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    1. Mentioned In 154 Articles

    2. In Vivo Sublayer Analysis Of Human Retinal Inner Plexiform Layer Obtained By Visible-Light Optical Coherence Tomography

      Explore bioRxiv.org Ophthalmology
      In Vivo Sublayer Analysis Of Human Retinal Inner Plexiform Layer Obtained By Visible-Light Optical Coherence Tomography
      Purpose: Growing evidence suggests, in glaucoma, the dendritic degeneration of subpopulation of the retinal ganglion cells (RGCs) may precede RGCs soma death. Since different RGCs synapse in different IPL sublayers, visualization of the lamellar structure of the IPL could enable both clinical and fundamental advances in glaucoma understanding and management. In this pilot study, we investigated whether visible-light optical coherence tomography (vis-OCT) could detect the difference in the inner plexiform ...
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      Mentions: Joel S. Schuman Hiroshi Ishikawa Northwestern University

    3. VIS-OCT needs stable, versatile light sources

      Explore Photonics.com Broadband Sources , Tunable Sources
      VIS-OCT needs stable, versatile light sources
      Optical coherence tomography (OCT) is the gold standard for noninvasive retinal imaging, enabling ophthalmologists to diagnose and treat multiple ocular diseases. Compared to traditional OCT, which uses near-infrared (NIR) wavelengths of light, visible-light OCT (VIS-OCT) offers superior spatial resolution and novel functional imaging capabilities. VIS-OCT provides the most accurate means for measuring retinal oxygen saturation, a key biomarker for understanding changes in tissue metabolism associated with the pathology of various ...
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      Mentions: Northwestern University Hao F. Zhang Roman V. Kuranov

    4. Reversed Neurovascular Coupling on Optical Coherence Tomography Angiography Is the Earliest Detectable Abnormality before Clinical Diabetic Retinopathy

      Explore MDPI Open Access Journals Platform Ophthalmology
      Reversed Neurovascular Coupling on Optical Coherence Tomography Angiography Is the Earliest Detectable Abnormality before Clinical Diabetic Retinopathy
      Diabetic retinopathy (DR) has traditionally been viewed as either a microvasculopathy or a neuropathy, though neurovascular coupling deficits have also been reported and could potentially be the earliest derangement in DR. To better understand neurovascular coupling in the diabetic retina, we investigated retinal hemodynamics by optical coherence tomography angiography (OCTA) in individuals with diabetes mellitus (DM) but without DR (DM no DR) and mild non-proliferative DR (mild NPDR) compared to ...
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      Mentions: Northwestern University

    5. Visible-Light Optical Coherence Tomography Fibergraphy for Quantitative Imaging of Retinal Ganglion Cell Axon Bundles

      Explore TVST Journal Ophthalmology
      Visible-Light Optical Coherence Tomography Fibergraphy for Quantitative Imaging of Retinal Ganglion Cell Axon Bundles
      Purpose : To develop a practical technique for visualizing and quantifying retinal ganglion cell (RGC) axon bundles in vivo. Methods : We applied visible-light optical coherence tomography (vis-OCT) to image the RGC axon bundles, referred to as vis-OCT fibergraphy, of healthy wild-type C57BL/6 mice. After vis-OCT imaging, retinas were flat-mounted, immunostained with anti-beta-III tubulin (Tuj1) antibody for RGC axons, and imaged with confocal microscopy. We quantitatively compared the RGC axon bundle ...
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      Mentions: Northwestern University Hao F. Zhang Roman V. Kuranov

    6. Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2

      Explore MDPI Open Access Journals Platform Ophthalmology
      Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2
      In this cross-sectional observational study, we investigated the relationship between photoreceptor layer disruption and telangiectasia in patients diagnosed with early stage macular telangiectasia type 2 (MacTel). A total of 31 eyes (17 patients) with MacTel were imaged with adaptive optics scanning laser ophthalmoscopy (AOSLO) and optical coherence tomography angiography (OCTA). Confocal AOSLO was used to visualize dark regions of nonwaveguiding outer segments, which we refer to as photoreceptor lesions. En-face ...
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      Mentions: Northwestern University

    7. Northwestern University Receives NIH Grant for Investigating Nanoscale Neuronal Damages in Early Glaucoma Towards Clinical Adoption

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      Northwestern University Receives NIH Grant for Investigating Nanoscale Neuronal Damages in Early Glaucoma Towards Clinical Adoption
      ... for clinical glaucoma diagnoses in a chronic model of experimental glaucoma.

      Northwestern University Receives a 2020 NIH Grant for $516,102 for Investigating Nanoscale Neuronal Damages in...

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      Mentions: National Institutes of Health Northwestern University Hao F. Zhang

    8. Standardisation of optical coherence tomography angiography nomenclature in uveitis: first survey results

      Explore BJO Online Ophthalmology
      Standardisation of optical coherence tomography angiography nomenclature in uveitis: first survey results
      Aim To standardise the nomenclature for reporting optical coherence angiography (OCT-A) findings in the field of uveitis. Methods Members of the International Uveitis Study Group, of the American Uveitis Society and of the Sociedad Panamericana de Infermedades Oculares that choose to participate responded to an online questionnaire about their preferred terminology when reporting on OCT-A findings in uveitis. The response of individuals with several publications on OCT-A (experts) was compared ...
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      Mentions: Case Western Reserve University Leiden University Northwestern University

    10. Northwestern University Receives NIH Grant for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      Northwestern University Receives NIH Grant for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography
      ...r improved monitoring of the functional status of the retina in DR in humans.

