model of colorectal cancer. In this study, OCT was utilized to evaluate the effectiveness of interventions with the experimental antitumor agent -difluoromethylornithine (DFMO) and a nonsteroidal anti-inflammatory drug sulindac during early [chemoprevention (CP)] and late stages [chemotherapy (CT)] of colon tumorigenesis. Biological endpoints for drug interventions included OCT-generated tumor number ...
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    6. In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis

      In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis
      Background and Objective Development of miniaturized imaging systems with molecular probes enables examination of molecular changes leading to initiation and progression of colorectal cancer in an azoxymethane (AOM)-induced mouse model of the disease. Through improved and novel studies of animal disease models, more effective diagnostic and treatment strategies may be developed for clinical translation. We introduce use of a miniaturized multimodal endoscope with lavage-delivered fluorescent probes to examine dynamic ...
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    7. Dual optical modality endoscopic imaging of cancer development in the mouse colon

      Dual optical modality endoscopic imaging of cancer development in the mouse colon
      Background and Objective We utilize a miniature, dual-modality endoscope that combines fluorescence-based surface magnifying chromoendoscopy (SMC) and optical coherence tomography (OCT) to follow the anatomical changes that occur during adenoma development in the mouse colon. Materials and Methods Twenty-five mice were treated with the carcinogen azoxymethane (AOM) to induce tumor development in the distal colon, or were treated with saline as control, and were imaged over six months. OCT detects ...
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    8. Diagnostic potential of multimodal imaging of ovarian tissue using optical coherence tomography and second-harmonic generation microscopy

      Diagnostic potential of multimodal imaging of ovarian tissue using optical coherence tomography and second-harmonic generation microscopy
      Ovarian cancer is particularly deadly because it is usually diagnosed after it has metastasized. We have previously identified features of ovarian cancer using optical coherence tomography (OCT) and second-harmonic generation (SHG) microscopy (targeting collagen). OCT provides an image of the ovarian microstructure, while SHG provides a high-resolution map of collagen fiber bundle arrangement. Here, we investigated the diagnostic potential of dual-modality OCT and SHG imaging. We conducted a fully crossed ...
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    9. In vivo time-serial multi-modality optical imaging in a mouse model of ovarian tumorigenesis

      In vivo time-serial multi-modality optical imaging in a mouse model of ovarian tumorigenesis
      Identification of the early microscopic changes associated with ovarian cancer may lead to development of a diagnostic test for high-risk women. In this study we use optical coherence tomography (OCT) and multiphoton microscopy (MPM) (collecting both two photon excited fluorescence [TPEF] and second harmonic generation [SHG]) to image mouse ovaries in vivo at multiple time points. We demonstrate the feasibility of imaging mouse ovaries in vivo during a long-term survival ...
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    10. In vivo three-dimensional optical coherence tomography and multiphoton microscopy in a mouse model of ovarian neoplasia

      In vivo three-dimensional optical coherence tomography and multiphoton microscopy in a mouse model of ovarian neoplasia
      ... multiphoton microscopy in a mouse model of ovarian neoplasia Jennifer M. Watson ; Samuel L. Marion ; Photini Faith Rice ; David L. Bentley ; David Besselsen ; Urs Utzinger ; Patricia B. Hoyer ; Jennifer K. Barton; In vi...
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    11. Endoscopic spectral domain optical coherence tomography of murine colonic morphology to determine effectiveness of chemopreventive and chemotherapeutic agents in colorectal cancer

      Endoscopic spectral domain optical coherence tomography of murine colonic morphology to determine effectiveness of chemopreventive and chemotherapeutic agents in colorectal cancer
      Optical coherence tomography (OCT) is a minimally-invasive imaging modality capable of tracking the development of individual colonic adenomas. As such, OCT can be used to evaluate the mechanisms and effectiveness of chemopreventive and chemotherapeutic agents in colorectal cancer models. The data presented here represent part of a larger study evaluating α-difluoromethylornithine (DFMO) and Sulindac as chemopreventive and chemotherapeutic agents using mice treated with the carcinogen azoxymethane (AOM). 27 A/J ...
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    12. Feasibility of optical coherence tomography imaging to characterize renal neoplasms: limitations in resolution and depth of penetration

      Feasibility of optical coherence tomography imaging to characterize renal neoplasms: limitations in resolution and depth of penetration
      Study Type - Diagnostic (exploratory cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Optical coherence tomography has been used for the diagnosis of retinal disease and has been used experimentally for imaging of vascular plaques, gastrointestinal pathology, bladder cancer, prostate cancer, and recently to examine benign kidney microanatomy. It has not been previously used to image kidney cancer. This study presents the ...
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    13. Feature Of The Week 1/16/11: University of Arizona Researchers Demonstrate In Vivo Dual Modality OCT & LIF Endoscopic System For Cancer Detection

      Feature Of The Week 1/16/11: University of Arizona Researchers Demonstrate In Vivo Dual Modality OCT & LIF Endoscopic System For Cancer Detection
      Feature Of The Week 1/16/11: The detection of cancer is complicated by the many forms of cancer. This implies that many forms of technologies will continue to play an important role in the study of the basic mechanisms of carcinogenesis, tools used for clinical diagnosis, and tools used to monitor and guide the progression of treatments. Optical Coherence Tomography (OCT) has emerged as another powerful technology to assist ...
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    14. In Vivo, Dual-Modality OCT/LIF Imaging Using a Novel VEGF Receptor-Targeted NIR Fluorescent Probe in the AOM-Treated Mouse Model

      In Vivo, Dual-Modality OCT/LIF Imaging Using a Novel VEGF Receptor-Targeted NIR Fluorescent Probe in the AOM-Treated Mouse Model
      ...ing Using a Novel VEGF Receptor-Targeted NIR Fluorescent Probe in the AOM-Treated Mouse Model Amy M. Winkler, Photini F. S. Rice, Jan Weichsel, Jennifer M. Watson, Marina V. Backer, Joseph M. Backer and Jennifer K. Barto...
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    15. Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon

      Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon
      ...ollege of Optical Sciences, 1657 East Helen Street, Building 240, P.O. Box 210240, Tucson, Arizona 85721-0240 Photini F. S. Rice University of Arizona, Department of Biomedical Engineering, 1657 East Helen Street, Buildi...
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  2. About Photini F. S. Rice

    Photini F. S. Rice

    Photini (Faith) F. S. Rice is in the Department of Biomedical Engineering at The University of Arizona.