1. Orazio Valsecchi

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    1. Mentioned In 13 Articles

    2. Mechanism of luminal patency of the self-expanding sideguard sidebranch stent: Evaluation by intravascular ultrasound and optical coherence tomography

      Mechanism of luminal patency of the self-expanding sideguard sidebranch stent: Evaluation by intravascular ultrasound and optical coherence tomography
      ...ography 1. Shixin Ma MD^1, 2. Akiko Maehara MD^1,*, 3. Karl E. Hauptmann MD^2, 4. Giulio Guagliumi MD^3, 5. Orazio Valsecchi MD^3, 6. Angelina N. Vassileva MD^3, 7. Yolande Appelman MD^4, 8. Giuseppe Sangiorgi MD^5, 9....
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    3. Volumetric assessment of lesion severity with optical coherence tomography: relationship with fractional flow reserve

      Volumetric assessment of lesion severity with optical coherence tomography: relationship with fractional flow reserve
      Aims: Frequency-domain optical coherence tomography (FD-OCT) provides a rapid tomographic scan of a coronary vessel, with an accurate reconstruction of its lumen profile. An FD-OCT-based metric that corresponds more closely with physiological significance of lesions may enable more precise guidance of interventional procedures. The aim of this feasibility study was to evaluate a new method for quantifying coronary lesion severity that estimates hyperaemic flow resistance of branched vessel segments imaged ...
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    4. Impact of different stent alloys on human vascular response to everolimus-eluting stent. An optical coherence tomography study. The OCTEVEREST

      Impact of different stent alloys on human vascular response to everolimus-eluting stent. An optical coherence tomography study. The OCTEVEREST
      Background: New generation drug-eluting stents (DES) incorporate thinner struts and novel alloys to improve clinical performance. Nevertheless, the impact of novel stent materials and designs on human vascular response to DES remains elusive. We sought to evaluate the in-vivo coronary artery response to platinum-chromium (PtCr) versus cobalt-chromium (CoCr) stents featuring the same durable polymer and antiproliferative drug by optical coherence tomography (OCT). Methods and Results: A total of 42 patients ...
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    5. Serial Assessment of Coronary Artery Response to Paclitaxel-Eluting Stents Using Optical Coherence Tomography

      Serial Assessment of Coronary Artery Response to Paclitaxel-Eluting Stents Using Optical Coherence Tomography
      Background—The paucity of longitudinal, serial high-resolution imaging studies has limited our understanding of in vivo arterial response to drug-eluting stents. We sought to investigate the human coronary response to paclitaxel-eluting stent implantation, using serial optical coherence tomography assessments. Methods and Results—Thirty patients with at least 2 significant coronary lesions in different vessels were treated with a paclitaxel-eluting stent. The most severe stenosis (lesion A) was treated at the ...
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    6. Examination of the In Vivo Mechanisms of Late Drug-Eluting Stent Thrombosis: Findings From Optical Coherence Tomography and Intravascular Ultrasound Imaging

      Examination of the In Vivo Mechanisms of Late Drug-Eluting Stent Thrombosis: Findings From Optical Coherence Tomography and Intravascular Ultrasound Imaging
      ...occai, MD*, Hideyuki Ikejima, MD*, Elena Ladich, MD, Nikoloz Lortkipanidze, MD*, Aleksandre Matiashvili, MD*, Orazio Valsecchi, MD*, Renu Virmani, MD, Gregg W. Stone, MD * Cardiovascular Department, Ospedali Riuniti, Ber...
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    7. Impact of Drug Release Kinetics on Vascular Response to Different Zotarolimus-Eluting Stents Implanted in Patients With Long Coronary Stenoses: The LongOCT Study (Optical Coherence Tomography in Long Lesions)

      Impact of Drug Release Kinetics on Vascular Response to Different Zotarolimus-Eluting Stents Implanted in Patients With Long Coronary Stenoses: The LongOCT Study (Optical Coherence Tomography in Long Lesions)
      ...anidze, MD*, Luigi Fiocca, MD*, Satoko Tahara, MD, PhD, Angelina Vassileva, MD*, Aleksandre Matiashvili, MD*, Orazio Valsecchi, MD*, Marco Costa, MD, PhD * Division of Cardiology, Cardiovascular Department, Ospedali Riun...
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    8. Strut Coverage and Late Malapposition With Paclitaxel-Eluting Stents Compared With Bare Metal Stents in Acute Myocardial Infarction: OCT Substudy of the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI)

