1. Osaka University

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    1. Mentioned In 124 Articles

    2. New severity grading system for Fuchs endothelial corneal dystrophy using anterior segment optical coherence tomography

      New severity grading system for Fuchs endothelial corneal dystrophy using anterior segment optical coherence tomography
      Purpose: To report a new severity grading system for Fuchs endothelial corneal dystrophy (FECD) using anterior segment optical coherence tomography (AS-OCT). Methods: This observational case series included 75 eyes of 43 patients with FECD and 33 eyes of 33 healthy subjects. Pachymetry and posterior elevation maps were used to determine the AS-OCT-based grading scores. FECD severity was graded from 0-3 as follows: 0, normal; 1, guttae only; 2, stromal oedema ...
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      Mentions: Osaka University
    3. Analysis of sweating by optical coherence tomography in patients with palmoplantar hyperhidrosis

      Analysis of sweating by optical coherence tomography in patients with palmoplantar hyperhidrosis
      Optical coherence tomography (OCT) is a high-resolution tomographic imaging technique that uses optical interference. OCT has enabled the non-invasive three-dimensional analysis of individual acrosyringia in the stratum corneum in human skin. However, no report on the measurement of sweating by OCT using clinical data from humans has been published to date. Twenty patients with hyperhidrosis and twenty healthy subjects were included in this study. Imaging of acrosyringia in the stratum ...
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    4. Difference of vascular healing between bioabsorbable-polymer and durable-polymer new generation drug-eluting stents: an optical coherence tomographic analysis

      Difference of vascular healing between bioabsorbable-polymer and durable-polymer new generation drug-eluting stents: an optical coherence tomographic analysis
      The comparison of bioabsorbable-polymer and durable-polymer stents has continued to be debated, and there is ongoing concern regarding vascular healing and late stent thrombosis. This study compared the vascular healing at 8-month follow-up by optical coherence tomography (OCT) between 4 different kinds of new generation drug-eluting stents (DESs). We enrolled 112 patients (112 de novo lesions) who underwent OCT guided percutaneous coronary intervention with 4 kinds of new generation DESs ...
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    5. Clinical impact of a new optical coherence tomography-derived volumetric method for evaluating stent expansion

      Clinical impact of a new optical coherence tomography-derived volumetric method for evaluating stent expansion
      The aim of this study was to investigate the impact of a new optical coherence tomography (OCT)-derived volumetric method for stent expansion (new-OCT method) to predict the target lesion revascularization (TLR) and compare the expansion findings between this new method and the conventional method because, in the real world, there are few clinical data on the new-OCT-method for stent expansion. One hundred forty lesions in 135 patients who underwent ...
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      Mentions: Osaka University
    6. Comparison of ocular surface squamous neoplasia and pterygium using anterior segment optical coherence tomography angiography

      Comparison of ocular surface squamous neoplasia and pterygium using anterior segment optical coherence tomography angiography
      Purpose To compare ocular surface squamous neoplasia (OSSN) and pterygium using anterior segment optical coherence tomography angiography (AS-OCTA). Observations Flow patterns of conjunctival vessels in patients with OSSN and pterygium were investigated using AS-OCTA. In case 1, slit-lamp examination of a 72-year-old woman revealed an elevated lesion with increased permeability of fluorescein in the inferior nasal conjunctiva of her left eye. AS-OCTA showed markedly meandering large blood vessels in both ...
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      Mentions: Osaka University
    7. Impact of asteroid hyalosis on internal higher-order aberrations in eyes with cataract accompanied by acoustic shadows on swept-source optical coherence tomography examination

