1. Northwestern University

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    1. Mentioned In 181 Articles

    2. Recent advances in optical coherence tomography for anterior segment imaging in small animals and their clinical implications

      Explore ScienceDirect Ophthalmology
      Recent advances in optical coherence tomography for anterior segment imaging in small animals and their clinical implications
      Anterior segment optical coherence tomography (AS-OCT) is a rapidly evolving area of OCT imaging, providing high-resolution and non-invasive volumetric imaging of the anterior segment. This review focuses on recent advances in AS-OCT imaging in small animals, which we categorize into ultrahigh-resolution, spectroscopic, magnetomotive, polarization-sensitive, and angiographic AS-OCTs. We summarize their technical foundations, review their applications to small animal imaging, and briefly discuss their current and future clinical applications.
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      Mentions: Northwestern University

    4. Macrophages in close proximity to the vitreoretinal interface are potential biomarkers of inflammation during retinal vascular disease

      Explore Journal of Neuroinflammation Ophthalmology
      Macrophages in close proximity to the vitreoretinal interface are potential biomarkers of inflammation during retinal vascular disease
      Background Diabetic retinopathy and retinal vein occlusion are vision threatening retinal vascular diseases. Current first-line therapy targets the vascular component, but many patients are treatment-resistant due to unchecked inflammation. Non-invasive inflammatory imaging biomarkers are a significant unmet clinical need for patients. Imaging of macrophage-like cells on the surface of the retina using clinical optical coherence tomography (OCT) is an emerging field. These cells are increased in patients with retinal vascular ...
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      Mentions: Northwestern University

    5. Deep Capillary Nonperfusion on OCT Angiography Predicts Complications in Eyes with Referable Nonproliferative Diabetic Retinopathy

      Explore ScienceDirect Ophthalmology
      Deep Capillary Nonperfusion on OCT Angiography Predicts Complications in Eyes with Referable Nonproliferative Diabetic Retinopathy
      Objective To evaluate the ability of capillary non-perfusion parameters on optical coherence tomography angiography (OCTA) to predict the development of clinically significant outcomes in eyes with referable non-proliferative DR (NPDR). Design Prospective longitudinal observational study Subjects 59 patients (74 eyes) with treatment-nave moderate and severe (referable) NPDR Methods Patients were imaged with OCTA at baseline and then followed for 1 year. We evaluated two OCTA capillary nonperfusion metrics, vessel density ...
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      Mentions: Northwestern University

    6. Characterization of retinal ganglion cell damage at single axon bundle level in mice by visible-light optical coherence tomography fibergraphy

      Explore LWW Online Ophthalmology
      Characterization of retinal ganglion cell damage at single axon bundle level in mice by visible-light optical coherence tomography fibergraphy
      Retinal ganglion cells (RGCs) receive synaptic inputs through their dendritic trees in the inner plexiform layer (IPL) and convey the visual information via their axons which form the optic nerve to the brain (Sanes and Masland, 2015). In glaucoma, RGCs and their axons degenerate and die, leading to irreversible vision loss and eventually blindness if left untreated (Quigley, 2016). The self-destructive programs in RGCs induced by glaucomatous insults are often ...
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      Mentions: Northwestern University

    7. Deep Capillary Geometric Perfusion Deficits on OCT Angiography Detect Clinically Referable Eyes with Diabetic Retinopathy

      Explore ScienceDirect Ophthalmology
      Deep Capillary Geometric Perfusion Deficits on OCT Angiography Detect Clinically Referable Eyes with Diabetic Retinopathy
      Purpose: To evaluate the sensitivity (SN) and specificity (SP) of optical coherence tomography angiography (OCTA) parameters for detecting clinically referable eyes with diabetic retinopathy (DR) in a cohort of patients with diabetes mellitus (DM). Design: Retrospective, cross-sectional study. Subjects: Patients with DM with various levels of DR. Methods: We measured vessel density, vessel length density (VLD), and geometric perfusion deficits (GPD) in the full retina, superficial (SCP) and deep capillary ...
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      Mentions: Northwestern University

    8. Retinal Vessel Density and Treatment Intensity among Adults with Retinal Vein Occlusion: A Swept-Source Optical Coherence Tomography Angiography Study

      Explore MDPI Open Access Journals Platform Ophthalmology
      Retinal Vessel Density and Treatment Intensity among Adults with Retinal Vein Occlusion: A Swept-Source Optical Coherence Tomography Angiography Study
      Previous studies have shown retinal vein occlusion (RVO) is associated with changes in vessel density visible on swept-source optical coherence tomography angiography (ss-OCTA). This study aimed to characterize retinal changes on ss-OCTA among RVO patients stratified by the need for continuous anti-VEGF therapy. This cross-sectional study of 24 RVO patients 18 years were imaged with SS-OCT-A. Patients were categorized into continuous vs. limited therapy (1 vs. no injections in previous ...
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      Mentions: Northwestern University

    9. Multiple forward scattering reduces the measured scattering coefficient of whole blood in visible-light optical coherence tomography

      Explore bioRxiv.org Ophthalmology
      Multiple forward scattering reduces the measured scattering coefficient of whole blood in visible-light optical coherence tomography
      Preview PDF Abstract Optical properties of blood encode oxygen-dependent information. Noninvasive optical detection of these properties is increasingly desirable to extract biomarkers for tissue health. Recently, visible-light optical coherence tomography (vis-OCT) demonstrated retinal oxygen saturation (sO2) measurements using the depth-resolved spectrum of blood. Such measurements rely on differences between the absorption and scattering coefficients of oxygenated and deoxygenated blood.
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      Mentions: Northwestern University

