1. Oregon Health & Science University

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    1. Mentioned In 436 Articles

    2. Ultrahigh sensitive optical microangiography reveals depth-resolved microcirculation and its longitudinal response to prolonged ischemic event within skeletal muscles in mice

      Ultrahigh sensitive optical microangiography reveals depth-resolved microcirculation and its longitudinal response to prolonged ischemic event within skeletal muscles in mice
      The primary pathophysiology of peripheral arterial disease is associated with impaired perfusion to the muscle tissue in the lower extremities. The lack of effective pharmacologic treatments that stimulate vessel collateralization emphasizes the need for an imaging method that can be used to dynamically visualize depth-resolved microcirculation within muscle tissues. Optical microangiography (OMAG) is a recently developed label-free imaging method capable of producing three-dimensional images of dynamic blood perfusion within microcirculatory ...
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    3. Simulation of basic characteristics of single-shot full-field optical coherence tomography using spatially phase-modulated reference light

      Simulation of basic characteristics of single-shot full-field optical coherence tomography using spatially phase-modulated reference light
      For the single-shot full-field optical coherence tomography (OCT) using spatially phase-modulated reference light, the basic characteristics have been simulated. At low spatial frequencies, the OCT signal intensity is enhanced twofold owing to subtractions, and with increasing the spatial frequency, the OCT signal intensity decreases 0.636 times at half the Nyquist frequency. OCT signal intensities also depend on orientations in images. Residual noninterference components of signal intensities between adjacent uniform ...
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    4. Ophthalmic OCT Reaches $1 Billion Per Year: But Reimbursement Clampdown Clouds Future Innovation

      Ophthalmic OCT Reaches $1 Billion Per Year: But Reimbursement Clampdown Clouds Future Innovation
      ...  Eric Swanson is the editor of OCT News. David Huang, MD, PhD, is affiliated with the Casey Eye Institute’s Oregon Health & Science University Center for Ophthalmic Optics & Lasers. Dr. Huang reports significant financ...
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    5. Investigation of Femtosecond Laser–Enabled Keratoplasty Wound Geometry Using Optical Coherence Tomography

      Investigation of Femtosecond Laser–Enabled Keratoplasty Wound Geometry Using Optical Coherence Tomography
      Purpose: To measure the wound geometry after femtosecond laser-enabled keratoplasty (FLEK) using optical coherence tomography (OCT). Design: Prospective nonrandomized clinical study and laboratory study. Participants: Patients who were candidates for penetrating keratoplasty at an academic referral center. Methods: Wound architecture was measured and analyzed by OCT in 8 eyes of 8 consecutive patients who underwent FLEK. Femtosecond laser lamellar cuts were performed on 3 eye bank corneas, and the wound ...
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    6. Biophotonics Modalities for High-Resolution Imaging of Microcirculatory Tissue Beds Using Endogenous Contrast: A Review on Present Scenario and Prospects

      Biophotonics Modalities for High-Resolution Imaging of Microcirculatory Tissue Beds Using Endogenous Contrast: A Review on Present Scenario and Prospects
      The microcirculation is a complex system, and the visualization of microcirculation has great significance in improving our understanding of pathophysiological processes in various disease conditions, in both clinical and fundamental studies. A range of techniques are available or emerging for investigating different aspect of the microcirculation in animals and humans. This paper reviews the recent developments in the field of high-resolution and high-sensitive optical imaging of microcirculatory tissue beds, emphasizing ...
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    7. Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photo-thermal optical coherence tomography

      Optical characterization and feasibility study of multifunctional polylactic-co-glycolic acid (PLGA) nanoparticles designed for photo-thermal optical coherence tomography
      Nanoparticles with plasmon-resonance absorption in the near-IR (NIR) optical range are of great interest in optical coherence tomography (OCT) for contrast enhancement and diagnostic interventions in molecular imaging. In this study, we characterized the optical properties of multifunctional NIR dye-loaded PLGA nanoparticles (approved by the U.S. Food and Drug Administration) to assess the feasibility of using contrast agent for photo-thermal OCT (PT-OCT) imaging. Tissue phantoms containing NIR dye-doped PLGA ...
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    8. Analysis of Deposit Depth and Morphology in Granular Corneal Dystrophy Type 2 Using Fourier Domain Optical Coherence Tomography

