1. Oscar Carrasco-Zevallos

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    1. Mentioned In 32 Articles

    2. Method and system for improving aiming during optical coherence tomography on young children by synchronization with retinal bifringence scanning

      Method and system for improving aiming during optical coherence tomography on young children by synchronization with retinal bifringence scanning
      The present invention is directed to a method and system for improved aiming during Optical Coherence Tomography (OCT) on young children and those unable to cooperate with OCT imaging by synchronization with retinal birefringence scanning (RBS). OCT is performed without knowing whether or not the subject is looking at the intended target. The present invention combines OCT retinal imaging, such as, but not limited to, time domain OCT, SDOCT, or ...
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    3. Feature of the Week 06/24/2018: Duke University Researchers Show Exciting Advances in Live OCT Volumes in Immersive Virtual Reality

      Feature of the Week 06/24/2018: Duke University Researchers Show Exciting Advances in Live OCT Volumes in Immersive Virtual Reality
      Virtual reality (VR) head-mounted displays are an attractive technology for viewing intrasurgical optical coherence tomography (OCT) volumes because they liberate surgeons from microscope oculars. We demonstrate real-time, interactive viewing of OCT volumes in a commercial HTC Vive immersive VR system using previously reported ray casting techniques. Furthermore, we show interactive manipulation and sectioning of volumes using handheld controllers and guidance of mock surgical procedures in porcine eyes exclusively within VR ...
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    4. Real-time visualization and interaction with static and live optical coherence tomography volumes in immersive virtual reality

      Real-time visualization and interaction with static and live optical coherence tomography volumes in immersive virtual reality
      Virtual reality (VR) head-mounted displays are an attractive technology for viewing intrasurgical optical coherence tomography (OCT) volumes because they liberate surgeons from microscope oculars. We demonstrate real-time, interactive viewing of OCT volumes in a commercial HTC Vive immersive VR system using previously reported ray casting techniques. Furthermore, we show interactive manipulation and sectioning of volumes using handheld controllers and guidance of mock surgical procedures in porcine eyes exclusively within VR ...
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    5. Volumetric Measurement of Subretinal Blebs Using Microscope-Integrated Optical Coherence Tomography

      Volumetric Measurement of Subretinal Blebs Using Microscope-Integrated Optical Coherence Tomography
      Purpose : We advance studies of subretinal treatments by developing a microscope-integrated optical coherence tomography (MIOCT) image-based method for measuring the volume of therapeutics delivered into the subretinal space. Methods : A MIOCT image-based volume measurement method was developed and assessed for accuracy and reproducibility by imaging an object of known size in model eyes. This method then was applied to subretinal blebs created by injection of diluted triamcinolone. Bleb volumes obtained ...
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    6. VISUALIZATION FROM INTRAOPERATIVE SWEPT-SOURCE MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY IN VITRECTOMY FOR COMPLICATIONS OF PROLIFERATIVE DIABETIC RETINOPATHY

      VISUALIZATION FROM INTRAOPERATIVE SWEPT-SOURCE MICROSCOPE-INTEGRATED OPTICAL COHERENCE TOMOGRAPHY IN VITRECTOMY FOR COMPLICATIONS OF PROLIFERATIVE DIABETIC RETINOPATHY
      Purpose: To evaluate the use of live volumetric (4D) intraoperative swept-source microscope-integrated optical coherence tomography in vitrectomy for proliferative diabetic retinopathy complications. Methods: In this prospective study, we analyzed a subgroup of patients with proliferative diabetic retinopathy complications who required vitrectomy and who were imaged by the research swept-source microscope-integrated optical coherence tomography system. In near real time, images were displayed in stereo heads-up display facilitating intraoperative surgeon feedback. Postoperative ...
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    7. Development of Optical Coherence Tomography Systems for Ophthalmic Imaging and Intrasurgical Guidance

      Development of Optical Coherence Tomography Systems for Ophthalmic Imaging and Intrasurgical Guidance
      Ophthalmic microsurgery is one of the most commonly performed surgical procedures in the world and it necessitates precise three-dimensional manipulation of tissue at submillimeter spatial scales. As a result, ophthalmic surgeons require an operating microscope to perform surgery and to asses alterations to the tissue. Unfortunately, modern operating microscopes provide a limited en face perspective of the three-dimensional surgical field, and surgeons must infer depth information using stereoscopy and cannot ...
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    8. Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology

      Characterization of Long Working Distance Optical Coherence Tomography for Imaging of Pediatric Retinal Pathology
      Purpose : We determined the feasibility of fovea and optic nerve head imaging with a long working distance (LWD) swept source optical coherence tomography (OCT) prototype in adults, teenagers, and young children. Methods : A prototype swept source OCT system with a LWD (defined as distance from the last optical element of the imaging system to the eye) of 350 mm with custom fixation targets was developed to facilitate imaging of children ...
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    9. Microscope-Integrated Optical Coherence Tomography Angiography in the Operating Room in Young Children With Retinal Vascular Disease

