1. Norman S. Nishioka

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    1. Mentioned In 23 Articles

    2. Clinical Translation of Tethered Confocal Microscopy Capsule for Unsedated Diagnosis of Eosinophilic Esophagitis

      Clinical Translation of Tethered Confocal Microscopy Capsule for Unsedated Diagnosis of Eosinophilic Esophagitis
      Esophagogastroduodenoscopy (EGD) is a widely used procedure, posing significant financial burden on both healthcare systems and patients. Moreover, EGD is time consuming, sometimes difficult to tolerate, and suffers from an imperfect diagnostic yield as the limited number of collected biopsies does not represent the whole organ. In this paper, we report on technological and clinical feasibility of a swallowable tethered endomicroscopy capsule, which is administered without sedation, to image large ...
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    3. Optical coherence tomography in gastroenterology: a review and future outlook

      Optical coherence tomography in gastroenterology: a review and future outlook
      Optical coherence tomography (OCT) is an imaging technique optically analogous to ultrasound that can generate depth-resolved images with micrometer-scale resolution. Advances in fiber optics and miniaturized actuation technologies allow OCT imaging of the human body and further expand OCT utilization in applications including but not limited to cardiology and gastroenterology. This review article provides an overview of current OCT development and its clinical utility in the gastrointestinal tract, including disease ...
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    4. Automated segmentation and characterization of esophageal wall in vivo by tethered capsule optical coherence tomography endomicroscopy

      Automated segmentation and characterization of esophageal wall in vivo by tethered capsule optical coherence tomography endomicroscopy
      Optical coherence tomography (OCT) is an optical diagnostic modality that can acquire cross-sectional images of the microscopic structure of the esophagus, including Barretts esophagus (BE) and associated dysplasia. We developed a swallowable tethered capsule OCT endomicroscopy (TCE) device that acquires high-resolution images of entire gastrointestinal (GI) tract luminal organs. This device has a potential to become a screening method that identifies patients with an abnormal esophagus that should be further ...
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    5. Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof

      Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof
      Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second ...
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    6. Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study

      Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study
      Background Biopsy surveillance protocols for the assessment of Barrett's esophagus can be subject to sampling errors, resulting in diagnostic uncertainty. Optical coherence tomography is a cross-sectional imaging technique that can be used to conduct volumetric laser endomicroscopy (VLE) of the entire distal esophagus. We have developed a biopsy guidance platform that places endoscopically visible marks at VLE-determined biopsy sites. Objective The objective of this study was to demonstrate in ...
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    7. 3D imaging for faster diagnosis of esophageal disease

      3D imaging for faster diagnosis of esophageal disease
      A tethered capsule that is swallowed by the patient offers a quick and pain-free method of screening and diagnosing gastrointestinal diseases. Diagnosing gastrointestinal (GI) diseases usually involves endoscopy, combining an invasive probe and video imaging or other optical methods. While effective, this method often causes patient discomfort and typically requires anesthesia, making it costly and time-consuming. Here we describe a new option for screening using a swallowable optomechanically engineered pill ...
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    8. CBORT 2013 OCT Symposium July 29th at Harvard Medical School Cambridge MA, USA

      CBORT 2013 OCT Symposium July 29th at Harvard Medical School Cambridge MA, USA
      OCT2013 the first international symposium hosted by the Center for Biomedical OCT Research and Translation at Harvard Medical School and Massachusetts General Hospital, will focus on the latest and greatest technical capabilities of OCT, provide an overview of the commercially available OCT systems, discuss advancements in numerous clinical application areas, and introduce emerging preclinical optical imaging techniques. The unique emphasis of technology and clinical utility presented in the symposium will ...
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    9. Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure

      Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure
      Here we introduce tethered capsule endomicroscopy, which involves swallowing an optomechanically engineered pill that captures cross-sectional microscopic images of the gut wall at 30 m (lateral) 7 m (axial) resolution as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for internal diseases.
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    10. NinePoint Medical Announces Formation of Clinical and Technology Advisory Boards

      NinePoint Medical Announces Formation of Clinical and Technology Advisory Boards
      ... endoscopic surveillance. He also serves as a specialist adviser to the UK Department of Health and NICE. -- Norman S. Nishioka, M.D., is a gastroenterologist at Massachusetts General Hospital and an associate professor...
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    11. Optical frequency domain imaging system and catheters for volumetric imaging of the human esophagus

      Optical frequency domain imaging system and catheters for volumetric imaging of the human esophagus
      Barrett's esophagus (BE) is a metaplastic disorder that can undergo dysplastic progression, leading to esophageal adenocarcinoma. Upper endoscopy is the standard of care for screening for BE, but this technique has a relatively low diagnostic accuracy and high cost due to the requirement of conscious sedation. Optical frequency domain imaging (OFDI) is a high-speed imaging modality that generates cross-sectional images of tissues with a resolution of approximately 10m that ...
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    12. Optical Coherence Tomography (OCT) Based Screening of Esophagus and Gastroesophageal Junction

      Optical Coherence Tomography (OCT) Based Screening of Esophagus and Gastroesophageal Junction
      The specific aim of this study is to determine the accuracy of Optical Coherence Tomography (OCT) imaging for screening and diagnosis of the distal esophagus in patients undergoing a clinical EGD procedure. The accuracy of results obtained using the developed OCT imaging probe will be determined and compared with those obtained through the traditional standard of care endoscopic biopsy. Three hundred consenting patients undergoing routine esophagogastroduodenoscopy (EGD) procedures will be ...
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    13. Barrett's Esophagus Screening Using Balloon-Based Optical Frequency Domain Imaging: A Comparison With Endoscopy

      ...Screening Using Balloon-Based Optical Frequency Domain Imaging: A Comparison With Endoscopy Melissa J. Suter, Norman S. Nishioka, Hongki Yoo, Mari Mino-Kenudson, Gregory Y. Lauwers, Benjamin J. Vakoc, Brett E. Bouma, Gui...
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    14. Combined Reflection Confocal Microscopy and Optical Coherence Tomography Imaging of Esophageal Biopsy

      Reflection confocal microscopy (RCM) and optical coherence tomography (OCT) are two non-contact optical imaging technologies that provide images of tissue cellular and architectural morphology, which are both used for histopathologic diagnosis. We have developed a combined RCM and OCT system to compare the accuracy of these imaging techniques for diagnosing esophageal pathology and to evaluate the potential utility of merging the two modalities into a single imaging system. Clinical study ...
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    15. 1-15 of 23 1 2 »
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  2. About Norman S. Nishioka

    Norman S. Nishioka

    Norman Shizuaki Nishioka is with the Gastrointestinal Unit and Wellman Center for Photomedicine at Massachusetts General Hospital  at Harvard Medical School.