1. Ou Tan

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    1. Mentioned In 63 Articles

    2. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography

      Explore OSA | OSA Publishing
      Split-spectrum amplitude-decorrelation angiography with optical coherence tomography
      Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT makes it very sensitive to the pulsatile bulk motion noise in the axial direction. To overcome this limitation, we developed split-spectrum amplitude-decorrelation angiography (SSADA) to improve the signal-to-noise ratio (SNR) of flow detection. The full OCT spectrum was split into several narrower ...
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      Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs

    3. Estimating Visual Field Mean Deviation using Optical Coherence Tomographic Nerve Fiber Layer Measurements in Glaucoma Patients

      Explore Nature Publishing Group Ophthalmology
      Estimating Visual Field Mean Deviation using Optical Coherence Tomographic Nerve Fiber Layer Measurements in Glaucoma Patients
      To construct an optical coherence tomography (OCT) nerve fiber layer (NFL) parameter that has maximal correlation and agreement with visual field (VF) mean deviation (MD). The NFL_MD parameter in dB scale was calculated from the peripapillary NFL thickness profile nonlinear transformation and VF area-weighted averaging. From the Advanced Imaging for Glaucoma study, 245 normal, 420 pre-perimetric glaucoma (PPG), and 289 perimetric glaucoma (PG) eyes were selected. NFL_MD had significantly higher ...
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      Mentions: David Huang Joel S. Schuman Oregon Health & Science University

    4. Sectorwise Visual Field Simulation Using Optical Coherence Tomographic Angiography Nerve Fiber Layer Plexus Measurements in Glaucoma

      Explore ScienceDirect Ophthalmology
      Sectorwise Visual Field Simulation Using Optical Coherence Tomographic Angiography Nerve Fiber Layer Plexus Measurements in Glaucoma
      Purpose To simulate 24-2 visual field (VF) using optical coherence tomographic angiography (OCTA) for glaucoma evaluation. Design Cross-sectional study. Methods One eye each of 39 glaucoma and 31 age-matched normal participants was scanned using 4.5-mm OCTA scans centered on the disc. The peripapillary retinal nerve fiber layer plexus capillary density (NFLP_CD, %area) was measured. The NFLP_CD and 24-2 VF maps were divided into 8 corresponding sectors using an extension ...
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      Mentions: David Huang Oregon Health & Science University Yali Jia

    5. Quantification of local circulation with OCT angiography

      Explore uspto.gov Ophthalmology , Patents
      Quantification of local circulation with OCT angiography
      Impaired intraocular blood flow within vascular beds in the human eye is associated with certain ocular diseases including, for example, glaucoma, diabetic retinopathy and age-related macular degeneration. A reliable method to quantify blood flow in the various intraocular vascular beds could provide insight into the vascular component of ocular disease pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), a new 3D angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) was developed for ...
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      Mentions: David Huang Oregon Health & Science University Yali Jia

    6. Systems and methods of glaucoma diagnosis based on frequency analysis of inner retinal surface profile measured by optical coherence tomography

      Explore uspto.gov Ophthalmology , Patents
      Systems and methods of glaucoma diagnosis based on frequency analysis of inner retinal surface profile measured by optical coherence tomography
      A method for detecting glaucoma in a subject based on spatial frequency analysis of the inner limiting membrane (ILM) as obtained from optical coherence tomography (OCT) image data is disclosed. Based on the spatial frequency content of the analyzed ILM profile, a quantity called the Retinal surface contour variability (RSCV) is calculated and the presence or absence of a glaucoma condition is determined based on the RSCV magnitude.
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      Mentions: David Huang Oregon Health & Science University Ou Tan

    7. Nerve Fiber Flux Analysis Using Wide-Field Swept-Source Optical Coherence Tomography

      Explore TVST Journal Ophthalmology
      Nerve Fiber Flux Analysis Using Wide-Field Swept-Source Optical Coherence Tomography
      Purpose : To devise a method to quantify nerve fibers over their arcuate courses over an extended peripapillary area using optical coherence tomography (OCT). Methods : Participants were imaged with 8 8-mm volumetric OCT scans centered at the optic disc. A new quantity, nerve fiber flux (NFF), represents the cross-sectional area transected perpendicular to the nerve fibers. The peripapillary area was divided into 64 tracks with equal flux. An iterative algorithm traced ...
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      Mentions: David Huang Oregon Health & Science University Ou Tan

    8. Assessment Of Retinal Blood Flow In Diabetic Retinopathy Using Doppler FOURIER-DOMAIN Optical Coherence Tomography

      Explore LWW Online Ophthalmology
      Assessment Of Retinal Blood Flow In Diabetic Retinopathy Using Doppler FOURIER-DOMAIN Optical Coherence Tomography
      Purpose: To evaluate retinal blood flow measurements in normal eyes and eyes with varying levels of diabetic retinopathy (DR) using Doppler Fourier-domain optical coherence tomography (FD-OCT). Methods: Twenty-two eyes of 19 subjects, 10 with severe nonproliferative DR (NPDR) and 12 with proliferative DR (PDR), were compared with 44 eyes of 40 healthy control subjects. All eyes were scanned by RTvue FD-OCT. Color disk photographs and cube/volume scans of the ...
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      Mentions: David Huang Oregon Health & Science University Ou Tan

    9. Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field

      Explore American Journal of Ophthalmology Ophthalmology
      Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field
      Purpose To compare longitudinal glaucoma progression detection using optical coherence tomography (OCT) and visual field (VF). Design Validity assessment Method We analyzed subjects with more than 5 follow-up visits (every 6 months) in the multi-center Advanced Imaging for Glaucoma Study. Fourier-domain optical coherence tomography (OCT) was used to map the thickness of the peripapillary retinal nerve fiber layer (NFL) and ganglion cell complex (GCC). OCT-based progression detection was defined as ...
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      Mentions: David Huang Joel S. Schuman Oregon Health & Science University

