1. Peter A. Calabresi

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    1. Mentioned In 62 Articles

    2. The International Multiple Sclerosis Visual System Consortium: Advancing Visual System Research in Multiple Sclerosis

      The International Multiple Sclerosis Visual System Consortium: Advancing Visual System Research in Multiple Sclerosis
      ...from Novartis. The remaining authors report no conflicts of interest. L. J. Balcer, L. J. Balk, A. U. Brandt, P. A. Calabresi, E. H. Martinez-Lapiscina, R. Nolan, F. Paul, A. Petzold, and S. Saidha contributed equally an...
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    3. Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research

      Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research
      Purpose To review the clinical and research value of optical coherence tomography angiography (OCTA) in the field of neurology. Methods Current literature involving OCTA were reviewed through PubMed using the search terms optical coherence tomography angiography, with multiple sclerosis, Alzheimers disease, optic neuropathy, or other closely-related terms. Results OCTA has been applied in research to advance our understanding of the pathobiology of neurological disorders. OCTA-derived blood flow and vessel density ...
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    4. Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

      Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study
      Background Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available. Methods In this multicentre, cohort study ...
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    5. Optical coherence tomography: A quantitative tool to measure neurodegeneration and facilitate testing of novel treatments for tissue protection in multiple sclerosis

      Optical coherence tomography: A quantitative tool to measure neurodegeneration and facilitate testing of novel treatments for tissue protection in multiple sclerosis
      Optical coherence tomography (OCT) is a relatively new imaging technology that has been introduced as a powerful biomarker in neurological disease, including multiple sclerosis. In this review, OCT as an imaging technique, its reproducibility and validation in multiple sclerosis, application to other neurodegenerative diseases and future technological directions are discussed.
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    6. Optical Coherence Tomography (OCT) and Predicting Multiple Sclerosis (MS) Progression (Video)

      Optical Coherence Tomography (OCT) and Predicting Multiple Sclerosis (MS) Progression (Video)
      Retinal thickness is a significant independent predictor of worsening disability in multiple sclerosis (MS) and should be incorporated into clinical trials and treatment decisions, according to a large longitudinal cohort study presented at the American Academy of Neurology (AAN) Annual Meeting Optical coherence tomography (OCT), which is used to measure retinal thickness, can help clinicians predict multiple sclerosis (MS) progression two to five years later, according to an international longitudinal ...
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    7. The APOSTEL recommendations for reporting quantitative optical coherence tomography studies

      The APOSTEL recommendations for reporting quantitative optical coherence tomography studies
      Objective: To develop consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results. Methods: A panel of experienced OCT researchers (including 11 neurologists, 2 ophthalmologists, and 2 neuroscientists) discussed requirements for performing and reporting quantitative analyses of retinal morphology and developed a list of initial recommendations based on experience and previous studies. The list of recommendations was subsequently revised during several meetings of the coordinating group. Results: We ...
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    8. Voxel based morphometry in optical coherence tomography: validation and core findings

      Voxel based morphometry in optical coherence tomography: validation and core findings
      Optical coherence tomography (OCT) of the human retina is now becoming established as an important modality for the detection and tracking of various ocular diseases. Voxel based morphometry (VBM) is a long standing neuroimaging analysis technique that allows for the exploration of the regional differences in the brain. There has been limited work done in developing registration based methods for OCT, which has hampered the advancement of VBM analyses in ...
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    9. Simultaneous segmentation of retinal surfaces and microcystic macular edema in SDOCT volumes

      Simultaneous segmentation of retinal surfaces and microcystic macular edema in SDOCT volumes
      Optical coherence tomography (OCT) is a noninvasive imaging modality that has begun to find widespread use in retinal imaging for the detection of a variety of ocular diseases. In addition to structural changes in the form of altered retinal layer thicknesses, pathological conditions may also cause the formation of edema within the retina. In multiple sclerosis, for instance, the nerve fiber and ganglion cell layers are known to thin. Additionally ...
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    10. Combined registration and motion correction of longitudinal retinal OCT data

      Combined registration and motion correction of longitudinal retinal OCT data
      Optical coherence tomography (OCT) has become an important modality for examination of the eye. To measure layer thicknesses in the retina, automated segmentation algorithms are often used, producing accurate and reliable measurements. However, subtle changes over time are difficult to detect since the magnitude of the change can be very small. Thus, tracking disease progression over short periods of time is difficult. Additionally, unstable eye position and motion alter the ...
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    11. Optical Coherence Tomography in Neurologic Disease (Textbook)

