1. Osaka University

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    1. Mentioned In 119 Articles

    2. Feature Of The Week 4/8/12: Researchers at Osaka and Nagoya University Investigate The Use of Ultrahigh Resolution OCT for Imaging Protein Crystals

      Feature Of The Week 4/8/12: Researchers at Osaka and Nagoya University Investigate The Use of Ultrahigh Resolution OCT for Imaging Protein Crystals
      technique used for atomic-resolution protein-structure studies, and currently, robotic automation is often used to monitor and optimize crystallization conditions. However, it is often difficult to identify, by conventional light microscopy, crystals that can be used for X-ray crystallography when micro-size, needle, and salt crystals are also present in the crystallization medium.For the work reported herein, we demonstrated that micro-scale, non-invasive, three-dimensional (3D) cross-sectional, μm-resolution imaging of protein crystals could ...
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    3. Three-dimensional, non-invasive, cross-sectional imaging of protein crystals using ultrahigh resolution optical coherence tomography

      Three-dimensional, non-invasive, cross-sectional imaging of protein crystals using ultrahigh resolution optical coherence tomography
      Micro-scale, non-invasive, three-dimensional cross-sectional imaging of protein crystals was successfully accomplished using ultra-high resolution optical coherence tomography (UHR-OCT) with low noise, Gaussian like supercontinuum. This technique facilitated visualization of protein crystals even those in medium that also contained substantial amounts of precipitates. We found the enhancement of the scattered signal from protein crystal by inclusion of agarose gel in the crystallization medium. Crystals of a protein and a salt in ...
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    4. Spectral dependence of ultra-low dark count superconducting single photon detector for the evaluation of broadband parametric fluorescence

      Spectral dependence of ultra-low dark count superconducting single photon detector for the evaluation of broadband parametric fluorescence
      Superconducting nanowire single photon detectors (SNSPD) have unique characteristics of ultra low dark counts and wide spectrum sensitivity. These natures are indispensable for the evaluation of ultra-broadband parametric fluorescence, which are used for the quantum optical coherence tomography and novel optical non-linear experiments. Here we report the spectral dependence of the detection efficiency of a meander type SNSPD device, having reduced strip width of 50 nm, over a wide spectrum ...
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      Mentions: Osaka University
    5. Choroidal observations in Vogt–Koyanagi–Harada disease using high-penetration optical coherence tomography

      Choroidal observations in Vogt–Koyanagi–Harada disease using high-penetration optical coherence tomography
      Background The aim of this work was to investigate the choroidal morphologic changes of Vogt–Koyanagi–Harada (VKH) disease in vivo using high-penetration optical coherence tomography (HP-OCT) with a long-wavelength light source (1,060 nm). Methods Fourteen patients with VKH disease were included in this study: 12 eyes of six patients with treatment-naive acute VKH in the first 6–12 months after diagnosis and 16 eyes of eight patients in ...
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    6. Effects of Age, Sex, and Axial Length on the Three-Dimensional Profile of Normal Macular Layer Structures

      Effects of Age, Sex, and Axial Length on the Three-Dimensional Profile of Normal Macular Layer Structures
      Purpose. To identify sex-related differences and age-related changes in individual retinal layer thicknesses in a population of healthy eyes across the lifespan, using spectral domain optical coherence tomography (SD-OCT). Methods. In seven institutes in Japan, mean thicknesses of the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor inner segment (IS), and photoreceptor ...
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    7. Generation of broadband spontaneous parametric fluorescence and its application to quantum optical coherence tomography

      Generation of broadband spontaneous parametric fluorescence and its application to quantum optical coherence tomography
      Optical coherence tomography (OCT) based on Michelson interferometer has widely been utilized in biology and medicine as a type of optical biopsy and quantum optical coherence tomography (QOCT) based on Hong-Ou-Mandel interferometer has recently been demonstrated. By use of quantum entangled photon pairs generated via spontaneous parametric down conversion (SPDC) process, axial resolution of QOCT can be better than that of OCT in principle for a source of same bandwidth ...
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    8. Evaluation of the Choroidal Thickness Using High-Penetration Optical Coherence Tomography With Long Wavelength in Highly Myopic Normal-Tension Glaucoma

