1. Patrick W. Serruys

    0 Comments Leave a Comment

    1-15 of 145 1 2 3 4 5 6 7 8 9 10 »
    1. Mentioned In 145 Articles

    2. Qvanteq Bioactive Coronary Stent System First in Man (FIM) Clinical Investigation

      Qvanteq Bioactive Coronary Stent System First in Man (FIM) Clinical Investigation

      Objective of this First in Man study is to assess feasibility and safety of Qvanteq's bioactive coronary stent for treatment of stable coronary artery disease patients with de novo coronary artery stenosis in native vessels. The proprietary surface of Qvanteq's bioactive coronary stent improves the in-growth behavior of the stent in the treated vessel. In-vivo animal studies revealed fast in-growth (similar to BMS), which however is not resulting in excessive tissue overgrowth as observed in BMS but rather has an efficacy profile similar to drug-eluting stent (DES), meaning suppression of tissue overgrowth. This should reduce the risk of ...

      Read Full Article
    3. Serial 2-Dimensional and 3-Dimensional Optical Coherence Tomography Assessment of Overhanging Struts of Drug-Eluting Absorbable Metal Scaffold

      Serial 2-Dimensional and 3-Dimensional Optical Coherence Tomography Assessment of Overhanging Struts of Drug-Eluting Absorbable Metal Scaffold

      A 75-year-old woman with stable angina pectoris underwent percutaneous coronary intervention of the left anterior descending coronary artery, whereby a 3.25/16-mm paclitaxel-eluting absorbable metal scaffold (DREAMS, Biotronik, Bülach, Switzerland) was successfully implanted. Post-procedural angiography showed excellent results without pinching of the side branch ostium. The patient experienced no procedure-related complications, and was discharged 48 h after the procedure on dual antiplatelet therapy. Optical coherence tomography (OCT) (LightLab Imaging, Westford, Massachusetts) was performed post-procedure and at 12 months follow-up. Post-procedurally, the scaffold was well expanded with good apposition of struts to the vessel wall, and a side branch ...

      Read Full Article
    4. Serial optical frequency domain imaging in STEMI patients: the follow-up report of TROFI study

      Serial optical frequency domain imaging in STEMI patients: the follow-up report of TROFI study

      Aims To investigate the incidence of incomplete stent apposition and to explore the impact of the presence of thrombus and protruding plaque after stent implantation on neointima formation at follow-up in ST-segment elevation myocardial infarction (STEMI) patients with serial optical frequency domain imaging (OFDI) investigations. Methods and results In a multi-centre study, 141 patients with ST elevation myocardial infarction <12 h from onset were randomized to either PPCI with thrombectomy (TB) using an Eliminate catheter (TB: n = 71) or without TB (non-TB: n = 70). OFDI after drug-eluting stenting was performed using TERUMO OFDI system. Per protocol, at follow-up 49 patients ...

      Read Full Article
    5. Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance: Implications for the Management of Incomplete Stent Apposition

      Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance: Implications for the Management of Incomplete Stent Apposition
      ...ngdom (M.G., C.D.M.); and Cardialysis, Rotterdam, The Netherlands (H.M.G.-G., P.W.S.). 1. Correspondence to Patrick W. Serruys, MD, PhD, or Nicolas Foin, MSc, PhD, ThoraxCenter, Erasmus University Medical Center, Ba-...
      Read Full Article
    6. In vivo evaluation of neointimal healing after stenting with optical coherence tomography (Thesis)

      In vivo evaluation of neointimal healing after stenting with optical coherence tomography (Thesis)

      Ischemic heart disease is still today the first cause of mortality in the world, especially in the developed countries. The vast majority of cases are due to atherosclerosis, a complex systemic degenerative process resulting in cholesterol accumulation in the extra-cellular space of the arterial intima, with inflammation, foam-cells formation, and necrosis. The clinical manifestations of coronary atherosclerosis comprise from stable angina, due to flow-limiting stenosis of the artery, to acute myocardial infarction or sudden death, when the atheroma gets complicated by thrombotic phenomena. The first revolution in the treatment of this disease came in 1977, when Andreas Grüntzig performed ...