      Microscope-Integrated Optical Coherence Tomography Angiography in the Operating Room in Young Children With Retinal Vascular Disease
      Importance Intraoperative optical coherence tomography (OCT) has gained traction as an important adjunct for clinical decision making during vitreoretinal surgery, and OCT angiography (OCTA) has provided novel insights in clinical evaluation of retinal diseases. To date, these two technologies have not been applied in combination to evaluate retinal vascular disease in the operating suite. Objective To conduct microscope-integrated, swept-source OCTA (MIOCTA) in children with retinal vascular disease. Design, Setting, and ...
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    10. Four-dimensional microscope- integrated optical coherence tomography to enhance visualization in glaucoma surgeries

      Four-dimensional microscope- integrated optical coherence tomography to enhance visualization in glaucoma surgeries
      We report the first use of swept-source microscope-integrated optical coherence tomography (SS-MIOCT) capable of live four-dimensional (4D) (three-dimensional across time) imaging intraoperatively to directly visualize tube shunt placement and trabeculectomy surgeries in two patients with severe open-angle glaucoma and elevated intraocular pressure (IOP) that was not adequately managed by medical intervention or prior surgery. We performed tube shunt placement and trabeculectomy surgery and used SS-MIOCT to visualize and record surgical ...
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    11. Review of intraoperative optical coherence tomography: technology and applications [Invited]

      Review of intraoperative optical coherence tomography: technology and applications [Invited]
      During microsurgery, en face imaging of the surgical field through the operating microscope limits the surgeons depth perception and visualization of instruments and sub-surface anatomy. Surgical procedures outside microsurgery, such as breast tumor resections, may also benefit from visualization of the sub-surface tissue structures. The widespread clinical adoption of optical coherence tomography (OCT) in ophthalmology and its growing prominence in other fields, such as cancer imaging, has motivated the development ...
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    12. Four-dimensional Microscope-Integrated Optical Coherence Tomography to Visualize Suture Depth in Strabismus Surgery

      Four-dimensional Microscope-Integrated Optical Coherence Tomography to Visualize Suture Depth in Strabismus Surgery
      The authors report the use of swept-source microscope-integrated optical coherence tomography (SS-MIOCT), capable of live four-dimensional (three-dimensional across time) intraoperative imaging, to directly visualize suture depth during lateral rectus resection. Key surgical steps visualized in this report included needle depth during partial and full-thickness muscle passes along with scleral passes.
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    13. Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions

      Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions
      The peripheral retina of the human eye offers a unique opportunity for assessment and monitoring of ocular diseases. We have developed a novel wide-field (70) optical coherence tomography system (WF-OCT) equipped with wavefront sensorless adaptive optics (WSAO) for enhancing the visualization of smaller (25) targeted regions in the peripheral retina. We iterated the WSAO algorithm at the speed of individual OCT B-scans (~20 ms) by using raw spectral interferograms to ...
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    14. Long working distance OCT with a compact 2f retinal scanning configuration for pediatric imaging

      Long working distance OCT with a compact 2f retinal scanning configuration for pediatric imaging
      Young and/or autistic children cannot be imaged with tabletop or handheld optical coherence tomography (OCT) because of their lack of attention and fear of large objects close to their face. We demonstrate a prototype retinal swept-source OCT system with a long working distance (from the last optical element to the subjects eye) to facilitate pediatric imaging. To reduce the number of optical elements and axial length compared to the ...
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    15. Needle Depth and Big-Bubble Success in Deep Anterior Lamellar Keratoplasty: An Ex Vivo Microscope-Integrated OCT Study

      Needle Depth and Big-Bubble Success in Deep Anterior Lamellar Keratoplasty: An Ex Vivo Microscope-Integrated OCT Study
      Purpose: To examine big-bubble (BB) formation success rates in deep anterior lamellar keratoplasty (DALK) at various corneal depths using real-time guidance from swept-source, microscope-integrated optical coherence tomography (SS-MIOCT). Methods: The DALK procedure was performed ex vivo with 34 human donor corneoscleral buttons on pressurized artificial anterior chambers using the BB technique employed by Anwar and Teichmann. We inserted a needle under controlled ex vivo conditions to corneal depths ranging from ...
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  2. About Oscar Carrasco-Zevallos

    Oscar Carrasco-Zevallos

    Oscar Carrasco-Zevallos received his B.S degree in biomedical engineering from Texas A&M University in 2012. He is currently a Ph.D. graduate student at Duke University, where he is supported by several fellowships including the NSF GRFP, Ford Foundation predoctoral fellowship, and the NIH T-32 Medical Imaging Training Grant. His research interests include development of optical coherence tomography systems for both anterior segment and retinal eye imaging.