1. Nicusor Iftimia

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    1. Mentioned In 35 Articles

    2. Handheld optical coherence tomography–reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins

      Handheld optical coherence tomography–reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins
      We present a hand-held implementation and preliminary evaluation of a combined optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) probe for detecting and delineating the margins of basal cell carcinomas (BCCs) in human skin in vivo . A standard OCT approach (spectrometer-based) with a central wavelength of 1310 nm and 0.11 numerical aperture (NA) was combined with a standard RCM approach (830-nm wavelength and 0.9 NA) into a ...
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    3. Integrating optical coherence tomography with laryngeal videostroboscopy

      Integrating optical coherence tomography with laryngeal videostroboscopy
      During clinical voice assessment, laryngologists and speech-language pathologists rely heavily on laryngeal endoscopy with videostroboscopy to evaluate pathology and dysfunction of the vocal folds. The cost effectiveness, ease of use, and synchronized audio and visual feedback provided by videostroboscopic assessment serve to maintain its predominant clinical role in laryngeal imaging. However, significant drawbacks include only two-dimensional spatial imaging and the lack of subsurface morphological information. A novel endoscope will be ...
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    4. Combined reflectance confocal microscopy-optical coherence tomography system for imaging of biological tissue

      Combined reflectance confocal microscopy-optical coherence tomography system for imaging of biological tissue
      A dual-modality apparatus for imaging of biological tissue includes a reflectance confocal microscopy (RCM) imaging apparatus and an optical coherence tomography (OCT) imaging apparatus. A first optical component reflects a first beam of light provided by a RCM imaging apparatus towards a sample and passes a second beam of light provided by an OCT imaging apparatus towards the sample, such that the first and second beam of lights share at ...
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    5. Airway compliance measured by anatomic optical coherence tomography

      Airway compliance measured by anatomic optical coherence tomography
      Quantification of airway compliance can aid in the diagnosis and treatment of obstructive airway disorders by detecting regions vulnerable to collapse. Here we evaluate the ability of a swept-source anatomic optical coherence tomography (SSaOCT) system to quantify airway cross-sectional compliance (CC) by measuring changes in the luminal cross-sectional area (CSA) under physiologically relevant pressures of 1040 cmH 2 O. The accuracy and precision of CC measurements are determined using simulations ...
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    6. Physical Sciences Incorporated Receives NIH Grant for Hand-Held RCM/OCT Probe for Skin Cancer Laser Therapy Guidance

      Physical Sciences Incorporated Receives NIH Grant for Hand-Held RCM/OCT Probe for Skin Cancer Laser Therapy Guidance
      ...5,423 for Hand-Held RCM/OCT Probe for Skin Cancer Laser Therapy Guidance.  The principal investigator is Nicusor Iftimia.  The program began in 2011 and ends in 2017.  Below is a summary of the proposed wo...
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    7. Investigation of middle ear anatomy and function with combined video otoscopy-phase sensitive OCT

      Investigation of middle ear anatomy and function with combined video otoscopy-phase sensitive OCT
      We report the development of a novel otoscopy probe for assessing middle ear anatomy and function. Video imaging and phase-sensitive optical coherence tomography are combined within the same optical path. A sound stimuli channel is incorporated as well to study middle ear function. Thus, besides visualizing the morphology of the middle ear, the vibration amplitude and frequency of the eardrum and ossicles are retrieved as well. Preliminary testing on cadaveric ...
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    8. Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study

      Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study
      We present a combined reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) approach, integrated within a single optical layout, for diagnosis of basal cell carcinomas (BCCs) and delineation of margins. While RCM imaging detects BCC presence (diagnoses) and its lateral spreading (margins) with measured resolution of 1 m 1m , OCT imaging delineates BCC depth spreading (margins) with resolution of 7 m 7m . When delineating margins in 20 specimens of ...
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    9. IMAGING WITH MULTIMODAL ADAPTIVE-OPTICS OPTICAL COHERENCE TOMOGRAPHY IN MULTIPLE EVANESCENT WHITE DOT SYNDROME: THE STRUCTURE AND FUNCTIONAL RELATIONSHIP

      IMAGING WITH MULTIMODAL ADAPTIVE-OPTICS OPTICAL COHERENCE TOMOGRAPHY IN MULTIPLE EVANESCENT WHITE DOT SYNDROME: THE STRUCTURE AND FUNCTIONAL RELATIONSHIP
      Purpose: To elucidate the location of pathological changes in multiple evanescent white dot syndrome (MEWDS) with the use of multimodal adaptive optics (AO) imaging . Methods: A 5-year observational case study of a 24-year-old female with recurrent MEWDS. Full examination included history, Snellen chart visual acuity, pupil assessment, intraocular pressures, slit lamp evaluation, dilated fundoscopic exam, imaging with Fourier-domain optical coherence tomography (FD-OCT), blue-light fundus autofluorescence (FAF), fundus photography, fluorescein angiography ...
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    10. Low coherence interferometry approach for aiding fine needle aspiration biopsie

      Low coherence interferometry approach for aiding fine needle aspiration biopsie
      We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation. Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.
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    11. Combined Reflectance Confocal Microscopy-Optical Coherence Tomography System for Imaging of Biological Tissue

      Combined Reflectance Confocal Microscopy-Optical Coherence Tomography System for Imaging of Biological Tissue
      A dual-modality apparatus for imaging of biological tissue includes a reflectance confocal microscopy (RCM) imaging apparatus and an optical coherence tomography (OCT) imaging apparatus. A first optical component reflects a first beam of light provided by a RCM imaging apparatus towards a sample and passes a second beam of light provided by an OCT imaging apparatus towards the sample, such that the first and second beam of lights share at ...
      Read Full Article
    12. Detection of breast surgical margins with optical coherence tomography imaging: a concept evaluation study

      Detection of breast surgical margins with optical coherence tomography imaging: a concept evaluation study
      This study aimed to evaluate the concept of using high-resolution optical coherence tomography (OCT) imaging to rapidly assess surgical specimens and determine if cancer positive margins were left behind in the surgical bed. A mouse model of breast cancer was used in this study. Surgical specimens from 30 animals were investigated with OCT and automated interpretation of the OCT images was performed and tested against histopathology findings. Specimens from 10 ...
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    13. Multi-functional adaptive optics retinal imaging

      Multi-functional adaptive optics retinal imaging
      An optical apparatus includes a system of optical components capable of operating in a scanning laser ophthalmoscope (SLO) mode and an optical coherence tomography (OCT) mode. The system of optical components includes a first optical module for the SLO mode, a second optical module for the OCT mode, and a first scanning device. The first optical module for the SLO mode includes a first source adapted to provide a first ...
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    14. 1-15 of 35 1 2 3 »
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  2. About Nicusor Iftimia

    Nicusor Iftimia

    Nicusor Iftimia is a scientist at Physical Sciences Incorporated.