1. NYU Langone Medical Center

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    1. Mentioned In 48 Articles

    2. 3D Microstructure of the Healthy Non-Human Primate Lamina Cribrosa by Optical Coherence Tomography Imaging

      3D Microstructure of the Healthy Non-Human Primate Lamina Cribrosa by Optical Coherence Tomography Imaging
      Purpose: The lamina cribrosa (LC) has an important role in the pathophysiology of ocular diseases. The purpose of this study is to characterize in vivo, noninvasively, and in 3D the structure of the LC in healthy non-human primates (NHPs). Methods: Spectral-domain optical coherence tomography (OCT; Leica, Chicago, IL) scans of the optic nerve head (ONH) were obtained from healthy adult rhesus macaques monkeys. Using a previously reported semi-automated segmentation algorithm ...
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    3. Virtual Reality Oculokinetic Perimetry Test Reproducibility and Relationship to Conventional Perimetry and OCT

      Virtual Reality Oculokinetic Perimetry Test Reproducibility and Relationship to Conventional Perimetry and OCT
      Purpose Vivid Vision Perimetry (VVP; Vivid Vision, Inc) is a novel method for performing in-office and home-based visual field assessment using a virtual reality platform and oculokinetic perimetry. Here we examine the reproducibility of VVP Swift and compare results with conventional standard automated perimetry (SAP) and spectral-domain (SD) OCT. Design Cross-sectional study. Participants Fourteen eyes of 7 patients with open-angle glaucoma (OAG) (average age, 64.6 years; 29% women) and ...
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    4. In Vivo Sublayer Analysis of Human Retinal Inner Plexiform Layer Obtained by Visible-Light Optical Coherence Tomography

      In Vivo Sublayer Analysis of Human Retinal Inner Plexiform Layer Obtained by Visible-Light Optical Coherence Tomography
      Purpose : Growing evidence suggests that dendrite retraction or degeneration in a subpopulation of the retinal ganglion cells (RGCs) may precede detectable soma abnormalities and RGC death in glaucoma. Visualization of the lamellar structure of the inner plexiform layer (IPL) could advance clinical management and fundamental understanding of glaucoma. We investigated whether visible-light optical coherence tomography (vis-OCT) could detect the difference in the IPL sublayer thicknesses between small cohorts of healthy ...
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    5. Proactive spectrometer matching for excess noise suppression in balanced visible light optical coherence tomography (OCT)

      Proactive spectrometer matching for excess noise suppression in balanced visible light optical coherence tomography (OCT)
      Supercontinuum sources for visible light spectral domain OCT (SDOCT) are noisy and often expensive. Balanced detection can reduce excess noise, but is rarely used in SDOCT. Here, we show that balanced detection can achieve effective excess noise cancellation across all depths if two linear array spectrometers are spectrally well-matched. We propose excess noise correlation matrices as tools to achieve such precise spectral matching. Using optomechanical adjustments, while monitoring noise correlations ...
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    6. Open Conjunctival Approach for Sub-Tenon's Xen Gel Stent Placement and Bleb Morphology by Anterior Segment Optical Coherence Tomography

      Open Conjunctival Approach for Sub-Tenon's Xen Gel Stent Placement and Bleb Morphology by Anterior Segment Optical Coherence Tomography
      Precis: Sub-Tenons implantation of the Xen Gel stent resulted in significant intraocular pressure lowering along with a low rate of postoperative bleb needling, and a favorable bleb morphology on anterior segment optical coherence tomography. Purpose: To assess clinical outcomes and bleb morphology following sub-Tenons implantation of the Xen Gel Stent (Allergan Inc., Dublin, Ireland). Methods: The medical records of patients who underwent sub-Tenons Xen Gel Stent implantation with intraoperative mitomycin-C ...
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    7. Optical Coherence Tomography and Glaucoma

      Optical Coherence Tomography and Glaucoma
      Early detection and monitoring are critical to the diagnosis and management of glaucoma, a progressive optic neuropathy that causes irreversible blindness. Optical coherence tomography (OCT) has become a commonly utilized imaging modality that aids in the detection and monitoring of structural glaucomatous damage. Since its inception in 1991, OCT has progressed through multiple iterations, from time-domain OCT, to spectral-domain OCT, to swept-source OCT, all of which have progressively improved the ...
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    8. Adaptive spectroscopic visible-light optical coherence tomography for human retinal oximetry

      Adaptive spectroscopic visible-light optical coherence tomography for human retinal oximetry
      Alterations in the retinal oxygen saturation (sO2) and oxygen consumption are associated with nearly all blinding diseases. A technology that can accurately measure retinal sO2 has the potential to improve ophthalmology care significantly. Recently, visible-light optical coherence tomography (vis-OCT) showed great promise for noninvasive, depth-resolved measurement of retinal sO2 as well as ultra-high resolution anatomical imaging. We discovered that spectral contaminants (SC), if not correctly removed, could lead to incorrect ...
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    9. In vivo Morphometry of Inner Plexiform Layer (IPL) Stratification in the Human Retina With Visible Light Optical Coherence Tomography

      In vivo Morphometry of Inner Plexiform Layer (IPL) Stratification in the Human Retina With Visible Light Optical Coherence Tomography
      From the bipolar cells to higher brain visual centers, signals in the vertebrate visual system are transmitted along parallel on and off pathways. These two pathways are spatially segregated along the depth axis of the retina. Yet, to our knowledge, there is no way to directly assess this anatomical stratification in vivo . Here, employing ultrahigh resolution visible light Optical Coherence Tomography (OCT) imaging in humans, we report a stereotyped reflectivity ...
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    10. MULTIMODAL IMAGING AND HISTOLOGIC EVIDENCE OF A NOVEL OPTICAL COHERENCE TOMOGRAPHY TERMINOLOGY

