1. Patrick W. Serruys

    0 Comments Leave a Comment

    1-15 of 176 1 2 3 4 ... 10 11 12 »
    1. Mentioned In 176 Articles

    2. Imaging outcomes of bioresorbable scaffold overlap: an optical coherence tomography analysis from the ABSORB EXTEND trial

      Imaging outcomes of bioresorbable scaffold overlap: an optical coherence tomography analysis from the ABSORB EXTEND trial
      Aims: The purpose of this study was to assess the vascular response and vessel healing of overlapped Absorb scaffolds (Abbott Vascular, Santa Clara, CA, USA) compared to non-overlapped devices in human coronary arteries as assessed by optical coherence tomography (OCT) in the same treated segment. Methods and results: The ABSORB EXTEND (NCT01023789) trial is a prospective, single-arm, openlabel clinical study which enrolled 800 patients. The planned overlap OCT subgroup in ...
      Read Full Article
    3. Is quantitative coronary angiography reliable in assessing the late lumen loss of the everolimus eluting bioresorbable polylactide scaffold in comparison with the cobalt chromium metallic stent?

      Is quantitative coronary angiography reliable in assessing the late lumen loss of the everolimus eluting bioresorbable polylactide scaffold in comparison with the cobalt chromium metallic stent?
      Aims: Immediately after stent/scaffold implantation, quantitative coronary angiography (QCA) with respect to optical coherence tomography (OCT) more severely underestimates the lumen diameter (LD) in Absorb than in XIENCE. This OCT-QCA discrepancy has not been evaluated at long-term follow-up. The present study aimed to assess the accuracy of QCA with reference to OCT in Absorb as compared to XIENCE.
      Read Full Article
    4. Fate of post-procedural malapposition of everolimus-eluting polymeric bioresorbable scaffold and everolimus-eluting cobalt chromium metallic stent in human coronary arteries: sequential assessment with optical coherence tomography in ABSORB Japan trial

      Fate of post-procedural malapposition of everolimus-eluting polymeric bioresorbable scaffold and everolimus-eluting cobalt chromium metallic stent in human coronary arteries: sequential assessment with optical coherence tomography in ABSORB Japan trial
      Aims The natural course of post-procedural incomplete strut apposition (ISA) after the implantation of bioresorbable scaffolds (BVS) remains unknown. The purpose of the present study was to evaluate the fate of post-procedural ISA after everolimus-eluting Absorb BVS in comparison with the second-generation everolimus-eluting cobalt chromium stent (CoCr-EES). Methods and results Fate of post-procedural ISA was evaluated by serial optical coherence tomography (OCT) in the ABSORB Japan randomized trial [OCT-1 subgroup ...
      Read Full Article
    5. Intracoronary optical coherence tomography: Clinical and research applications and intravascular imaging software overview

      Intracoronary optical coherence tomography: Clinical and research applications and intravascular imaging software overview
      By providing valuable information about the coronary artery wall and lumen, intravascular imaging may aid in optimizing interventional procedure results and thereby could improve clinical outcomes following percutaneous coronary intervention (PCI). Intravascular optical coherence tomography (OCT) is a light-based technology with a tissue penetration of approximately 1 to 3 mm and provides near histological resolution. It has emerged as a technological breakthrough in intravascular imaging with multiple clinical and research ...
      Read Full Article
    6. Accuracy of coronary computed tomography angiography for bioresorbable scaffold luminal investigation: a comparison with optical coherence tomography

      Accuracy of coronary computed tomography angiography for bioresorbable scaffold luminal investigation: a comparison with optical coherence tomography
      To establish the accuracy of coronary computed tomography angiography (CTA) for in-scaffold quantitative evaluation with optical coherence tomography (OCT) as a reference. The translucent backbone of the bioresorbable scaffold allow us to evaluate non-invasively the coronary lumen with coronary CTA. In the ABSORB first-in-man studies, coronary CTA was shown to be feasible for quantitative luminal assessment. Nevertheless, a comparison with an intravascular modality with higher resolution has never been performed ...
      Read Full Article
    7. Variability in the measurement of minimum fibrous cap thickness and reproducibility of fibroatheroma classification by optical coherence tomography using manual versus semi-automatic assessment

