1. Patrick W. Serruys

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    1. Mentioned In 155 Articles

    2. Short-term effects of Nano+™ polymer-free sirolimus-eluting stents on native coronary vessels: an optical coherence tomography imaging study

      Short-term effects of Nano+™ polymer-free sirolimus-eluting stents on native coronary vessels: an optical coherence tomography imaging study

      Aims: Newly developed drug-eluting stents (DES) aim to promote early endothelialisation and prevent stent thrombosis. We sought to evaluate the extent of neointima growth by optical coherence tomography (OCT) three months after implantation of a polymer-free stent with a nano-sized-pore surface eluting sirolimus. Methods and results: In this prospective, multicentre, open-label study, patients were enrolled with documented stable angina or silent ischaemia and planned intervention for up to two de novo coronary lesions (in different vessels), with lesion length of ≤18 mm. The primary OCT endpoint was the percentage of in-stent neointimal volume obstruction at three months. The secondary endpoints ...

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    3. Association of wall shear stress with long-term vascular healing response following bioresorbable vascular scaffold implantation

      Association of wall shear stress with long-term vascular healing response following bioresorbable vascular scaffold implantation

      Bioresorbable vascular scaffolds (BVS) could potentially overcome pitfalls of metal stents, such as late failure and neoatherosclerosis [1]. At the long-term follow-up of the everolimus-eluting BVS (Absorb BVS 1.0; Abbott Vascular, Santa Clara, CA), complete strut bioresorption accompanied by late luminal enlargement and development of a signal-rich layer covering underlying thrombogenic plaque components were observed by optical coherence tomography (OCT) 5 years after implantation [1,2]. The vascular architecture after bioresorption resembled a native non-obstructive atherosclerotic plaque with varying morphology among subjects [1].

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    4. Early and late optical coherence tomography findings following everolimus-eluting bioresorbable vascular scaffold implantation in myocardial infarction: a preliminary report

      Early and late optical coherence tomography findings following everolimus-eluting bioresorbable vascular scaffold implantation in myocardial infarction: a preliminary report

      Introduction: Although bioresorbable vascular scaffolds (BVS) have been used with promising results in patients with stable and unstable angina, little is known about the acute vascular response following BVS implantation in myocardial infarction. We present angiographic and OCT findings from the first patients undergoing bioresorbable vascular scaffold (BVS) implantation for non-ST-elevation myocardial infarction (NSTEMI) or ST-elevation myocardial infarction (STEMI) in our institution. Methods: The first 5 patients with NSTEMI and the first 5 patients with STEMI who underwent BVS implantation in our institution, followed by optical coherence tomography (OCT) imaging of the treated culprit vessel, were included in this series ...

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    5. Incidence and Imaging Outcomes of Acute Scaffold Disruption and Late Structural Discontinuity After Implantation of the Absorb Everolimus-Eluting Fully Bioresorbable Vascular Scaffold: OCT Assessment in the ABSORB Cohort B Trial (A Clinical Evaluation of

      Incidence and Imaging Outcomes of Acute Scaffold Disruption and Late Structural Discontinuity After Implantation of the Absorb Everolimus-Eluting Fully Bioresorbable Vascular Scaffold: OCT Assessment in the ABSORB Cohort B Trial (A Clinical Evaluation of

      Objectives This study sought to describe the frequency and clinical impact of acute scaffold disruption and late strut discontinuity of the second-generation Absorb bioresorbable polymeric vascular scaffolds (Absorb BVS, Abbott Vascular, Santa Clara, California) in the ABSORB (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions) cohort B study by optical coherence tomography (OCT) post-procedure and at 6, 12, 24, and 36 months. Background Fully bioresorbable scaffolds are a novel approach to treatment for coronary narrowing that provides transient vessel support with drug delivery capability without ...

