1. Patrick W. Serruys

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    1. Mentioned In 169 Articles

    2. Evaluation of vascular healing of polymer-free sirolimus-eluting stents in native coronary artery stenosis: a serial follow-up at three and six months with optical coherence tomography imaging

      Evaluation of vascular healing of polymer-free sirolimus-eluting stents in native coronary artery stenosis: a serial follow-up at three and six months with optical coherence tomography imaging
      Aims: Our aim was to assess vascular response after polymer-free sirolimus-eluting stent (SES) implantation by using an optical coherence tomography (OCT)-derived vascular healing score (HS), quantifying the deficiency of healing. Methods and results: In a prospective, multicentre, single-arm, open-label study, OCT examinations were performed at three months in 45 patients (47 lesions). Per protocol, 24 lesions which had not reached adequate vascular healing according to study criteria were scheduled ...
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    3. Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology

      Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology
      Cumulative evidence from histology-based studies demonstrate that the currently available intravascular imaging techniques have fundamental limitations that do not allow complete and detailed evaluation of plaque morphology and pathobiology, limiting the ability to accurately identify high-risk plaques. To overcome these drawbacks, new efforts are developing for data fusion methodologies and the design of hybrid, dual-probe catheters to enable accurate assessment of plaque characteristics, and reliable identification of high-risk lesions. Today ...
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    4. Bioresorption and Vessel Wall Integration of a Fully Bioresorbable Polymeric Everolimus-Eluting Scaffold Optical Coherence Tomography, Intravascular Ultrasound, and Histological Study in a Porcine Model With 4-Year Follow-Up

      Bioresorption and Vessel Wall Integration of a Fully Bioresorbable Polymeric Everolimus-Eluting Scaffold Optical Coherence Tomography, Intravascular Ultrasound, and Histological Study in a Porcine Model With 4-Year Follow-Up
      Objectives The aim of the present study was to investigate the relationship between the integration process and luminal enlargement with the support of light intensity (LI) analysis on optical coherence tomography (OCT), echogenicity analysis on intravascular ultrasound, and histology up to 4 years in a porcine model. Background In pre-clinical and clinical studies, late luminal enlargement has been demonstrated at long-term follow-up after everolimus-eluting poly-l-lactic acid coronary scaffold implantation. However ...
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    5. Optical coherence tomography evaluation of intermediate-term healing of different stent types: systemic review and meta-analysis

      Optical coherence tomography evaluation of intermediate-term healing of different stent types: systemic review and meta-analysis
      Aims The intermediate-term incidence of strut malapposition (SM) and uncovered struts (US), and the degree of neointimal thickness (NIT) according to stent type have not been characterized. Methods and results All studies of 50 patients in which optical coherence tomography was performed between 6 and 12 months after stent implantation were included. The incidences of SM and US were the co-primary end points, while NIT was the secondary end point ...
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    6. Micell Technologies Completes Enrollment in OCT Study Designed to Evaluate Superior Performance of MiStent SES Compared to Xience

      Micell Technologies Completes Enrollment in OCT Study Designed to Evaluate Superior Performance of MiStent SES Compared to Xience
      ...sent a patient benefit over current drug-eluting stents." "Micell thanks the Steering Committee consisting of Patrick W. Serruys, M.D., Ph.D., Professor of Interventional Cardiology at Erasmus University, Rotterdam, The ...
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    7. Edge Vascular Response After Resorption of the Everolimus-Eluting Bioresorbable Vascular Scaffold – A 5-Year Serial Optical Coherence Tomography Study –

      Edge Vascular Response After Resorption of the Everolimus-Eluting Bioresorbable Vascular Scaffold – A 5-Year Serial Optical Coherence Tomography Study –
      Background: The edge vascular response (EVR) has been linked to important prognostic implications in patients treated with permanent metallic stents. We aimed to investigate the relationship of EVR with the geometric changes in the everolimus-eluting bioresorbable scaffold using serial optical coherence tomography (OCT) analysis. Methods and Results: In the first-in-man ABSORB trial, 28 patients (29 lesions) underwent serial OCT at 4 different time points (Cohort B1: post-procedure, 6, 24, and ...
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    8. Biomechanical stress in coronary atherosclerosis: emerging insights from computational modelling

