1. Nippon Medical School

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    1. Mentioned In 52 Articles

    2. Postprandial Hyperchylomicronemia and Thin-Cap Fibroatheroma in Nonculprit Lesions A Multivessel Optical Coherence Tomography Study

      Postprandial Hyperchylomicronemia and Thin-Cap Fibroatheroma in Nonculprit Lesions A Multivessel Optical Coherence Tomography Study
      Objective Although postprandial hypertriglyceridemia can be a risk factor for coronary artery disease, the extent of its significance remains unknown. This study aimed to investigate the correlation between the postprandial lipid profiles rigorously estimated with the meal tolerance test and the presence of lipid-rich plaque, such as thin-cap fibroatheroma (TCFA), in the nonculprit lesion. Approach and Results A total of 30 patients with stable coronary artery disease who underwent a ...
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    3. Postprandial Hyperchylomicronemia and Thin-Cap Fibroatheroma in Non-culprit Lesions: a Multivessel Optical Coherence Tomography Study

      Postprandial Hyperchylomicronemia and Thin-Cap Fibroatheroma in Non-culprit Lesions: a Multivessel Optical Coherence Tomography Study
      Objective: Although postprandial hypertriglyceridemia potentially plays a role as a risk factor for coronary artery disease (CAD), details of its significance remain unknown. This study aimed to investigate the correlation between the postprandial lipid profiles rigorously estimated with the meal tolerance test and the presence of lipid-rich plaque, such as thin-cap fibroatheroma (TCFA), in the non-culprit lesion. Methods: Thirty patients with stable CAD who underwent a multivessel study using optical ...
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    4. Relation of Coronary Culprit Lesion Morphology Determined by Optical Coherence Tomography and Cardiac Outcomes to Serum Uric Acid Levels in Patients with Acute Coronary Syndrome

      Relation of Coronary Culprit Lesion Morphology Determined by Optical Coherence Tomography and Cardiac Outcomes to Serum Uric Acid Levels in Patients with Acute Coronary Syndrome
      The aims of the current study were to elucidate features of culprit lesion plaque morphology using optical coherence tomography (OCT) in relation to elevated serum uric acid (sUA) levels and to clarify the impact of sUA levels on adverse clinical outcomes in patients with acute coronary syndrome (ACS). Clinical data and outcomes were compared between ACS patients with sUA 6 mg/dL (high-sUA; n=506) and sUA 6.0 mg ...
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    5. Features and Outcomes of Patients with Calcified Nodules at Culprit Lesions of Acute Coronary Syndrome: An Optical Coherence Tomography Study

      Features and Outcomes of Patients with Calcified Nodules at Culprit Lesions of Acute Coronary Syndrome: An Optical Coherence Tomography Study
      Objectives: We sought to clarify clinical features and outcomes related to calcified nodules (CN) compared with plaque rupture (PR) and plaque erosion (PE) detected by optical coherence tomography (OCT) at the culprit lesions in patients with acute coronary syndrome (ACS). Methods: Based on OCT findings for culprit lesion plaque morphologies, ACS patients with analyzable OCT images ( n = 362) were classified as CN, PR, PE, and other. Results: The prevalence of ...
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    6. Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study

      Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography : A 4-Year Follow-Up Study
      Background Lipid-rich plaque (LRP) is thought to be a precursor to cardiac events. However, its clinical significance in coronary arteries has never been systematically investigated. Objectives This study investigated the prevalence and clinical significance of LRP in the nonculprit region of the target vessel in patients undergoing percutaneous coronary intervention (PCI). Methods The study included 1,474 patients from 20 sites across 6 countries undergoing PCI, who had optical coherence ...
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    7. EuroIntervention Intravascular ultrasound and optical coherence tomography images for direct right coronary artery injury after tricuspid valve annuloplasty

      EuroIntervention Intravascular ultrasound and optical coherence tomography images for direct right coronary artery injury after tricuspid valve annuloplasty
      A 76-year-old female was admitted with dyspnoea and leg oedema. Echocardiography showed severe mitral and tricuspid valve regurgitation with marked right ventricular (RV) dilatation, and coronary angiography showed intact left and right coronary arteries (RCA) (Online Figure 1) . She was diagnosed with heart failure due to combined valvular disease and underwent tricuspid valve (the Kay bicuspidisation technique without ring) and mitral valve annuloplasty. After the operation, she suffered from myocardial ...
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    8. Optical coherence tomography visualisation of burst balloon catheter trapped by coronary stent

      Optical coherence tomography visualisation of burst balloon catheter trapped by coronary stent
      A 69-year-old man with prior anterior myocardial infarction underwent percutaneous coronary intervention for significant stenosis of the left anterior descending (LAD) artery. High-pressure inflation by non-compliant balloon was required because of severe calcification in the culprit lesion. The balloon ruptured during inflation and an angiographic filling defect appeared in the LAD. The balloon catheter was pulled out of the body and the tip and membranous part of the catheter was ...
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    9. Matrix Metalloproteinase-9 as a Marker for Plaque Rupture and a Predictor of Adverse Clinical Outcome in Patients with Acute Coronary Syndrome: An Optical Coherence Tomography Study

      Matrix Metalloproteinase-9 as a Marker for Plaque Rupture and a Predictor of Adverse Clinical Outcome in Patients with Acute Coronary Syndrome: An Optical Coherence Tomography Study
      Objectives: The present study sought to clarify the relationship between matrix metalloproteinase-9 (MMP-9) levels and plaque morphology demonstrated by optical coherence tomography (OCT), and to examine their prognostic impacts in patients with acute coronary syndrome (ACS). Methods: MMP-9 levels were measured for patients with ACS (n = 249). Among 249 patients, 120 with evaluable OCT images were categorized into patients with ruptured plaques (n = 65) and those with nonruptured plaques (n ...
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    10. Flow-limiting thrombosis after intracoronary coil embolisation: optical coherence tomography during acute myocardial infarction

      Flow-limiting thrombosis after intracoronary coil embolisation: optical coherence tomography during acute myocardial infarction
      A 75-year-old female was transferred to our hospital with sudden onset chest pain radiating to the left arm. She had a history of hypertension, chronic kidney disease treated with regular haemodialysis, and a prior anterior myocardial infarction. Electrocardiography upon admission showed ST-segment elevation in broad anterior leads. Previous coronary angiography had illustrated chronic total occlusion (CTO) at the mid-left anterior descending artery (LAD) and collateral flow from the 2nd diagonal ...
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    11. Target lesion evaluation by multiple modalities in vivo: near-infrared spectroscopy (NIRS), virtual histology intravascular ultrasound, optical coherence tomography, and angioscopy

      Target lesion evaluation by multiple modalities in vivo: near-infrared spectroscopy (NIRS), virtual histology intravascular ultrasound, optical coherence tomography, and angioscopy
      A 60-year-old man presented with ischaemic heart failure. We conducted coronary angiography (CAG) after improvement of the heart failure. On CAG, there was a hazy stenosis in the proximal left anterior descending artery (Figure 1, Moving image 1) . The lesion was observed by four modalities: near-infrared spectroscopy (NIRS), virtual histology intravascular ultrasound (VH-IVUS), optical coherence tomography (OCT), and angioscopy. NIRS detected lipid core plaque with echolucency on greyscale IVUS. VH-IVUS ...
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    12. Longitudinal stent deformation as a cause of very late stent thrombosis: Optical coherence tomography images

      Longitudinal stent deformation as a cause of very late stent thrombosis: Optical coherence tomography images
      A 73-year-old male with hypertension, diabetes mellitus and dyslipidemia was transferred to our hospital because of severe chest pain. He had a history of previous percutaneous coronary intervention for stable angina pectoris at another hospital 18 months before the current admission. In a previous coronary angiography (CAG), severe stenosis was found at the mid-left anterior descending artery (LAD)/diagonal bifurcation. A 3.0/28-mm platinum chromium, paclitaxel-eluting stent was deployed ...
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    13. Detailed Morphological Changes of Foveoschisis in Patient with X-Linked Retinoschisis Detected by SD-OCT and Adaptive Optics Fundus Camera

      Detailed Morphological Changes of Foveoschisis in Patient with X-Linked Retinoschisis Detected by SD-OCT and Adaptive Optics Fundus Camera
      Purpose . To report the morphological and functional changes associated with a regression of foveoschisis in a patient with X-linked retinoschisis (XLRS). Methods . A 42-year-old man with XLRS underwent genetic analysis and detailed ophthalmic examinations. Functional assessments included best-corrected visual acuity (BCVA), full-field electroretinograms (ERGs), and multifocal ERGs (mfERGs). Morphological assessments included fundus photography, spectral-domain optical coherence tomography (SD-OCT), and adaptive optics (AO) fundus imaging. After the baseline clinical data were ...
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    14. The Role of Multiple Imaging Modalities to Disclose the Mechanism of ACS Angioscopy in Comparison to Other Imaging Modalities Including OCT, IVUS and CTA (Book Chapter)

      The Role of Multiple Imaging Modalities to Disclose the Mechanism of ACS Angioscopy in Comparison to Other Imaging Modalities Including OCT, IVUS and CTA (Book Chapter)
      This book presents a thorough review of coronary angioscopy, ranging from instructions on its use to the latest advances. Starting with the structure and fundamental principles of angioscopy, it shows readers how to apply the image to comprehensive care of coronary-artery patients. Plentiful color photos and illustrations will enable readers to investigate and classify plaques and thrombi and to evaluate coronary stent- and drug-based therapies. The authors are leading researchers ...
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    15. Assessment of vascular response after drug-eluting stents implantation in patients with diabetes mellitus: an optical coherence tomography sub-study of the J-DESsERT

      Assessment of vascular response after drug-eluting stents implantation in patients with diabetes mellitus: an optical coherence tomography sub-study of the J-DESsERT
      ...Medicine, Memorial Heart Center, Iwate Medical School, Morioka, Japan Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan Division of Cardiology, Kawasaki Medical School, Kurashiki, Japan Divisi...
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  2. About Nippon Medical School

    Nippon Medical School

    Nippon Medical School is a private university in Bunkyo, Tokyo, Japan. The predecessor of the school was founded 1876.