1. Nizhny Novgorod State Medical Academy

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    1. Mentioned In 64 Articles

    2. Effects of gamma irradiation on collagen damage and remodeling

      Effects of gamma irradiation on collagen damage and remodeling
      Purpose: The studys objective was to evaluate the dose-time dependences of structural changes occurring in collagen within 24 hours to three months after gamma-irradiation at doses from 2 to 40 Gy in vivo . Materials and methods: Rat's tail tendon was chosen as in vivo model, with its highly ordered collagen structure allowing the changes to be interpreted unambiguously. Macromolecular level (I) was investigated by differential scanning calorimetry (DSC); fibers ...
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    3. Recent Trends in Multimodal Optical Coherence Tomography. II. The Correlation-Stability Approach in OCT Elastography and Methods for Visualization of Microcirculation

      Recent Trends in Multimodal Optical Coherence Tomography. II. The Correlation-Stability Approach in OCT Elastography and Methods for Visualization of Microcirculation
      The second part of this paper continues the discussion of possibilities for combining functionally different types of biomedical characterization of tissues using optical coherence tomography (OCT). In the first part, polarization-sensitive imaging and conventional approaches to elastographic mapping in OCT were considered. Here, we consider an unconventional approach to elastographic mapping based on the analysis of variability of OCT images of the deformed tissue, omitting the stage of the displacement-field ...
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    4. A model for simulating speckle-pattern evolution based on close to reality procedures used inspectral-domain OCT

      A model for simulating speckle-pattern evolution based on close to reality procedures used inspectral-domain OCT
      A robust model for simulating speckle-pattern evolution in optical coherence tomography (OCT) depending on the OCT system parameters and tissue deformation is reported. The model is based on the application of close to reality procedures used in spectral-domain OCT scanners. It naturally generates images reproducing properties of real images in spectral-domain OCT, including the pixelized structure and finite depth of unambiguous imaging, influence of the optical spectrum shape, dependence on ...
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    5. Speckle statistics in OCT images: Monte Carlo simulations and experimental studies

      Speckle statistics in OCT images: Monte Carlo simulations and experimental studies
      The speckle pattern of an optical coherence tomography (OCT) image carries potentially useful sample information that may assist in tissue characterization. Recent biomedical resultsin vivoindicate that the distribution of signal intensities within an OCT tissue image is well described by a log-normal-like (Gamma) function. To fully understand and exploit this finding, an OCT Monte Carlo model that accounts for speckle effects was developed. The resultant Monte Carlo speckle statistics predictions ...
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    6. Combining the correlation-stability approach to OCT elastography with the speckle-variance evaluation for quantifying the stiffness differences

      Combining the correlation-stability approach to OCT elastography with the speckle-variance evaluation for quantifying the stiffness differences
      We discuss an advanced variant of the correlation-stability (CS) approach to OCT elastography that is capable of quantifying the stiffness differences. The modified variant is based on natural combination of CS approach with the speckle-variance (SV) approach. It allows one to determine the strain dependence of the normalized speckle intensity variance function for two compared subsets taken from the OCT images corresponding to the initial and deformed states of the ...
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    7. Towards free-hand implementation of OCT elastography: displacement-based approaches versus correlation-stability ones

      Towards free-hand implementation of OCT elastography: displacement-based approaches versus correlation-stability ones
      In this report, we present a comparative discussion of a recently proposed method of elastographic mapping based on comparison of correlation stability (CS) of different parts of sequentially obtained OCT images of the strained tissue and more conventional correlation approaches to elastographic mapping based on the initial reconstruction of the displacement field. The performed study is based on numerical simulations of speckle patterns generated by reproducing main features of image ...
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    8. Method of optical coherence tomography with parallel depth-resolved signal reception and fibre-optic phase modulators

      Method of optical coherence tomography with parallel depth-resolved signal reception and fibre-optic phase modulators
      The method of optical coherence tomography with the scheme of parallel reception of the interference signal (P-OCT) is developed on the basis of spatial paralleling of the reference wave by means of a phase diffraction grating producing the appropriate time delay in the MachZehnder interferometer. The absence of mechanical variation of the optical path difference in the interferometer essentially reduces the time required for 2D imaging of the object internal ...
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    9. Elastographic mapping in optical coherence tomography using an unconventional approach based on correlation stability

      Elastographic mapping in optical coherence tomography using an unconventional approach based on correlation stability
      An approach to elastographic mapping in optical coherence tomography (OCT) using comparison of correlation stability of sequentially obtained intensity OCT images of the studied strained tissue is discussed. The basic idea is that for stiffer regions, the OCT image is distorted to a smaller degree. Consequently, cross-correlation maps obtained with compensation of trivial translational motion of the image parts using a sliding correlation window can represent the spatial distribution of ...
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    10. Morphological changes in skin of different phototypes under the action of topical corticosteroid therapy and tacrolimus

