1. Northwestern University

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    1. Mentioned In 101 Articles

    2. Importance of Considering the Middle Capillary Plexus on OCT Angiography in Diabetic Retinopathy

      Importance of Considering the Middle Capillary Plexus on OCT Angiography in Diabetic Retinopathy
      Purpose : To quantify microvasculature changes in the superficial (SCP), middle (MCP), and deep capillary plexuses (DCP) in diabetic retinopathy (DR). Methods : Retrospective cross-sectional study at a tertiary academic referral center, in which 26 controls (44 eyes), 27 diabetic subjects without retinopathy (44 eyes), 32 subjects with nonproliferative retinopathy (52 eyes), and 27 subjects with proliferative retinopathy (40 eyes) were imaged with optical coherence tomography angiography (OCTA). Outcome measures included parafoveal ...
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    3. MULTILEVEL ISCHEMIA IN DISORGANIZATION OF THE RETINAL INNER LAYERS ON PROJECTION-RESOLVED OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      MULTILEVEL ISCHEMIA IN DISORGANIZATION OF THE RETINAL INNER LAYERS ON PROJECTION-RESOLVED OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
      Purpose: To examine the relationship between ischemia and disorganization of the retinal inner layers ( DRIL ). Methods: Cross-sectional retrospective study of 20 patients (22 eyes) with diabetic retinopathy presenting to a tertiary academic referral center, who had DRIL on structural optical coherence tomography ( OCT ) using Spectralis HRA + OCT (Heidelberg Engineering, Heidelberg, Germany) and OCT angiography with XR Avanti (Optovue Inc, Fremont, CA) on the same day. Optical coherence tomography angiography images ...
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    4. Optical Coherence Tomography Angiography In ADULT-ONSET Foveomacular Vitelliform Dystrophy

      Optical Coherence Tomography Angiography In ADULT-ONSET Foveomacular Vitelliform Dystrophy
      Purpose: To determine the ability of optical coherence tomography angiography (OCTA) to detect choroidal neovascularization (CNV) in the pseudohypopyon stage of adult-onset foveomacular vitelliform dystrophy. Methods: Prospective case series of eight consecutive patients with adult-onset foveomacular vitelliform dystrophy with at least one eye in the pseudohypopyon stage (a total of 14 eyes). Patients were assessed with spectral domain OCT, flourescein angiography, and OCTA. Main outcome measures were the presence or ...
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    5. In vivo broadband visible light optical coherence tomography probe enables inverse spectroscopic analysis

      In vivo broadband visible light optical coherence tomography probe enables inverse spectroscopic analysis
      We report the design and characterization of a 6 mm outer diameter pull-back circumferential scanning visible optical coherence tomography probe. The probes large visible bandwidth (500695 nm) allowed for inverse spectroscopic analysis and an axial resolution of 1.1 m 1.1m in tissue. We verify spectral imaging capabilities by measuring microsphere backscattering spectra and demonstrate in vivo spatial nanoscale characterization of tissue.
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    6. Visible-light optical coherence tomography: a review

      Visible-light optical coherence tomography: a review
      Visible-light optical coherence tomography (vis-OCT) is an emerging imaging modality, providing new capabilities in both anatomical and functional imaging of biological tissue. It relies on visible light illumination, whereas most commercial and investigational OCTs use near-infrared light. As a result, vis-OCT requires different considerations in engineering design and implementation but brings unique potential benefits to both fundamental research and clinical care of several diseases. Here, we intend to provide a ...
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    7. Small Hyperreflective Intraretinal Material Observable on Spectral-Domain Optical Coherence Tomography in High Myopia

      Small Hyperreflective Intraretinal Material Observable on Spectral-Domain Optical Coherence Tomography in High Myopia
      With the rapid adoption of spectraldomain optical coherence tomography (SD-OCT) in clinical practice and recent advances in technology, SD-OCT has become an important tool for detecting and managing retinal pathology. The diagnosis of degenerative changes in pathologic myopia can sometimes be difficult and delayed, as the clinical presentation may be subtle. In this series, SD-OCT proved useful in the detection of small hyperreflective intraretinal material in cases in which retinal ...
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    8. RESIDUAL CHOROIDAL VESSELS IN ATROPHY CAN MASQUERADE AS CHOROIDAL NEOVASCULARIZATION ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY: Introducing a Clinical and Software Approach

