1. Pete H. Tomlins

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    1. Mentioned In 40 Articles

    2. Heart rate sensitive optical coherence angiography

      Heart rate sensitive optical coherence angiography
      Optical coherence angiography (OCA) enables visualisation of three-dimensional micro-vasculature from optical coherence tomography data volumes. Typically, various statistical methods are used to discriminate static tissue from blood flow within vessels. In this paper, we introduce a new method that relies upon the beating heart frequency to isolate blood vessels from the surrounding tissue. Vascular blood flow is assumed to be more strongly modulated by the heart-beat compared to surrounding tissue ...
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    3. Heart-rate sensitive optical coherence angiography for measuring vascular changes due to posttraumatic brain injury in mice

      Heart-rate sensitive optical coherence angiography for measuring vascular changes due to posttraumatic brain injury in mice
      Traumatic brain injury (TBI) results in direct vascular disruption, triggering edema, and reduction in cerebral blood flow. Therefore, understanding the pathophysiology of brain microcirculation following TBI is important for the development of effective therapies. Optical coherence angiography (OCA) is a promising tool for evaluating TBI in rodent models. We develop an approach to OCA that uses the heart-rate frequency to discriminate between static tissue and vasculature. This method operates on ...
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    4. Dynamic measurement of the optical properties of bovine enamel demineralization models using four-dimensional optical coherence tomography

      Dynamic measurement of the optical properties of bovine enamel demineralization models using four-dimensional optical coherence tomography
      Dental enamel mineral loss is multifactorial and is consequently explored using a variety of in vitro models. Important factors include the presence of acidic pH and its specific ionic composition, which can both influence lesion characteristics. Optical coherence tomography (OCT) has been demonstrated as a promising tool for studying dental enamel demineralization. However, OCT-based characterization and comparison of demineralization model dynamics are challenging without a consistent experimental environment. Therefore, an ...
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    5. Methods to assess sensitivity of optical coherence tomography systems

      Methods to assess sensitivity of optical coherence tomography systems
      Measuring the sensitivity of an optical coherence tomography (OCT) system determines the minimum sample reflectivity it can detect and provides a figure of merit for system optimization and comparison. The published literature lacks a detailed description of OCT sensitivity measurement procedures. Here we describe a commonly-used measurement method and introduce two new phantom-based methods, which also offer a means to directly visualize low reflectivity conditions relevant to biological tissue. We ...
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    6. Institute of Physics and University of Manchester Optical Coherence Tomography II Meeting December 3rd Manchester UK

      Institute of Physics and University of Manchester Optical Coherence Tomography II Meeting December 3rd Manchester UK
      We invite you to join us for an exciting day discussing recent developments in optical coherence tomography (OCT). This follows on our successful meeting in 2011. We hope this meeting will be of interest to a broad audience coming from industry, clinics and academia. Send us your talk and poster abstracts! Topics include, but are not limited to: Clinical applications of OCT (e.g. ophthalmology, cardiology, dermatology) Industrial applications of ...
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    7. Optical Coherence Tomography Conference at the University of Manchester December 3rd 2014

      Optical Coherence Tomography Conference at the University of Manchester December 3rd 2014
      We invite you to join us for an exciting day discussing recent developments in optical coherence tomography (OCT). This follows on our successful meeting in 2011. The meeting will be organised around 2-3 invited talks, technical sessions with poster sessions interspersed. We hope this meeting will be of interest to a broad audience coming from industry, clinics and academia. There is no fee for this meeting, however registration is required ...
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    8. Scanning Methods And Apparatus

      Scanning Methods And Apparatus
      There is provided a method of identifying a region of interest in sample. The method comprises obtaining one or more optical coherence tomography (OCT) axial scans at one or more locations over the sample surface; for each axial scan, determining an integrated total of OCT intensity over the depth of the scan, and determining an attenuation depth into the sample at which a predetermined fraction of the integrated total is ...
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    9. Multi-system comparison of optical coherence tomography performance with point spread function phantoms

