1. Northwestern University

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    1. Mentioned In 111 Articles

    2. Monitoring Acute Stroke in Mouse Model Using Laser Speckle Imaging-Guided Visible-Light Optical Coherence Tomography

      Monitoring Acute Stroke in Mouse Model Using Laser Speckle Imaging-Guided Visible-Light Optical Coherence Tomography
      Objective: Monitoring hemodynamic and vascular changes in the acute stages of mouse stroke models is invaluable in studying ischemic stroke pathophysiology. However, there lacks a tool to simultaneously and dynamically investigate these changes. Methods: We integrated laser speckle imaging (LSI) and visible-light optical coherence tomography (Vis-OCT) to reveal dynamic vascular responses in acute stages in the distal middle cerebral artery occlusion (dMCAO) model in rodents. LSI provides full-field, real-time imaging ...
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    3. Spectral Contrast Optical Coherence Tomography Angiography Enables Single-Scan Vessel Imaging

      Spectral Contrast Optical Coherence Tomography Angiography Enables Single-Scan Vessel Imaging
      Optical Coherence Tomography angiography relies on motion for contrast and requires at least two data acquisitions per point-wise scanning location. We present a method termed Spectral Contrast Optical Coherence Tomography Angiography using visible light which relies on the spectral signatures of blood to obtain angiography from a single scan using endogenous contrast. We demonstrate the molecular sensitivity of this method enabling lymphatic, blood, and tissue discrimination.
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    4. Statistical Model of Optical Coherence Tomography Angiography Parameters That Correlate With Severity of Diabetic Retinopathy

      Statistical Model of Optical Coherence Tomography Angiography Parameters That Correlate With Severity of Diabetic Retinopathy
      Purpose : To determine whether combining quantitative optical coherence tomography angiography (OCTA) parameters can achieve high sensitivity and specificity to distinguish eyes with nonproliferative diabetic retinopathy (NPDR) from those with proliferative diabetic retinopathy (PDR) as well as eyes with diabetes and no DR (NoDR) from those with clinical DR (any DR). Methods : This cross-sectional study included 28 eyes (17 patients) with NoDR, 54 eyes (34 patients) with NPDR, and 56 eyes ...
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    5. Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography

      Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography
      Measuring capillary oxygenation and the surrounding ultrastructure can allow one to monitor a microvascular niche and better understand crucial biological mechanisms. However, capillary oximetry and pericapillary ultrastructure are challenging to measure in vivo. Here, we demonstrate a novel optical imaging system, Dual-band Dual-scan Inverse Spectroscopic Optical Coherence Tomography (D2- ISOCT), that, for the first time, can simultaneously obtain the following metrics in vivo using endogenous contrast: (1) capillary-level oxygen saturation ...
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    6. Human Parafoveal Capillary Vascular Anatomy and Connectivity Revealed by Optical Coherence Tomography Angiography

      Human Parafoveal Capillary Vascular Anatomy and Connectivity Revealed by Optical Coherence Tomography Angiography
      Purpose : To assess the connection among arterioles, venules, and capillaries in three retinal capillary plexuses using optical coherence tomography angiography (OCTA). Methods : This was a prospective, cross-sectional, observational study including 20 eyes of 10 healthy subjects. En face and cross-sectional OCTA images were segmented to study the superficial (SCP), middle (MCP), and deep capillary plexuses (DCP). Using thin slabs and manual segmentation within the three plexuses, we examined the connections ...
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    7. Visible-light optical coherence tomography oximetry based on circumpapillary scan and graph-search segmentation

      Visible-light optical coherence tomography oximetry based on circumpapillary scan and graph-search segmentation
      Visible-light optical coherence tomography (vis-OCT) enables retinal oximetry by measuring the oxygen saturation of hemoglobin (sO 2 ) from within individual retinal blood vessels. The sO 2 calculation requires reliable estimation of the true spectrum of backscattered light from the posterior vessel wall. Unfortunately, subject motion and image noise make averaging from multiple A-lines at the same depth position challenging, and lead to inaccurate sO 2 estimation. In this study, we ...
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    8. RESIDUAL CHOROIDAL VESSELS IN ATROPHY CAN MASQUERADE AS CHOROIDAL NEOVASCULARIZATION ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY: Introducing a Clinical and Software Approach

