1. Pearse A. Keane

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    1. Mentioned In 111 Articles

    2. Automated quantification of posterior vitreous inflammation: optical coherence tomography scan number requirements

      Automated quantification of posterior vitreous inflammation: optical coherence tomography scan number requirements
      Quantifying intraocular inflammation is crucial in managing uveitis patients. We assessed the minimum B-scan density for reliable automated vitreous intensity (VI) assessment, using a novel approach based on optical coherence tomography (OCT). OCT volume scans centered on the macula were retrospectively collected in patients with uveitis. Nine B-scans per volume scan at fixed locations were automatically analyzed. The following B-scan selections were compared against the average score of 9 B-scans ...
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    3. Phenotyping of retinal neovascularization in ischemic retinal vein occlusion using wide field OCT angiography

      Phenotyping of retinal neovascularization in ischemic retinal vein occlusion using wide field OCT angiography
      Background/objectives Abnormal retinal neovascularization caused by ischemic retinal vein occlusion (RVO) is a frequent cause of visually significant vitreous hemorrhage. The early detection of new vessels may be challenging and often requires the use of invasive tests such as fundus fluorescein angiography (FA). We demonstrate the use of wide-field optical coherence tomography angiography (WF-OCTA) in the detection and characterization of neovascularization secondary to ischemic RVO. Subjects/methods We conducted ...
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    4. Optical coherence tomography in the 2020s—outside the eye clinic

      Optical coherence tomography in the 2020s—outside the eye clinic
      Optical coherence tomography (OCT) is a paragon of success in the translation of biophotonics science to clinical practice. OCT systems have become ubiquitous in eye clinics but access beyond this is limited by their cost, size and the skill required to operate the devices. Remarkable progress has been made in the development of OCT technology to improve the speed of acquisition, the quality of images and into functional extensions of ...
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    5. Artificial Intelligence Algorithms to Diagnose Glaucoma and Detect Glaucoma Progression: Translation to Clinical Practice

      Artificial Intelligence Algorithms to Diagnose Glaucoma and Detect Glaucoma Progression: Translation to Clinical Practice
      Purpose : This concise review aims to explore the potential for the clinical implementation of artificial intelligence (AI) strategies for detecting glaucoma and monitoring glaucoma progression. Methods : Nonsystematic literature review using the search combinations Artificial Intelligence, Deep Learning, Machine Learning, Neural Networks, Bayesian Networks, Glaucoma Diagnosis, and Glaucoma Progression. Information on sensitivity and specificity regarding glaucoma diagnosis and progression analysis as well as methodological details were extracted. Results : Numerous AI strategies ...
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    6. The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons

      The eye, the kidney, and cardiovascular disease: old concepts, better tools, and new horizons
      Chronic kidney disease (CKD) is common, with hypertension and diabetes mellitus acting as major risk factors for its development. Cardiovascular disease is the leading cause of death worldwide and the most frequent end point of CKD. There is an urgent need for more precise methods to identify patients at risk of CKD and cardiovascular disease. Alterations in microvascular structure and function contribute to the development of hypertension, diabetes, CKD, and ...
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    7. Predicting conversion to wet age-related macular degeneration using deep learning

      Predicting conversion to wet age-related macular degeneration using deep learning
      Progression to exudative wet age-related macular degeneration (exAMD) is a major cause of visual deterioration. In patients diagnosed with exAMD in one eye, we introduce an artificial intelligence (AI) system to predict progression to exAMD in the second eye. By combining models based on three-dimensional (3D) optical coherence tomography images and corresponding automatic tissue maps, our system predicts conversion to exAMD within a clinically actionable 6-month time window, achieving a ...
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    8. Widefield optical coherence tomography angiography for early detection and objective evaluation of proliferative diabetic retinopathy

      Widefield optical coherence tomography angiography for early detection and objective evaluation of proliferative diabetic retinopathy
      Purpose To evaluate the utility of widefield optical coherence tomography angiography (WF-OCTA) compared with clinical examination in grading diabetic retinopathy in patients diagnosed clinically with proliferative diabetic retinopathy (PDR) or severe non-proliferative diabetic retinopathy (NPDR). Design This retrospective observational case series included patients diagnosed clinically with PDR or severe NPDR. Patients underwent standard clinical examination and WF-OCTA imaging (PLEX Elite 9000, Carl Zeiss Meditec AG) using 1212 montage scans between ...
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    9. Automated Pupillometry using a Prototype Binocular Optical Coherence Tomography System

      Automated Pupillometry using a Prototype Binocular Optical Coherence Tomography System
      Purpose To determine the test-retest reliability and diagnostic accuracy of a binocular optical coherence tomography (OCT) prototype (Envision Diagnostics, USA) for pupillometry. Design Assessment of diagnostic reliability and accuracy. Methods Fifty participants with RAPD confirmed using the swinging flashlight method (mean age 49.6 years) and 50 healthy controls (mean age 31.3 years) were examined. Participants twice underwent an automated pupillometry exam using a binocular OCT system that presents ...
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    10. Subclinical Macular Changes And Disease Laterality In Pediatric Coats Disease Determined By Quantitative Optical Coherence Tomography Angiography