      Multi-system comparison of optical coherence tomography performance with point spread function phantoms
      Point spread function (PSF) phantoms based on unstructured distributions of sub-resolution particles in a transparent matrix have proven effective for evaluating resolution and its spatial variation in optical coherence tomography (OCT) systems. Measurements based on PSF phantoms have the potential to become a standard test method for consistent, objective and quantitative inter-comparison of OCT system performance. Towards this end, we have evaluated three PSF phantoms and investigated their ability to ...
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    10. Quantitative optical coherence tomography of fluid-filled oral mucosal lesions

      Quantitative optical coherence tomography of fluid-filled oral mucosal lesions
      The decision of selecting the most representative site for the biopsy of fluid-filled lesions can be difficult. This may be attributed to the poor delineation of the correct lesional site by clinical observation alone. In this study, optical coherence tomography is used to quantify the contrast between solid- and fluid-filled lesions by measuring the light intensity change at the tissuefluid interface (intensity drop). This parameter was measured from sequential axial ...
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    11. Scanning Methods And Apparatus

      Scanning Methods And Apparatus
      There is provided a method of identifying a region of interest in sample. The method comprises obtaining one or more optical coherence tomography (OCT) axial scans at one or more locations over the sample surface; for each axial scan, determining an integrated total of OCT intensity over the depth of the scan, and determining an attenuation depth into the sample at which a predetermined fraction of the integrated total is ...
      Read Full Article
    12. Feature Of The Week 2/5/12: Queen Mary University of London Researchers Investigate Quantitative Analysis of OCT and Histopathology Images of Normal and Dysplastic Oral Mucosal Tissues

      Feature Of The Week 2/5/12: Queen Mary University of London Researchers Investigate Quantitative Analysis of OCT and Histopathology Images of Normal and Dysplastic Oral Mucosal Tissues
      Selecting the most representative site for biopsy is crucial in establishing a definitive diagnosis of oral epithelial dysplasia. The current process involves clinical examination that can be subjective and prone to sampling errors. The aim of this study was therefore to investigate the use of optical coherence tomography (OCT) for differentiation of normal and dysplastic oral epithelial samples, with a view to developing an objective and reproducible approach for biopsy ...
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  2. About Pete H. Tomlins

    Pete H. Tomlins

    Pete Tomlins is at Queen Mary University of London.  Formerly, Dr. Tomlins was a Senior Scientist in the Optical Technologies Group at the UK’s National Physical Laboratory (NPL), where he leads a portfolio of projects in biomedical optics. His primary research interest is in quantitative OCT and understanding the physical origin of contrast in OCT images. A particular interest is cell and tissue optics where Pete is developing experimental methods to determine the spatially distributed optical properties of human tissue, correlating these with the presence and progress of disease. Optical properties of particular interest are refractive index, dispersion, absorption and scattering. A multiple-angle variant of OCT has been developed by Pete Tomlins group to perform these measurements, along with computational models and optical phantoms. Further interests include tissue engineering, where Pete has used Doppler OCT to determine the complex fluid flow within artificial tissue scaffolds, and dental composites research.

    Pete manages a number of collaborations with leading commercial and research organisation, and plans to increase the number and scope of such partnerships along with the activity at NPL.

  3. Quotes

    1. We anticipate that eventually such phantoms will be shipped with OCT systems when they are used clinically, together with a set of guidelines highlighting how they are to be used.
      In Spotting the signs: Improving resolution of systems used to image human tissue could help early identification of life-threatening diseases
    2. By removing the point-spread function from the data, we have actually seen an improvement of several microns in resolution of an OCT instrument, which is very exciting. We have demonstrated that you can now resolve two points that previously couldn't be resolved.
      In Spotting the signs: Improving resolution of systems used to image human tissue could help early identification of life-threatening diseases