1. Nicolaus Copernicus University

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    1. Mentioned In 150 Articles

    2. Swept source optical coherence tomography and tunable lens technology for comprehensive imaging and biometry of the whole eye

      Swept source optical coherence tomography and tunable lens technology for comprehensive imaging and biometry of the whole eye
      Standard optical systems in ophthalmology are strictly dedicated either to retinal or to anterior segment imaging due to the refractive properties of the eye. We demonstrate a swept source optical coherence tomography platform with an electrically tunable lens (ETL) for versatile 3D in vivo imaging of both the eyes anterior segment and the retina. The optimized optical setup with adaptive operational states of the ETL permits focusing on the retina ...
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    3. Complementary use of Optical Coherence Tomography (OCT) and Reflection FTIR spectroscopy for in-situ non-invasive monitoring of varnish removal from easel paintings

      Complementary use of Optical Coherence Tomography (OCT) and Reflection FTIR spectroscopy for in-situ non-invasive monitoring of varnish removal from easel paintings
      Although the solvent removal of unwanted layers (e.g. aged varnishes, overpaints, oxalate patinas, dirt from easel paintings is one of the most frequently performed restoration treatments) it is questioned regarding its controllability and safety to the artwork. There is thus a need for developing suited diagnostic methodologies able to inform restorers on the chemical, optical and morphological effects of cleaning. To this aim, we have explored the possibility of ...
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    4. Optical coherence tomography in diagnosis and monitoring multiple sclerosis

      Optical coherence tomography in diagnosis and monitoring multiple sclerosis
      This paper presents application of optical coherence tomography (OCT) for diagnosis and monitoring of multiple sclerosis (MS). The peripapillary retinal nerve fibre layer thinning and the reduced total macular volume analysis are shown. With the course of the MS, the severity of these abnormalities increases which reflects the progressive degeneration of retinal ganglion cells and nerve fibres. The OCT parameters are sensitive, non-invasive indicators useful in assessing the progression of ...
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    5. Feature Of The Week 10/08/2017: Optical Coherence Microscopy as a Novel, Non-Invasive Method for the 4D Live Imaging of Early Mammalian Embryos

      Feature Of The Week 10/08/2017: Optical Coherence Microscopy as a Novel, Non-Invasive Method for the 4D Live Imaging of Early Mammalian Embryos
      ...d preimplantation embryo diagnostics. For more information see recent Article . Courtesy Karol Karnowski from Nicolaus Copernicus University . Imaging of living cells based on traditional fluorescence and confocal laser ...
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    6. Classification of biological micro-objects using optical coherence tomography

      Classification of biological micro-objects using optical coherence tomography
      We report on the development of a technique for differentiating between biological micro-objects using a rigorous, full-wave model of OCT image formation. We model an existing experimental prototype which uses OCT to interrogate a microfluidic chip containing the blood cells. A full-wave model is required since the technique uses light back-scattered by a scattering substrate, rather than by the cells directly. The light back-scattered by the substrate is perturbed upon ...
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    7. Optical coherence microscopy as a novel, non-invasive method for the 4D live imaging of early mammalian embryos

      Optical coherence microscopy as a novel, non-invasive method for the 4D live imaging of early mammalian embryos
      Imaging of living cells based on traditional fluorescence and confocal laser scanning microscopy has delivered an enormous amount of information critical for understanding biological processes in single cells. However, the requirement for a high numerical aperture and fluorescent markers still limits researchers ability to visualize the cellular architecture without causing short- and long-term photodamage. Optical coherence microscopy (OCM) is a promising alternative that circumvents the technical limitations of fluorescence imaging ...
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    8. Twenty-five years of optical coherence tomography: the paradigm shift in sensitivity and speed provided by Fourier domain OCT

      Twenty-five years of optical coherence tomography: the paradigm shift in sensitivity and speed provided by Fourier domain OCT
      Optical coherence tomography (OCT) has become one of the most successful optical technologies implemented in medicine and clinical practice mostly due to the possibility of non-invasive and non-contact imaging by detecting back-scattered light. OCT has gone through a tremendous development over the past 25 years. From its initial inception in 1991 [Science 254 , 1178 (1991)] it has become an indispensable medical imaging technology in ophthalmology. Also in fields like cardiology ...
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    9. Massively parallel data processing for quantitative total flow imaging with optical coherence microscopy and tomography

