1. Oregon Health & Science University

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    1. Mentioned In 460 Articles

    2. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography

      Split-spectrum amplitude-decorrelation angiography with optical coherence tomography
      Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT makes it very sensitive to the pulsatile bulk motion noise in the axial direction. To overcome this limitation, we developed split-spectrum amplitude-decorrelation angiography (SSADA) to improve the signal-to-noise ratio (SNR) of flow detection. The full OCT spectrum was split into several narrower ...
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    3. OCT angiography improves views of retina blood flow

      OCT angiography improves views of retina blood flow
      Projects from Boston and Portland could help translation of OCTA into clinics. Retina blood flow: vital for diagnosis Optical coherence tomography angiography (OCTA) is a promising technique for imaging of blood vessels, in which sequential OCT scans of the same tissue cross-section reveal the sites of blood flow within those tissues, and can allow the blood oxygen content to be calculated. Examination of the retina is one promising application area ...
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    4. Oregon Health & Science University Receives NIH Grant for Optical Coherence Tomography Differential Diagnosis and Treatment of Irregular Corneas

      Oregon Health & Science University Receives NIH Grant for Optical Coherence Tomography Differential Diagnosis and Treatment of Irregular Corneas
      To see well, the cornea must maintain near perfect clarity and shape. Several disease processes can distort corneal shape and degrade vision. These include ectasia/keratoconus (stromal thinning and bulging), primary epithelial deformation (contact lens-related warpage, dry eye, epithelial basement membrane dystrophy), and stromal changes (scar, stromal dystrophy, surgery). Some of these conditions can appear similar on standard anterior topography and yet require very different treatments. Therefore a goal of ...
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    5. Oregon Health & Science University Receives a NIH Grant for Wide-Field and Projection-Resolved Optical Coherence Tomography Angiography in Diabetic Retinopathy

      Oregon Health & Science University Receives a NIH Grant  for Wide-Field and Projection-Resolved Optical Coherence Tomography Angiography in Diabetic Retinopathy
      ...te WF- and PR-OCTA measurements of nonperfusion and neovascularization in comparison with ultrawide-field FA. Oregon Health & Science University Receives a 2020 NIH Grant for $424,803 for Wide-Field and Projection-Resolv...
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    6. Oregon Health & Science University Receives NIH Grant for Functional and Structural Optical Coherence Tomography for Glaucoma

      Oregon Health & Science University Receives NIH Grant for Functional and Structural Optical Coherence Tomography for Glaucoma
      ...e benefit of glaucoma therapies that work through neuroprotection or regeneration, compared to monitoring VF. Oregon Health & Science University Receives a 2020 NIH Grant for $564,228 for Functional and Structural Optica...
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    7. Real-time retinal layer segmentation of OCT Volumes with GPU and Deep learning

      Real-time retinal layer segmentation of OCT Volumes with GPU and Deep learning
      Segmentation of retinal layers in optical coherence tomography (OCT) is an essential step in OCT image analysis for screening, diagnosis, and assessment of retinal disease progression. Real-time segmentation together with high-speed OCT volume acquisition allows rendering of en face OCT of arbitrary retinal layers, which can be used to increase the yield rate of high-quality scans, provide real-time feedback during image-guided surgeries, and compensate aberrations in adaptive optics (AO) OCT ...
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    8. Oregon Health and Sciences University Receives a 2020 NIH Grant for Artificial Intelligence Assisted Panoramic Optical Coherence Tomography for Retinopathy of Prematurity

      Oregon Health and Sciences University Receives a 2020 NIH Grant  for Artificial Intelligence Assisted Panoramic Optical Coherence Tomography for Retinopathy of Prematurity
      Oregon Health and Sciences University Receives a 2020 NIH Grant for $341,800 for Artificial Intelligence Assisted Panoramic Optical Coherence Tomography for Retinopathy of Prematurity. The principal investigator is Yifan Jian. Below is a summary of the proposed work. The long-term goal of this project is to determine whether optical coherence tomography (OCT) and OCT angiography (OCTA) might lead more accurate and objective diagnosis, earlier intervention, and improved outcomes in ...
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    9. Sensorless adaptive-optics optical coherence tomographic angiography

      Sensorless adaptive-optics optical coherence tomographic angiography
      Optical coherence tomographic angiography (OCTA) can image the retinal blood flow but visualization of the capillary caliber is limited by the low lateral resolution. Adaptive optics (AO) can be used to compensate ocular aberrations when using high numerical aperture (NA), and thus improve image resolution. However, previously reported AO-OCTA instruments were large and complex, and have a small sub-millimeter field of view (FOV) that hinders the extraction of biomarkers with ...
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    10. Automated segmentation of retinal fluid volumes from structural and angiographic optical coherence tomography using deep learning

