1. Petra E. Wilder-Smith

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    1. Mentioned In 27 Articles

    2. Intra-operative point-of-procedure delineation of oral cancer margins using optical coherence tomography

      Intra-operative point-of-procedure delineation of oral cancer margins using optical coherence tomography
      Objectives Surgical margin status is a significant determinant of treatment outcome in oral cancer. Negative surgical margins can decrease the loco-regional recurrence by five-fold. The current standard of care of intraoperative clinical examination supplemented by histological frozen section, can result in a risk of positive margins from 5 to 17 percent. In this study, we attempted to assess the utility of intraoperative optical coherence tomography (OCT) imaging with automated diagnostic ...
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    3. Optical Coherence Tomography as an Oral Cancer Screening Adjunct in a Low Resource Settings

      Optical Coherence Tomography as an Oral Cancer Screening Adjunct in a Low Resource Settings
      Oral cancer is the sixth most common cancer worldwide, predominantly seen in low and middle-income countries (LMIC). Two thirds of all cases are detected at a late stage when prognosis and treatment outcomes are poor. Oral lesions are commonly detected by visual inspection, followed by invasive surgical biopsy and time consuming histopathological analysis. Optical Coherence Tomography (OCT), a minimally invasive tomographic imaging technology, can be used to non-invasively identify premalignant ...
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    4. Stimuli-disassembling gold nanoclusters for diagnosis of early stage oral cancer by optical coherence tomography

      Stimuli-disassembling gold nanoclusters for diagnosis of early stage oral cancer by optical coherence tomography
      A key design consideration in developing contrast agents is obtaining distinct, multiple signal changes in diseased tissue. Plasmonic gold nanoparticles (Au NPs) have been developed as contrast agents due to their strong surface plasmon resonance (SPR). This study aims to demonstrate that stimuli-responsive plasmonic Au nanoclusters (Au NCs) can be used as a contrast agent for optical coherence tomography (OCT) in detecting early-stage cancer. Au NPs were clustered via acid-cleavable ...
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    5. Comparison of caries diagnostic modalities: A clinical study in 40 subjects

      Comparison of caries diagnostic modalities: A clinical study in 40 subjects
      Background and Objectives Few studies have been published that evaluate the usefulness of different caries- diagnostic modalities in general dental practice. The goal of this study was to compare the results of screening for coronal dental caries in a general dental practice using clinical observations, radiographs, laser fluorescence (DIAGNOdent) (LF), and optical coherence tomography (OCT). Diagnostic agreement between OCT and LF versus standard clinical techniques for detecting caries was determined ...
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    6. UC Irvine Receives NIH Grant for A Low-Cost Simple Oral Cancer Screening Device For Low-Resource Settings

      UC Irvine Receives NIH Grant for A Low-Cost Simple Oral Cancer Screening Device For Low-Resource Settings
      ...7 for A Low-Cost Simple Oral Cancer Screening Device For Low-Resource Settings. The principle Investigator is Petra Wilder-Smith. The program began in 2012 and ends in 2014. Below is a summary of the proposed work.

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    7. A prospective study to assess in vivo optical coherence tomography imaging for early detection of chemotherapy-induced oral mucositis

      A prospective study to assess in vivo optical coherence tomography imaging for early detection of chemotherapy-induced oral mucositis
      Background and Objective Oral mucositis (OM) is a common and severe complication of many cancer therapies. Currently, prediction and early detection are not possible and objective monitoring remains problematic. Goal of this prospective study is to assess non-invasive imaging using optical coherence tomography (OCT) for early detection and evaluation of chemotherapy-induced OM in 48 patients, 12 of whom developed clinical mucositis. Study Design/Materials and Methods In 48 patients receiving ...
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    8. An imaging-based approach to the evaluation of xerostomia

      An imaging-based approach to the evaluation of xerostomia
      Background and Objective Goal was to evaluate the potential of in vivo optical coherence tomography (OCT) imaging to determine the response of patients with xerostomia to a dry mouth toothpaste versus fluoride toothpaste placebo. Study Design/Materials and Methods Ten subjects with xerostomia participated in this double-blind, crossover, placebo-controlled study. After examination and OCT imaging, subjects used the first product for 15 days, followed by a 7-day washout period, and ...
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    9. Ability of optical coherence tomography to detect caries beneath commonly used dental sealants

      Ability of optical coherence tomography to detect caries beneath commonly used dental sealants
      Background and Objective The onset and progression of early tooth decay is often preventable with dental sealants. However, occasionally decay progresses underneath the sealant. Current technology does not permit monitoring of potential lesion progression or arrest. Dental sealants themselves mask the visual cues that identify early tooth decay, and radiographs are not sufficiently sensitive. Therefore, clinicians can be reluctant to use dental sealant. The objective of this ex vivo study ...
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  2. About Petra E. Wilder-Smith

    Petra E. Wilder-Smith

    Petra Wilder-Smith is a researcher at the Beckman Laser Institute and Medical Clinic at the University of California at Irvine.

  3. Quotes

    1. The inexpensive, very small, robust portable diagnostic system for oral cancer based on OCT will be used to screen for oral cancer in the field by basic level healthcare workers in India, and a simple diagnostic algorithm will indicate further diagnostic and treatment needs for each individual.
      In Indo-US experts to develop solar-powered oral cancer detector