1. Oregon Health & Science University

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    1. Mentioned In 316 Articles

    2. Two from MIT share National Academy of Engineering Fritz J. and Dolores H. Russ Prize

      Two from MIT share National Academy of Engineering Fritz J. and Dolores H. Russ Prize
      The National Academy of Engineering (NAE) 2017 Fritz J. and Dolores H. Russ Prize was awarded to a team of researchers, including two MIT affiliates, for their work in optical coherence tomography. The award committee noted that the research demonstrated creative engineering to invent imaging technology essential for preventing blindness and treating vascular and other diseases. The Russ Prize, established in October of 1999, recognizes an outstanding bioengineering achievement in ...
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    3. Hematocrit dependence of flow signal in optical coherence tomography angiography

      Hematocrit dependence of flow signal in optical coherence tomography angiography
      The hematocrit dependence of flow signal (split-spectrum amplitude decorrelation angiography-SSADA decorrelation value) was investigated in this paper. Based on the normalized field temporal correlation function and concentration dependent particle scattering properties, the relationship between hematocrit and flow signal was analytically derived. Experimental verification of the relationship was performed with custom-designed microfluidic chips and human blood with 45%, 40% and 32% hematocrit. It was found that, in large flow channels and ...
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    4. Optical coherence tomography angiography of non-exudative choroidal neovascularization

      Optical coherence tomography angiography of non-exudative choroidal neovascularization
      Age-related macular degeneration (AMD) has been classified in two groups, neovascular and non-neovascular, which historically has been synonymous with exudative and non-exudative, respectively. Neovascular AMD occurs when pathologic blood vessels, choroidal neovascularization (CNV), arise from the choroid and extend above Bruchs membrane toward the outer retina. Often these vessels are exudative in nature, resulting in leakage of fluid, lipid exudate, or blood causing vision loss. The exudation from CNV allows ...
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    5. Choriocapillaris evaluation in choroideremia using optical coherence tomography angiography

      Choriocapillaris evaluation in choroideremia using optical coherence tomography angiography
      The choriocapillaris plays an important role in supporting the metabolic demands of the retina. Studies of the choriocapillaris in disease states with optical coherence tomography angiography (OCTA) have proven insightful. However, image artifacts complicate the identification and quantification of the choriocapillaris in degenerative diseases such as choroideremia. Here, we demonstrate a supervised machine learning approach to detect intact choriocapillaris based on training with results from an expert grader. We trained ...
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    6. Optical coherence tomographic angiography of choroidal neovascularization ill-defined with fluorescein angiography

      Optical coherence tomographic angiography of choroidal neovascularization ill-defined with fluorescein angiography
      Purpose To evaluate the morphological structure of ill-defined choroidal neovascularisation (CNV) with traditional fluorescein angiography (FA) compared with optical coherence tomographic angiography (OCTA). Methods A retrospective case series study of 11 eyes with ill-defined CNV on FA was performed. Eyes were scanned with commercially available spectral-domain optical coherence tomography (OCT) (70 000 A-scans/s). The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to distinguish blood flow from static tissue. En ...
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    7. In vivo imaging of coral tissue and skeleton with optical coherence tomography

      In vivo imaging of coral tissue and skeleton with optical coherence tomography
      Optical coherence tomography (OCT) is a non-invasive three-dimensional imaging technique with micrometer resolution allowing microstructural characterization of tissues in vivo and in real time. We present the first application of OCT for in vivo imaging of tissue and skeleton structure of intact living corals spanning a variety of morphologies and tissue thickness. OCT visualized different coral tissue layers (e.g. endoderm vs ectoderm), special structures such as mesenterial filaments and ...
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    8. Optical Coherence Tomography Angiography Characteristics of Iris Melanocytic Tumors

      Optical Coherence Tomography Angiography Characteristics of Iris Melanocytic Tumors
      Purpose To evaluate tumor vasculature with optical coherence tomography angiography (OCTA) in malignant iris melanomas and benign iris lesions. Design Cross-sectional observational clinical study. Participants Patients with iris lesions and healthy volunteers. Methods Eyes were imaged using OCTA systems operating at 1050- and 840-nm wavelengths. Three-dimensional OCTA scans were acquired. Iris melanoma patients treated with radiation therapy were imaged again after I-125 plaque brachytherapy at 6 and 18 months. Main ...
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    9. Novel Macular Findings on Optical Coherence Tomography in Incontinentia Pigmenti