      Read Full Article
    7. Effect of the Endothelial Shear Stress Patterns on Neointimal Proliferation Following Drug-Eluting Bioresorbable Vascular Scaffold Implantation : An Optical Coherence Tomography Study

      Effect of the Endothelial Shear Stress Patterns on Neointimal Proliferation Following Drug-Eluting Bioresorbable Vascular Scaffold Implantation : An Optical Coherence Tomography Study

      Objectives The goal of this study was to investigate the effect of endothelial shear stress (ESS) on neointimal formation following an Absorb bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, California) implantation. Background Cumulative evidence, derived from intravascular ultrasound–based studies, has demonstrated a strong association between local ESS patterns and neointimal formation in bare-metal stents, whereas in drug-eluting stents, there are contradictory data about the effect of ESS on the vessel wall healing process. The effect of ESS on neointimal development following a bioresorbable scaffold implantation remains unclear. Methods Twelve patients with an obstructive lesion in a relatively straight ...

      Read Full Article
    8. 3D optical coherence tomography: new insights into the process of optimal rewiring of side branches during bifurcational stenting

      3D optical coherence tomography: new insights into the process of optimal rewiring of side branches during bifurcational stenting

      Aims: We describe three-dimensional optical coherence tomography (3D-OCT) guided bifurcation stenting and the clinical utility of 3D-OCT. Methods and results: Twenty-two consecutive patients who underwent OCT examination to confirm the recrossing position after stent implantation in a bifurcation lesion were enrolled. Frequency domain OCT images were obtained to check the recrossing position and 3D reconstructions were performed off-line. The recrossing position was clearly visualised in 18/22 (81.8%) cases. In 13 cases, serial 3D-OCT could be assessed both before and after final kissing balloon post-dilation (FKBD). We divided these cases into two groups according to the presence of the ...

      Read Full Article
    9. Fusion of optical coherence tomographic and angiographic data for more accurate evaluation of the endothelial shear stress patterns and neointimal distribution after bioresorbable scaffold implantation: comparison with intravascular ultrasound-derived rec

      Fusion of optical coherence tomographic and angiographic data for more accurate evaluation of the endothelial shear stress patterns and neointimal distribution after bioresorbable scaffold implantation: comparison with intravascular ultrasound-derived rec

      Intravascular ultrasound (IVUS)-based reconstructions have been traditionally used to examine the effect of endothelial shear stress (ESS) on neointimal formation. The aim of this analysis is to compare the association between ESS and neointimal thickness (NT) in models obtained by the fusion of optical coherence tomography (OCT) and coronary angiography and in the reconstructions derived by the integration of IVUS and coronary angiography. We analyzed data from six patients implanted with an Absorb bioresorbable vascular scaffold that had biplane angiography, IVUS and OCT investigation at baseline and 6 or 12 months follow-up. The IVUS and OCT follow-up data were ...

      Read Full Article
    10. Flow disturbances in stent-related coronary evaginations: a computational fluid-dynamic simulation study

      Flow disturbances in stent-related coronary evaginations: a computational fluid-dynamic simulation study

      Aims: Angiographic ectasias and aneurysms in stented segments have been associated with late stent thrombosis. Using optical coherence tomography (OCT), some stented segments show coronary evaginations reminiscent of ectasias. The purpose of this study was to explore, using computational fluid-dynamic (CFD) simulations, whether OCT-detected coronary evaginations can induce local changes in blood flow. Methods and results: OCT-detected evaginations are defined as outward bulges in the luminal vessel contour between struts, with the depth of the bulge exceeding the actual strut thickness. Evaginations can be characterised cross ectionally by depth and along the stented segment by total length. Assuming an ellipsoid ...

      Read Full Article
    11. Coronary evaginations are associated with positive vessel remodelling and are nearly absent following implantation of newer-generation drug-eluting stents: an optical coherence tomography and intravascular ultrasound study

      Coronary evaginations are associated with positive vessel remodelling and are nearly absent following implantation of newer-generation drug-eluting stents: an optical coherence tomography and intravascular ultrasound study

      Objectives The purpose of this study was to assess the occurrence, predictors, and mechanisms of optical coherence tomography (OCT)-detected coronary evaginations following drug-eluting stent (DES) implantation. Background Angiographic ectasias and aneurysms in stented segments have been associated with a risk of late stent thrombosis. Using OCT, some stented segments show coronary evaginations reminiscent of ectasias. Methods Evaginations were defined as outward bulges in the luminal contour between struts. They were considered major evaginations (MEs) when extending ≥3 mm along the vessel length, with a depth ≥10% of the stent diameter. A total of 228 patients who had sirolimus (SES ...

