1. Northwestern University

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    1. Mentioned In 166 Articles

    2. In vivo imaging of the inner retinal layer structure in mice after eye-opening using visible-light optical coherence tomography

      Explore ScienceDirect Ophthalmology
      In vivo imaging of the inner retinal layer structure in mice after eye-opening using visible-light optical coherence tomography
      The growth of the mouse eye and retina after birth is a dynamic, highly regulated process. In this study, we applied visible-light optical coherence tomography (vis-OCT), a non-invasive imaging technique, to examine developing retinal layer structures after eye-opening. We introduced a resampled circumpapillary B-scan averaging technique to improve the inter-layer contrast, enabling retinal layer thickness measurements as early as postnatal day 13 (P13) - right after eye-opening. We confirmed vis-OCT measurements ...
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      Mentions: Northwestern University

    3. Systems for coherent light detection and related methods

      Explore uspto.gov Patents
      Systems for coherent light detection and related methods
      Systems for coherent light detection are provided, including a system comprising a light source configured to generate light; a first optical assembly configured to split the light into a reference arm and a sample arm; a second optical assembly configured to illuminate a sample with light of the sample arm, thereby generating a sample signal; a third optical assembly configured to combine the sample signal with light of the reference ...
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      Mentions: Thorlabs Axsun Technologies Northwestern University

    4. Utility of IOLMaster 700 Swept-Source Optical Coherence Tomography in Detecting Macular Disease for Preoperative Cataract Surgery Patients

      Explore Medical Journals Publisher Ophthalmology
      Utility of IOLMaster 700 Swept-Source Optical Coherence Tomography in Detecting Macular Disease for Preoperative Cataract Surgery Patients
      ...estern University Feinberg School of Medicine, Chicago, USA was approved by the Institutional Review Board of Northwestern University and was conducted in accordance with the principles of the Declaration of Helsinki. Th...
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      Mentions: Optovue Heidelberg Engineering Carl Zeiss Meditec

    5. Macrophage-Like Cell Density Is Increased in Proliferative Diabetic Retinopathy Characterized by Optical Coherence Tomography Angiography

      Explore IOVS Journal Ophthalmology
      Macrophage-Like Cell Density Is Increased in Proliferative Diabetic Retinopathy Characterized by Optical Coherence Tomography Angiography
      Purpose: To quantitatively characterize macrophage-like cells (MLCs) at the vitreoretinal interface in different severity stages of diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA). Methods: The study included 72 eyes of 72 subjects: 18 healthy controls, 22 diabetes mellitus (DM) without DR, 17 nonproliferative DR (NPDR), and 15 proliferative DR (PDR). We obtained repeated (average, 6.5; range, 3-10) macular OCTA scans for each eye. We registered and averaged ...
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      Mentions: Northwestern University

    6. Layered viscoelastic properties of granular biofilms

      Explore ScienceDirect NDE/NDT
      Layered viscoelastic properties of granular biofilms
      Granular biofilms are dense spherical complex biological systems composed mainly of multi-microbial cells, water, and extracellular polymeric substances (EPS). They facilitate efficient purification and settling of activated sludge in wastewater treatment processes . The viscoelastic properties of these complex biofilm systems are important characteristics that control their growth and dictate how they respond to hydrodynamic forces and chemical stimuli. However, the viscoelastic properties of granular biofilms are poorly understood. In this ...
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      Mentions: Northwestern University

    7. Balanced-detection visible-light optical coherence tomography

      Explore bioRxiv.org Ophthalmology
      Balanced-detection visible-light optical coherence tomography
      Increases in speed and sensitivity enabled rapid clinical adoption of optical coherence tomography (OCT) in ophthalmology. Recently visible-light OCT (vis-OCT) achieved ultrahigh axial resolution, improved tissue contrast, and new functional imaging capabilities, demonstrating the potential to improve clincal care further. However, limited speed and sensitivity caused by the high relative intensity noise (RIN) in supercontinuum lasers impeded the clinical adoption of vis-OCT. To overcome these limitations, we developed balanced-detection vis-OCT ...
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      Mentions: Northwestern University Opticent Health

