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    1. Mentioned In 15 Articles

    2. In Vivo Sublayer Analysis of Human Retinal Inner Plexiform Layer Obtained by Visible-Light Optical Coherence Tomography

      Explore IOVS Journal Ophthalmology
      In Vivo Sublayer Analysis of Human Retinal Inner Plexiform Layer Obtained by Visible-Light Optical Coherence Tomography
      Purpose : Growing evidence suggests that dendrite retraction or degeneration in a subpopulation of the retinal ganglion cells (RGCs) may precede detectable soma abnormalities and RGC death in glaucoma. Visualization of the lamellar structure of the inner plexiform layer (IPL) could advance clinical management and fundamental understanding of glaucoma. We investigated whether visible-light optical coherence tomography (vis-OCT) could detect the difference in the IPL sublayer thicknesses between small cohorts of healthy ...
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      Mentions: Oregon Health & Science University Northwestern University Opticent Health

    3. Balanced-detection visible-light optical coherence tomography

      Explore bioRxiv.org Ophthalmology
      Balanced-detection visible-light optical coherence tomography
      Increases in speed and sensitivity enabled rapid clinical adoption of optical coherence tomography (OCT) in ophthalmology. Recently visible-light OCT (vis-OCT) achieved ultrahigh axial resolution, improved tissue contrast, and new functional imaging capabilities, demonstrating the potential to improve clincal care further. However, limited speed and sensitivity caused by the high relative intensity noise (RIN) in supercontinuum lasers impeded the clinical adoption of vis-OCT. To overcome these limitations, we developed balanced-detection vis-OCT ...
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      Mentions: Northwestern University Opticent Health

    4. Intrinsic spectrally-dependent background in spectroscopic visible-light optical coherence tomography

      Explore OSA | OSA Publishing
      Intrinsic spectrally-dependent background in spectroscopic visible-light optical coherence tomography
      Visible-light optical coherence tomography (vis-OCT) has enabled new spectroscopic applications, such as retinal oximetry, as a result of increased optical absorption and scattering contacts in biological tissue and improved axial resolution. Besides extracting tissue properties from back-scattered light, spectroscopic analyses must consider spectral alterations induced by image reconstruction itself. We investigated an intrinsic spectral bias in the background noise floor, which is hereby referred to as the spectrally-dependent background (SDBG ...
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      Mentions: Northwestern University Opticent Health

    6. VIS-OCT Opens Eyes to New Approaches

      Explore Photonics.com
      VIS-OCT Opens Eyes to New Approaches
      First reported in 1991 by Huang and colleagues 1 , OCT has become an important imaging tool for ophthalmology following innovations over the past three decades. OCT noninvasively provides 3D in vivo optical biopsy with microscopic resolution in the eye at a depth range up to the choroid 2 . Besides 3D anatomical imaging, OCT can also provide functional information. The most notable functional extension is OCT angiography (OCTA), which can map ...
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      Mentions: Northwestern University Opticent Health

    8. Longitudinal deep-brain imaging in mouse using visible-light optical coherence tomography through chronic microprism cranial window

      Explore OSA | OSA Publishing Developmental Biology , Neurology
      Longitudinal deep-brain imaging in mouse using visible-light optical coherence tomography through chronic microprism cranial window
      We longitudinally imaged both the superficial and deep cortical microvascular networks in brains of healthy mice and in a mouse model of stroke in vivo using visible-light optical coherence tomography (vis-OCT). We surgically implanted a microprism in mouse brains sealed by a chronic cranial window. The microprism enabled vis-OCT to image the entire depth of the mouse cortex. Following microprism implantation, we imaged the mice for 28 days and found ...
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      Mentions: Northwestern University Opticent Health

    9. Speckle reduction in visible-light optical coherence tomography using scan modulation

      Explore SPIE Digital Library Ophthalmology
      Speckle reduction in visible-light optical coherence tomography using scan modulation
      We present a technique to reduce speckle in visible-light optical coherence tomography (vis-OCT) that preserves fine structural details and is robust against sample motion. Specifically, we locally modulate B-scans orthogonally to their axis of acquisition. Such modulation enables acquisition of uncorrelated speckle patterns from similar anatomical locations, which can be averaged to reduce speckle. To verify the effectiveness of speckle reduction, we performed in-vivo retinal imaging using modulated raster and ...
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      Mentions: Northwestern University Opticent Health NYU Langone Medical Center

    10. Designing visible-light optical coherence tomography towards clinics

      Explore Home
      Designing visible-light optical coherence tomography towards clinics
      Background: The capabilities of visible-light optical coherence tomography (vis-OCT) in noninvasive anatomical and functional retinal imaging have been demonstrated by multiple groups in both rodents and healthy human subjects. Translating laboratory prototypes to an integrated clinical-environment-friendly system is required to explore the full potential of vis-OCT in disease management. Methods: We developed and optimized a portable vis-OCT system for human retinal imaging in clinical settings. We acquired raster- and circular-scan ...
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      Mentions: Northwestern University Opticent Health NYU Langone Medical Center

    14. Monitoring Acute Stroke in Mouse Model Using Laser Speckle Imaging-Guided Visible-Light Optical Coherence Tomography

      Explore IEEE Xplore Developmental Biology , Neurology
      Monitoring Acute Stroke in Mouse Model Using Laser Speckle Imaging-Guided Visible-Light Optical Coherence Tomography
      Objective: Monitoring hemodynamic and vascular changes in the acute stages of mouse stroke models is invaluable in studying ischemic stroke pathophysiology. However, there lacks a tool to simultaneously and dynamically investigate these changes. Methods: We integrated laser speckle imaging (LSI) and visible-light optical coherence tomography (Vis-OCT) to reveal dynamic vascular responses in acute stages in the distal middle cerebral artery occlusion (dMCAO) model in rodents. LSI provides full-field, real-time imaging ...
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      Mentions: Northwestern University Opticent Health

    15. Opticent Receives NIH Grant for Method for Accurate Retinal Oxygen Metabolic Rate Extraction

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      Opticent Receives NIH Grant for Method for Accurate Retinal Oxygen Metabolic Rate Extraction
      ...MRO2 dysregulation in early development, progression, and management of DR. Collaborating with the Zhang lab, Opticent Health’s goal is to translate vis-OCT from bench to bedside and to provide physicians with advanced c...
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      Mentions: National Institutes of Health Northwestern University Opticent Health
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    1. Two Engineering Openings at Startup Company Opticent Health
      15 articles also mentioned Northwestern University
    2. Designing visible-light optical coherence tomography towards clinics
      3 articles also mentioned NYU Langone Medical Center
    3. In Vivo Sublayer Analysis of Human Retinal Inner Plexiform Layer Obtained by Visible-Light Optical Coherence Tomography
      1 articles also mentioned Oregon Health & Science University
    4. Opticent Receives NIH Grant for Method for Accurate Retinal Oxygen Metabolic Rate Extraction
      1 articles also mentioned National Institutes of Health