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1. Mentioned In 157 Articles
2. Longitudinal Changes on Optical Coherence Tomography Angiography in Retinal Vein Occlusion
  
  Explore MDPI Open Access Journals Platform Apr 6 2021 Ophthalmology
  
  Background: To evaluate the longitudinal changes on optical coherence tomography angiography (OCTA) in retinal vein occlusion (RVO). Methods: Retrospective study of patients with RVO treated with intravitreal anti-vascular endothelial growth factors (VEGF) for macular edema. Foveal avascular zone (FAZ) area, vessel density (VD), vessel length density (VLD), and adjusted flow index (AFI) were calculated. The unaffected eye of each participant was used as a control. Results: Twelve RVO eyes were ...
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  Mentions: Northwestern University Università Vita-Salute San Raffaele
3. Optical Coherence Tomography Angiography Quality Across Three Multicenter Clinical Studies of Diabetic Retinopathy
  
  Explore TVST Journal Mar 6 2021 Ophthalmology
  
  Purpose : To explore optical coherence tomography angiography (OCTA) quality and associated factors in multicenter clinical studies. Methods : OCTA scans were obtained from participants with diabetic retinopathy from three DRCR Retina Network clinical studies using the Optovue AngioVue and ZEISS AngioPlex. Macular (3 3 mm and 6 6 mm) and optic nerve scans were captured. Quality was assessed by the Casey Reading Center. Scans were considered poor if the signal strength ...
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  Mentions: Optovue Oregon Health & Science University Harvard University
4. Intrinsic spectrally-dependent background in spectroscopic visible-light optical coherence tomography
  
  Explore OSA | OSA Publishing Feb 2 2021
  
  Visible-light optical coherence tomography (vis-OCT) has enabled new spectroscopic applications, such as retinal oximetry, as a result of increased optical absorption and scattering contacts in biological tissue and improved axial resolution. Besides extracting tissue properties from back-scattered light, spectroscopic analyses must consider spectral alterations induced by image reconstruction itself. We investigated an intrinsic spectral bias in the background noise floor, which is hereby referred to as the spectrally-dependent background (SDBG ...
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  Mentions: Northwestern University Opticent Health
5. In Vivo Sublayer Analysis Of Human Retinal Inner Plexiform Layer Obtained By Visible-Light Optical Coherence Tomography
  
  Explore bioRxiv.org Jan 9 2021 Ophthalmology
  
  Purpose: Growing evidence suggests, in glaucoma, the dendritic degeneration of subpopulation of the retinal ganglion cells (RGCs) may precede RGCs soma death. Since different RGCs synapse in different IPL sublayers, visualization of the lamellar structure of the IPL could enable both clinical and fundamental advances in glaucoma understanding and management. In this pilot study, we investigated whether visible-light optical coherence tomography (vis-OCT) could detect the difference in the inner plexiform ...
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  Mentions: Northwestern University NYU Langone Medical Center
6. VIS-OCT needs stable, versatile light sources
  
  Explore Photonics.com Nov 19 2020 Broadband Sources , Tunable Sources
  
  Optical coherence tomography (OCT) is the gold standard for noninvasive retinal imaging, enabling ophthalmologists to diagnose and treat multiple ocular diseases. Compared to traditional OCT, which uses near-infrared (NIR) wavelengths of light, visible-light OCT (VIS-OCT) offers superior spatial resolution and novel functional imaging capabilities. VIS-OCT provides the most accurate means for measuring retinal oxygen saturation, a key biomarker for understanding changes in tissue metabolism associated with the pathology of various ...
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  Mentions: Northwestern University Opticent Health
7. Reversed Neurovascular Coupling on Optical Coherence Tomography Angiography Is the Earliest Detectable Abnormality before Clinical Diabetic Retinopathy
  
  Explore MDPI Open Access Journals Platform Nov 3 2020 Ophthalmology
  
  Diabetic retinopathy (DR) has traditionally been viewed as either a microvasculopathy or a neuropathy, though neurovascular coupling deficits have also been reported and could potentially be the earliest derangement in DR. To better understand neurovascular coupling in the diabetic retina, we investigated retinal hemodynamics by optical coherence tomography angiography (OCTA) in individuals with diabetes mellitus (DM) but without DR (DM no DR) and mild non-proliferative DR (mild NPDR) compared to ...
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  Mentions: Northwestern University
8. Visible-Light Optical Coherence Tomography Fibergraphy for Quantitative Imaging of Retinal Ganglion Cell Axon Bundles
  
  Explore TVST Journal Oct 13 2020 Ophthalmology
  
  Purpose : To develop a practical technique for visualizing and quantifying retinal ganglion cell (RGC) axon bundles in vivo. Methods : We applied visible-light optical coherence tomography (vis-OCT) to image the RGC axon bundles, referred to as vis-OCT fibergraphy, of healthy wild-type C57BL/6 mice. After vis-OCT imaging, retinas were flat-mounted, immunostained with anti-beta-III tubulin (Tuj1) antibody for RGC axons, and imaged with confocal microscopy. We quantitatively compared the RGC axon bundle ...
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  Mentions: Northwestern University
9. Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2
  