      Novel Macular Findings on Optical Coherence Tomography in Incontinentia Pigmenti
      Incontinentia pigmenti (IP) is a rare, X-linked disease with ophthalmic findings in 35% to 77% of cases. 1 - 4 Classic retinal manifestations include peripheral retinal ischemia and subsequent sequelae, but phenotypic presentations are myriad. 1 - 4 Foveal hypoplasia is a known manifestation of IP, and foveal architectural abnormalities in older children have recently been described on optical coherence tomography (OCT). 1 , 5 In the present case, a 3-week-old girl with ...
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    10. Two-dimensional phase unwrapping in Doppler Fourier domain optical coherence tomography

      Two-dimensional phase unwrapping in Doppler Fourier domain optical coherence tomography
      For phase-related imaging modalities using interferometric techniques, it is important to develop effective method to recover phase information that is mathematically wrapped. In this paper, we propose and demonstrate a two-dimensional (2D) method to achieve effective phase unwrapping in Doppler Fourier-domain (FD) optical coherence tomography (OCT), and recover the discontinuous phase distribution in retinal blood flow successfully for the first time in Doppler OCT studies. The proposed method is based ...
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    11. Visualization of 3 Distinct Retinal Plexuses by Projection-Resolved Optical Coherence Tomography Angiography in Diabetic Retinopathy

      Visualization of 3 Distinct Retinal Plexuses by Projection-Resolved Optical Coherence Tomography Angiography in Diabetic Retinopathy
      Importance Projection artifacts in optical coherence tomography angiography (OCTA) blur the retinal vascular plexuses together and limit visualization of the individual plexuses. Objective To describe projection-resolved (PR) OCTA in eyes with diabetic retinopathy (DR) and healthy eyes. Design, Setting, and Participants In this case-control study, patients with DR and healthy controls were enrolled in this observational study from January 26, 2015, to December 4, 2015, at a tertiary academic center ...
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    12. Automated Quantification of Nonperfusion in Three Retinal Plexuses Using Projection-Resolved Optical Coherence Tomography Angiography in Diabetic Retinopathy

      Automated Quantification of Nonperfusion in Three Retinal Plexuses Using Projection-Resolved Optical Coherence Tomography Angiography in Diabetic Retinopathy
      Purpose : The purpose of this study was to evaluate an automated algorithm for detecting avascular area (AA) in optical coherence tomography angiograms (OCTAs) separated into three individual plexuses using a projection-resolved technique. Methods : A 3 3 mm macular OCTA was obtained in 13 healthy and 13 mild nonproliferative diabetic retinopathy (NPDR) participants. A projection-resolved algorithm segmented OCTA into three vascular plexuses: superficial, intermediate, and deep. An automated algorithm detected AA ...
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    13. Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology

      Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology
      Artifacts introduced by eye motion in optical coherence tomography angiography (OCTA) affect the interpretation of images and the quantification of parameters with clinical value. Eradication of such artifacts in OCTA remains a technical challenge. We developed an algorithm that recognizes five different types of motion artifacts and used it to evaluate the performance of three motion removal technologies. On en face maximum projection of flow images, the summed flow signal ...
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    14. Compensation for Reflectance Variation in Vessel Density Quantification by Optical Coherence Tomography Angiography

      Compensation for Reflectance Variation in Vessel Density Quantification by Optical Coherence Tomography Angiography
      Purpose : To compensate for reflectance variation when quantifying vessel density by optical coherence tomography angiography (OCTA). Methods : Healthy participants received 66-mm macular and 4.54.5-mm optic nerve head (ONH) angiography scans on a 70-kHz spectral-domain optical coherence tomography system. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to compute the OCTA signal. Mean reflectance projection and maximum decorrelation projection were used to create en face OCT and OCTA images ...
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    15. Calibration of optical coherence tomography angiography with a microfluidic chip

      Calibration of optical coherence tomography angiography with a microfluidic chip
      A microfluidic chip with microchannels ranging from 8 to 96 m 96m was used to mimic blood vessels down to the capillary level. Blood flow within the microfluidic channels was analyzed with split-spectrum amplitude-decorrelation angiography (SSADA)-based optical coherence tomography (OCT) angiography. It was found that the SSADA decorrelation value was related to both blood flow speed and channel width. SSADA could differentiate nonflowing blood inside the microfluidic channels from ...
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  2. About Oregon Health & Science University

    Oregon Health & Science University

    Oregon Health & Science University (OHSU) is a public university in Oregon with a main campus, including three hospitals, in Portland and a smaller campus in Hillsboro. It was formed in 1974 as the University of Oregon Health Sciences Center, combining state dentistry, medicine, and nursing programs into a single center. It was renamed Oregon Health Sciences University in 1981 and took its current name in 2001, as part of a merger with the Oregon Graduate Institute of Science and Technology (OGI) in Hillsboro. In addition, the university has several partnership programs including a joint PharmD Pharmacy program with Oregon State University.