      Automated segmentation of retinal fluid volumes from structural and angiographic optical coherence tomography using deep learning
      Purpose: We proposed a deep convolutional neural network (CNN), named Retinal Fluid Segmentation Network (ReF-Net) to segment volumetric retinal fluid on optical coherence tomography (OCT) volume. Methods: 3 3-mm OCT scans were acquired on one eye by a 70-kHz OCT commercial AngioVue system (RTVue-XR; Optovue, Inc.) from 51 participants in a clinical diabetic retinopathy (DR) study (45 with retinal edema and 6 healthy controls). A CNN with U-Net-like architecture was ...
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    11. Optical Coherence Tomography Reveals Light-Dependent Retinal Responses in Alzheimer’s Disease

      Optical Coherence Tomography Reveals Light-Dependent Retinal Responses in Alzheimer’s Disease
      Spectral-domain optical coherence tomography (SD-OCT) is an accessible clinical tool for measuring structural changes to the retina, and increasingly as a biomarker for brain-predominant neurodegenerative diseases like Alzheimers. Information about retinal function can also be extracted from OCT images, but is under-studied, with literature examples often employing challenging protocols or requiring specialized hardware. The first goal of this study was to verify that functional retinal imaging was feasible with a ...
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    12. Retinal capillary oximetry with visible light optical coherence tomography

      Retinal capillary oximetry with visible light optical coherence tomography
      Assessing oxygen saturation (sO 2 ) remains challenging but is nonetheless necessary for understanding retinal metabolism. We and others previously achieved oximetry on major retinal vessels and measured the total retinal oxygen metabolic rate in rats using visible-light optical coherence tomography. Here we extend oximetry measurements to capillaries and investigate all three retinal vascular plexuses by amplifying and extracting the spectroscopic signal from each capillary segment under the guidance of optical ...
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    13. Intraoperative optical coherence tomographic findings in patients undergoing subretinal gene therapy surgery

      Intraoperative optical coherence tomographic findings in patients undergoing subretinal gene therapy surgery
      Background To analyze intraoperative OCT (iOCT) findings during subretinal gene therapy. Methods A single-center, retrospective, observational, case series study of twenty one eyes submitted to subretinal gene therapy. Intrasurgical high definition videos were included for analyzes. Cases with absence of iOCT video or unsuccessful bleb creation were excluded. Sharp needle tip (SNT) or blunted needle tip (BNT) and their interaction with neurosensory retina were evaluated. Presence of subretinal air bubbles ...
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    14. Depth-resolved optimization of a real-time sensorless adaptive optics optical coherence tomography

      Depth-resolved optimization of a real-time sensorless adaptive optics optical coherence tomography
      Sensorless adaptive optics optical coherence tomography (AO-OCT) is a technology to image retinal tissue with high resolution by compensating ocular aberrations without wavefront sensors. In this Letter, a fast and robust hill-climbing algorithm is developed to optimize five Zernike modes in AO-OCT with a numerical aperture between that of conventional AO and commercial OCT systems. The merit function is generated in real time using graphics processing unit while axially tracking ...
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    15. Optical coherence tomography angiography avascular area association with one-year treatment requirement and disease progression in diabetic retinopathy

      Optical coherence tomography angiography avascular area association with one-year treatment requirement and disease progression in diabetic retinopathy
      Purpose To assess the association between optical coherence tomography angiography (OCTA) quantified avascular areas (AA) and diabetic retinopathy (DR) severity, progression and treatment requirement in the following year. Design Prospective cohort study. Methods We recruited diabetic patients from tertiary academic retina practice and obtained 3x3-mm macular OCTA scans with AngioVue system and standard 7-field color photographs at baseline and 1-year visit. A masked grader determined the DR severity from the ...
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    16. Systems and methods to remove shadowgraphic flow projections on OCT angiography

      Systems and methods to remove shadowgraphic flow projections on OCT angiography
      Methods and systems for suppressing shadowgraphic flow projection artifacts in OCT angiography images of a sample are disclosed. In one example approach, normalized OCT angiography data is analyzed at the level of individual A-scans to classify signals as either flow or projection artifact. This classification information is then used to suppress projection artifacts in the three dimensional OCT angiography dataset.
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  2. About Oregon Health & Science University

    Oregon Health & Science University

    Oregon Health & Science University (OHSU) is a public university in Oregon with a main campus, including three hospitals, in Portland and a smaller campus in Hillsboro. It was formed in 1974 as the University of Oregon Health Sciences Center, combining state dentistry, medicine, and nursing programs into a single center. It was renamed Oregon Health Sciences University in 1981 and took its current name in 2001, as part of a merger with the Oregon Graduate Institute of Science and Technology (OGI) in Hillsboro. In addition, the university has several partnership programs including a joint PharmD Pharmacy program with Oregon State University.