1. Northwestern University

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    1. Mentioned In 174 Articles

    2. Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomograph

      Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomograph
      Field carcinogenesis is the initial stage of cancer progression. Understanding field carcinogenesis is valuable for both cancer biology and clinical medicine. Here, we used inverse spectroscopic optical coherence tomography to study colorectal cancer (CRC) and pancreatic cancer (PC) field carcinogenesis. Depth-resolved optical and ultrastructural properties of the mucosa were quantified from histologically normal rectal biopsies from patients with and without colon adenomas ( n = 85 ) as well as from histologically normal ...
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    3. Absolute retinal blood flow measurement with a dual-beam Doppler optical coherence tomography

      Absolute retinal blood flow measurement with a dual-beam Doppler optical coherence tomography
      Purpose:To test the capability of a novel dual-beam Doppler optical coherence tomography (OCT) technique for simultaneous in vivo measurement of the Doppler angle and, thus, the absolute retinal blood velocity and the retinal flow rate, without the influence of motion artifacts. Methods:A novel dual-beam Doppler spectral domain OCT (SD-OCT) was developed. The two probing beams are separated with a controllable distance along an arbitrary direction, both of which ...
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    4. Pilot Study of Doppler optical coherence tomography of retinal blood flow following laser photocoagulation in poorly controlled diabetic patients

      Pilot Study of Doppler optical coherence tomography of retinal blood flow following laser photocoagulation in poorly controlled diabetic patients
      ...hwestern University, 645 N. Michigan Ave# 440, Chicago, Illinois, 60611, United States 1. ↵* Ophthalmology, Northwestern University, 645 N. Michigan Ave# 440, Chicago, Illinois, 60611, United States Afawzimd{at}gmail.c...
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    5. Review of En-Face Choroidal Imaging Using Spectral-Domain Optical Coherence Tomography

      Review of En-Face Choroidal Imaging Using Spectral-Domain Optical Coherence Tomography
      Investigations of choroidal vasculature have been of particular interest given choroidal vascular dysfunction are thought to be related with a number pathologic conditions such as central serous chorioretinopathy and various forms of AMD, including polypoidal choroidal vasculopathy. On the other hand, en face imaging of the choroid allows an exceptional alternative to histopathologic evaluation of the choroid, and can be used to quantify choroidal vascular structures. Our former study verified ...
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    6. Can OCT be sensitive to nanoscale structural alterations in biological tissue?

      Can OCT be sensitive to nanoscale structural alterations in biological tissue?
      Exploration of nanoscale tissue structures is crucial in understanding biological processes. Although novel optical microscopy methods have been developed to probe cellular features beyond the diffraction limit, nanometer-scale quantification remains still inaccessible forin situtissue. Here we demonstrate that, without actually resolving specific geometrical feature, OCT can be sensitive to tissue structural properties at the nanometer length scale. The statistical mass-density distribution in tissue is quantified by its autocorrelation function modeled ...
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    7. Combining light and sound for retinal imaging

      Combining light and sound for retinal imaging
      Photoacoustic ophthalmoscopy provides exceptional contrast when visualizing the retina, assisting in the early diagnosis of some eye diseases. The diagnosis, treatment, and prognosis of eye diseases have greatly benefited from innovation in modern ophthalmic imaging technologies. Photoacoustic ophthalmoscopy (PAOM) is a 3D imaging method that allows non-invasive visualization of the back of the eye through angiography (where an x-ray-based technique is used to create an image). But unlike an angiogram ...
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    8. Watching while listening to the interaction of photons with bio-tissues

      Watching while listening to the interaction of photons with bio-tissues
      Using a single light source to carry out optical coherence tomography and photoacoustic microscopy simultaneously enables novel studies of optical scattering and absorption in biological tissues. Optical coherence tomography (OCT) and photoacoustic microscopy (PAM) are two microscopic, three-dimensional, noninvasive imaging modalities that are based on different contrast mechanisms. OCT mainly images the optical scattering properties of a sample whereas PAM images optical absorption. Due to these different contrast mechanisms, OCT ...
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    9. Optical Coherence Photoacoustic Microscopy

      Optical Coherence Photoacoustic Microscopy
      A system and method for providing an optical coherence photoacoustic (OC-PAM) microscopy. An OC-PAM microscope includes a light source that outputs light, a scanner, a detector, a transducer, and an image processing module. The scanner receives the light and scans the light across a sample. The detector receives reflected light from the sample in response to the scanned light. The transducer detects photoacoustic waves induced in the sample by the ...
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    10. A Pilot Study of Morphometric Analysis of Choroidal Vasculature In Vivo, Using En Face Optical Coherence Tomography

      A Pilot Study of Morphometric Analysis of Choroidal Vasculature In Vivo, Using En Face Optical Coherence Tomography
      Purpose To study the ability of volumetric spectral domain optical coherence tomography (SD-OCT) to perform quantitative measurement of the choroidal vasculature in vivo . Methods Choroidal vascular density and vessel size were quantified using en face choroidal scans from various depths below the retinal pigment epithelium (RPE) in 58 eyes of 58 patients with either epiretinal membranes (ERM), early age-related macular degeneration (AMD), or reticular pseudo-drusen (RPD). For each patient, we ...
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    11. 136-150 of 174 « 1 2 ... 7 8 9 10 11 12 »
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  2. About Northwestern University

    Northwestern University

    Northwestern University is a private research university located in Evanston, Illinois and downtown Chicago, Illinois.  Several of Northwestern's professional schools such as the School of Law, the Feinberg School of Medicine, and parts of the Kellogg School of Management are located in the Streeterville neighborhood of downtown Chicago. 

    Biophotonics Laboratory at Northwestern University.  The main direction of the Biophotonics laboratory (Principal Investigator: Prof. Vadim Backman) is the development of novel optical spectral and imaging techniques for non-invasive screening, diagnosis and detection of disease as well as characterization of biological and bioengineered tissue.