      Optical Coherence Tomography in Neurologic Disease (Textbook)
      Shortly after the invention of the first two-dimensional optical coherence tomography (OCT) scans by James Fujimoto and colleagues at the Massachusetts Institute of Technology in 1991, ophthalmologists recognized the extraordinary potential for OCT to facilitate quantitative assessment of the neuroretina. OCT rapidly became a commonplace tool in ophthalmologic practice to identify both inflammatory and degenerative conditions affecting the optic nerve and retina. The utility of OCT to detect and quantify ...
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    12. Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

      Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study
      Background Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available. Methods In this multicentre, cohort study ...
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    13. Leading Edge Collaboration in Eye-Related Research Earns Investigators at NYU Langone Medical Center, Johns Hopkins, and the UT Southwestern Medical Center the 2015 Barancik Prize for Innovation in MS Research

      Leading Edge Collaboration in Eye-Related Research Earns Investigators at NYU Langone Medical Center, Johns Hopkins, and the UT Southwestern Medical Center the 2015 Barancik Prize for Innovation in MS Research
      The collaborative team of Drs. Laura Balcer , Peter Calabresi and Elliot Frohman have been selected as the winners of the 2015 Barancik Prize for Innovation in MS Research. This team of physician-scientists have worked together for almost 10 years to produce novel, ground-breaking and impactful research about the anatomy and biology of the retina and other structures of the eye in people with multiple sclerosis (MS). In their more than ...
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    14. Optical coherence tomography reflects brain atrophy in multiple sclerosis: A four-year study

      Optical coherence tomography reflects brain atrophy in multiple sclerosis: A four-year study
      Objective The aim of this work was to determine whether atrophy of specific retinal layers and brain substructures are associated over time, in order to further validate the utility of optical coherence tomography (OCT) as an indicator of neuronal tissue damage in patients with multiple sclerosis (MS). Methods Cirrus high-definition OCT (including automated macular segmentation) was performed in 107 MS patients biannually (median follow-up: 46 months). Three-Tesla magnetic resonance imaging ...
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    15. Optical coherence tomography reflects brain atrophy in MS: A four year study

      Optical coherence tomography reflects brain atrophy in MS: A four year study
      Objective : To determine whether atrophy of specific retinal layers and brain substructures are associated over time, in order to further validate the utility of optical coherence tomography (OCT) as an indicator of neuronal tissue damage in patients with multiple sclerosis (MS). Methods : Cirrus high definition OCT (including automated macular segmentation) was performed in 107 MS patients biannually (median follow-up: 46-months). Three-tesla magnetic resonance imaging brain scans (including brain-substructure volumetrics) were ...
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    16. Segmentation of microcystic macular edema in Cirrus OCT scans with an exploratory longitudinal study

      Segmentation of microcystic macular edema in Cirrus OCT scans with an exploratory longitudinal study
      Microcystic macular edema (MME) is a term used to describe pseudocystic spaces in the inner nuclear layer (INL) of the human retina. It has been noted in multiple sclerosis (MS) as well as a variety of other diseases. The processes that lead to MME formation and their change over time have yet to be explained sufficiently. The low rate at which MME occurs within such diverse patient groups makes the ...
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  2. About Peter A. Calabresi

    Peter A. Calabresi

    Peter Calabresi is and Associate Professor of Neurology at John Hopkins and the Director of the Johns Hopkins Multiple Sclerosis Center.  Dr. Peter Calabresi received his undergraduate degree from Yale University and his medical degree from Brown University. He then completed an internship and residency training in internal medicine at Strong Memorial Hospital. He went on to complete a fellowship in neuroimmunology at the National Institutes of Health.

  3. Quotes

    1. The eye is the window into the brain and by measuring how healthy the eye is, we can determine how healthy the rest of the brain is...Eye scans are not that expensive, are really safe, and are widely used in ophthalmology, and now that we have evidence of their predictive value in MS, we think they are ready for prime time. We should be using this new quantitative tool to learn more about disease progression, including nerve damage and brain atrophy.
      In Using The Eye as a "Window To The Brain"