      Biomechanical stress in coronary atherosclerosis: emerging insights from computational modelling
      Coronary plaque rupture is the most common cause of vessel thrombosis and acute coronary syndrome. The accurate early detection of plaques prone to rupture may allow prospective, preventative treatment; however, current diagnostic methods remain inadequate to detect these lesions. Established imaging features indicating vulnerability do not confer adequate specificity for symptomatic rupture. Similarly, even though experimental and computational studies have underscored the importance of endothelial shear stress in progressive atherosclerosis ...
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    9. Quantitative assessment of the stent/scaffold strut embedment analysis by optical coherence tomography

      Quantitative assessment of the stent/scaffold strut embedment analysis by optical coherence tomography
      The degree of stent/scaffold embedment could be a surrogate parameter of the vessel wall-stent/scaffold interaction and could have biological implications in the vascular response. We have developed a new specific software for the quantitative evaluation of embedment of struts by optical coherence tomography (OCT). In the present study, we described the algorithm of the embedment analysis and its reproducibility. The degree of embedment was evaluated as the ratio ...
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    10. Progression of calcification after implantation of a fully bioresorbable scaffold: A serial and combined IVUS-OCT follow-up of 5 years

      Progression of calcification after implantation of a fully bioresorbable scaffold: A serial and combined IVUS-OCT follow-up of 5 years
      A 72-year-old female enrolled in the ABSORB Cohort B2 trial underwent successful percutaneous coronary intervention of the proximal left anterior descending artery with a 3 18 mm Absorb everolimus-eluting Bioresorbable scaffold (Absorb BVS, Abbott Vascular, CA). Optical coherence tomography (OCT) and intravascular ultrasound (IVUS) images after the procedure showed optimal scaffold expansion without any mechanical complication (Fig. 1: Post-A, C). As protocol mandated, follow-up invasive coronary imagings (angiography, OCT, IVUS ...
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    11. Bioresorbable vascular scaffold treatment induces the formation of neointimal cap that seals the underlying plaque without compromising the luminal dimensions: a concept based on serial optical coherence tomography data

      Bioresorbable vascular scaffold treatment induces the formation of neointimal cap that seals the underlying plaque without compromising the luminal dimensions: a concept based on serial optical coherence tomography data
      Aims: To evaluate the implications of an Absorb bioresorbable vascular scaffold (Absorb BVS) on the morphology of the superficial plaques. Methods and results: Forty-six patients who underwent Absorb BVS implantation and 20 patients implanted with bare metal stents (BMS) who had serial optical coherence tomographic examination at baseline and follow-up were included in this analysis. The thin-capped fibroatheromas (TCFA) were identified in the device implantation regions and in the adjacent ...
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    12. Incidence and potential mechanism of resolved, persistent and newly acquired malapposition three days after implantation of self-expanding or balloon-expandable stents in a STEMI population: insights from optical coherence tomography in the APPOSITION II

      Incidence and potential mechanism of resolved, persistent and newly acquired malapposition three days after implantation of self-expanding or balloon-expandable stents in a STEMI population: insights from optical coherence tomography in the APPOSITION II
      Aims: The aim of the current study was to investigate the frequency and mechanisms of sequential incomplete stent apposition (ISA) changes such as persistent, resolved or newly acquired ISA during the first three days after primary PCI (pPCI) in a matched segment-level analysis, with the comparison between self-expanding and balloon-expandable stents assessed by optical coherence tomography (OCT). Methods and results: The current analysis is a substudy of the APPOSITION II ...
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    13. Comparative analysis method of permanent metallic stents (XIENCE) and bioresorbable poly-L-lactic (PLLA) scaffolds (Absorb) on optical coherence tomography at baseline and follow-up

