1. Peter J. Fitzgerald

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    1. Mentioned In 8 Articles

    2. First-in-Human Evaluation of a Bioabsorbable Polymer–Coated Sirolimus-Eluting Stent: Imaging and Clinical Results of the DESSOLVE I Trial (DES With Sirolimus and a Bioabsorbable Polymer for the Treatment of Patients With De Novo Lesion in the Native Coro

      First-in-Human Evaluation of a Bioabsorbable Polymer–Coated Sirolimus-Eluting Stent: Imaging and Clinical Results of the DESSOLVE I Trial (DES With Sirolimus and a Bioabsorbable Polymer for the Treatment of Patients With De Novo Lesion in the Native Coro

      Objectives This first-in-human multicenter study sought to examine prospectively the safety and efficacy of a new, cobalt chromium thin-strut, coronary absorbable polymer–coated, sirolimus-eluting stent. Background Bioabsorbable polymers on drug-eluting stents may lower the long-term risks of inflammation, delayed healing, and adverse events. Methods We enrolled patients with symptomatic coronary artery disease with stable or unstable angina pectoris and >50% diameter stenosis, amenable to coverage with a ≤23-mm long stent in a vessel 2.5 to 3.5 mm in diameter. All patients received dual antiplatelet therapy after implantation. Patients, in groups of 10, underwent repeat angiography, intravascular ultrasound, and ...

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    3. Variability in quantitative and qualitative analysis of intravascular ultrasound and frequency domain optical coherence tomography

      Variability in quantitative and qualitative analysis of intravascular ultrasound and frequency domain optical coherence tomography

      Background: Frequency-domain optical coherence tomography (FD-OCT) is an intravascular imaging technique now available in the United States. However, the importance of level of training required for analysis using intravascular ultrasound (IVUS) and FD-OCT is unclear. The aim of this study was to evaluate inter- and intra-observer variability between expert and beginner analysts interpreting IVUS and FD-OCT images. Methods and results : Two independent expert analysts and two independent beginner analysts evaluated a total of 226±2 stent cross-sections with IVUS and 232±2 stent cross-sections with FD-OCT in 14 patients after stenting. Inter- and intra-observer variability for determining stent volume index ...

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    4. Consensus Standards for Acquisition, Measurement, and Reporting of Intravascular Optical Coherence Tomography Studies: A Report From the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation

      Consensus Standards for Acquisition, Measurement, and Reporting of Intravascular Optical Coherence Tomography Studies: A Report From the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation
      ...uke Dijkstra, PhD, Carlo Di Mario, MD, PhD, Darius Dudeck, MD, PhD, Erlin Falk, MD, PhD, Marc D. Feldman, MD, Peter Fitzgerald, MD, Hector Garcia, MD, Nieves Gonzalo, MD, Juan F. Granada, MD, Giulio Guagliumi, MD, Niels ...
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    5. Evaluation of the Peri-strut Low Intensity Area Following Sirolimus- and Paclitaxel-Eluting Stents Implantation: Insights From an Optical Coherence Tomography Study in Humans

      Evaluation of the Peri-strut Low Intensity Area Following Sirolimus- and Paclitaxel-Eluting Stents Implantation: Insights From an Optical Coherence Tomography Study in Humans
      Background: In previous pathological studies, paclitaxel-eluting stents (PES) showed greater fibrin deposition around stent struts, while sirolimus-eluting stent (SES) showed predominance of inflammatory cells with less fibrin deposition than PES. However, there are limited in-vivo data clarifying those qualitative differences in the process of vascular healing after 1st-generation drug-eluting stents (DES) implantation. A recent animal study has shown that peri-strut low intensity area (PLIA) seen in optical coherence tomography (OCT) imaging might represent the process of hyaluronic acid and proteoglycan replacing fibrin. Methods: A total of 60 patients who underwent 6-month follow-up OCT after SES (n=34) and PES (n ...
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    6. Feature Of The Week 6/14/09: Assessing Sirolimus-Eluting Stent Implantation by Optical Coherence Tomography

      Feature Of The Week 6/14/09: Assessing Sirolimus-Eluting Stent Implantation by Optical Coherence Tomography
      Feature Of The Week 6/14/09: Heart disease is a leading cause of death in the industrialize world. Since the early 1990's when the Palmaz bare medal stent was introduced, stents have continued to play a major role in the treatment of heart disease. The stent market is over $5B and there is intense pressure to improve stent technology from both a healthcare and market share perspective. Optical Coherence Tomography is unique in its ability to provide critical information in assessing the impact, safety, and efficacy of stents. Some recent work by researchers at Kobe University and Stanford ...
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    7. In Vivo Comparison Between Optical Coherence Tomography and Intravascular Ultrasound for Detecting Small Degrees of In-Stent Neointima After Stent Implantation

      ...ki Ikeno, MD*,1, Tomomi Koizumi, MD, PhD*, Fermin Tio, MD, Alan C. Yeung, MD, FACC*, Paul G. Yock, MD, FACC*, Peter J. Fitzgerald, MD, PhD, FACC*, William F. Fearon, MD, FACC*,* * Division of Cardiovascular Medicine, Sta...
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    8. Local Determinants of Thrombus Formation Following Sirolimus-Eluting Stent Implantation Assessed by Optical Coherence Tomography

      ...awara, MD*, Takahiro Sawada, MD*, Naoki Miyoshi, MD*, Hiroki Kato, MD*, Bon-Kwon Koo, MD, Yasuhiro Honda, MD, Peter J. Fitzgerald, MD, PhD, Ken-ichi Hirata, MD* * Department of Internal Medicine, Division of Cardiovascul...
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    9. Local Determinants and Clinical Significance of Thrombus Formation Following Sirolimus-Eluting Stent Implantation: Insights from Optical Coherence Tomography Analysis

      Angioscopic analyses have shown the presence of subclinical thrombus in sirolimus-eluting stents (SES) is more common than the clinical incidence of stent thrombosis. However, the determinants and long term significance of subclinical thrombus remain unknown. Thirty five patients (44 stents) who received SES underwent 6 months follow-up optical coherence tomography (OCT). Patients were divided into 2 groups according to the presence of thrombus by OCT. Cross-sectional images were analyzed every 1mm. Stent eccentricity index (SEI; minimum stent diameter divided by maximum stent diameter) was determined in each cross section (CS). To assess the unevenness of neointimal thickness (NIT), a neointimal ...
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  2. About Peter J. Fitzgerald

    Peter J. Fitzgerald

    Peter J. Fitzgerald is the Co-Director of the Center for Research in Cardiovascular Interventions and Director of the Cardiovascular Core Analysis Laboratory (CCAL) at Stanford University Medical School and with the Center for Cardiovascular Technology, Division of Cardiovascular Medicine at Stanford University. He is an Interventional Cardiologist and has a PhD in Engineering. Presently, Dr. Fitzgerald s laboratory includes 14 postdoctoral fellows and graduate engineering students focusing on state-of-the-art technologies in Cardiovascular Medicine. He has led or participated in over 80 clinical trials, published over 300 manuscripts/ chapters, and lectures worldwide.