    10. Advances in Optical Coherence Tomography for Retinal Oximetry and Angiography (Thesis)

      Explore ProQuest Ophthalmology , Student Theses
      Advances in Optical Coherence Tomography for Retinal Oximetry and Angiography (Thesis)
      Optical coherence tomography (OCT) is a high-resolution, non-contact, three-dimensional imaging technique, which has revolutionized the diagnosis and treatment of retinal diseases. Visible-light OCT (vis-OCT) extends OCT by enabling retinal oximetry the measurement of oxygen saturation of hemoglobin from within individual retinal blood vessels. Three advances in the vis-OCT technique are presented: an improved vis-OCT oximetry method based on circumpapillary scan and graph-search segmentation; the calibration, simulation, and correction of spectroscopic ...
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      Mentions: Northwestern University

    11. High-speed balanced-detection visible-light optical coherence tomography in the human retina using subpixel spectrometer calibration

      Explore IEEE Xplore Ophthalmology
      High-speed balanced-detection visible-light optical coherence tomography in the human retina using subpixel spectrometer calibration
      Increases in speed and sensitivity enabled rapid clinical adoption of optical coherence tomography (OCT) in ophthalmology. Recently, visible-light OCT (vis-OCT) achieved ultrahigh axial resolution, improved tissue contrast, and provided new functional imaging capabilities, demonstrating the potential to improve clinical care further. However, limited speed and sensitivity caused by the high relative intensity noise (RIN) in supercontinuum lasers impeded the clinical adoption of vis-OCT. To overcome these limitations, we developed balanced-detection ...
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      Mentions: Northwestern University

    12. In Vivo Sublayer Analysis of Human Retinal Inner Plexiform Layer Obtained by Visible-Light Optical Coherence Tomography

      Explore IOVS Journal Ophthalmology
      In Vivo Sublayer Analysis of Human Retinal Inner Plexiform Layer Obtained by Visible-Light Optical Coherence Tomography
      Purpose : Growing evidence suggests that dendrite retraction or degeneration in a subpopulation of the retinal ganglion cells (RGCs) may precede detectable soma abnormalities and RGC death in glaucoma. Visualization of the lamellar structure of the inner plexiform layer (IPL) could advance clinical management and fundamental understanding of glaucoma. We investigated whether visible-light optical coherence tomography (vis-OCT) could detect the difference in the IPL sublayer thicknesses between small cohorts of healthy ...
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      Mentions: Oregon Health & Science University Northwestern University Opticent Health

    13. Perspectives on diabetic retinopathy from advanced retinal vascular imaging

      Explore Nature Publishing Group Ophthalmology
      Perspectives on diabetic retinopathy from advanced retinal vascular imaging
      Diabetic retinopathy (DR) is a microvascular complication of diabetes and the most common cause of acquired vision loss in adults worldwide. DR is associated with long-term chronic hyperglycaemia and its detrimental effects on the neurovascular structure and function of the retina. Direct imaging of the retinal vasculature and staging of DR has been traditionally based on fundoscopy and fluorescein angiography, which provide only 2D views of the retina, and in ...
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      Mentions: Northwestern University

    14. Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure

      Explore Frontiers Otolaryngology
      Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure
      After acoustic trauma, there can be loss of synaptic connections between inner hair cells and auditory neurons in the cochlea, which may lead to hearing abnormalities including speech-in-noise difficulties, tinnitus, and hyperacusis. We have previously studied mice with blast-induced cochlear synaptopathy and found that they also developed a build-up of endolymph, termed endolymphatic hydrops. In this study, we used optical coherence tomography to measure endolymph volume in live CBA/CaJ ...
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      Mentions: University of Southern California Northwestern University

    15. New Method for Reducing Artifactual Flow Deficits Caused by Compensation Techniques in the Choriocapillaris with Optical Coherence Tomography Angiography

      Explore LWW Online Ophthalmology
      New Method for Reducing Artifactual Flow Deficits Caused by Compensation Techniques in the Choriocapillaris with Optical Coherence Tomography Angiography
      Purpose: To mitigate artifactual choriocapillaris flow deficits in optical coherence tomography angiography (OCTA), which are a side effect of inverse structural OCT compensation. Methods: In a modified algorithm, we set pixels in the original structural OCT that were greater than one standard deviation above the mean intensity (hyperreflective regions) to the mean pixel intensity of the image to remove hyporeflective regions in the inverse slab. We compared this algorithm to ...
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      Mentions: Northwestern University
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  4. About Northwestern University

    Northwestern University

    Northwestern University is a private research university located in Evanston, Illinois and downtown Chicago, Illinois.  Several of Northwestern's professional schools such as the School of Law, the Feinberg School of Medicine, and parts of the Kellogg School of Management are located in the Streeterville neighborhood of downtown Chicago. 

    Biophotonics Laboratory at Northwestern University.  The main direction of the Biophotonics laboratory (Principal Investigator: Prof. Vadim Backman) is the development of novel optical spectral and imaging techniques for non-invasive screening, diagnosis and detection of disease as well as characterization of biological and bioengineered tissue.

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