      Northwestern University Receives a 2020 NIH Grant for $50,520 for Oxygen Delivery and Metabolism in Diabetic R...

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      Mentions: National Institutes of Health Northwestern University

    11. Advances in Optical Coherence Tomography for Retinal Oximetry and Angiography (Thesis)

      Explore Log In Ophthalmology , Student Theses
      Advances in Optical Coherence Tomography for Retinal Oximetry and Angiography (Thesis)
      Optical coherence tomography (OCT) is a high-resolution, non-contact, three-dimensional imaging technique, which has revolutionized the diagnosis and treatment of retinal diseases. Visible-light OCT (vis-OCT) extends OCT by enabling retinal oximetry the measurement of oxygen saturation of hemoglobin from within individual retinal blood vessels. Three advances in the vis-OCT technique are presented: an improved vis-OCT oximetry method based on circumpapillary scan and graph-search segmentation; the calibration, simulation, and correction of spectroscopic ...
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      Mentions: Northwestern University

    12. Visible light optical coherence tomography angiography (vis-OCTA) facilitates local microvascular oximetry in the human retina

      Explore OSA | OSA Publishing Ophthalmology
      Visible light optical coherence tomography angiography (vis-OCTA) facilitates local microvascular oximetry in the human retina
      We report herein the first visible light optical coherence tomography angiography (vis-OCTA) for human retinal imaging. Compared to the existing vis-OCT systems, we devised a spectrometer with a narrower bandwidth to increase the spectral power density for OCTA imaging, while retaining the major spectral contrast in the blood. We achieved a 100 kHz A-line rate, the fastest acquisition speed reported so far for human retinal vis-OCT. We rigorously optimized the ...
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      Mentions: Northwestern University Boston University Ji Yi

    13. Acute Hyperglycemia Reverses Neurovascular Coupling During Dark to Light Adaptation in Healthy Subjects on Optical Coherence Tomography Angiography

      Explore IOVS Journal Ophthalmology
      Acute Hyperglycemia Reverses Neurovascular Coupling During Dark to Light Adaptation in Healthy Subjects on Optical Coherence Tomography Angiography
      Purpose : To test the hypothesis that hyperglycemia perturbs neurovascular\ coupling and compromises retinal vascular response during transition from dark to light in healthy subjects using optical coherence tomography angiography (OCTA). Methods : Ten eyes of 10 healthy subjects were tested, first during fasting and then after receiving a 75-g oral glucose solution. In both sessions, OCTA imaging was done in the dark-adapted state and at 50 seconds, 2 minutes, 5 minutes ...
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      Mentions: Northwestern University

    14. Caffeine Delays Retinal Neurovascular Coupling during Dark to Light Adaptation in Healthy Eyes Revealed by Optical Coherence Tomography Angiography

      Explore IOVS Journal Ophthalmology
      Caffeine Delays Retinal Neurovascular Coupling during Dark to Light Adaptation in Healthy Eyes Revealed by Optical Coherence Tomography Angiography
      Purpose : The purpose of this study was to investigate the acute effects of caffeine on retinal hemodynamics during dark to light adaptation using optical coherence tomography angiography (OCTA). Methods : Thirteen healthy individuals (13 eyes) underwent OCTA imaging after dark adaptation and at repeated intervals during the transition to ambient light in two imaging sessions: control and after ingesting 200 mg of caffeine. We analyzed the parafoveal vessel density (VD) and ...
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      Mentions: Northwestern University

    15. Spectrally dependent roll-off in visible-light optical coherence tomography

      Explore OSA | OSA Publishing
      Spectrally dependent roll-off in visible-light optical coherence tomography
      Recent development of visible-light optical coherence tomography (vis-OCT) has introduced new applications for noninvasive spectroscopic imaging. However, the measured spectra may be altered by spectrally dependent roll-off (SDR). We formulated a mathematical model for SDR that accounted for nonuniform wavenumber spacing, optical aberrations, and misalignments in the spectrometer. We simulated SDR based on this model and found strong agreement with measurements from a vis-OCT system. We verified that SDR altered ...
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      Mentions: Northwestern University Hao F. Zhang

    16. Visible light optical coherence tomography angiography (vis-OCTA)

      Explore bioRxiv.org Ophthalmology
      Visible light optical coherence tomography angiography (vis-OCTA)
      We report herein the first visible light optical coherence tomography angiography (vis-OCTA) for human retinal imaging. Compared to the existing vis-OCT systems, we devised a spectrometer with a narrower bandwidth to increase the spectral power density for OCTA imaging, while retaining the major spectral contrast in the blood. We achieved a 100 kHz A-line rate, the fastest acquisition speed reported so far for human retinal vis-OCT. We rigorously optimized the ...
      Read Full Article
      Mentions: Northwestern University Boston University
    17. 1-15 of 154 1 2 3 4 ... 9 10 11 »
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  4. About Northwestern University

    Northwestern University

    Northwestern University is a private research university located in Evanston, Illinois and downtown Chicago, Illinois.  Several of Northwestern's professional schools such as the School of Law, the Feinberg School of Medicine, and parts of the Kellogg School of Management are located in the Streeterville neighborhood of downtown Chicago. 

    Biophotonics Laboratory at Northwestern University.  The main direction of the Biophotonics laboratory (Principal Investigator: Prof. Vadim Backman) is the development of novel optical spectral and imaging techniques for non-invasive screening, diagnosis and detection of disease as well as characterization of biological and bioengineered tissue.

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