      RESIDUAL CHOROIDAL VESSELS IN ATROPHY CAN MASQUERADE AS CHOROIDAL NEOVASCULARIZATION ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY: Introducing a Clinical and Software Approach
      Purpose: To present a postprocessing approach in optical coherence tomography angiography (OCTA) to facilitate the visualization and interpretation of lesions in age-related macular degeneration with coexisting atrophy and choroidal neovascularization (CNV). Methods: This retrospective study included 32 eyes of 26 patients with atrophy and treated CNV and 8 eyes with treatment-naive geographic atrophy . En face optical coherence tomography slabs highlighting atrophy were pseudocolored and merged with the corresponding OCTA. Cross-sectional ...
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    9. Importance of Considering the Middle Capillary Plexus on OCT Angiography in Diabetic Retinopathy

      Importance of Considering the Middle Capillary Plexus on OCT Angiography in Diabetic Retinopathy
      Purpose : To quantify microvasculature changes in the superficial (SCP), middle (MCP), and deep capillary plexuses (DCP) in diabetic retinopathy (DR). Methods : Retrospective cross-sectional study at a tertiary academic referral center, in which 26 controls (44 eyes), 27 diabetic subjects without retinopathy (44 eyes), 32 subjects with nonproliferative retinopathy (52 eyes), and 27 subjects with proliferative retinopathy (40 eyes) were imaged with optical coherence tomography angiography (OCTA). Outcome measures included parafoveal ...
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    10. MULTILEVEL ISCHEMIA IN DISORGANIZATION OF THE RETINAL INNER LAYERS ON PROJECTION-RESOLVED OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      MULTILEVEL ISCHEMIA IN DISORGANIZATION OF THE RETINAL INNER LAYERS ON PROJECTION-RESOLVED OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
      Purpose: To examine the relationship between ischemia and disorganization of the retinal inner layers ( DRIL ). Methods: Cross-sectional retrospective study of 20 patients (22 eyes) with diabetic retinopathy presenting to a tertiary academic referral center, who had DRIL on structural optical coherence tomography ( OCT ) using Spectralis HRA + OCT (Heidelberg Engineering, Heidelberg, Germany) and OCT angiography with XR Avanti (Optovue Inc, Fremont, CA) on the same day. Optical coherence tomography angiography images ...
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    11. Optical Coherence Tomography Angiography In ADULT-ONSET Foveomacular Vitelliform Dystrophy

      Optical Coherence Tomography Angiography In ADULT-ONSET Foveomacular Vitelliform Dystrophy
      Purpose: To determine the ability of optical coherence tomography angiography (OCTA) to detect choroidal neovascularization (CNV) in the pseudohypopyon stage of adult-onset foveomacular vitelliform dystrophy. Methods: Prospective case series of eight consecutive patients with adult-onset foveomacular vitelliform dystrophy with at least one eye in the pseudohypopyon stage (a total of 14 eyes). Patients were assessed with spectral domain OCT, flourescein angiography, and OCTA. Main outcome measures were the presence or ...
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    12. In vivo broadband visible light optical coherence tomography probe enables inverse spectroscopic analysis

      In vivo broadband visible light optical coherence tomography probe enables inverse spectroscopic analysis
      We report the design and characterization of a 6 mm outer diameter pull-back circumferential scanning visible optical coherence tomography probe. The probes large visible bandwidth (500695 nm) allowed for inverse spectroscopic analysis and an axial resolution of 1.1 m 1.1m in tissue. We verify spectral imaging capabilities by measuring microsphere backscattering spectra and demonstrate in vivo spatial nanoscale characterization of tissue.
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  2. About Northwestern University

    Northwestern University

    Northwestern University is a private research university located in Evanston, Illinois and downtown Chicago, Illinois.  Several of Northwestern's professional schools such as the School of Law, the Feinberg School of Medicine, and parts of the Kellogg School of Management are located in the Streeterville neighborhood of downtown Chicago. 

    Biophotonics Laboratory at Northwestern University.  The main direction of the Biophotonics laboratory (Principal Investigator: Prof. Vadim Backman) is the development of novel optical spectral and imaging techniques for non-invasive screening, diagnosis and detection of disease as well as characterization of biological and bioengineered tissue.