      Impact of asteroid hyalosis on internal higher-order aberrations in eyes with cataract accompanied by acoustic shadows on swept-source optical coherence tomography examination
      Increased internal higher-order aberrations (HOAs) have been reported in eyes with asteroid hyalosis, which is usually asymptomatic. This report describes two patients with cataract and concurrent asteroid hyalosis. In the first case, internal HOAs were within the normal range and swept-source optical coherence tomography (SS-OCT) did not show acoustic shadows. After cataract surgery, visual acuity improved and internal HOAs remained within normal limits. However, in the second case, SS-OCT revealed ...
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      Mentions: Osaka University
    8. Anterior segment optical coherence tomography and in vivo confocal microscopy in cases of mucopolysaccharidosis

      Anterior segment optical coherence tomography and in vivo confocal microscopy in cases of mucopolysaccharidosis
      Purpose To report anterior segment evaluation in patients with mucopolysaccharidosis 1 using anterior segment optical coherence tomography and in vivo confocal microscopy. Observations Case 1 involved a 26-year-old man with mucopolysaccharidosis 1 HurlerScheie syndrome who presented with a corrected distance visual acuity of 20/67 in the right eye and 20/50 in the left eye because of bilateral corneal opacification. He had undergone bone marrow transplantation at the age ...
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      Mentions: Osaka University
    9. Change in optical axial length after cataract surgery: segmental method versus composite method

      Change in optical axial length after cataract surgery: segmental method versus composite method
      Purpose: To compare the changes in axial length (AL) obtained after cataract surgery by partial coherence interferometry (PCI), swept-source optical coherence tomography (SS-OCT) with the composite method (CM), and SS-OCT with the segmental method (SM). Setting: National Hospital Organization, Tokyo Medical Center, Japan. Design: Retrospective case series. Methods: Two hundred and sixty-eight eyes in 139 patients who underwent cataract surgery were included. AL was measured preoperatively and 1 month postoperatively ...
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      Mentions: Osaka University
    10. Comparison of composite and segmental methods for acquiring optical axial length with swept-source optical coherence tomography

      Comparison of composite and segmental methods for acquiring optical axial length with swept-source optical coherence tomography
      This study compared the optical axial length (AL) obtained by composite and segmental methods using swept-source optical coherence tomography (SS-OCT) devices, and demonstrated its effects on the post-operative refractive errors (RE) one month after cataract surgery. Conventional AL measured with the composite method used the mean refractive index. The segmented-AL method used individual refractive indices for each ocular medium. The composite AL (24.522.03mm) was significantly longer ( P 0 ...
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      Mentions: Osaka University
    11. Frequency-domain optical coherence tomography system in the terahertz region

      Frequency-domain optical coherence tomography system in the terahertz region
      In this study, a frequency-domain optical coherence tomography (FD-OCT) system in the terahertz frequency range was developed. To generate tunable continuous-wave terahertz radiation, the outputs of two near-infrared external cavity diode lasers were mixed in an antenna-coupled photo-mixer. Using the FD-OCT system, tomographic profiling of the front and back surfaces of a high-resistivity silicon plate was realized.
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      Mentions: Osaka University
    12. Retinal Neovascularization–Simulating Retinal Capillary Reperfusion in Branch Retinal Vein Occlusion, Imaged by Wide-Field Optical Coherence Tomography Angiography

      Retinal Neovascularization–Simulating Retinal Capillary Reperfusion in Branch Retinal Vein Occlusion, Imaged by Wide-Field Optical Coherence Tomography Angiography
      Retinal neovascularization is a complication of retinal vascular diseases, such as diabetic retinopathy, retinopathy of prematurity, and retinal vein occlusion. Antivascular endothelial growth factor therapy or laser photocoagulation arrests proliferative retinopathy after neovascularization; however, substantial reperfusion has sometimes been reported. 1 - 3 We report a case of branch retinal vein occlusion manifesting with retinal nonperfusion, covered by retinal neovascularization and appearing as retinal capillary reperfusion. In this case, optical coherence ...
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      Mentions: Osaka University
    13. Neointimal characteristics comparison between biodegradable-polymer and durable-polymer drug-eluting stents: 3-month follow-up optical coherence tomography light property analysis from the RESTORE registry