      Analysis of Deposit Depth and Morphology in Granular Corneal Dystrophy Type 2 Using Fourier Domain Optical Coherence Tomography
      Purpose: Granular corneal dystrophy type 2 (GCD2) causes the formation of corneal deposits having 3 different morphological types. We used Fourier domain optical coherence tomography to assess the depths of each type according to the morphology. Methods: A prospective study was performed in 54 eyes of 54 heterozygous patients with GCD2. Corneal deposits of 54 patients with GCD2 were classified into 3 morphological types: type 1, diffuse haze; type 2 ...
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    9. Flicker-induced changes in retinal blood flow assessed by Doppler optical coherence tomography

      Flicker-induced changes in retinal blood flow assessed by Doppler optical coherence tomography
      We used Doppler Fourier-domain optical coherence tomography (OCT) to investigate flicker-induced changes of total retinal blood flow. Total retinal blood flow was measured by summing flows in veins imaged in double-circular scans around the optic disc. In 3 healthy volunteers, total retinal blood flow was measured before and 10-15 seconds after 30 seconds of flicker stimulation. The average blood flow increased 22.2% (p = 0.002). The total venous and ...
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    10. Effects of age on ocular anterior segment dimensions measured by optical coherence tomography

      Effects of age on ocular anterior segment dimensions measured by optical coherence tomography
      Background Older subjects tend to have smaller ocular anterior segment. The present study aimed to measure anterior segment dimensions with optical coherence tomography (OCT) and quantitatively assess the effect of age and other factors. Methods Anterior segment OCT images were obtained in normal subjects residing in the greater Los Angeles area. Four line scans were acquired at the 90˚, 45˚, 0˚ and 135˚ meridians of each eye. Computer calipers acquired ...
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    11. A differentially amplified motion in the ear for near-threshold sound detection

      A differentially amplified motion in the ear for near-threshold sound detection
      The ear is a remarkably sensitive pressure fluctuation detector. In guinea pigs, behavioral measurements indicate a minimum detectable sound pressure of ~20 μPa at 16 kHz. Such faint sounds produce 0.1-nm basilar membrane displacements, a distance smaller than conformational transitions in ion channels. It seems that noise within the auditory system would swamp such tiny motions, making weak sounds imperceptible. Here we propose a new mechanism contributing to a ...
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    12. Ophthalmic OCT Reaches $1 Billion Per Year: But reimbursement clampdown clouds future innovation.

      Ophthalmic OCT Reaches $1 Billion Per Year: But reimbursement clampdown clouds future innovation.
      Long gone are the days when a new medical product could be easily introduced based solely on improved patient outcomes. To optimize the probability of success, a new product now needs to demonstrate that it can both improve patient outcomes and reduce costs. To the clinical practice manager, an attractive product will need to recoup its cost in the near term and generate revenues in a predictable and easily quantifiable ...
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    13. Measurement of strain and strain rate in embryonic chick heart in vivo using spectral domain optical coherence tomography

      Measurement of strain and strain rate in embryonic chick heart in vivo using spectral domain optical coherence tomography
      The ability to measure in vivo strain and strain rate in embryonic chick heart is one of the key requirements for understanding the mechanisms of cardiac development. Due to its high temporal and spatial resolution as well as its fast imaging capability, optical coherence tomography (OCT) has the potential to reveal the complex myocardial activity in the living chick heart. We describe a method to evaluate the in vivo strain ...
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    14. Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT

      Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT
      Doppler OCT provides depth-resolved information on flow in biological tissues. In this article, we demonstrate ultrahigh speed swept source/Fourier domain OCT for visualization and quantitative assessment of retinal blood flow. Using swept laser technology, the system operated in the 1050-nm wavelength range at a high axial scan rate of 200 kHz. The rapid imaging speed not only enables volumetric imaging with high axial scan densities, but also enables measurement ...
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    15. 346-360 of 436 « 1 2 ... 21 22 23 24 25 26 27 28 29 »
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  2. About Oregon Health & Science University

    Oregon Health & Science University

    Oregon Health & Science University (OHSU) is a public university in Oregon with a main campus, including three hospitals, in Portland and a smaller campus in Hillsboro. It was formed in 1974 as the University of Oregon Health Sciences Center, combining state dentistry, medicine, and nursing programs into a single center. It was renamed Oregon Health Sciences University in 1981 and took its current name in 2001, as part of a merger with the Oregon Graduate Institute of Science and Technology (OGI) in Hillsboro. In addition, the university has several partnership programs including a joint PharmD Pharmacy program with Oregon State University.