      Evaluation of the Choroidal Thickness Using High-Penetration Optical Coherence Tomography With Long Wavelength in Highly Myopic Normal-Tension Glaucoma
      ...rsity Graduate School of Medicine, Suita, Japan , * Yasushi Ikuno Affiliations + Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan + Corresponding Author Information Inquiries to Yas...
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    9. Spectral-Domain Optical Coherence Tomographic Findings in Punctate Inner Choroidopathy

      Spectral-Domain Optical Coherence Tomographic Findings in Punctate Inner Choroidopathy
      Purpose: To investigate the pathology of punctate inner choroidopathy (PIC) using spectral-domain optical coherence tomography. Methods: We retrospectively reviewed spectral-domain optical coherence tomography findings of 14 cases with active PIC. We obtained specific appearance of the active PIC lesion that were characterized by yellowish/white round spots in fundus examination with fluorescein leakage. Fluorescein angiogram and confocal indocyanine green angiogram were also reviewed. Results: Three cases (21%) of 14 were ...
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    10. Combined two-photon microscopy and optical coherence tomography using individually optimized sources

      Combined two-photon microscopy and optical coherence tomography using individually optimized sources
      The combination of two-photon microscopy (TPM) and optical coherence tomography (OCT) is useful in conducting in-vivo tissue studies, because they provide complementary information regarding tissues. In the present study, we developed a new combined system using separate light sources and scanners for individually optimal imaging conditions. TPM used a Ti-Sapphire laser and provided molecular and cellular information in microscopic tissue regions. Meanwhile, OCT used a wavelength-swept source centered at 1300 ...
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    11. Dynamic analysis for mental sweating of a group of eccrin sweat glands on a human fingertip by optical coherence tomography

      Dynamic analysis for mental sweating of a group of eccrin sweat glands on a human fingertip by optical coherence tomography
      OCT is highly potential for in vivo observation of human sweating dynamics which affects activity of the sympathetic nerve. In this paper, we demonstrate dynamic OCT analysis of mental sweating of a group of eccrin sweat glands. The sweating dynamics is tracked simultaneously for nineteen sweat glands by time-sequential piled-up en-face OCT images with the frame spacing of 3.3 sec. Strong non-uniformity is observed in mental sweating where the ...
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      Mentions: Osaka University
    12. Ultrahigh-Resolution Optical Coherence Tomography in 1.7 µm Region with Fiber Laser Supercontinuum in Low-Water-Absorption Samples

      Ultrahigh-Resolution Optical Coherence Tomography in 1.7 µm Region with Fiber Laser Supercontinuum in Low-Water-Absorption Samples
      ... Computer Science, Nagoya University, Nagoya 464-8603, Japan 1Division of Advanced Science and Biotechnology, Osaka University, Suita, Osaka 565-0871, Japan Ultrahigh-resolution, high-penetration-depth optical coherence ...
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    13. Detection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy

      Detection of photoreceptor disruption by adaptive optics fundus imaging and Fourier-domain optical coherence tomography in eyes with occult macular dystrophy
      ...unji Kusaka1, Tatsuo Yamaguchi2, Toshifumi Mihashi2, Takashi Fujikado1 1Department of Applied Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan; 2Topcon Research Institute, Itabashi, Japan Purpos...
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  2. About Osaka University

    Osaka University

    Osaka University is a major national university located in Osaka, Japan. It is the sixth oldest university in Japan as the Osaka Prefectural Medical College, and formerly one of the Imperial Universities of Japan. Numerous prominent scientists worked at the Osaka University such as the Nobel Laureate in Physics Hideki Yukawa.  Also see Osaka University Medical School.  We aim to develop the research capability of our researchers and offer them comprehensive medical knowledge so that they can engage in research activities independently. We strive to foster extensively knowledgeable health care specialists with a flexible and methodical mind. We aim to train scientists and doctors who can meet present health care needs in the specialized field of nursing, as well as embrace the development of science. In addition, we endeavor to nurture scientists who are able to provide 21st Century intellectual leadership in the fields of Nursing and Medical Technology and Science.