      Comparative analysis method of permanent metallic stents (XIENCE) and bioresorbable poly-L-lactic (PLLA) scaffolds (Absorb) on optical coherence tomography at baseline and follow-up
      Aims: Fully bioresorbable Absorb poly-L-lactic-acid (PLLA) scaffolds (Abbott Vascular, Santa Clara, CA, USA) are a novel approach for the treatment of coronary narrowing. Due to the translucency of the material (PLLA), the optical coherence tomography (OCT) measurement methods used in the ABSORB trials were unique but not applicable for permanent metallic stents. When the Absorb scaffold and metallic stents are compared in the context of randomised trials, it is challenging ...
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    14. Impact of the orbital atherectomy system on a coronary calcified lesion: quantitative analysis by light attenuation in optical coherence tomography

      Impact of the orbital atherectomy system on a coronary calcified lesion: quantitative analysis by light attenuation in optical coherence tomography
      A 64-year-old female with chronic kidney disease was scheduled to undergo stenting of a severely calcified lesion in the left anterior descending coronary artery following preparation of the lesion by orbital atherectomy performed with the Diamondback 360 Coronary Orbital Atherectomy System (OAS), 1.25 mm Classic Crown (Cardiovascular Systems, Inc., St. Paul, MN, USA) (Figure 1A) (pre- and post-OAS angiography: Figure 1B-1C and Figure 1B-1C , respectively). The first run was ...
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    15. New implication of three-dimensional optical coherence tomography in optimising bifurcation PCI

      New implication of three-dimensional optical coherence tomography in optimising bifurcation PCI
      With the advance of optical coherence tomography (OCT) technology, three-dimensional (3D) reconstruction based on the optical coherence tomography has become feasible. In bifurcation lesions, 3D OCT may guide positioning of the wire through the appropriate (distal) cells. The early studies suggested that such a guidance strategy could reduce the incidence of malapposition in bifurcation lesions. The pre-installed real-time 3D OCT on the console will promote the utilisation of 3D assessment ...
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    16. Short-term effects of Nano+™ polymer-free sirolimus-eluting stents on native coronary vessels: an optical coherence tomography imaging study

      Short-term effects of Nano+™ polymer-free sirolimus-eluting stents on native coronary vessels: an optical coherence tomography imaging study
      Aims: Newly developed drug-eluting stents (DES) aim to promote early endothelialisation and prevent stent thrombosis. We sought to evaluate the extent of neointima growth by optical coherence tomography (OCT) three months after implantation of a polymer-free stent with a nano-sized-pore surface eluting sirolimus. Methods and results: In this prospective, multicentre, open-label study, patients were enrolled with documented stable angina or silent ischaemia and planned intervention for up to two de ...
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    17. 1-15 of 169 1 2 3 4 ... 10 11 12 »
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  2. About Patrick W. Serruys

    Patrick W. Serruys

    Patrick W. Serruys is a Professor of Interventional Cardiology, Erasmus University, Thoraxcentrum Rotterdam, Netherlands. Prof. Dr. Patrick Serruys comes from Belgium and studied at the University of Leuven. In 1972 he obtained his doctor's degree at the University of Leuven. He worked at this university in the Cardiology department until 1976 and then joined the Thoraxcenter in Rotterdam. In 1986 he obtained his PhD on the thesis: "Transluminal coronary angioplasty: an investigational tool and a non operative treatment of acute myocardial ischemia". In 1988 he was appointed Professor of Interventional Cardiology at the Thoraxcenter of the Erasmus MC.

  3. Quotes

    1. The positive 30-day results reaffirm my belief that a device that bioresorbs, or disappears, into the body after restoring blood flow is the next logical step in the treatment of cardiovascular disease.
      In Abbott Announces Positive Data From Absorb Trial on Its Bioresorbable Vascular Scaffold Technology
    2. I am very happy with the 12-month results of the LEADERS study, which confirm the 9-month results. The Biosensors drug eluting stent, combining the novel biolimus drug and an abluminal biodegradable polymer, is a very promising technology for our patients long term benefit
      In iosensors DES Demonstrates Superior Strut Coverage to Industry Leading DES