BACKGROUND AND OBJECTIVE: To investigate the potential of ultrahigh-speed swept-source optical coherence tomography angiography (OCTA) to visualize retinal and choroidal vascular changes in patients with exudative age-related macular degeneration (AMD). PATIENTS AND METHODS: Observational, prospective cross-sectional study. An ultrahigh-speed swept-source prototype was used to perform OCTA of the retinal and choriocapillaris microvasculature in 63 eyes of 32 healthy controls and 19 eyes of 15 patients with exudative AMD. MAIN OUTCOME MEASURE: qualitative comparison of the retinal and choriocapillaris microvasculature in the two groups. RESULTS: Choroidal neovascularization (CNV) was clearly visualized in 16 of the 19 eyes with exudative AMD, located ...
Purpose: To investigate the relationship between drusen area measurements from color fundus images (CFIs) and spectral domain optical coherence tomography (SDOCT) datasets. Methods: Forty-two eyes from thirty Patients with drusen in the absence of geographic atrophy were recruited into a prospective study. Digital color fundus images and SDOCT images (CirrusTM HD-OCT) were obtained at baseline and at follow-up visits at 3 and 6 months. Registered, matched circles centered on the fovea with diameters of 3 mm and 5 mm were identified on both the CFIs and the SDOCT images. SDOCT drusen measurements were obtained using a commercially available proprietary algorithm ...
To demonstrate the feasibility of using a 1,050-nm swept-source optical coherence tomography (SS-OCT) system to achieve noninvasive retinal vasculature imaging in human eyes. MATERIALS AND METHODS: Volumetric data sets were acquired using a 1-µm SS-OCT prototype that operated at a 100-kHz A-line rate. A scanning protocol designed to allow for motion contrast processing, referred to as OCT angiography or optical microangiography (OMAG), was used to scan an approximately 3 × 3–mm area in the central macular region of the retina within approximately 4.5 seconds. An intensity differentiation-based OMAG algorithm was used to extract three-dimensional retinal functional microvasculature ...
Advances in retinal pharmacology have significantly improved outcomes for patients with a range of chronic retinal conditions, including age-related macular degeneration, macular edema, retinal vascular disorders and diseases of the vitreomacular interface. Maximizing the efficacy of available treatments requires the appropriate use of optical coherence tomography (OCT) to diagnose these conditions and to monitor the efficacy of treatment. In this webinar series, leading clinicians and researchers will discuss the role of OCT in detecting structural changes associated with a range of retinal diseases and provide clinical pearls on using tools such as thickness maps, automated change analysis and angiography in ...
The Association for Research in Vision and Ophthalmology (ARVO)has approved a new Special Interest Group (SIG) for the 2014 ARVO Annual Meeting, May 4-8, 2014, in Orlando, Florida. The SIG is titled: En Face OCT imaging of the Eye – SIG, Session Number: 355. The Organizer is Andre Romano and includes the following speakers: David Huang, James Fujimoto, Philip Rosenfeld. Bruno Lumbroso, Gabriel Coscas, Min Wang, Richard Rosen. More can be found by clicking HERE .
Purpose:To determine whether the minimum intensity of the optical coherence tomography (OCT) A-scans within the retina can predict locations of growth at the margin of geographic atrophy (GA) and the growth rate outside the margin. Methods:OCT scans were analyzed at baseline and 52 weeks. Expert graders manually segmented OCT images of GA. The 52-week follow-up scans were registered to the baseline scan coordinates for comparison. OCT Minimum Intensity (MI) values were studied within a 180-micron margin around the boundary of GA at baseline. Baseline MI values were compared in areas of progression and non-progression of the GA, and ...
The First international meeting on “en face”OCT in Rome Saturday December 14. Co-organizers are Bruno Lumbroso (Rome) Philip Rosenfeld (Miami) and Gabriel Coscas (Paris). Duration one day. We will discuss next developments of clinical “en face” OCT and clinical applications of this technique. For more information click HERE . Meeting Site ( www.symposiacongressi.eu and secretariat anna.porro@symposiacongressi.eu )).
Purpose: To evaluate drusenoid retinal pigment epithelial detachments (DPED) secondary to age-related macular degeneration (AMD) using spectral-domain optical coherence tomography imaging. Methods: In this prospective natural history study, eyes from patients with the diagnosis of nonexudative AMD and DPEDs were followed for at least 6 months. Eyes were scanned using the Cirrus spectral-domain optical coherence tomography instrument and the 200 x 200 A-scan raster pattern. A custom software was used to quantify volumetric changes in DPEDs and to detect the evolution and formation of geographic atrophy and choroidal neovascularization. Changes in DPED area and volume and development of the advanced ...
Philip J. Rosenfeld, MD, is a professor of ophthalmology at the Bascom Palmer Eye Institure at the University of Miami.