1. Pavel D. Agrba

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    1. Mentioned In 15 Articles

    2. Silicon nanoparticles as contrast agents in the methods of optical biomedical diagnostics

      Silicon nanoparticles as contrast agents in the methods of optical biomedical diagnostics
      The efficiency of light scattering by nanoparticles formed using the method of picosecond laser ablation of silicon in water and by nanoparticles of mechanically grinded mesoporous silicon is compared. The ensembles of particles of both types possess the scattering coefficients sufficient to use them as contrast agents in optical coherence tomography (OCT), particularly in the range of wavelengths 7001000 nm, where the absorption of both silicon and most biological and ...
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    3. Effect of temperature regime and compression in OCT imaging of skin in vivo

      Effect of temperature regime and compression in OCT imaging of skin in vivo
      Optical coherence tomography (OCT) is a modern technique for imaging of internal structures of biotissue of up to several millimeters in depth with a resolution of several micrometers. However, various external conditions can distort the diagnostic capabilities of an OCT image. Mechanical compression and temperature regime are the two conditions which mostly affect the diagnostic OCT images obtained with a contact probe. It is shown here that the application of ...
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    4. Towards advanced OCT clinical applications

      Towards advanced OCT clinical applications
      In this paper we report on our recent achievement in application of conventional and cross-polarization OCT (CP OCT) modalities for in vivo clinical diagnostics in different medical areas including gynecology, dermatology, and stomatology. In gynecology, CP OCT was employed for diagnosing fallopian tubes and cervix; in dermatology OCT for monitoring of treatment of psoriasis, scleroderma and atopic dermatitis; and in stomatology for diagnosis of oral diseases. For all considered application ...
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    5. Laser-ablated silicon nanoparticles: optical properties and perspectives in optical coherencetomography

      Laser-ablated silicon nanoparticles: optical properties and perspectives in optical coherencetomography
      Due to their biocompatibility silicon nanoparticles have high potential in biomedical applications, especially in optical diagnostics. In this paper we analyze properties of the silicon nanoparticles formed via laser ablation in water and study the possibility of their application as contrasting agents in optical coherence tomography (OCT). The nanoparticles suspension was produced by picosecond laser irradiation of monocrystalline silicon wafers in water. According to transmission electron microcopy analysis the silicon ...
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    6. Identification of layers in optical coherence tomography of skin: comparative analysis of experimental and Monte Carlo simulated images

      Identification of layers in optical coherence tomography of skin: comparative analysis of experimental and Monte Carlo simulated images
      .... 4 Nizhny Novgorod Research Institute of Traumatology and Orthopedics, Nizhny Novgorod, Russia ^* Address: P. D. Agrba N.I. Lobachevsky Nizhny Novgorod State University, Gagarin av., 23, Nizhny Novgorod 603950, Russia...
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    7. Morphological changes in skin of different phototypes under the action of topical corticosteroid therapy and tacrolimus

      Morphological changes in skin of different phototypes under the action of topical corticosteroid therapy and tacrolimus
      Background/purpose The present study aimed to investigate the influence of topical corticosteroid therapy and tacrolimus on morphological indices of different skin phototypes and to optimize topical therapy using the OCT technique. Methods Twenty healthy volunteers aging from 20 to 30 (14 men and 6 women) took part in the study: 10 persons with skin phototype I, II and 10 persons with skin phototype V, VI. Morphological state of the ...
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    8. Complex assessment of age-specific morphofunctional features of skin of different anatomic localizations

      Complex assessment of age-specific morphofunctional features of skin of different anatomic localizations
      ... 3. ^3 Nizhny Novgorod Research Institute of Traumatology and Orthopedics, Nizhny Novgorod, Russia ^*Address: P. D. Agrba Institute of Applied Physics of RAS 603950 Ulyanov St. 46, Nizhny Novgorod Russia e-mail: agrbapd@...
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    9. Continuous optical coherence tomography monitoring of nanoparticles accumulation in biological tissues

