1. Pearse A. Keane

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    1. Mentioned In 91 Articles

    2. Clinically applicable deep learning for diagnosis and referral in retinal disease

      Explore Nature Publishing Group Ophthalmology
      Clinically applicable deep learning for diagnosis and referral in retinal disease
      The volume and complexity of diagnostic imaging is increasing at a pace faster than the availability of human expertise to interpret it. Artificial intelligence has shown great promise in classifying two-dimensional photographs of some common diseases and typically relies on databases of millions of annotated images. Until now, the challenge of reaching the performance of expert clinicians in a real-world clinical pathway with three-dimensional diagnostic scans has remained unsolved. Here ...
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      Mentions: University College London Adnan Tufail Pearse A. Keane

    3. Now DeepMind's AI can spot eye disease just as well as your doctor

      Explore WIRED UK Ophthalmology
      Now DeepMind's AI can spot eye disease just as well as your doctor
      When Pearse Keane started using optical coherence tomography (OCT) scanners to peer to the back of a person's eye in Los Angeles a decade ago, the machines were relatively crude. "The devices were lower resolution, they had much slower image acquisition speeds," says Keane, a consultant ophthalmic surgeon at Moorfields Eye Hospital and researcher at University College, London. From 2007, Keane spent two years studying scans from OCT machines ...
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      Mentions: University College London Pearse A. Keane

    4. Artificial intelligence tool 'as good as experts' at detecting eye problems

      Explore theguardian.com Ophthalmology
      Artificial intelligence tool 'as good as experts' at detecting eye problems
      A new machine-learning system is as good as the best human experts at detecting eye problems and referring patients for treatment, say scientists. The groundbreaking artificial intelligence system, developed by the AI-outfit DeepMind with Moorfields eye hospital NHS foundation trust and University College London, was capable of correctly referring patients with more than 50 different eye diseases for further treatment with 94% accuracy, matching or beating world-leading eye specialists.
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      Mentions: University College London Pearse A. Keane

    5. Artificial intelligence 'did not miss a single urgent case'

      Explore BBC - Homepage Ophthalmology
      Artificial intelligence 'did not miss a single urgent case'
      A study by Moorfields Eye Hospital in London and the Google company DeepMind found that a machine could learn to read complex eye scans and detect more than 50 eye conditions. Doctors hope artificial intelligence could soon play a major role in helping to identify patients who need urgent treatment. They hope it will also reduce delays. A team at DeepMind, based in London, created an algorithm, or mathematical set ...
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      Mentions: Imperial College London University College London Pearse A. Keane

    7. Feature Of The Week 07/08/2018: Retinal Nerve Fibre Layer Thickness & Cognition - Results from UK Biobank

      Explore Optical Coherence Tomography News Neurology , Ophthalmology
      Feature Of The Week 07/08/2018: Retinal Nerve Fibre Layer Thickness & Cognition - Results from UK Biobank
      Importance: Identifing potential screening tests for future cognitive decline is a priority for developing treatments for and the prevention of dementia. Objective: To examine the potential of retinal nerve fiber layer (RNFL) thickness measurement in identifying those at greater risk of cognitive decline in a large community cohort of healthy people. Design, Setting, and Participants: UK Biobank is a prospective, multicenter, community-based study of UK residents aged 40 to 69 ...
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      Mentions: University College London Topcon Medical Systems Oxford University

    8. Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline A Study Using Optical Coherence Tomography

      Explore The JAMA Network Neurology , Ophthalmology
      Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline A Study Using Optical Coherence Tomography
      ...niversity of Liverpool, Ruth E. Hogg, PhD, Queens University Belfast, Pirro Hysi, PhD, King's College London, Pearse A. Keane, MD, NIHR Biomedical Research Centre, Sir Peng T. Khaw, PhD, NIHR Biomedical Research Centre, ...
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      Mentions: University College London Praveen J. Patel Axel Petzold

    9. The EXPLORE Study - The Use of Binocular OCT Imaging for the Assessment of Ocular Disease

      Explore Home - ClinicalTrials.gov Ophthalmology , Clinical Trials
      The EXPLORE Study - The Use of Binocular OCT Imaging for the Assessment of Ocular Disease
      Optical coherence tomography (OCT) is an imaging modality, first described in 1991, that provides cross-sectional images of the eye in a non-invasive manner. OCT is analogous to ultrasonography but measures the "echoes" of light waves rather than sound and, as a result, generates extremely high-resolution images (~5 m axial resolution). Although OCT has already proven revolutionary in ophthalmology, current OCT systems are large, expensive, and require skilled personnel for image ...
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      Mentions: Pearse A. Keane

    10. Use of a Binocular Optical Coherence Tomography System to Evaluate Strabismus in Primary Position

      Explore The JAMA Network Ophthalmology
      Use of a Binocular Optical Coherence Tomography System to Evaluate Strabismus in Primary Position
      Importance Current clinical methods for assessing strabismus can be prone to error. Binocular optical coherence tomography (OCT) has the potential to assess and quantify strabismus objectively and in an automated manner. Objective To evaluate the use of a binocular OCT prototype to assess the presence and size of strabismus. Design, Setting, and Participants Fifteen participants with strabismus were recruited in 2016 as part of the EASE study from Moorfields Eye ...
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      Mentions: National Institutes of Health University College London Pearse A. Keane