    8. Northwestern University Receives NIH Grant for Investigating Nanoscale Neuronal Damages in Early Glaucoma Towards Clinical Optical Detection

      Explore Optical Coherence Tomography News Ophthalmology , Funding
      Northwestern University Receives NIH Grant for Investigating Nanoscale Neuronal Damages in Early Glaucoma Towards Clinical Optical Detection
      ...ural and functional metrics used for clinical glaucoma diagnoses in a chronic model of experimental glaucoma. Northwestern University Receives a 2021 NIH Grant for $507,515 for Investigating Nanoscale Neuronal Damages in...
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      Mentions: National Institutes of Health Northwestern University

    9. Origins of subdiffractional contrast in optical coherence tomography

      Explore OSA | OSA Publishing
      Origins of subdiffractional contrast in optical coherence tomography
      We demonstrate that OCT images quantify subdiffractional tissue structure. Optical coherence tomography (OCT) measures stratified tissue morphology with spatial resolution limited by the temporal coherence length. Spectroscopic OCT processing, on the other hand, has enabled nanoscale sensitive analysis, presenting an unexplored question: how does subdiffractional information get folded into the OCT image and how does one best analyze to allow for unambiguous quantification of ultrastructure? We first develop an FDTD ...
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      Mentions: Northwestern University

    10. Adaptive spectroscopic visible-light optical coherence tomography for human retinal oximetry

      Explore bioRxiv.org Ophthalmology
      Adaptive spectroscopic visible-light optical coherence tomography for human retinal oximetry
      Alterations in the retinal oxygen saturation (sO2) and oxygen consumption are associated with nearly all blinding diseases. A technology that can accurately measure retinal sO2 has the potential to improve ophthalmology care significantly. Recently, visible-light optical coherence tomography (vis-OCT) showed great promise for noninvasive, depth-resolved measurement of retinal sO2 as well as ultra-high resolution anatomical imaging. We discovered that spectral contaminants (SC), if not correctly removed, could lead to incorrect ...
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      Mentions: Northwestern University NYU Langone Medical Center

    11. Longitudinal Changes on Optical Coherence Tomography Angiography in Retinal Vein Occlusion

      Explore MDPI Open Access Journals Platform Ophthalmology
      Longitudinal Changes on Optical Coherence Tomography Angiography in Retinal Vein Occlusion
      Background: To evaluate the longitudinal changes on optical coherence tomography angiography (OCTA) in retinal vein occlusion (RVO). Methods: Retrospective study of patients with RVO treated with intravitreal anti-vascular endothelial growth factors (VEGF) for macular edema. Foveal avascular zone (FAZ) area, vessel density (VD), vessel length density (VLD), and adjusted flow index (AFI) were calculated. The unaffected eye of each participant was used as a control. Results: Twelve RVO eyes were ...
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      Mentions: Northwestern University Università Vita-Salute San Raffaele

    12. Optical Coherence Tomography Angiography Quality Across Three Multicenter Clinical Studies of Diabetic Retinopathy

      Explore TVST Journal Ophthalmology
      Optical Coherence Tomography Angiography Quality Across Three Multicenter Clinical Studies of Diabetic Retinopathy
      Purpose : To explore optical coherence tomography angiography (OCTA) quality and associated factors in multicenter clinical studies. Methods : OCTA scans were obtained from participants with diabetic retinopathy from three DRCR Retina Network clinical studies using the Optovue AngioVue and ZEISS AngioPlex. Macular (3 3 mm and 6 6 mm) and optic nerve scans were captured. Quality was assessed by the Casey Reading Center. Scans were considered poor if the signal strength ...
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      Mentions: Optovue Oregon Health & Science University Harvard University

