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    1. Mentioned In 10 Articles

    2. VIS-OCT Opens Eyes to New Approaches

      VIS-OCT Opens Eyes to New Approaches
      First reported in 1991 by Huang and colleagues 1 , OCT has become an important imaging tool for ophthalmology following innovations over the past three decades. OCT noninvasively provides 3D in vivo optical biopsy with microscopic resolution in the eye at a depth range up to the choroid 2 . Besides 3D anatomical imaging, OCT can also provide functional information. The most notable functional extension is OCT angiography (OCTA), which can map ...
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    3. Longitudinal deep-brain imaging in mouse using visible-light optical coherence tomography through chronic microprism cranial window

      Longitudinal deep-brain imaging in mouse using visible-light optical coherence tomography through chronic microprism cranial window
      We longitudinally imaged both the superficial and deep cortical microvascular networks in brains of healthy mice and in a mouse model of stroke in vivo using visible-light optical coherence tomography (vis-OCT). We surgically implanted a microprism in mouse brains sealed by a chronic cranial window. The microprism enabled vis-OCT to image the entire depth of the mouse cortex. Following microprism implantation, we imaged the mice for 28 days and found ...
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    4. Speckle reduction in visible-light optical coherence tomography using scan modulation

      Speckle reduction in visible-light optical coherence tomography using scan modulation
      We present a technique to reduce speckle in visible-light optical coherence tomography (vis-OCT) that preserves fine structural details and is robust against sample motion. Specifically, we locally modulate B-scans orthogonally to their axis of acquisition. Such modulation enables acquisition of uncorrelated speckle patterns from similar anatomical locations, which can be averaged to reduce speckle. To verify the effectiveness of speckle reduction, we performed in-vivo retinal imaging using modulated raster and ...
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    5. Designing visible-light optical coherence tomography towards clinics

      Designing visible-light optical coherence tomography towards clinics
      Background: The capabilities of visible-light optical coherence tomography (vis-OCT) in noninvasive anatomical and functional retinal imaging have been demonstrated by multiple groups in both rodents and healthy human subjects. Translating laboratory prototypes to an integrated clinical-environment-friendly system is required to explore the full potential of vis-OCT in disease management. Methods: We developed and optimized a portable vis-OCT system for human retinal imaging in clinical settings. We acquired raster- and circular-scan ...
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    6. Monitoring Acute Stroke in Mouse Model Using Laser Speckle Imaging-Guided Visible-Light Optical Coherence Tomography

      Monitoring Acute Stroke in Mouse Model Using Laser Speckle Imaging-Guided Visible-Light Optical Coherence Tomography
      Objective: Monitoring hemodynamic and vascular changes in the acute stages of mouse stroke models is invaluable in studying ischemic stroke pathophysiology. However, there lacks a tool to simultaneously and dynamically investigate these changes. Methods: We integrated laser speckle imaging (LSI) and visible-light optical coherence tomography (Vis-OCT) to reveal dynamic vascular responses in acute stages in the distal middle cerebral artery occlusion (dMCAO) model in rodents. LSI provides full-field, real-time imaging ...
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    7. Opticent Receives NIH Grant for Method for Accurate Retinal Oxygen Metabolic Rate Extraction

      Opticent Receives NIH Grant for Method for Accurate Retinal Oxygen Metabolic Rate Extraction
      ...MRO2 dysregulation in early development, progression, and management of DR. Collaborating with the Zhang lab, Opticent Health’s goal is to translate vis-OCT from bench to bedside and to provide physicians with advanced c...
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