      Read Full Article
    12. Natural history of optical coherence tomography-detected non-flow-limiting edge dissections following drug-eluting stent implantation

      Natural history of optical coherence tomography-detected non-flow-limiting edge dissections following drug-eluting stent implantation

      Aims: Angiographic evidence of edge dissections has been associated with a risk of early stent thrombosis. Optical coherence tomography (OCT) is a high-resolution technology detecting a greater number of edge dissections -particularly non-flow-limiting- compared to angiography. Their natural history and clinical implications remain unclear. The objectives of the present study were to assess the morphology, healing response, and clinical outcomes of OCT-detected edge dissections using serial OCT imaging at baseline and at one year following drug-eluting stent (DES) implantation. Methods and results: Edge dissections were defined as disruptions of the luminal surface in the 5 mm segments proximal and distal ...

      Read Full Article
    13. New Developments in Hybrid Optical Coherence Tomographic Imaging: Current Status and Potential Implications in Clinical Practice and Research

      New Developments in Hybrid Optical Coherence Tomographic Imaging: Current Status and Potential Implications in Clinical Practice and Research

      Optical coherence tomography (OCT) is a relatively new imaging technique that was introduced to overcome limitations of previous imaging modalities. OCT provides high resolution cross-sectional images of the coronaries which permit detailed evaluation of the luminal morphology and assessment of coronary artery pathology. These unique qualities render OCT a useful tool in clinical practice and research arena. However, apart from its significant advantages OCT imaging has also considerable limitations. To overcome the pitfalls of OCT, fusion of this modality with other imaging techniques has been proposed. Today several hybrid catheter and sophisticated data fusion methodologies have been developed for this ...

      Read Full Article
    14. In vivo assessment of the three-dimensional haemodynamic micro-environment following drug-eluting bioresorbable vascular scaffold implantation in a human coronary artery: fusion of frequency domain optical coherence tomography and angiography

      In vivo assessment of the three-dimensional haemodynamic micro-environment following drug-eluting bioresorbable vascular scaffold implantation in a human coronary artery: fusion of frequency domain optical coherence tomography and angiography

      The biplane angiographic data, acquired after implantation of an everolimus-eluting bioresorbable vascular scaffold (Absorb™ BVS; Abbott Vascular, Santa Clara, CA, USA) in the right coronary artery of a 46-year-old patient, were separately fused with frequency domain optical coherence tomography (FD-OCT) and intravascular ultrasound (IVUS) data to reconstruct the three-dimensional (3-D) anatomy. The local shear stress (SS) distribution in the FD-OCT- and IVUS-based models was assessed using computational fluid dynamics. The FD-OCT-based reconstruction (Figure 1A) allowed imaging of the lumen irregularities in the scaffolded segment due to strut protrusion (Figure 1B), which caused recirculation zones around the struts (Figure 1C). In ...

      Read Full Article
    15. 1-15 of 145 1 2 3 4 5 6 7 8 9 10 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. About Patrick W. Serruys

    Patrick W. Serruys

    Patrick W. Serruys is a Professor of Interventional Cardiology, Erasmus University, Thoraxcentrum Rotterdam, Netherlands. Prof. Dr. Patrick Serruys comes from Belgium and studied at the University of Leuven. In 1972 he obtained his doctor's degree at the University of Leuven. He worked at this university in the Cardiology department until 1976 and then joined the Thoraxcenter in Rotterdam. In 1986 he obtained his PhD on the thesis: "Transluminal coronary angioplasty: an investigational tool and a non operative treatment of acute myocardial ischemia". In 1988 he was appointed Professor of Interventional Cardiology at the Thoraxcenter of the Erasmus MC.

  3. Quotes

    1. The positive 30-day results reaffirm my belief that a device that bioresorbs, or disappears, into the body after restoring blood flow is the next logical step in the treatment of cardiovascular disease.
      In Abbott Announces Positive Data From Absorb Trial on Its Bioresorbable Vascular Scaffold Technology
    2. I am very happy with the 12-month results of the LEADERS study, which confirm the 9-month results. The Biosensors drug eluting stent, combining the novel biolimus drug and an abluminal biodegradable polymer, is a very promising technology for our patients long term benefit
      In iosensors DES Demonstrates Superior Strut Coverage to Industry Leading DES