      RESIDUAL CHOROIDAL VESSELS IN ATROPHY CAN MASQUERADE AS CHOROIDAL NEOVASCULARIZATION ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY: Introducing a Clinical and Software Approach
      Purpose: To present a postprocessing approach in optical coherence tomography angiography (OCTA) to facilitate the visualization and interpretation of lesions in age-related macular degeneration with coexisting atrophy and choroidal neovascularization (CNV). Methods: This retrospective study included 32 eyes of 26 patients with atrophy and treated CNV and 8 eyes with treatment-naive geographic atrophy. En face optical coherence tomography slabs highlighting atrophy were pseudocolored and merged with the corresponding OCTA. Cross-sectional ...
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    9. OCT Angiography Imaging in Serpiginous Choroidopathy

      OCT Angiography Imaging in Serpiginous Choroidopathy
      Purpose To report OCTA findings in 3 cases, 2 active and 1 inactive, of serpiginous choroidopathy (SC) and describe OCTA changes in response to treatment. Design Retrospective case series. Participants We studied 6 eyes of 3 patients with SC. Methods Retrospective case series of 3 patients with SC undergoing multimodal imaging, including OCTA. In 1 treated eye, both pre- and posttreatment images were compared. Main Outcome Measures Description of OCTA ...
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    10. Spectroscopic Doppler analysis for visible-light optical coherence tomography

      Spectroscopic Doppler analysis for visible-light optical coherence tomography
      Retinal oxygen metabolic rate can be effectively measured by visible-light optical coherence tomography (vis-OCT), which simultaneously quantifies oxygen saturation and blood flow rate in retinal vessels through spectroscopic analysis and Doppler measurement, respectively. Doppler OCT relates phase variation between sequential A-lines to the axial flow velocity of the scattering medium. The detectable phase shift is between and due to its periodicity, which limits the maximum measurable unambiguous velocity without phase ...
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    11. Opticent Receives NIH Grant for Method for Accurate Retinal Oxygen Metabolic Rate Extraction

      Opticent Receives NIH Grant for Method for Accurate Retinal Oxygen Metabolic Rate Extraction
      ... has the potential to significantly improve the management of proliferative DR. Prof. Hao F. Zhang’s group at Northwestern University demonstrated in 2013 that visible light optical coherence tomography (vis-OCT) can acc...
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    12. Methodology for Image-driven High-resolution Additive Manufacturing Using Discretized Data Set

      Methodology for Image-driven High-resolution Additive Manufacturing Using Discretized Data Set
      Additive manufacturing of patient-specific biomedical devices from 3D medical scans involves several steps of conversion which can introduce error into the final part. This is particularly critical to the fabrication of minute anatomical features, such as microvasculature. We show a direct conversion of the raw optical coherence tomography (OCT) volumetric data into photomasks in bitmap format, which streamlines the typical process steps used in 3D printing medical scans. OCT scans ...
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    13. Optical coherence tomography angiography of retinal vascular occlusions produced by imaging-guided laser photocoagulation

      Optical coherence tomography angiography of retinal vascular occlusions produced by imaging-guided laser photocoagulation
      Retinal vascular occlusive diseases represent a major form of vision loss worldwide. Rodent models of these diseases have traditionally relied upon a slit-lamp biomicroscope to help visualize the fundus and subsequently aid delivery of high-power laser shots to a target vessel. Here we describe a multimodal imaging system that can produce, image, and monitor retinal vascular occlusions in rodents. The system combines a spectral-domain optical coherence tomography system for cross-sectional ...
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    14. Biological tissue analysis by inverse spectroscopic optical coherence tomography

      Biological tissue analysis by inverse spectroscopic optical coherence tomography
      A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (ISOCT) is disclosed. Tissue is modeled as a medium with continuous refractive index (RI) fluctuation and such a fluctuation is described by the RI correlation functions. By measuring optical quantities of tissue (including the scattering power of the OCT spectrum, the reflection albedo .alpha. defined as the ratio of scattering coefficient ...
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  2. About Northwestern University

    Northwestern University

    Northwestern University is a private research university located in Evanston, Illinois and downtown Chicago, Illinois.  Several of Northwestern's professional schools such as the School of Law, the Feinberg School of Medicine, and parts of the Kellogg School of Management are located in the Streeterville neighborhood of downtown Chicago. 

    Biophotonics Laboratory at Northwestern University.  The main direction of the Biophotonics laboratory (Principal Investigator: Prof. Vadim Backman) is the development of novel optical spectral and imaging techniques for non-invasive screening, diagnosis and detection of disease as well as characterization of biological and bioengineered tissue.