1. Omer P. Kocaoglu

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    1. Mentioned In 23 Articles

    2. Photoreceptor disc shedding in the living human eye

      Photoreceptor disc shedding in the living human eye
      Cone photoreceptors undergo a daily cycle of renewal and shedding of membranous discs in their outer segments (OS), the portion responsible for light capture. These physiological processes are fundamental to maintaining photoreceptor health, and their dysfunction is associated with numerous retinal diseases. While both processes have been extensively studied in animal models and postmortem eyes, little is known about them in the living eye, in particular human. In this study ...
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    3. A Review of Adaptive Optics Optical Coherence Tomography: Technical Advances, Scientific Applications, and the Future

      A Review of Adaptive Optics Optical Coherence Tomography: Technical Advances, Scientific Applications, and the Future
      Purpose : Optical coherence tomography (OCT) has enabled virtual biopsy of the living human retina, revolutionizing both basic retina research and clinical practice over the past 25 years. For most of those years, in parallel, adaptive optics (AO) has been used to improve the transverse resolution of ophthalmoscopes to foster in vivo study of the retina at the microscopic level. Here, we review work done over the last 15 years to ...
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    4. Imaging human retinal pigment epithelium cells using adaptive optics optical coherence tomography

      Imaging human retinal pigment epithelium cells using adaptive optics optical coherence tomography
      Retinal pigment epithelium (RPE) cells are vital to health of the outer retina, but are often compromised in ageing and major ocular diseases that lead to blindness. Early manifestation of RPE disruption occurs at the cellular level, and while biomarkers at this scale hold considerable promise, RPE cells have proven extremely challenging to image in the living human eye. We present a novel method based on optical coherence tomography (OCT ...
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    5. Retinal imaging system for the mouse or rat or other small animals

      Retinal imaging system for the mouse or rat or other small animals
      A small animal imaging system comprising a base element and a camera coupled to the base element, the camera being sized to image the eye of a small animal. A light-emitting diode is also included coupled to the base element. An OCT imaging apparatus is also included coupled to the base element. An X-Y scanner is also included coupled to the base element in communication with the OCT imaging apparatus.
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    6. Feature Of The Week 01/11/15: Indiana University Demonstrates Adaptive Optics Optical Coherence Tomography at 1 MHz

      Feature Of The Week 01/11/15: Indiana University Demonstrates Adaptive Optics Optical Coherence Tomography at 1 MHz
      ...l-domain technology in the 700 to 915 nm spectral band. For more information see recent Article . Courtesy of Omer Kocaoglu from Indiana University . Since its first report in 1991, OCT has undergone tremendous advances ...
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    7. Adaptive-optics optical coherence tomography processing using a graphics processing unit

      Adaptive-optics optical coherence tomography processing using a graphics processing unit
      Graphics processing units are increasingly being used for scientific computing for their powerful parallel processing abilities, and moderate price compared to super computers and computing grids. In this paper we have used a general purpose graphics processing unit to process adaptive-optics optical coherence tomography (AOOCT) images in real time. Increasing the processing speed of AOOCT is an essential step in moving the super high resolution technology closer to clinical viability.
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    8. The cellular origins of the outer retinal bands in optical coherence tomography images

      The cellular origins of the outer retinal bands in optical coherence tomography images
      Purpose: To test the recently proposed hypothesis that the second OCT outer retinal band originates from the inner segment ellipsoid, by measuring: 1) thickness of this band within single cones, and 2) its respective distance from the external limiting membrane and outer segment tips. Methods: Adaptive optics OCT images were obtained from four normal subjects. Images were obtained at foveal (2∘) and perifoveal (5∘) locations. Cones (n = 9593) were identified ...
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    9. Adaptive optics optical coherence tomography for measuring phase and reflectance dynamics of photoreceptors

      Adaptive optics optical coherence tomography for measuring phase and reflectance dynamics of photoreceptors
      Optical coherence tomography with adaptive optics (AO-OCT) is a noninvasive method for imaging the living retina at the microscopic level. We used AO-OCT technology to follow changes in cone photoreceptor outer segment (OS) length and reflectance. To substantially increase sensitivity of the length measurements, a novel phase retrieval technique was demonstrated, capable of detecting changes on a nanometer scale. We acquired volume videos of 0.65°x0.65° retinal patches ...
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    10. Adaptive optics and the eye (super resolution OCT)

      Adaptive optics and the eye (super resolution OCT)
      The combination of adaptive optics (AO) and optical coherence tomography (OCT) was first reported 8 years ago and has undergone tremendous technological advances since then. The technical benefits of adding AO to OCT (increased lateral resolution, smaller speckle, and enhanced sensitivity) increase the imaging capability of OCT in ways that make it well suited for three-dimensional (3D) cellular imaging in the retina. Today, AO–OCT systems provide ultrahigh 3D resolution ...
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    11. 1-15 of 23 1 2 »
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  2. About Omer P. Kocaoglu

    Omer P. Kocaoglu

    Omer Pars Kocaoglu earned his B.S. in medical physics (2001) and his M.S. in biomedical engineering (2003) from Bogazici University (Istanbul, Turkey). He earned his Ph.D. in biomedical engineering (2008) from University of Miami (Coral Gables, FL) with his dissertation experiments conducted at the Bascom Palmer Eye Institute. His thesis involved development of an imaging system for rodent eye that captured simultaneous optical coherence tomography (OCT) and color fundus images. Afterwards, he joined Professor Miller's laboratory at Indiana University School of Optometry (IUSO) as a postdoctoral fellow. His research focused on the development and use of high-speed, high-resolution OCT systems with adaptive optics (AO-OCT). He advanced to the rank of Research Associate in 2009 and then faculty as Assistant Research Scientist in 2012. His current work focuses on further AO-OCT developments – in particular novel methods for active tracking and high-speed imaging – for imaging the living human retina at the cellular level.