      Neointimal characteristics comparison between biodegradable-polymer and durable-polymer drug-eluting stents: 3-month follow-up optical coherence tomography light property analysis from the RESTORE registry
      We aimed to quantitatively assess a possible difference of the neointimal quality between biodegradable polymer- (BP-) and durable polymer drug-eluting stents (DP-DESs). We conducted a single-center all-comer prospective cohort study: the RESTORE registry (UMIN000033009). All patients who received successful OCT examination at planned 3-month follow-up after DES implantation were analyzed. Study population was divided into 2 groups, BP-DES versus DP-DES groups. We evaluated standard OCT variables, coverage percent, and the ...
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    14. The Effect of Gas Tamponade on the Intraocular Lens Position and Refractive Error after Phacovitrectomy: A Swept-source Anterior Segment OCT Analysis

      The Effect of Gas Tamponade on the Intraocular Lens Position and Refractive Error after Phacovitrectomy: A Swept-source Anterior Segment OCT Analysis
      Objective To investigate the intraocular lens position and refractive outcomes following cataract surgery and phacovitrectomy using swept-source anterior segment optical coherence tomography (SS-ASOCT). Design Retrospective case series Subjects Patients underwent cataract surgery (Group A; 34 eyes), phacovitrectomy without gas tamponade (Group B; 20 eyes), and phacovitrectomy with gas tamponade (Group C; 22 eyes). Methods Various parameters associated with the anterior chamber and lens were measured by SS-ASOCT (CASIA2) before and ...
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    15. Deep learning based noise reduction method for automatic 3D segmentation of the anterior of lamina cribrosa in optical coherence tomography volumetric scans

      Deep learning based noise reduction method for automatic 3D segmentation of the anterior of lamina cribrosa in optical coherence tomography volumetric scans
      A deep-learning (DL) based noise reduction algorithm, in combination with a vessel shadow compensation method and a three-dimensional (3D) segmentation technique, has been developed to achieve, to the authors best knowledge, the first automatic segmentation of the anterior surface of the lamina cribrosa (LC) in volumetric ophthalmic optical coherence tomography (OCT) scans. The present DL-based OCT noise reduction algorithm was trained without the need of noise-free ground truth images by ...
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    16. Cornea Findings of Spectral Domain Anterior Segment Optical Coherence Tomography in Uveitic Eyes of Various Etiologies

      Cornea Findings of Spectral Domain Anterior Segment Optical Coherence Tomography in Uveitic Eyes of Various Etiologies
      Purpose: To evaluate the morphologic appearance of keratic precipitates (KPs) with spectral domain anterior segment optical coherence tomography (AS-OCT) for the diagnosis of uveitic eyes of various etiologies. Methods: In all, 153 eyes of 153 patients with different types of uveitis were examined to investigate the morphologic appearance of KPs. The study included 63 eyes with herpetic iridocyclitis/endotheliitis, 58 eyes with ocular sarcoidosis, 5 eyes with Fuchs heterochromic iridocyclitis ...
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      Mentions: Osaka University
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  2. About Osaka University

    Osaka University

    Osaka University is a major national university located in Osaka, Japan. It is the sixth oldest university in Japan as the Osaka Prefectural Medical College, and formerly one of the Imperial Universities of Japan. Numerous prominent scientists worked at the Osaka University such as the Nobel Laureate in Physics Hideki Yukawa.  Also see Osaka University Medical School.  We aim to develop the research capability of our researchers and offer them comprehensive medical knowledge so that they can engage in research activities independently. We strive to foster extensively knowledgeable health care specialists with a flexible and methodical mind. We aim to train scientists and doctors who can meet present health care needs in the specialized field of nursing, as well as embrace the development of science. In addition, we endeavor to nurture scientists who are able to provide 21st Century intellectual leadership in the fields of Nursing and Medical Technology and Science.