      Variability in the measurement of minimum fibrous cap thickness and reproducibility of fibroatheroma classification by optical coherence tomography using manual versus semi-automatic assessment
      Aims: The minimum fibrous cap thickness (FCT) is considered a major criterion of coronary plaque vulnerability according to autopsy studies. We aimed to assess the reproducibility in the measurement of the optical coherence tomography (OCT)-detected minimum FCT and the agreement in the classification of thin-cap fibroatheroma (TCFA), by a software-based semi-automatic method compared with the manual method. Methods and results: A total of 50 frames with fibroatheromas (FA) were ...
      Read Full Article
    8. Two-year clinical, angiographic, and serial optical coherence tomographic follow-up after implantation of an everolimus-eluting bioresorbable scaffold and an everolimus-eluting metallic stent: insights from the randomised ABSORB Japan trial

      Two-year clinical, angiographic, and serial optical coherence tomographic follow-up after implantation of an everolimus-eluting bioresorbable scaffold and an everolimus-eluting metallic stent: insights from the randomised ABSORB Japan trial
      Aims: We sought to investigate two-year clinical and serial optical coherence tomography (OCT) outcomes after implantation of a fully bioresorbable vascular scaffold (BVS) or a cobalt-chromium everolimus-eluting stent (CoCr-EES). Methods and results: In the ABSORB Japan trial, 400 patients were randomised in a 2:1 ratio to BVS (N=266) or CoCr-EES (N=134). A pre-specified OCT subgroup (N=125, OCT-1 group) underwent angiography and OCT post procedure and at ...
      Read Full Article
    9. Evaluation of vascular healing of polymer-free sirolimus-eluting stents in native coronary artery stenosis: a serial follow-up at three and six months with optical coherence tomography imaging

      Evaluation of vascular healing of polymer-free sirolimus-eluting stents in native coronary artery stenosis: a serial follow-up at three and six months with optical coherence tomography imaging
      Aims: Our aim was to assess vascular response after polymer-free sirolimus-eluting stent (SES) implantation by using an optical coherence tomography (OCT)-derived vascular healing score (HS), quantifying the deficiency of healing. Methods and results: In a prospective, multicentre, single-arm, open-label study, OCT examinations were performed at three months in 45 patients (47 lesions). Per protocol, 24 lesions which had not reached adequate vascular healing according to study criteria were scheduled ...
      Read Full Article
    10. Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology

      Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology
      Cumulative evidence from histology-based studies demonstrate that the currently available intravascular imaging techniques have fundamental limitations that do not allow complete and detailed evaluation of plaque morphology and pathobiology, limiting the ability to accurately identify high-risk plaques. To overcome these drawbacks, new efforts are developing for data fusion methodologies and the design of hybrid, dual-probe catheters to enable accurate assessment of plaque characteristics, and reliable identification of high-risk lesions. Today ...
      Read Full Article
    11. Bioresorption and Vessel Wall Integration of a Fully Bioresorbable Polymeric Everolimus-Eluting Scaffold Optical Coherence Tomography, Intravascular Ultrasound, and Histological Study in a Porcine Model With 4-Year Follow-Up

      Bioresorption and Vessel Wall Integration of a Fully Bioresorbable Polymeric Everolimus-Eluting Scaffold Optical Coherence Tomography, Intravascular Ultrasound, and Histological Study in a Porcine Model With 4-Year Follow-Up
      Objectives The aim of the present study was to investigate the relationship between the integration process and luminal enlargement with the support of light intensity (LI) analysis on optical coherence tomography (OCT), echogenicity analysis on intravascular ultrasound, and histology up to 4 years in a porcine model. Background In pre-clinical and clinical studies, late luminal enlargement has been demonstrated at long-term follow-up after everolimus-eluting poly-l-lactic acid coronary scaffold implantation. However ...
      Read Full Article
    12. Optical coherence tomography evaluation of intermediate-term healing of different stent types: systemic review and meta-analysis