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    6. OCT Assessment of the Long-Term Vascular Healing Response 5 Years After Everolimus-Eluting Bioresorbable Vascular Scaffold

      OCT Assessment of the Long-Term Vascular Healing Response 5 Years After Everolimus-Eluting Bioresorbable Vascular Scaffold

      Background Although recent observations suggest a favorable initial healing process of the everolimus-eluting bioresorbable vascular scaffold (BVS), little is known regarding long-term healing response. Objectives This study assessed the in vivo vascular healing response using optical coherence tomography (OCT) 5 years after elective first-in-man BVS implantation. Methods Of the 14 living patients enrolled in the Thoraxcenter Rotterdam cohort of the ABSORB A study, 8 patients underwent invasive follow-up, including OCT, 5 years after implantation. Advanced OCT image analysis included luminal morphometry, assessment of the adluminal signal-rich layer separating the lumen from other plaque components, visual and quantitative tissue characterization, and ...

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    7. Scaffold and Edge Vascular Response Following Implantation of Everolimus-Eluting Bioresorbable Vascular Scaffold : A 3-Year Serial Optical Coherence Tomography Study

      Scaffold and Edge Vascular Response Following Implantation of Everolimus-Eluting Bioresorbable Vascular Scaffold : A 3-Year Serial Optical Coherence Tomography Study

      Objectives This study sought to investigate the in-scaffold vascular response (SVR) and edge vascular response (EVR) after implantation of an everolimus-eluting bioresorbable scaffold (BRS) using serial optical coherence tomography (OCT) imaging. Background Although studies using intravascular ultrasound have evaluated the EVR in metal stents and BRSs, there is a lack of OCT-based SVR and EVR assessment after BRS implantation. Methods In the ABSORB Cohort B (ABSORB Clinical Investigation, Cohort B) study, 23 patients (23 lesions) in Cohort B1 and 17 patients (18 lesions) in Cohort B2 underwent truly serial OCT examinations at 3 different time points (Cohort B1: post-procedure, 6 ...

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    8. Long-term invasive follow-up of the everolimus-eluting bioresorbable vascular scaffold: five-year results of multiple invasive imaging modalities

      Long-term invasive follow-up of the everolimus-eluting bioresorbable vascular scaffold: five-year results of multiple invasive imaging modalities

      Aims: The Paradise Ultrasound Renal Denervation System is a next-generation catheter-based device which was used to investigate whether the target ablation area can be controlled by changing ultrasound energy and duration to optimise nerve injury while preventing damage to the arterial wall. Methods and results: Five ultrasound doses were tested in a thermal gel model. Catheter-based ultrasound denervation was performed in 15 swine (29 renal arteries) to evaluate five different doses in vivo , and animals were euthanised at seven days for histopathologic assessment. In the gel model, the peak temperature was highest in the low power-long duration (LP-LD) dose, followed ...

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    9. Bioresorbable vascular scaffold treatment induces the formation of neointimal cap that seals the underlying plaque without compromising the luminal dimensions: a concept based on serial optical coherence tomography data

      Bioresorbable vascular scaffold treatment induces the formation of neointimal cap that seals the underlying plaque without compromising the luminal dimensions: a concept based on serial optical coherence tomography data

      Aims: To evaluate the implications of an Absorb bioresorbable vascular scaffold (Absorb BVS) on the morphology of the superficial plaques. Methods and results: Forty-six patients who underwent Absorb BVS implantation and 20 patients implanted with bare metal stents (BMS) who had serial optical coherence tomographic examination at baseline and follow-up were included in this analysis. The thin-capped fibroatheromas (TCFA) were identified in the device implantation regions and in the adjacent native coronary segments. Within all regions, circumferential locations of TCFA and calcific tissues were identified, and the neointimal thickness was measured at follow-up. At six to 12-month follow-up, only 8 ...

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    10. Qvanteq Bioactive Coronary Stent System First in Man (FIM) Clinical Investigation

      Qvanteq Bioactive Coronary Stent System First in Man (FIM) Clinical Investigation

      Objective of this First in Man study is to assess feasibility and safety of Qvanteq's bioactive coronary stent for treatment of stable coronary artery disease patients with de novo coronary artery stenosis in native vessels. The proprietary surface of Qvanteq's bioactive coronary stent improves the in-growth behavior of the stent in the treated vessel. In-vivo animal studies revealed fast in-growth (similar to BMS), which however is not resulting in excessive tissue overgrowth as observed in BMS but rather has an efficacy profile similar to drug-eluting stent (DES), meaning suppression of tissue overgrowth. This should reduce the risk of ...

