1. Northwestern University

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    1. Mentioned In 87 Articles

    2. Biological tissue analysis by inverse spectroscopic optical coherence tomography

      Biological tissue analysis by inverse spectroscopic optical coherence tomography
      A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT) is disclosed. Tissue is modeled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. By measuring optical quantities of tissue (including the scattering power of the OCT spectrum, the reflection albedo .alpha. defined as the ratio of scattering coefficient ...
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    3. Northwestern University Receives NIH Grant for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography

      Northwestern University Receives NIH Grant for Oxygen Delivery and Metabolism in Diabetic Retinopathy Using Visible-Light Optical Coherence Tomography
      ... and inform future strategies for improved monitoring of the functional status of the retina in DR in humans. Northwestern University Receives a 2017 NIH Grant for $48,576 for Oxygen Delivery and Metabolism in Diabetic R...
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    4. Colposcopic imaging using visible-light optical coherence tomography

      Colposcopic imaging using visible-light optical coherence tomography
      High-resolution colposcopic optical coherence tomography (OCT) provides key anatomical measures, such as thickness and minor traumatic injury of vaginal epithelium, of the female reproductive tract noninvasively. This information can be helpful in both fundamental investigations in animal models and disease screenings in humans. We present a fiber-based visible-light OCT and two probe designs for colposcopic application. One probe conducts circular scanning using a DC motor, and the other probe is ...
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    5. Devices, methods, and systems of functional optical coherence tomography

      Devices, methods, and systems of functional optical coherence tomography
      The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide ...
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    6. Retinal oximetry in humans using visible-light optical coherence tomography [Invited]

      Retinal oximetry in humans using visible-light optical coherence tomography [Invited]
      We measured hemoglobin oxygen saturation (sO 2 ) in the retinal circulation in healthy humans using visible-light optical coherence tomography (vis-OCT). The measurements showed clear oxygenation differences between central retinal arteries and veins close to the optic nerve head. Spatial variations at different vascular branching levels were also revealed. In addition, we presented theoretical and experimental results to establish that noises in OCT intensity followed Rice distribution. We used this knowledge ...
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    7. Feature Of The Week 10/16/2016: Real-time Functional Analysis of Inertial Microfluidic Devices via Spectral Domain Optical Coherence Tomography

      Feature Of The Week 10/16/2016: Real-time Functional Analysis of Inertial Microfluidic Devices via Spectral Domain Optical Coherence Tomography
      ...tial microfluidic particle sorting devices. For more information see recent Article . Courtesy Cheng Sun from Northwestern University . Inertial microfluidic devices have recently attracted considerable interest due to t...
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    8. Real-time Functional Analysis of Inertial Microfluidic Devices via Spectral Domain Optical Coherence Tomography

      Real-time Functional Analysis of Inertial Microfluidic Devices via Spectral Domain Optical Coherence Tomography
      We report the application of spectral-domain optical coherence tomography (SD-OCT) technology that enables real-time functional analysis of sorting microparticles and cells in an inertial microfluidic device. We demonstrated high-speed, high-resolution acquisition of cross-sectional images at a frame rate of 350Hz, with a lateral resolution of 3m and an axial resolution of 1m within the microfluidic channel filled with water. We analyzed the temporal sequence of cross-sectional SD-OCT images to determine ...
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    9. Choroidal Findings in Eyes With Birdshot Chorioretinitis Using Enhanced-Depth Optical Coherence Tomography

      Choroidal Findings in Eyes With Birdshot Chorioretinitis Using Enhanced-Depth Optical Coherence Tomography
      Purpose : The purposes of this study were to describe choroidal findings observed using optical coherence tomography with enhanced depth imaging (EDI-OCT) in eyes with birdshot chorioretinitis (BSCR) and to test the hypothesis that these findings are related to participant demographics, clinical characteristics, and treatment. Methods : In a multicenter, cross-sectional study, 172 eyes of 86 individuals with BSCR underwent a standardized clinical evaluation, including defined protocols for EDI-OCT imaging, with macular ...
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    10. Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography

      Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography
      In cancer biology, there has been a recent effort to understand tumor formation in the context of the tissue microenvironment. In particular, recent progress has explored the mechanisms behind how changes in the cell-extracellular matrix ensemble influence progression of the disease. The extensive use of in vitro tissue culture models in simulant matrix has proven effective at studying such interactions, but modalities for non-invasively quantifying aspects of these systems are ...
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    11. Optical coherence photoacoustic microscopy

      Optical coherence photoacoustic microscopy
      A system and method for providing an optical coherence photoacoustic (OC-PAM) microscopy. An OC-PAM microscope includes a light source that outputs light, a scanner, a detector, a transducer, and an image processing module. The scanner receives the light and scans the light across a sample. The detector receives reflected light from the sample in response to the scanned light. The transducer detects photoacoustic waves induced in the sample by the ...
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    12. Imaging hemodynamic response after ischemic stroke in mouse cortex using visible-light optical coherence tomography

      Imaging hemodynamic response after ischemic stroke in mouse cortex using visible-light optical coherence tomography
      Visible-light optical coherence tomography (Vis-OCT) is an emerging technology that can image hemodynamic response in microvasculature. Vis-OCT can retrieve blood oxygen saturation (sO 2 ) mapping using intrinsic optical absorption contrast while providing high-resolution anatomical vascular structures at the same time. To improve the accuracy of Vis-OCT oximetry on vessels embedded in highly scattering medium, i.e., brain cortex, we developed and formulated a novel dual-depth sampling and normalization strategy that ...
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    13. Macular Effects of Silicone Oil Tamponade: Optical Coherence Tomography Findings During and After Silicone Oil Removal

      Macular Effects of Silicone Oil Tamponade: Optical Coherence Tomography Findings During and After Silicone Oil Removal
      Objective : To investigate retinal morphologic changes during silicone oil tamponade and after its removal using spectral domain OCT (SD-OCT) imaging. Materials and Methods : Retrospective review of 12 patients who underwent silicone oil tamponade for repair of retinal detachments. Macular OCT scans and volumetric thickness maps were examined qualitatively and quantitatively. Results : Volumetric OCT revealed two distinct patterns during silicone oil: macular thickening (Group A) and macular thinning (Group B). In ...
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    14. 1-15 of 87 1 2 3 4 5 6 »
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  2. About Northwestern University

    Northwestern University

    Northwestern University is a private research university located in Evanston, Illinois and downtown Chicago, Illinois.  Several of Northwestern's professional schools such as the School of Law, the Feinberg School of Medicine, and parts of the Kellogg School of Management are located in the Streeterville neighborhood of downtown Chicago. 

    Biophotonics Laboratory at Northwestern University.  The main direction of the Biophotonics laboratory (Principal Investigator: Prof. Vadim Backman) is the development of novel optical spectral and imaging techniques for non-invasive screening, diagnosis and detection of disease as well as characterization of biological and bioengineered tissue.