    11. WIDEFIELD SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING OF PERIPHERAL ROUND RETINAL HOLES WITH OR WITHOUT RETINAL DETACHMENT

      Explore LWW Online Ophthalmology
      WIDEFIELD SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY IMAGING OF PERIPHERAL ROUND RETINAL HOLES WITH OR WITHOUT RETINAL DETACHMENT
      Purpose: To describe the widefield spectral-domain optical coherence tomography features of peripheral round retinal holes, with or without associated retinal detachment (RD). Methods: Retrospective, observational study of 28 eyes with peripheral round retinal holes, with and without RD. Patients underwent imaging with a widefield 50-degree spectral-domain optical coherence tomography (Heidelberg Engineering, Germany) and Optos ultra-widefield imaging systems (Optos, United Kingdom). Results: Vitreous attachment at the site of the retinal hole ...
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      Mentions: Heidelberg Engineering University College London Optos

    12. COMPARING FUNDUS FLUORESCEIN ANGIOGRAPHY AND SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN THE EVALUATION OF DIABETIC MACULAR PERFUSION

      Explore LWW Online Ophthalmology
      COMPARING FUNDUS FLUORESCEIN ANGIOGRAPHY AND SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN THE EVALUATION OF DIABETIC MACULAR PERFUSION
      Purpose: To compare fundus fluorescein angiography (FFA) and swept-source optical coherence tomography angiography (SS-OCTA) in the evaluation of macular perfusion in diabetic patients. Methods: Forty-one eyes (21 diabetic patients) seen at Moorfields Eye Hospital (London) over a 1-month interval underwent color fundus photography, FFA, and SS-OCTA imaging of the capillary superficial plexus using 2 different protocols: 3 3 mm and 4.5 4.5 mm. Quantitative assessment (foveal avascular zone ...
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      Mentions: University College London Adnan Tufail Pearse A. Keane

    13. Optical coherence tomography angiography: a review of current and future clinical applications

      Explore Home - Springer Ophthalmology
      Optical coherence tomography angiography: a review of current and future clinical applications
      Optical coherence tomography angiography is a non-invasive imaging technique that now allows for simultaneous in vivo imaging of the morphology as well as the vasculature in the eye. In this review, we provide an update on the existing clinical applications of optical coherence tomography angiography technology from the anterior to posterior segment of the eye. We also discuss the limitations of optical coherence tomography angiography technology, as well as the ...
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      Mentions: University College London Medical University of Vienna Singapore Eye Research Institute

    14. Characteristic optical coherence tomography findings in patients with primary vitreoretinal lymphoma: a novel aid to early diagnosis

      Explore BJO Online Ophthalmology
      Characteristic optical coherence tomography findings in patients with primary vitreoretinal lymphoma: a novel aid to early diagnosis
      Background The diagnosis of primary vitreoretinal lymphoma (PVRL) poses significant difficulties; presenting features are non-specific and confirmation usually necessitates invasive vitreoretinal biopsy. Diagnosis is often delayed, resulting in increased morbidity and mortality. Non-invasive imaging modalities such as spectral domain optical coherence tomography (SD-OCT) offer simple and rapid aids to diagnosis. We present characteristic SD-OCT images of patients with biopsy-positive PVRL and propose a number of typical features, which we believe ...
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      Mentions: University College London Praveen J. Patel Pearse A. Keane

    15. Segmentation error in spectral domain optical coherence tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension

      Explore BMC Ophthalmology Ophthalmology
      Segmentation error in spectral domain optical coherence tomography measures of the retinal nerve fibre layer thickness in idiopathic intracranial hypertension
      Background Optical Coherence Tomography (OCT) imaging is being increasingly used in clinical practice for the monitoring of papilloedema. The aim is to characterise the extent and location of the Retinal Nerve Fibre Layer (RNFL) Thickness automated segmentation error (SegE) by manual refinement, in a cohort of Idiopathic Intracranial Hypertension (IIH) patients with papilloedema and compare this to controls. Methods Baseline Spectral Domain OCT (SDOCT) scans from patients with IIH, and ...
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      Mentions: University College London Pearse A. Keane

    16. A Study of the Natural History of Vitreomacular Traction Syndrome by OCT

      Explore Ophthalmology Ophthalmology
      A Study of the Natural History of Vitreomacular Traction Syndrome by OCT
      Purpose To examine the natural history of vitreomacular traction syndrome (VMTS) in the absence of other ocular comorbidities. Design Retrospective clinical case series. Participants A total of 183 eyes of 159 patients diagnosed with VMTS with no other ocular comorbidity. Methods Patients with VMTS were identified from an OCT database at Moorfields Eye Hospital, London. Sequential OCT scans and patient notes were reviewed over a minimum period of 6 months ...
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      Mentions: Pearse A. Keane
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  4. About Pearse A. Keane

    Pearse A. Keane

    Pearse A. Keane is with the NIHR Biomedical Research Center for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.

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