    13. Intrinsic spectrally-dependent background in spectroscopic visible-light optical coherence tomography

      Explore OSA | OSA Publishing
      Intrinsic spectrally-dependent background in spectroscopic visible-light optical coherence tomography
      Visible-light optical coherence tomography (vis-OCT) has enabled new spectroscopic applications, such as retinal oximetry, as a result of increased optical absorption and scattering contacts in biological tissue and improved axial resolution. Besides extracting tissue properties from back-scattered light, spectroscopic analyses must consider spectral alterations induced by image reconstruction itself. We investigated an intrinsic spectral bias in the background noise floor, which is hereby referred to as the spectrally-dependent background (SDBG ...
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      Mentions: Northwestern University Opticent Health

    14. In Vivo Sublayer Analysis Of Human Retinal Inner Plexiform Layer Obtained By Visible-Light Optical Coherence Tomography

      Explore bioRxiv.org Ophthalmology
      In Vivo Sublayer Analysis Of Human Retinal Inner Plexiform Layer Obtained By Visible-Light Optical Coherence Tomography
      Purpose: Growing evidence suggests, in glaucoma, the dendritic degeneration of subpopulation of the retinal ganglion cells (RGCs) may precede RGCs soma death. Since different RGCs synapse in different IPL sublayers, visualization of the lamellar structure of the IPL could enable both clinical and fundamental advances in glaucoma understanding and management. In this pilot study, we investigated whether visible-light optical coherence tomography (vis-OCT) could detect the difference in the inner plexiform ...
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      Mentions: Northwestern University NYU Langone Medical Center

    15. VIS-OCT needs stable, versatile light sources

      Explore Photonics.com Broadband Sources , Tunable Sources
      VIS-OCT needs stable, versatile light sources
      Optical coherence tomography (OCT) is the gold standard for noninvasive retinal imaging, enabling ophthalmologists to diagnose and treat multiple ocular diseases. Compared to traditional OCT, which uses near-infrared (NIR) wavelengths of light, visible-light OCT (VIS-OCT) offers superior spatial resolution and novel functional imaging capabilities. VIS-OCT provides the most accurate means for measuring retinal oxygen saturation, a key biomarker for understanding changes in tissue metabolism associated with the pathology of various ...
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      Mentions: Northwestern University Opticent Health

    16. Reversed Neurovascular Coupling on Optical Coherence Tomography Angiography Is the Earliest Detectable Abnormality before Clinical Diabetic Retinopathy

      Explore MDPI Open Access Journals Platform Ophthalmology
      Reversed Neurovascular Coupling on Optical Coherence Tomography Angiography Is the Earliest Detectable Abnormality before Clinical Diabetic Retinopathy
      Diabetic retinopathy (DR) has traditionally been viewed as either a microvasculopathy or a neuropathy, though neurovascular coupling deficits have also been reported and could potentially be the earliest derangement in DR. To better understand neurovascular coupling in the diabetic retina, we investigated retinal hemodynamics by optical coherence tomography angiography (OCTA) in individuals with diabetes mellitus (DM) but without DR (DM no DR) and mild non-proliferative DR (mild NPDR) compared to ...
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      Mentions: Northwestern University
    17. 1-15 of 166 1 2 3 4 ... 9 10 11 »
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  4. About Northwestern University

    Northwestern University

    Northwestern University is a private research university located in Evanston, Illinois and downtown Chicago, Illinois.  Several of Northwestern's professional schools such as the School of Law, the Feinberg School of Medicine, and parts of the Kellogg School of Management are located in the Streeterville neighborhood of downtown Chicago. 

    Biophotonics Laboratory at Northwestern University.  The main direction of the Biophotonics laboratory (Principal Investigator: Prof. Vadim Backman) is the development of novel optical spectral and imaging techniques for non-invasive screening, diagnosis and detection of disease as well as characterization of biological and bioengineered tissue.

  5. Related Topics

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