      Continuous optical coherence tomography monitoring of nanoparticles accumulation in biological tissues
      In this study, dynamics of nanoparticles penetrating and accumulating in biotissue (healthy skin) was investigated in vivo by the noninvasive method of optical coherence tomography (OCT). Gold nanoshells and titanium dioxide nanoparticles were studied. The processes of the nanoparticles penetration and accumulation in biotissue are accompanied by the changes in optical properties of skin which affect the OCT images. The continuous OCT monitoring of the process of the nanoparticles penetration ...
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    10. Plasmon resonance gold nanoparticles for improving optical diagnostics and photothermal therapy of tumor

      Plasmon resonance gold nanoparticles for improving optical diagnostics and photothermal therapy of tumor
      The study was performed on 16 CBA-line female mice with transplanted cervical cancer. 0.2 ml of gold nanoparticle solution with a concentration of 109 particles/ml were injected into the animals intravenously. The particles were 200-250 nm in size; the plasmon-resonance related extinction maximum was at the wavelength of 850-950 nm. Accumulation of the nanoparticles into tumor node was visualized by the method of optical coherence tomography (OCT). When ...
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    11. Feature Of The Week 1/31/10: Mechanical Compression Effect in Optical Coherence Tomography Imaging of Biotissues

      Feature Of The Week 1/31/10: Mechanical Compression Effect in Optical Coherence Tomography Imaging of Biotissues
      Feature Of The Week 1/31/10: The majority of pathological processes in biotissues lead to their structural changes. The information about such changes is important for correct diagnostics and choice of proper treatment strategy. These changes can be detected using the optical coherence tomography (OCT). For application of OCT diagnostics in endoscopic studies the development of sufficient OCT-probes is required. However, the developed endoscopic OCT-probes are contact and their ...
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    12. Compression as a method for increasing the informativity of optical coherence tomography of biotissues

      Compression as a method for increasing the informativity of optical coherence tomography of biotissues
      The efficiency of the mechanical compression of biotissues for improving the differentiation between pathological changes in the structure of a biotissue observed by the method of optical coherence tomography (OCT) is investigated. The effect of the compression in the OCT-images of samples of the human rectum affected by inflammation and carcinoma is studied ex vivo. It is shown that the use of compression makes it possible to differentiate between these ...
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    13. Detection of nanoparticles accumulation in biological tissues by optical coherence tomography in vivo

      Detection of nanoparticles accumulation in biological tissues by optical coherence tomography in vivo
      Dynamics of nanoparticles penetrating and accumulating in healthy (skin) and pathologically altered (tumor) tissue was investigated in vivo by the method of optical coherence tomography (OCT). Gold nanoshells having the size of 130/15 nm and titanium dioxide nanoparticles 40-100 nm in size were stud ... [Proc. SPIE 7188, 71880L (2009)] published Mon Feb 16, 2009.
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    14. Contrasting properties of gold nanoparticles for optical coherence tomography: phantom, in vivo studies and Monte Carlo simulation

      Contrasting properties of gold nanoparticles for optical coherence tomography: phantom, in vivo studies and Monte Carlo simulation
      Abstract. The possibility of using silica–gold nanoshells with 150 nm silica core size and 25 nm thick gold shell as contrasting agents for optical coherence tomography (OCT) is analyzed. Experiments on agar biotissue phantoms showed that the penetration of nanoshells into the phantoms increases the intensity of the optical coherence tomography (OCT) signal and the brightness of the corresponding areas of the OCT image. In vivo experiments on rabbit ...
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  2. About Pavel D. Agrba

    Pavel D. Agrba

    Pavel D. Agrba is a junior researcher in Laboratory of Biophotonics of Institute of Applied Physics of Russian Academy of Sciences and PhD student in N.I. Lobachevsky State University of Nizhni Novgorod. He graduated from Radiophysics Department of N.I. Lobachevsky State University of Nizhni Novgorod in 2008. His scientific interests are in the areas of light propagation in highly scattering media (including biotissues), optical coherent tomography (OCT), techniques for optical clearing and contrast enhancement in OCT-images, polarization optical spectroscopy (POS) and optical diffuse tomography (ODT).