1. Norman S. Nishioka

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    1. Mentioned In 26 Articles

    2. Balloon catheter-based radiofrequency ablation monitoring in porcine esophagus using optical coherence tomography

      Explore OSA | OSA Publishing Gastroenterology , Probes
      Balloon catheter-based radiofrequency ablation monitoring in porcine esophagus using optical coherence tomography
      We present a microscopic image guidance platform for radiofrequency ablation (RFA) using a clinical balloon-catheter-based optical coherence tomography (OCT) system, currently used in the surveillance of Barretts esophagus patients. Our integrated thermal therapy delivery and monitoring platform consists of a flexible, customized bipolar RFA electrode array designed for use with a clinical balloon OCT catheter and a processing algorithm to accurately map the thermal coagulation process. Non-uniform rotation distortion was ...
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      Mentions: Brett E. Bouma Massachusetts Institute of Technology Massachusetts General Hospital

    3. Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients

      Explore OSA | OSA Publishing Gastroenterology
      Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients
      Tethered capsule endomicroscopy (TCE) is an emerging screening technology that comprehensively obtains microstructural OCT images of the gastrointestinal (GI) tract in unsedated patients. To advance clinical adoption of this imaging technique, it will be important to validate TCE images with co-localized histology, the current diagnostic gold standard. One method for co-localizing OCT images with histology is image-targeted laser marking, which has previously been implemented using a driveshaft-based, balloon OCT catheter ...
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      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    4. Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy

      Explore SPIE Digital Library Gastroenterology
      Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy
      Tethered capsule endomicroscopy (TCE) is a new method for performing comprehensive microstructural OCT imaging of gastrointestinal (GI) tract in unsedated patients in a well-tolerated and cost-effective manner. These features of TCE bestow it with significant potential to improve the screening, surveillance and management of various upper gastrointestinal diseases. To achieve clinical adoption of this imaging technique, it is important to validate it with co-registered histology, the current diagnostic gold standard ...
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      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    5. Clinical Translation of Tethered Confocal Microscopy Capsule for Unsedated Diagnosis of Eosinophilic Esophagitis

      Explore Nature Publishing Group Gastroenterology , Microscopy
      Clinical Translation of Tethered Confocal Microscopy Capsule for Unsedated Diagnosis of Eosinophilic Esophagitis
      Esophagogastroduodenoscopy (EGD) is a widely used procedure, posing significant financial burden on both healthcare systems and patients. Moreover, EGD is time consuming, sometimes difficult to tolerate, and suffers from an imperfect diagnostic yield as the limited number of collected biopsies does not represent the whole organ. In this paper, we report on technological and clinical feasibility of a swallowable tethered endomicroscopy capsule, which is administered without sedation, to image large ...
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      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    6. Optical coherence tomography in gastroenterology: a review and future outlook

      Explore SPIE Digital Library Gastroenterology
      Optical coherence tomography in gastroenterology: a review and future outlook
      Optical coherence tomography (OCT) is an imaging technique optically analogous to ultrasound that can generate depth-resolved images with micrometer-scale resolution. Advances in fiber optics and miniaturized actuation technologies allow OCT imaging of the human body and further expand OCT utilization in applications including but not limited to cardiology and gastroenterology. This review article provides an overview of current OCT development and its clinical utility in the gastrointestinal tract, including disease ...
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      Mentions: Columbia University Massachusetts General Hospital Harvard University

    7. Automated segmentation and characterization of esophageal wall in vivo by tethered capsule optical coherence tomography endomicroscopy

      Explore OSA | OSA Publishing Gastroenterology , Probes
      Automated segmentation and characterization of esophageal wall in vivo by tethered capsule optical coherence tomography endomicroscopy
      Optical coherence tomography (OCT) is an optical diagnostic modality that can acquire cross-sectional images of the microscopic structure of the esophagus, including Barretts esophagus (BE) and associated dysplasia. We developed a swallowable tethered capsule OCT endomicroscopy (TCE) device that acquires high-resolution images of entire gastrointestinal (GI) tract luminal organs. This device has a potential to become a screening method that identifies patients with an abnormal esophagus that should be further ...
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      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    8. Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof

      Explore uspto.gov Patents , Probes
      Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof
      Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second ...
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      Mentions: Guillermo J. Tearney Brett E. Bouma Massachusetts General Hospital

    9. Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study

      Explore Gastrointestinal Endoscopy Gastroenterology
      Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study
      Background Biopsy surveillance protocols for the assessment of Barrett's esophagus can be subject to sampling errors, resulting in diagnostic uncertainty. Optical coherence tomography is a cross-sectional imaging technique that can be used to conduct volumetric laser endomicroscopy (VLE) of the entire distal esophagus. We have developed a biopsy guidance platform that places endoscopically visible marks at VLE-determined biopsy sites. Objective The objective of this study was to demonstrate in ...
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      Mentions: Guillermo J. Tearney Brett E. Bouma Massachusetts General Hospital

    11. 3D imaging for faster diagnosis of esophageal disease

      Explore Home: SPIE.org Gastroenterology
      3D imaging for faster diagnosis of esophageal disease
      A tethered capsule that is swallowed by the patient offers a quick and pain-free method of screening and diagnosing gastrointestinal diseases. Diagnosing gastrointestinal (GI) diseases usually involves endoscopy, combining an invasive probe and video imaging or other optical methods. While effective, this method often causes patient discomfort and typically requires anesthesia, making it costly and time-consuming. Here we describe a new option for screening using a swallowable optomechanically engineered pill ...
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      Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University

    12. CBORT 2013 OCT Symposium July 29th at Harvard Medical School Cambridge MA, USA

      Explore Optical Coherence Tomography News
      CBORT 2013 OCT Symposium July 29th at Harvard Medical School Cambridge MA, USA
      OCT2013 the first international symposium hosted by the Center for Biomedical OCT Research and Translation at Harvard Medical School and Massachusetts General Hospital, will focus on the latest and greatest technical capabilities of OCT, provide an overview of the commercially available OCT systems, discuss advancements in numerous clinical application areas, and introduce emerging preclinical optical imaging techniques. The unique emphasis of technology and clinical utility presented in the symposium will ...
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      Mentions: Brett E. Bouma Johannes F. de Boer Seok-Hyun Yun

    14. Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure

      Explore Nature Publishing Group Gastroenterology
      Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure
      Here we introduce tethered capsule endomicroscopy, which involves swallowing an optomechanically engineered pill that captures cross-sectional microscopic images of the gut wall at 30 m (lateral) 7 m (axial) resolution as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for internal diseases.
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      Mentions: Guillermo J. Tearney Brett E. Bouma Massachusetts General Hospital

    15. NinePoint Medical Announces Formation of Clinical and Technology Advisory Boards

      Explore Optical Coherence Tomography News Gastroenterology , Other Business News
      NinePoint Medical Announces Formation of Clinical and Technology Advisory Boards
      ... endoscopic surveillance. He also serves as a specialist adviser to the UK Department of Health and NICE. -- Norman S. Nishioka, M.D., is a gastroenterologist at Massachusetts General Hospital and an associate professor...
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      Mentions: Guillermo J. Tearney Brett E. Bouma University of Pittsburgh

    16. Optical frequency domain imaging system and catheters for volumetric imaging of the human esophagus

      Explore Photonics Society of Poland Gastroenterology , Oncology
      Optical frequency domain imaging system and catheters for volumetric imaging of the human esophagus
      Barrett's esophagus (BE) is a metaplastic disorder that can undergo dysplastic progression, leading to esophageal adenocarcinoma. Upper endoscopy is the standard of care for screening for BE, but this technique has a relatively low diagnostic accuracy and high cost due to the requirement of conscious sedation. Optical frequency domain imaging (OFDI) is a high-speed imaging modality that generates cross-sectional images of tissues with a resolution of approximately 10m that ...
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      Mentions: Guillermo J. Tearney Brett E. Bouma Massachusetts Institute of Technology
    17. 1-15 of 26 1 2 »
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  4. About Norman S. Nishioka

    Norman S. Nishioka

    Norman Shizuaki Nishioka is with the Gastrointestinal Unit and Wellman Center for Photomedicine at Massachusetts General Hospital  at Harvard Medical School.

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