      Strut Coverage and Late Malapposition With Paclitaxel-Eluting Stents Compared With Bare Metal Stents in Acute Myocardial Infarction: OCT Substudy of the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI)
      ...ki, MD; Aleksandre Matiashvili, MD; Nikoloz Lortkipanidze, MD; Laurian Mihalcsik, MD; Antonio Trivisonno, MD; Orazio Valsecchi, MD; Gary S. Mintz, MD; Ovidiu Dressler, MD; Helen Parise, ScD; Akiko Maehara, MD; Ecaterina ...
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    9. Optical coherence tomography in ST-elevation myocardial infarction treated with novel drug-eluting stent: preprocedural, post implant and 2-month follow-up findings

      Optical coherence tomography in ST-elevation myocardial infarction treated with novel drug-eluting stent: preprocedural, post implant and 2-month follow-up findings
      The use of drug-eluting stents (DES) allowed the reduction in the need for repeat revascularization. At the culprit site in acute myocardial infarction patients treated with first-generation DES, the interaction between the eluted drug and the underlying necrotic core may generate different patterns of pathologic vessel response and delayed healing. A new generation DES intrepide elutes trapidil. Its modes of action are neither cytotoxic nor cytostatic, and may promote normal ...
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    10. Strut Coverage and Vessel Wall Response to a New-Generation Paclitaxel-Eluting Stent With an Ultrathin Biodegradable Abluminal Polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI)

      Strut Coverage and Vessel Wall Response to a New-Generation Paclitaxel-Eluting Stent With an Ultrathin Biodegradable Abluminal Polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI)
      ...ortkipanidze, MD; Angelina Vassileva, MD; Jeffrey J. Popma, MD; Dominic J. Allocco, MD; Keith D. Dawkins, MD; Orazio Valsecchi, MD and Marco A. Costa, MD, PhD From the Division of Cardiology (G.G., V.S., G.M., A.A., L.F....
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    11. Strut Coverage and Vessel Wall Response to Zotarolimus-Eluting and Bare-Metal Stents Implanted in Patients With ST-Segment Elevation Myocardial Infarction: The Octami (Optical Coherence Tomography in Acute Myocardial Infarction) Study

      Strut Coverage and Vessel Wall Response to Zotarolimus-Eluting and Bare-Metal Stents Implanted in Patients With ST-Segment Elevation Myocardial Infarction: The Octami (Optical Coherence Tomography in Acute Myocardial Infarction) Study
      ...cca, MD*, Giuseppe Musumeci, MD*, Aleksandre Matiashvili, MD*, Nikoloz Lortkipanidze, MD*, Satoko Tahara, MD, Orazio Valsecchi, MD*, Marco Costa, MD, PhD * Division of Cardiology, Cardiovascular Department, Ospedali Riun...
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    12. Optical Coherence Tomography Assessment of In Vivo Vascular Response After Implantation of Overlapping Bare-Metal and Drug-Eluting Stents

      Optical Coherence Tomography Assessment of In Vivo Vascular Response After Implantation of Overlapping Bare-Metal and Drug-Eluting Stents
      ...uki, MD, Luigi Fiocca, MD*, Aleksandre Matiashvili, MD*, Nikoloz Lortkipanidze, MD*, Antonio Trivisonno, MD*, Orazio Valsecchi, MD*, Giuseppe Biondi-Zoccai, MD, Marco A. Costa, MD, PhD on behalf of the ODESSA Trial Inves...
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    13. Assessment of Heterogeneity of Strut-Level Neointima Hyperplasia After Stent Implantation by Optical Coherence Tomography

      Background: Optical coherence tomography (OCT) permits a highly accurate NIH assessment at each strut level within a cross-section. The aim of this study is to evaluate heterogeneity of NIH among different stents. Methods: Patients enrolled in ODESSA were assessed. ODESSA was a prospective randomized trial designed to evaluate strut coverage of overlapped (OLP) vs. non-OLP stent segments for the treatment of de-novo, native coronary artery stenosis with four different stent ...
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    14. Unhealed Plaque Ruptures After Stenting in Acute Myocardial Infarction Assessed by Intracoronary Optical Coherence Tomography: Incidence, Predictors, and Clinical Implication

      Backgrounds: Non healing after stenting a ruptured thin capped fibroatheroma in acute myocardial infarction (AMI) has been suggested to be a possible cause of late stent thrombosis. Optical coherence tomography (OCT) provides detailed information of ruptured plaques and stent strut coverage. We used OCT to assess the incidence, predictors, and implications of residual plaque rupture after stenting in AMI. Methods: The HORIZONS-AMI trial was a prospective, multicenter, dual arm factorial ...
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  2. About Orazio Valsecchi

    Orazio Valsecchi

    Orazio Valsecchi is from the Cardiovascular Department at Ospedali Riuniti di Bergamo in Bergamo, Italy.