      Optical coherence tomography evaluation of intermediate-term healing of different stent types: systemic review and meta-analysis
      Aims The intermediate-term incidence of strut malapposition (SM) and uncovered struts (US), and the degree of neointimal thickness (NIT) according to stent type have not been characterized. Methods and results All studies of 50 patients in which optical coherence tomography was performed between 6 and 12 months after stent implantation were included. The incidences of SM and US were the co-primary end points, while NIT was the secondary end point ...
      Read Full Article
    13. Micell Technologies Completes Enrollment in OCT Study Designed to Evaluate Superior Performance of MiStent SES Compared to Xience

      Micell Technologies Completes Enrollment in OCT Study Designed to Evaluate Superior Performance of MiStent SES Compared to Xience
      ...sent a patient benefit over current drug-eluting stents." "Micell thanks the Steering Committee consisting of Patrick W. Serruys, M.D., Ph.D., Professor of Interventional Cardiology at Erasmus University, Rotterdam, The ...
      Read Full Article
    14. Edge Vascular Response After Resorption of the Everolimus-Eluting Bioresorbable Vascular Scaffold – A 5-Year Serial Optical Coherence Tomography Study –

      Edge Vascular Response After Resorption of the Everolimus-Eluting Bioresorbable Vascular Scaffold – A 5-Year Serial Optical Coherence Tomography Study –
      Background: The edge vascular response (EVR) has been linked to important prognostic implications in patients treated with permanent metallic stents. We aimed to investigate the relationship of EVR with the geometric changes in the everolimus-eluting bioresorbable scaffold using serial optical coherence tomography (OCT) analysis. Methods and Results: In the first-in-man ABSORB trial, 28 patients (29 lesions) underwent serial OCT at 4 different time points (Cohort B1: post-procedure, 6, 24, and ...
      Read Full Article
    15. Biomechanical stress in coronary atherosclerosis: emerging insights from computational modelling

      Biomechanical stress in coronary atherosclerosis: emerging insights from computational modelling
      Coronary plaque rupture is the most common cause of vessel thrombosis and acute coronary syndrome. The accurate early detection of plaques prone to rupture may allow prospective, preventative treatment; however, current diagnostic methods remain inadequate to detect these lesions. Established imaging features indicating vulnerability do not confer adequate specificity for symptomatic rupture. Similarly, even though experimental and computational studies have underscored the importance of endothelial shear stress in progressive atherosclerosis ...
      Read Full Article
    16. Quantitative assessment of the stent/scaffold strut embedment analysis by optical coherence tomography

      Quantitative assessment of the stent/scaffold strut embedment analysis by optical coherence tomography
      The degree of stent/scaffold embedment could be a surrogate parameter of the vessel wall-stent/scaffold interaction and could have biological implications in the vascular response. We have developed a new specific software for the quantitative evaluation of embedment of struts by optical coherence tomography (OCT). In the present study, we described the algorithm of the embedment analysis and its reproducibility. The degree of embedment was evaluated as the ratio ...
      Read Full Article
    17. 1-15 of 176 1 2 3 4 ... 10 11 12 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. About Patrick W. Serruys

    Patrick W. Serruys

    Patrick W. Serruys is a Professor of Interventional Cardiology, Erasmus University, Thoraxcentrum Rotterdam, Netherlands. Prof. Dr. Patrick Serruys comes from Belgium and studied at the University of Leuven. In 1972 he obtained his doctor's degree at the University of Leuven. He worked at this university in the Cardiology department until 1976 and then joined the Thoraxcenter in Rotterdam. In 1986 he obtained his PhD on the thesis: "Transluminal coronary angioplasty: an investigational tool and a non operative treatment of acute myocardial ischemia". In 1988 he was appointed Professor of Interventional Cardiology at the Thoraxcenter of the Erasmus MC.

  3. Quotes

    1. The positive 30-day results reaffirm my belief that a device that bioresorbs, or disappears, into the body after restoring blood flow is the next logical step in the treatment of cardiovascular disease.
      In Abbott Announces Positive Data From Absorb Trial on Its Bioresorbable Vascular Scaffold Technology
    2. I am very happy with the 12-month results of the LEADERS study, which confirm the 9-month results. The Biosensors drug eluting stent, combining the novel biolimus drug and an abluminal biodegradable polymer, is a very promising technology for our patients long term benefit
      In iosensors DES Demonstrates Superior Strut Coverage to Industry Leading DES