  Explore MDPI Open Access Journals Platform Sep 29 2020 Ophthalmology
  
  In this cross-sectional observational study, we investigated the relationship between photoreceptor layer disruption and telangiectasia in patients diagnosed with early stage macular telangiectasia type 2 (MacTel). A total of 31 eyes (17 patients) with MacTel were imaged with adaptive optics scanning laser ophthalmoscopy (AOSLO) and optical coherence tomography angiography (OCTA). Confocal AOSLO was used to visualize dark regions of nonwaveguiding outer segments, which we refer to as photoreceptor lesions. En-face ...
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  Mentions: Northwestern University
10. Northwestern University Receives NIH Grant for Investigating Nanoscale Neuronal Damages in Early Glaucoma Towards Clinical Adoption
  
  Explore Optical Coherence Tomography News Aug 11 2020 Ophthalmology , Funding
  
  ... for clinical glaucoma diagnoses in a chronic model of experimental glaucoma.
  Northwestern University Receives a 2020 NIH Grant for $516,102 for Investigating Nanoscale Neuronal Damages in...
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  Mentions: National Institutes of Health Northwestern University
11. Standardisation of optical coherence tomography angiography nomenclature in uveitis: first survey results
  
  Explore BJO Online Jul 31 2020 Ophthalmology
  
  Aim To standardise the nomenclature for reporting optical coherence angiography (OCT-A) findings in the field of uveitis. Methods Members of the International Uveitis Study Group, of the American Uveitis Society and of the Sociedad Panamericana de Infermedades Oculares that choose to participate responded to an online questionnaire about their preferred terminology when reporting on OCT-A findings in uveitis. The response of individuals with several publications on OCT-A (experts) was compared ...
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  Mentions: Case Western Reserve University Leiden University Northwestern University
12. Researchers capture cell-level details of curved cornea
  
  Explore EurekAlert! Jul 23 2020 Ophthalmology
  
  ... board of more than 60 associate editors from around the world and is overseen by Editor-in-Chief Prem Kumar, Northwestern University, USA. For more information, visit Optica. About The Optical Society Founded in 1916, T...
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  Mentions: Northwestern University ESPCI ParisTech
13. Northwestern University Receives NIH Grant for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography
  
  Explore Optical Coherence Tomography News Jul 14 2020 Ophthalmology , Funding
  
  ...r improved monitoring of the functional status of the retina in DR in humans.
  Northwestern University Receives a 2020 NIH Grant for $50,520 for Oxygen Delivery and Metabolism in Diabetic R...
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  Mentions: National Institutes of Health Northwestern University
14. Advances in Optical Coherence Tomography for Retinal Oximetry and Angiography (Thesis)
  
  Explore Log In Jul 13 2020 Ophthalmology , Student Theses
  
  Optical coherence tomography (OCT) is a high-resolution, non-contact, three-dimensional imaging technique, which has revolutionized the diagnosis and treatment of retinal diseases. Visible-light OCT (vis-OCT) extends OCT by enabling retinal oximetry the measurement of oxygen saturation of hemoglobin from within individual retinal blood vessels. Three advances in the vis-OCT technique are presented: an improved vis-OCT oximetry method based on circumpapillary scan and graph-search segmentation; the calibration, simulation, and correction of spectroscopic ...
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  Mentions: Northwestern University
15. Visible light optical coherence tomography angiography (vis-OCTA) facilitates local microvascular oximetry in the human retina
  
  Explore OSA | OSA Publishing Jul 6 2020 Ophthalmology
  
  We report herein the first visible light optical coherence tomography angiography (vis-OCTA) for human retinal imaging. Compared to the existing vis-OCT systems, we devised a spectrometer with a narrower bandwidth to increase the spectral power density for OCTA imaging, while retaining the major spectral contrast in the blood. We achieved a 100 kHz A-line rate, the fastest acquisition speed reported so far for human retinal vis-OCT. We rigorously optimized the ...
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  Mentions: Northwestern University Boston University
16. Acute Hyperglycemia Reverses Neurovascular Coupling During Dark to Light Adaptation in Healthy Subjects on Optical Coherence Tomography Angiography
  
  Explore IOVS Journal May 3 2020 Ophthalmology
  
  Purpose : To test the hypothesis that hyperglycemia perturbs neurovascular\ coupling and compromises retinal vascular response during transition from dark to light in healthy subjects using optical coherence tomography angiography (OCTA). Methods : Ten eyes of 10 healthy subjects were tested, first during fasting and then after receiving a 75-g oral glucose solution. In both sessions, OCTA imaging was done in the dark-adapted state and at 50 seconds, 2 minutes, 5 minutes ...
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  Mentions: Northwestern University
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