      MULTIMODAL IMAGING AND HISTOLOGIC EVIDENCE OF A NOVEL OPTICAL COHERENCE TOMOGRAPHY TERMINOLOGY
      Purpose: To clarify the histologic basis of bacillary layer detachment (BALAD) through a review of current literature and an analysis of retinal imaging. Methods: We reviewed the literature for previous reports of BALAD. An analysis of retinal images was performed to support anatomic conclusions. Results: A total of 164 unique patients with BALAD on optical coherence tomography (OCT) were identified from the published literature. Twenty-two underlying etiologies, all associated with ...
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    11. Determining the Location of the Fovea Centralis Via En-Face SLO and Cross-Sectional OCT Imaging in Patients Without Retinal Pathology

      Determining the Location of the Fovea Centralis Via En-Face SLO and Cross-Sectional OCT Imaging in Patients Without Retinal Pathology
      Purpose: The purpose was to establish the position of the fovea centralis to the optic nerve via en-face, near-infrared spectral domain optical coherence tomography (NIR-OCT) in healthy patients. This may shed light on physiological variability and be used for studying subtle cases of foveal ectopia in macular pathology and after retinal detachment. Methods: SD-OCT data of 890 healthy eyes were retrospectively analyzed. Exclusion criteria included axial myopia causing tilting of ...
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    12. The APOSTEL 2.0 Recommendations for Reporting Quantitative Optical Coherence Tomography Studies

      The APOSTEL 2.0 Recommendations for Reporting Quantitative Optical Coherence Tomography Studies
      Objective: To update the consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results, thus revising the previously published Advised Protocol for OCT Study Terminology and Elements (APOSTEL) recommendations. Methods: To identify studies reporting quantitative OCT results, we performed a PubMed search for the terms "quantitative" and "optical coherence tomography" from 2015 to 2017. Corresponding authors of the identified publications were invited to provide feedback on the initial ...
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    13. Visible Light Optical Coherence Tomography (OCT) Quantifies Subcellular Contributions to Outer Retinal Band 4

      Visible Light Optical Coherence Tomography (OCT) Quantifies Subcellular Contributions to Outer Retinal Band 4
      Purpose : To use visible light optical coherence tomography (OCT) to investigate subcellular reflectivity contributions to the outermost (4th) of the retinal hyperreflective bands visualized by current clinical near-infrared (NIR) OCT. Methods : Visible light OCT, with 1.0 m axial resolution, was performed in 28 eyes of 19 human subjects (2157 years old) without history of ocular pathology. Two foveal and three extrafoveal hyperreflective zones were consistently depicted within band 4 ...
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    14. In Vivo Sublayer Analysis Of Human Retinal Inner Plexiform Layer Obtained By Visible-Light Optical Coherence Tomography

      In Vivo Sublayer Analysis Of Human Retinal Inner Plexiform Layer Obtained By Visible-Light Optical Coherence Tomography
      Purpose: Growing evidence suggests, in glaucoma, the dendritic degeneration of subpopulation of the retinal ganglion cells (RGCs) may precede RGCs soma death. Since different RGCs synapse in different IPL sublayers, visualization of the lamellar structure of the IPL could enable both clinical and fundamental advances in glaucoma understanding and management. In this pilot study, we investigated whether visible-light optical coherence tomography (vis-OCT) could detect the difference in the inner plexiform ...
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    15. Multimodal Imaging Crucial in Finding the Cause of Heart Attack in Women with Non-Obstructive Coronary Artery Disease - NYU Langone Health

      Multimodal Imaging Crucial in Finding the Cause of Heart Attack in Women with Non-Obstructive Coronary Artery Disease - NYU Langone Health
      N ew research presented today at the American Heart Associations Scientific Sessions 2020 found that additional imaging tests can determine the underlying reason for heart attacks in most women without coronary artery narrowing . A correct diagnosis can guide appropriate medical treatment. Led by researchers and clinicians at NYU Grossman School of Medicine, the study examined women with MINOCA, or myocardial infarction with non-obstructive coronary arteries, a condition that accounts for ...
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    16. Detection of features associated with neovascular age-related macular degeneration in ethnically distinct data sets by an optical coherence tomography: trained deep learning algorithm

      Detection of features associated with neovascular age-related macular degeneration in ethnically distinct data sets by an optical coherence tomography: trained deep learning algorithm
      Background The ability of deep learning (DL) algorithms to identify eyes with neovascular age-related macular degeneration (nAMD) from optical coherence tomography (OCT) scans has been previously established. We herewith evaluate the ability of a DL model, showing excellent performance on a Korean data set, to generalse onto an American data set despite ethnic differences. In addition, expert graders were surveyed to verify if the DL model was appropriately identifying lesions ...
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  2. About NYU Langone Medical Center

    NYU Langone Medical Center is an academic medical center located in New York City , New York , United States , affiliated with New York University . The Medical Center comprises the NYU School of Medicine and three hospitals: Tisch Hospital , the Rusk Institute of Rehabilitation Medicine , and the Hospital for Joint Diseases , and recently NYU Lutheran Medical Center . [1] NYU Langone Medical Center also operates over thirty ambulatory facilities in Manhattan, Brooklyn, Queens and Long Island. [2] In 2016, NYU Langone Medical Center acquired Winthrop University Hospital . [3] NYU Langone Medical Center overlooks the East River .