      Morphological changes in skin of different phototypes under the action of topical corticosteroid therapy and tacrolimus
      ...steroid therapy and tacrolimus. Skin Research and Technology. doi: 10.1111/srt.12095 Author Information 1. ^1 Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russia 2. ^2 Institute of Applied Physics of RAS, Nizh...
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    11. Combined use of fluorescence cystoscopy and cross-polarization OCT for diagnosis of bladder cancer and correlation with immunohistochemical markers

      Combined use of fluorescence cystoscopy and cross-polarization OCT for diagnosis of bladder cancer and correlation with immunohistochemical markers
      The combined use of fluorescence cystoscopy and cross-polarization optical coherence tomography (CP OCT) with quantitative estimation of the OCT signal was assessed in 92 bladder zones. It demonstrated the diagnostic accuracy in detecting superficial bladder cancer of 93.6%, sensitivity 96.4%, specificity 92.1%, positive predictive value 87% and negative predictive value 97.9%. Quantitative estimation of OCT signal standard deviation in cross-polarization (CP OCT SD index) makes the ...
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    12. Dual instrument for in vivo and ex vivo OCT imaging in an ENT department

      Dual instrument for in vivo and ex vivo OCT imaging in an ENT department
      A dual instrument is assembled to investigate the usefulness of optical coherence tomography (OCT) imaging in an ear, nose and throat (ENT) department. Instrument 1 is dedicated to in vivo laryngeal investigation, based on an endoscope probe head assembled by compounding a miniature transversal flying spot scanning probe with a commercial fiber bundle endoscope. This dual probe head is used to implement a dual channel nasolaryngeal endoscopy-OCT system. The two ...
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    13. Feature Of The Week 9/16/12: Institute of Applied Physics/Russian Academy of Sciences Investigates Criteria for Pathology Recognition in Optical Coherence Tomography of Fallopian Tubes

      Feature Of The Week 9/16/12: Institute of Applied Physics/Russian Academy of Sciences Investigates Criteria for Pathology Recognition in Optical Coherence Tomography of Fallopian Tubes
      The problems of revealing causes of infertility and chronic pelvic pains are currently of great significance. The World Health Organization (WHO) reports on the level of infertile marriages which grew up to 12-18% worldwide in the recent 2-3 decades and its classification includes unexplained infertility, when there are no visible objective causes of impairment of reproductive function. On the one hand, unexplained infertility is associated with prevalence of asymptomatic and ...
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    14. Evaluation of oral mucosa collagen condition with cross-polarization optical coherence tomography

      Evaluation of oral mucosa collagen condition with cross-polarization optical coherence tomography
      The goal of the research was analysis of the effect of collagen condition in formation of cross-polarized CP OCT images. We used of the CP OCT technique for studying collagen condition on an example of oral mucosa. Special histologic picrosirius red (PSR) staining of cheek mucosa specimens was used with subsequent assessing of the result of collagen staining in polarized light. High correlation (r = 0.692, p = 0.0001) between ...
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    15. Complex assessment of age-specific morphofunctional features of skin of different anatomic localizations

      Complex assessment of age-specific morphofunctional features of skin of different anatomic localizations
      ...c localizations. Skin Research and Technology. doi: 10.1111/j.1600-0846.2012.00613.x Author Information 1. ^1 Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russia 2. ^2 Institute of Applied Physics of RAS, Nizh...
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    16. Laser hyperthermia of tumors using gold nanoparticles monitored by optical coherence tomography and acoustic thermometry

      Laser hyperthermia of tumors using gold nanoparticles monitored by optical coherence tomography and acoustic thermometry
      Local laser hyperthermia of grafted RShM-5 tumors in mice with the use of plasmon resonant gold nanoparticles has been carried out. Accumulation of particles in the tumor was monitored in vivo noninvasively by optical coherence tomography. Thereby it was determined that the maximal content of nanoparticles in the tumor was reached within 5 h after intravenous administration, and laser hyperthermia was performed at this time. Monitoring the tumor temperature during ...
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  2. About Nizhny Novgorod State Medical Academy

    Nizhny Novgorod State Medical Academy

    Nizhny Novgorod State Medical Academy is one of the medical schools in Russia which is located in the city of Nizhny Novgorod. This medical school is currently ranked number 7 out of 46 higher medical institutions in Russia, acknowledged by World Health Organization and is recognized by the governments of some other countries which send their students to this academy for medical education and training. This academy also is associated with many teaching hospitals distributed throughout the city, where the students learn many basic clinical skills. The administrative office of the academy is situated in Minin and Pozharsky Square (located alongside the Volga River and the medical students live in dormitories on Meditsinskaya Street in Prioksky City District.