1. Northwestern University

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    1. Mentioned In 144 Articles

    2. Visible light optical coherence tomography angiography (vis-OCTA) facilitates local microvascular oximetry in the human retina

      Visible light optical coherence tomography angiography (vis-OCTA) facilitates local microvascular oximetry in the human retina
      We report herein the first visible light optical coherence tomography angiography (vis-OCTA) for human retinal imaging. Compared to the existing vis-OCT systems, we devised a spectrometer with a narrower bandwidth to increase the spectral power density for OCTA imaging, while retaining the major spectral contrast in the blood. We achieved a 100 kHz A-line rate, the fastest acquisition speed reported so far for human retinal vis-OCT. We rigorously optimized the ...
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    3. Acute Hyperglycemia Reverses Neurovascular Coupling During Dark to Light Adaptation in Healthy Subjects on Optical Coherence Tomography Angiography

      Acute Hyperglycemia Reverses Neurovascular Coupling During Dark to Light Adaptation in Healthy Subjects on Optical Coherence Tomography Angiography
      Purpose : To test the hypothesis that hyperglycemia perturbs neurovascular\ coupling and compromises retinal vascular response during transition from dark to light in healthy subjects using optical coherence tomography angiography (OCTA). Methods : Ten eyes of 10 healthy subjects were tested, first during fasting and then after receiving a 75-g oral glucose solution. In both sessions, OCTA imaging was done in the dark-adapted state and at 50 seconds, 2 minutes, 5 minutes ...
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    4. Caffeine Delays Retinal Neurovascular Coupling during Dark to Light Adaptation in Healthy Eyes Revealed by Optical Coherence Tomography Angiography

      Caffeine Delays Retinal Neurovascular Coupling during Dark to Light Adaptation in Healthy Eyes Revealed by Optical Coherence Tomography Angiography
      Purpose : The purpose of this study was to investigate the acute effects of caffeine on retinal hemodynamics during dark to light adaptation using optical coherence tomography angiography (OCTA). Methods : Thirteen healthy individuals (13 eyes) underwent OCTA imaging after dark adaptation and at repeated intervals during the transition to ambient light in two imaging sessions: control and after ingesting 200 mg of caffeine. We analyzed the parafoveal vessel density (VD) and ...
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    5. Spectrally dependent roll-off in visible-light optical coherence tomography

      Spectrally dependent roll-off in visible-light optical coherence tomography
      Recent development of visible-light optical coherence tomography (vis-OCT) has introduced new applications for noninvasive spectroscopic imaging. However, the measured spectra may be altered by spectrally dependent roll-off (SDR). We formulated a mathematical model for SDR that accounted for nonuniform wavenumber spacing, optical aberrations, and misalignments in the spectrometer. We simulated SDR based on this model and found strong agreement with measurements from a vis-OCT system. We verified that SDR altered ...
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    6. Visible light optical coherence tomography angiography (vis-OCTA)

      Visible light optical coherence tomography angiography (vis-OCTA)
      We report herein the first visible light optical coherence tomography angiography (vis-OCTA) for human retinal imaging. Compared to the existing vis-OCT systems, we devised a spectrometer with a narrower bandwidth to increase the spectral power density for OCTA imaging, while retaining the major spectral contrast in the blood. We achieved a 100 kHz A-line rate, the fastest acquisition speed reported so far for human retinal vis-OCT. We rigorously optimized the ...
      Read Full Article
    7. Application of automated quantification of fluid volumes to anti-VEGF therapy of neovascular age-related macular degeneration

      Application of automated quantification of fluid volumes to anti-VEGF therapy of neovascular age-related macular degeneration
      Purpose Anti-VEGF treatment of neovascular age-related macular degeneration (AMD) is a highly effective advance in the retinal armentarium. Optical coherence tomography (OCT) offering three-dimensional imaging of the retina is widely used to guide treatment. Although poor outcomes reported from clinical practice are multifactorial, availability of reliable, reproducible, and quantitative evaluation tools to accurately measure the fluid response i.e. a VEGF meter may be a better means of monitoring and ...
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    8. Exploring in vivo Optical Imaging Oximetry by Visible Light Optical Coherence Tomography (Thesis)

      Exploring in vivo Optical Imaging Oximetry by Visible Light Optical Coherence Tomography (Thesis)
      Biological functions rely on microvasculature to deliver oxygen and nutrients and carry away metabolic waste. Measuring microvascular oxygen saturation (sO2), the fraction of oxygensaturated hemoglobin relative to total hemoglobin (unsaturated + saturated) in the blood, can assess tissue oxygenation and provide insights into tissue metabolism, inflammation, and oxygen-related pathologies. Several major diseases, such as cancer, diabetes mellitus, cardiovascular diseases, hypertension, chronic kidney disease, and neurodegenerative diseases, are related to local microvascular ...
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    9. In Vivo Imaging of Schlemm's Canal and Limbal Vascular Network in Mouse Using Visible-Light OCT