      Massively parallel data processing for quantitative total flow imaging with optical coherence microscopy and tomography
      We present an application of massively parallel processing of quantitative flow measurements data acquired using spectral optical coherence microscopy (SOCM). The need for massive signal processing of these particular datasets have been a major hurdle for many applications based on SOCM. In view of this difficulty, we implemented and adapted quantitative total flow estimation algorithms on graphics processing units (GPU) and achieved a 150 fold reduction in processing time when ...
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    10. Spectrometer calibration for spectroscopic Fourier domain optical coherence tomography

      Spectrometer calibration for spectroscopic Fourier domain optical coherence tomography
      We propose a simple and robust procedure for Fourier domain optical coherence tomography (FdOCT) that allows to linearize the detected FdOCT spectra to wavenumber domain and, at the same time, to determine the wavelength of light for each point of detected spectrum. We show that in this approach it is possible to use any measurable physical quantity that has linear dependency on wavenumber and can be extracted from spectral fringes ...
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    11. Extended-focus optical coherence microscopy for high-resolution imaging of the murine brain

      Extended-focus optical coherence microscopy for high-resolution imaging of the murine brain
      We propose a new method and optical instrumentation for mouse brain imaging based on extended-focus optical coherence microscopy. This in vivo imaging technique allows the evaluation of the cytoarchitecture at cellular level and the circulation system dynamics in three dimensions. This minimally invasive and non-contact approach is performed without the application of contrasting agents. The optical design achieved a resolution of 2.2 m over a distance of 800 m ...
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    12. Non-contact investigation of the corneal biomechanics with air-puff swept source optical coherence tomography

      Non-contact investigation of the corneal biomechanics with air-puff swept source optical coherence tomography
      In this paper, we use swept source optical coherence tomography combined with air-puff module (air-puff SS-OCT) to investigate the properties of the cornea. During OCT measurement the cornea was stimulated by short, air pulse, and corneal response was recorded. In this preliminary study, the air-puff SS-OCT instrument was applied to measure behavior of the porcine corneas under varied, well-controlled intraocular pressure conditions. Additionally, the biomechanical response of the corneal tissue ...
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    13. Coherence properties of fast frequency swept lasers revealed via full electric field reconstruction

      Coherence properties of fast frequency swept lasers revealed via full electric field reconstruction
      A novel, time-resolved interferometric technique is presented allowing the reconstruction of the complex electric field output of a fast frequency swept laser in a single-shot measurement. The power of the technique is demonstrated by examining a short cavity swept source designed for optical coherence tomography applications, with a spectral bandwidth of 18 THz. This novel analysis of the complete electric field reveals the modal structure and modal evolution of the ...
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    14. Imaging of the stroke-related changes in the vascular system of the mouse brain with the use of extended focus Optical Coherence Microscopy

      Imaging of the stroke-related changes in the vascular system of the mouse brain with the use of extended focus Optical Coherence Microscopy
      We used Optical Coherence Microscopy (OCM) to monitor structural and functional changes due to ischemic stroke in small animals brains in vivo. To obtain lateral resolution of 2.2 m over the range of 600 m we used extended focus configuration of OCM instrument involving Bessel beam. It provided access to detailed 3D information about the changes in brain vascular system up to the level of capillaries across I and ...
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  2. About Nicolaus Copernicus University

    Nicolaus Copernicus University

    Nicolaus Copernicus University (NCU) founded in Torun in 1945 is one of the biggest academic institutions in Poland with the total number of 14 divisions, 54 faculties and 40.000 students. The Medical Physics Group is part of the Institute of Physics of the Nicolaus Copernicus University.  Department of Biophysics and Medical Physics at the Nicolaus Copernicus University.  The department members use both experimental (optics and optical spectroscopy) and theoretical (quantum chemistry and molecular dynamics) methods to investigate the structure and dynamic of biologically relevant molecules and tissues.  Nicolaus Copernicus University Collegium Medicum is the Medical College of NCU.