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    11. Serial 2-Dimensional and 3-Dimensional Optical Coherence Tomography Assessment of Overhanging Struts of Drug-Eluting Absorbable Metal Scaffold

      Serial 2-Dimensional and 3-Dimensional Optical Coherence Tomography Assessment of Overhanging Struts of Drug-Eluting Absorbable Metal Scaffold

      A 75-year-old woman with stable angina pectoris underwent percutaneous coronary intervention of the left anterior descending coronary artery, whereby a 3.25/16-mm paclitaxel-eluting absorbable metal scaffold (DREAMS, Biotronik, Bülach, Switzerland) was successfully implanted. Post-procedural angiography showed excellent results without pinching of the side branch ostium. The patient experienced no procedure-related complications, and was discharged 48 h after the procedure on dual antiplatelet therapy. Optical coherence tomography (OCT) (LightLab Imaging, Westford, Massachusetts) was performed post-procedure and at 12 months follow-up. Post-procedurally, the scaffold was well expanded with good apposition of struts to the vessel wall, and a side branch ...

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    12. Serial optical frequency domain imaging in STEMI patients: the follow-up report of TROFI study

      Serial optical frequency domain imaging in STEMI patients: the follow-up report of TROFI study

      Aims To investigate the incidence of incomplete stent apposition and to explore the impact of the presence of thrombus and protruding plaque after stent implantation on neointima formation at follow-up in ST-segment elevation myocardial infarction (STEMI) patients with serial optical frequency domain imaging (OFDI) investigations. Methods and results In a multi-centre study, 141 patients with ST elevation myocardial infarction <12 h from onset were randomized to either PPCI with thrombectomy (TB) using an Eliminate catheter (TB: n = 71) or without TB (non-TB: n = 70). OFDI after drug-eluting stenting was performed using TERUMO OFDI system. Per protocol, at follow-up 49 patients ...

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    13. Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance: Implications for the Management of Incomplete Stent Apposition

      Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance: Implications for the Management of Incomplete Stent Apposition
      ...ngdom (M.G., C.D.M.); and Cardialysis, Rotterdam, The Netherlands (H.M.G.-G., P.W.S.). 1. Correspondence to Patrick W. Serruys, MD, PhD, or Nicolas Foin, MSc, PhD, ThoraxCenter, Erasmus University Medical Center, Ba-...
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    14. 1-15 of 155 1 2 3 4 ... 9 10 11 »
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  2. About Patrick W. Serruys

    Patrick W. Serruys

    Patrick W. Serruys is a Professor of Interventional Cardiology, Erasmus University, Thoraxcentrum Rotterdam, Netherlands. Prof. Dr. Patrick Serruys comes from Belgium and studied at the University of Leuven. In 1972 he obtained his doctor's degree at the University of Leuven. He worked at this university in the Cardiology department until 1976 and then joined the Thoraxcenter in Rotterdam. In 1986 he obtained his PhD on the thesis: "Transluminal coronary angioplasty: an investigational tool and a non operative treatment of acute myocardial ischemia". In 1988 he was appointed Professor of Interventional Cardiology at the Thoraxcenter of the Erasmus MC.

  3. Quotes

    1. The positive 30-day results reaffirm my belief that a device that bioresorbs, or disappears, into the body after restoring blood flow is the next logical step in the treatment of cardiovascular disease.
      In Abbott Announces Positive Data From Absorb Trial on Its Bioresorbable Vascular Scaffold Technology
    2. I am very happy with the 12-month results of the LEADERS study, which confirm the 9-month results. The Biosensors drug eluting stent, combining the novel biolimus drug and an abluminal biodegradable polymer, is a very promising technology for our patients long term benefit
      In iosensors DES Demonstrates Superior Strut Coverage to Industry Leading DES