      In Vivo Imaging of Schlemm's Canal and Limbal Vascular Network in Mouse Using Visible-Light OCT
      Purpose : To validate the ability of visible-light optical coherence tomography (vis-OCT) in imaging the full Schlemm's canal (SC) and its surrounding limbal vascular network in mice in vivo through a compound circumlimbal scan. Methods : We developed an anterior segment vis-OCT system and a compound circumlimbal scanning method, which montages eight rotated raster scans. We calibrated the circumlimbal scan geometry using a three-dimensional printed phantom eyeball before imaging wild-type C57BL ...
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    10. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF FOCAL CHOROIDAL EXCAVATION AND THE CHOROIDAL STROMA VARIATIONS WITH OCCURRENCE OF EXCAVATION

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF FOCAL CHOROIDAL EXCAVATION AND THE CHOROIDAL STROMA VARIATIONS WITH OCCURRENCE OF EXCAVATION
      Purpose: To describe retinal and choroidal vascular changes and choroidal stroma variations occurring in focal choroidal excavation (FCE). Methods: Study design was a cross-sectional case series. Consecutive patients affected by FCE and healthy controls were recruited. All patients underwent complete ophthalmologic assessment and multimodal imaging, including structural optical coherence tomography and optical coherence tomography angiography. Choroidal thickness and stromal index were calculated from structural optical coherence tomography images. Moreover, we ...
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    11. Optical coherence tomography angiography reveals progressive worsening of retinal vascular geometry in diabetic retinopathy and improved geometry after panretinal photocoagulation

      Optical coherence tomography angiography reveals progressive worsening of retinal vascular geometry in diabetic retinopathy and improved geometry after panretinal photocoagulation
      Purpose To quantify vessel tortuosity and fractal dimension of the superficial capillary plexus (SCP) of the macula in different stages of diabetic retinopathy (DR), and following panretinal photocoagulation (PRP) using optical coherence tomography angiography (OCTA). Methods 75 eyes of 75 subjects were divided into five groups; healthy controls, diabetes with no clinical DR, non-proliferative diabetic retinopathy (NPDR), proliferative diabetic retinopathy (PDR) and patients who received PRP for PDR (PDR+PRP ...
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    12. An optical coherence tomography-based grading of diabetic maculopathy proposed by an international expert panel: The European School for Advanced Studies in Ophthalmology classification

      An optical coherence tomography-based grading of diabetic maculopathy proposed by an international expert panel: The European School for Advanced Studies in Ophthalmology classification
      Aims: To present an authoritative, universal, easy-to-use morphologic classification of diabetic maculopathy based on spectral domain optical coherence tomography. Methods: The first draft of the project was developed based on previously published classifications and a literature search regarding the spectral domain optical coherence tomography quantitative and qualitative features of diabetic maculopathy. This draft was sent to an international panel of retina experts for a first revision. The panel met at ...
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    13. Measuring light scattering and absorption in corals with Inverse Spectroscopic Optical Coherence Tomography (ISOCT): a new tool for non-invasive monitoring

      Measuring light scattering and absorption in corals with Inverse Spectroscopic Optical Coherence Tomography (ISOCT): a new tool for non-invasive monitoring
      The success of reef-building corals for 200 million years has been dependent on the mutualistic interaction between the coral host and its photosynthetic endosymbiont dinoflagellates (family Symbiodiniaceae) that supply the coral host with nutrients and energy for growth and calcification. While multiple light scattering in coral tissue and skeleton significantly enhance the light microenvironment for Symbiodiniaceae, the mechanisms of light propagation in tissue and skeleton remain largely unknown due to ...
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    14. New imaging platform examines mechanisms behind coral bleaching

      New imaging platform examines mechanisms behind coral bleaching
      As coral reefs deteriorate in the face of climate change, an interdisciplinary Northwestern Engineering research team has developed an innovative method to image coral nanoscale structures and quantify pigment absorption in live corals, an indicator of coral health. The imaging platform could become a valuable tool to help marine biologists better understand coral physiology as well measure and monitor coral health. Reef building corals provide a home to more than ...
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    15. VIS-OCT Opens Eyes to New Approaches

      VIS-OCT Opens Eyes to New Approaches
      First reported in 1991 by Huang and colleagues 1 , OCT has become an important imaging tool for ophthalmology following innovations over the past three decades. OCT noninvasively provides 3D in vivo optical biopsy with microscopic resolution in the eye at a depth range up to the choroid 2 . Besides 3D anatomical imaging, OCT can also provide functional information. The most notable functional extension is OCT angiography (OCTA), which can map ...
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  2. About Northwestern University

    Northwestern University

    Northwestern University is a private research university located in Evanston, Illinois and downtown Chicago, Illinois.  Several of Northwestern's professional schools such as the School of Law, the Feinberg School of Medicine, and parts of the Kellogg School of Management are located in the Streeterville neighborhood of downtown Chicago. 

    Biophotonics Laboratory at Northwestern University.  The main direction of the Biophotonics laboratory (Principal Investigator: Prof. Vadim Backman) is the development of novel optical spectral and imaging techniques for non-invasive screening, diagnosis and detection of disease as well as characterization of biological and bioengineered tissue.