    10. Optical coherence tomography angiography enhances the detection of optic nerve damage in multiple sclerosis

      Explore BJO Online Ophthalmology
      Optical coherence tomography angiography enhances the detection of optic nerve damage in multiple sclerosis
      Background Quantitative assessment of optic nerve damage is important in the evaluation of optic neuritis (ON) and multiple sclerosis (MS). Objective To detect optic nerve damage using optical coherence tomography (OCT) and OCT angiography in MS. Methods Peripapillary retinal nerve fibre layer (NFL) thickness, macular ganglion cell complex (GCC) thickness and Optic Nerve Head Flow Index (ONH-FI) were measured. The ONH-FI was defined as flow signal averaged over the optic ...
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      Mentions: David Huang Oregon Health & Science University Yali Jia

    11. Handheld OCT Angiography and Ultra–Wide-Field OCT in Retinopathy of Prematurity

      Explore The JAMA Network Ophthalmology
      Handheld OCT Angiography and Ultra–Wide-Field OCT in Retinopathy of Prematurity
      Importance Retinopathy of prematurity (ROP) is a leading cause of childhood blindness worldwide. Optical coherence tomography (OCT) has improved the care of adults with vitreoretinal disease, and OCT angiography (OCTA) is demonstrating promise as a technique to visualize the retinal vasculature with lower risk and cost than fluorescein angiography. However, to date, there are no commercially available devices able to obtain ultrawide-field OCT or OCTA images in neonates. Objective To ...
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      Mentions: David Huang Oregon Health & Science University Ou Tan

    12. Methods and systems to measure corneal epithelial thickness and power, stromal thickness, subepithelial corneal power and topography for disease diagnosis

      Explore uspto.gov Ophthalmology , Patents
      Methods and systems to measure corneal epithelial thickness and power, stromal thickness, subepithelial corneal power and topography for disease diagnosis
      This invention discloses methods and systems for measuring corneal epithelial thickness and power, stromal thickness, subepitheila corneal power and topography. The systems and methods disclosed herein are non-invasive, non-contact and automated imaging methods which preferably makes use of Fourier-domain optical tomography. Also disclosed herein are scanning patterns and image analysis methods for utilizing and analyzing Fourier-domain optical coherence tomography images to obtain information about conical epithelial and stromal properties as ...
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      Mentions: David Huang University of Southern California Ou Tan

    13. Retinal Blood Flow Response to Hyperoxia Measured With En Face Doppler Optical Coherence Tomography

      Explore IOVS Journal Ophthalmology
      Retinal Blood Flow Response to Hyperoxia Measured With En Face Doppler Optical Coherence Tomography
      Purpose : To use multiplane en face Doppler optical coherence tomography (OCT) to measure the change in total retinal blood flow (TRBF) in response to hyperoxia. Methods : One eye of each healthy human participant ( n = 8) was scanned with a commercial high-speed (70-kHz) spectral OCT system. Three repeated scans were captured at baseline and after 10 minutes of oxygen (hyperoxia) by open nasal mask. The procedure was performed twice on day ...
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      Mentions: David Huang Oregon Health & Science University Yali Jia

    14. Glaucoma Increases Retinal Surface Contour Variability as Measured by Optical Coherence Tomography

      Explore IOVS Journal Ophthalmology
      Glaucoma Increases Retinal Surface Contour Variability as Measured by Optical Coherence Tomography
      Purpose : We investigated the feasibility of glaucoma detection by measuring retinal surface contour variability (RSCV) using optical coherence tomography (OCT). Methods : The peripapillary region in one eye of each participant was scanned over an 8 8 mm area with a swept source OCT prototype. The retinal surface contour was sampled at approximately 1.5- to 3.5-mm radius circles centered on the optic nerve head. The RSCV is defined as ...
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      Mentions: David Huang Oregon Health & Science University Ou Tan

    16. Subclinical keratoconus detection by pattern analysis of corneal and epithelial thickness maps with optical coherence tomography

      Explore ScienceDirect Ophthalmology
      Subclinical keratoconus detection by pattern analysis of corneal and epithelial thickness maps with optical coherence tomography
      Purpose To screen for subclinical keratoconus by analyzing corneal, epithelial, and stromal thickness map patterns with Fourier-domain optical coherence tomography (OCT). Setting Four centers in the United States. Design Cross-sectional observational study. Methods Eyes of normal subjects, subclinical keratoconus eyes, and the topographically normal eye of a unilateral keratoconus patient were studied. Corneas were scanned using a 26000 Hz Fourier-domain OCT system (RTVue). Normal subjects were divided into training and ...
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      Mentions: David Huang Oregon Health & Science University Ou Tan
    17. 1-15 of 63 1 2 3 4 5 »
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  4. About Ou Tan

    Ou Tan

    Ou Tan, PhD, is an Assistant Professor of Research Ophthalmology at the Keck School of Medicine of the University of Southern California. He joined the faculty at Doheny Eye Institute in September 2004. Dr. Tan earned his PhD in Biomedical Engineering from Zhejiang University, Hangzhou, China, in 2000. He completed his post-doctoral research at National Institute of Radiology Science, Chiba, Japan, in 2002. He acted as a research associate in Cleveland Clinic Foundation from 2002 to 2004. His research of interest includes medical image analysis and computer aided diagnosis in glaucoma, diabetic retinopathy, and age related macular degeneration with optical coherence tomography.

  5. Related Topics

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    2. Pilot Study of Optical Coherence Tomography Measurement of Retinal Blood Flow in Retinal and Optic Nerve Diseases
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    3. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography
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