      Subclinical Macular Changes And Disease Laterality In Pediatric Coats Disease Determined By Quantitative Optical Coherence Tomography Angiography
      Purpose: To determine vascular change at the macula in both eyes in unilateral pediatric Coats disease using optical coherence tomography angiography. Methods: Retrospective case-series. Thirteen eyes of pediatric patients with a diagnosis of unilateral Coats disease of various stages were compared with 13 fellow eyes. Optical coherence tomography angiography images were acquired using the RTVue XR Avanti. Scans were analyzed with novel projection artifact removal software and improved segmentation. Vascular ...
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    11. Correspondence: Trends in Retina Specialist Imaging Utilization From 2012 to 2016 in the United States Medicare Fee-for-Service Population

      Correspondence: Trends in Retina Specialist Imaging Utilization From 2012 to 2016 in the United States Medicare Fee-for-Service Population
      We read with great interest the recent report by Wibbelsman and associates titled Trends in Retina Specialist Imaging Utilization from 2012 to 2016 in the USA Medicare fee-for-service Population.1 Despite the prominent role of optical coherence tomography (OCT) in ophthalmic practice, there is a surprising scarcity of published literature on the frequency of its application.
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    12. Optical coherence tomography (OCT) in unconscious and systemically unwell patients using a mobile OCT device: a pilot study

      Optical coherence tomography (OCT) in unconscious and systemically unwell patients using a mobile OCT device: a pilot study
      Objective This study aims to evaluate the feasibility of retinal imaging in critical care using a novel mobile optical coherence tomography (OCT) device. The Heidelberg SPECTRALIS FLEX module (Heidelberg Engineering, Heidelberg, Germany) is an OCT unit with a boom arm, enabling ocular OCT assessment in less mobile patients. Design We undertook an evaluation of the feasibility of using the SPECTRALIS FLEX for undertaking ocular OCT images in unconscious and critically ...
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    13. Pearse Keane Q&A: how open access AI is bringing ophthalmology into focus

      Pearse Keane Q&A: how open access AI is bringing ophthalmology into focus
      Since 2016, Moorfields Eye Hospital in London has been working with DeepMind, one of the worlds leading artificial intelligence companies. Through the partnership, researchers hope to use over one million anonymised retinal images to train artificial intelligence (AI) in the automated diagnosis of optical coherence tomography (OCT) images. OCT images are extremely complex and can take clinicians a long time to analyse, which can impact how quickly patients can receive ...
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    14. Objective evaluation of proliferative diabetic retinopathy using optical coherence tomography

      Objective evaluation of proliferative diabetic retinopathy using optical coherence tomography
      Purpose To present the routine use of optical coherence tomography (OCT) and OCT angiography (OCTA) for the objective diagnosis and monitoring of proliferative diabetic retinopathy (PDR). Design Retrospective observational case series. Subjects Patients with diabetic retinopathy imaged using a standardized PDR-protocol Methods Patients routinely imaged with a standardized PDR-protocol between March 2017 and January 2019 were included. This included a 12x9 mm structural OCT volume centered on the macula and ...
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    15. OCT Angiography in Acute Posterior Multifocal Placoid Pigment Epitheliopathy

      OCT Angiography in Acute Posterior Multifocal Placoid Pigment Epitheliopathy
      BACKGROUND AND OBJECTIVE: To describe retinal and choroidal findings in different stages of acute posterior multifocal placoid pigment epitheliopathy (APMPPE). PATIENTS AND METHODS: Retrospective, noncomparative case series studied by fundus biomicroscopy, fundus autofluorescence (FAF), fluorescein angiography (FA), indocyanine green angiography (ICGA), spectral-domain optical coherence tomographic (SD-OCT), and swept-source OCT angiography (SS-OCTA). RESULTS: Six eyes of three patients with bilateral APMPPE were included. FAF showed multifocal, branched patches of hyperautofluorescence with ...
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    16. Anterior segment optical coherence tomographic angiography assessment of acute chemical injury

      Anterior segment optical coherence tomographic angiography assessment of acute chemical injury
      Purpose To compare routine clinical examination with optical coherence tomography angiography (OCTA) for the assessment of limbal conjunctival ischemia following a chemical burn. Setting Validity analysis Methods We assessed ten participants (15 eyes) with an acute chemical injury. Clinical photographs were used to determine the extent of any limbal conjunctival epithelial defect and ischemia. These were compared with the extent of limbal ischemia identified on OCTA images of the ocular ...
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    17. 1-15 of 111 1 2 3 4 5 6 7 8 »
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  2. About Pearse A. Keane

    Pearse A. Keane

    Pearse A. Keane is with the NIHR Biomedical Research Center for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom.