1. Nicolaus Copernicus University

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    1. Mentioned In 175 Articles

    2. Differentiation of morphotic elements in human blood using optical coherence tomography and a microfluidic setup

      Differentiation of morphotic elements in human blood using optical coherence tomography and a microfluidic setup
      We demonstrate a novel optical method for the detection and differentiation between erythrocytes and leukocytes that uses amplitude and phase information provided by optical coherence tomography (OCT). Biological cells can introduce significant phase modulation with substantial scattering anisotropy and dominant forward-scattered light. Such physical properties may favor the use of a trans-illumination imaging technique. However, an epi-illumination mode may be more practical and robust in many applications. This study describes ...
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    3. The application of macro-X-ray fluorescence and optical coherence tomography for examination of parchment manuscripts

      The application of macro-X-ray fluorescence and optical coherence tomography for examination of parchment manuscripts
      Macro-X-ray fluorescence (XRF) is a newly commercially available research tool very useful in the examination of artwork. Its novelty lies in its ability to create maps of the distribution of chemical elements on scales of a few milimetres. In this contribution, its use together with optical coherence tomography (OCT) in the inspection of an illuminated manuscript is reported for the first time. The former technique is used both for mapping ...
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    4. Blue-light Fourier-domain optical-coherence microscopy with linear k-sampling using second-harmonic generation

      Blue-light Fourier-domain optical-coherence microscopy with linear k-sampling using second-harmonic generation
      We demonstrate Fourier-domain optical-coherence microscopy (OCM) method that uses blue light for high-resolution microscopic imaging. Spectrally broad bandwidth is obtained by means of second-harmonic generation of Ti:sapphire laser light on the nonlinear crystal. Angular scanning of the crystal performed by a resonant scanner results in second-harmonic generation for a broad range of frequencies producing blue light with central wavelength of 402 nm and bandwidth of 35 nm in one ...
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    5. Spectroscopy by joint spectral and time domain optical coherence tomography

      Spectroscopy by joint spectral and time domain optical coherence tomography
      We present the methodology for spectroscopic examination of absorbing media being the combination of Spectral Optical Coherence Tomography and Fourier Transform Spectroscopy. The method bases on the joint Spectral and Time OCT computational scheme and simplifies data analysis procedure as compared to the mostly used windowing-based Spectroscopic OCT methods. The proposed experimental setup is self-calibrating in terms of wavelength-pixel assignment. The performance of the method in measuring absorption spectrum was ...
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    6. Wavelength to pixel calibration for FdOCT

      Wavelength to pixel calibration for FdOCT
      We show that in Fourier domain Optical Coherence Tomography (FdOCT) it is possible to determine the wavelength of light for each point of the detected spectrum using any measurable physical quantity that has linear dependency on wavenumber. The presented approach is robust as the actual values of the measured quantity have no importance for the algorithm. As example we calibrate a SOCT spectrometer using Doppler frequency induced in time-dependent spectral ...
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    7. Detection of small biological objects by phase-sensitive optical coherence tomography

      Detection of small biological objects by phase-sensitive optical coherence tomography
      We demonstrate a novel label-free OCT method allowing optical detection and differentiation of moving micro-objects, such as blood cells. In this study we use phase-sensitive Fd-OCT/OCM system with broadband light source (axial resolution: 3 m in tissue and lateral resolution 48 m) and fluidic sample setup. The novel part of this method is that the optical identification is based on optical signal coming from optically uniform scattering media localized ...
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    8. Feature Of The Week 02/15/15: Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis

      Feature Of The Week 02/15/15: Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis
      ...ecent Article . Courtesy of Jan Nowak from Poznan University of Medical Sciences and Ireneusz Grulkowski from Nicolaus Copernicus University . Cystic fibrosis (CF) is a genetic disease that affects multiple organs due to...
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    9. Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis

      Optical Coherence Tomography Identifies Lower Labial Salivary Gland Surface Density in Cystic Fibrosis
      The labial minor salivary glands (LSGs) are easily accessible mucus-secreting structures of the alimentary tract that may provide new information on the basis of gastrointestinal complications of cystic fibrosis (CF). It was shown that they are destructed in the course of cystic fibrosis. We employed wide-field, micrometer resolution in vivo optical coherence tomography to assess the surface density of LSGs in 18 patients with CF and 18 healthy subjects. The ...
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    10. Feature Of The Week 11/9/14: Dynamics of a Short Cavity Swept Source OCT Laser

      Feature Of The Week 11/9/14: Dynamics of a Short Cavity Swept Source OCT Laser
      Great advances in OCT speed and sensitivity have been possible due to the introduction of fast frequency swept laser sources. One of the most commonly used swept source devices is a short (~5 cm) cavity Fabry-Perot laser. We present both experimental characterisation and numerical modelling of such an OCT swept source and also analyse the underlying physics to better understand how such sources may be optimised. For the experimental characterisation ...
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    11. 46-60 of 175 « 1 2 3 4 5 6 7 ... 10 11 12 »
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  2. About Nicolaus Copernicus University

    Nicolaus Copernicus University

    Nicolaus Copernicus University (NCU) founded in Torun in 1945 is one of the biggest academic institutions in Poland with the total number of 14 divisions, 54 faculties and 40.000 students. The Medical Physics Group is part of the Institute of Physics of the Nicolaus Copernicus University.  Department of Biophysics and Medical Physics at the Nicolaus Copernicus University.  The department members use both experimental (optics and optical spectroscopy) and theoretical (quantum chemistry and molecular dynamics) methods to investigate the structure and dynamic of biologically relevant molecules and tissues.  Nicolaus Copernicus University Collegium Medicum is the Medical College of NCU.