1. National Yang-Ming University

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    1. Mentioned In 27 Articles

    2. Intelligent epidural needle placement using fiber-probe optical coherence tomography in a piglet model

      Intelligent epidural needle placement using fiber-probe optical coherence tomography in a piglet model
      Incorrect needle placement during an epidural block causes medical complications such as dural puncture or spinal cord injury. We propose a system combining an optical coherence tomography imaging probe with an automatic identification algorithm to objectively identify the epidural needle-tip position and thus reduce complications during epidural needle insertion. Eight quantitative features were extracted from each two-dimensional optical coherence tomography image during insertion of the needle tip from the skin ...
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    3. Review: Optical Scanning Probe for Optical Coherence Tomography

      Review: Optical Scanning Probe for Optical Coherence Tomography
      Optical coherence tomography (OCT) has become an important medical imaging modality. However, low penetration depth limits its application. Therefore, the optical scanning probe plays an important role in OCT systems for clinical applications. This article reviews OCT methodology and the mechanisms of an optical scanning probe. Recent developments of OCT probe and related clinical applications are summerized. Various OCT probe techniques (e.g., side imaging and forward imaging) have been ...
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    4. Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages

      Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages
      Differentiating between early malignancy and benign lesions in oral cavities is difficult using current optical tools. As has been shown in previous studies, microvascular changes in squamous epithelium can be regarded as a key marker for diagnosis. We propose the combination of structural and vascular optical coherence tomography (OCT) imaging for the investigation of disease related changes. Progressive thickness changes of epithelium and the destruction of underlying lamina propria was ...
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    5. Label-free, multi-contrast optical coherence tomography for study of skin melanoma mice in vivo

      Label-free, multi-contrast optical coherence tomography for study of skin melanoma mice in vivo
      The lymphatic system plays an important role in inflammation and cancer such as melanoma. Due to the limitations of current developed imaging techniques, visualization of lymphatic vessels within the tissue in vivo has been challenging. Optical imaging of lymphatic vessel is gaining increased interests because it does not involve any radiation and can achieve very high resolution. Here, we developed a multi-contrast, label-free optical coherence tomography (OCT) imaging technology with ...
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    6. Quantitative evaluation of retinal degeneration in royal college of surgeons rats by contrast enhanced ultrahigh resolution optical coherence tomography

      Quantitative evaluation of retinal degeneration in royal college of surgeons rats by contrast enhanced ultrahigh resolution optical coherence tomography
      This study presents a spectral domain optical coherence tomography (SD-OCT) using supercontinuum laser combined with a fundus photography for in vivo high-resolution imaging of retinal degeneration in Royal College of Surgeons (RCS-/- rat). These findings were compared with the Sprague-Dawley (SD) rats and the corresponding histology. Quantitative measurements show that changes in thickness were not significantly different between SD control and young RCS retinas (4 weeks). However, in old RCS ...
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    7. Detection of oral early cancerous lesion by using polarization-sensitive optical coherence tomography: mice model

      Detection of oral early cancerous lesion by using polarization-sensitive optical coherence tomography: mice model
      Oral cancer is the 11th most common cancer worldwide, especially in a male adult. The median age of death in oral cancer was 55 years, 10-20 years earlier than other cancers. Presently, oral cancer is often found in late stage, because the lesion is often flat in early stage and is difficult to diagnose under traditional white light imaging. The only definitive method for determining cancer is an invasive biopsy ...
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    8. Correlation between baseline retinal microstructures in spectral-domain optic coherence tomography and need for early intervention in central serous chorioretinopathy

      Correlation between baseline retinal microstructures in spectral-domain optic coherence tomography and need for early intervention in central serous chorioretinopathy
      Purpose To investigate the association between baseline retinal microstructures observed with spectral-domain optical coherence tomography (OCT) and the need for early intervention in central serous chorioretinopathy (CSC). Methods Cases of acute CSC from July 2011 to December 2014 were retrospectively reviewed. OCT images were further classified using six parameters: foveal serous retinal detachment; pigment epithelial detachment; fibrinous exudates in the subretinal space; retinal pigment epithelium bumps; thickened outer retinal layer ...
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    9. A Feasibility Study of Broadband White Light Emitting Diode (WLED) based Full-Field Optical Coherence Microscopy (FF-OCM) using Derivative-based Algorithm

      A Feasibility Study of Broadband White Light Emitting Diode (WLED) based Full-Field Optical Coherence Microscopy (FF-OCM) using Derivative-based Algorithm
      Developing cost-effective and fast detection methods in full-field optical coherence microscopy (FF-OCM) platform for biological applications is of prime focus today. In this paper, we report a cost-effective Linnik type FF-OCM system with a single broadband white light emitting diode (WLED) (470-850nm, 0=630nm) light source in conjunction with a derivative-based image reconstruction algorithm. Sequential two-dimensional (2D) multiple phase-shifted interferograms were obtained by moving the sample stage using piezoelectric transducer ...
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    10. Spectral-domain optical coherence tomography findings of peripapillary staphyloma.

      Spectral-domain optical coherence tomography findings of peripapillary staphyloma.
      A 10-year-old girl presented with blurred vision in her right eye since birth. Birth, developmental and medical histories were otherwise unremarkable. Her best corrected visual acuity was 20/30 and 20/20 in the right and left eyes, respectively, with bilateral mild myopia (3.5 dioptres). Anterior segment, lens, ocular motility, Ishihara test and intraocular pressure were normal. Relative afferent papillary defect was negative. Normal fundus was found in the ...
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    11. Optical coherence detection with stimulated emission: a feasibility study

      Optical coherence detection with stimulated emission: a feasibility study
      A stimulated emission (SE) based optical coherence tomography (OCT) setup has been established for feasibility study. The setup conducts coherent gating for depth resolution using fluorescence based stimulated emission, an unprecedented scheme. The resulting depth resolution of this interferometric OCT setup is approximately 66 m, determined by the coherence of the stimulation light source. Additionally, the SE signal can be used to obtain fluorescence lifetime.
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    12. Quantitative and rapid estimations of human sub-surface skin mass using ultra-high-resolution spectral domain optical coherence tomography

      Quantitative and rapid estimations of human sub-surface skin mass using ultra-high-resolution spectral domain optical coherence tomography
      ... National Yang-Ming University, Taipei, Taiwan 2. 2 Biophotonics & Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei, Taiwan 3. 3 Department of Dermatology, Taipei City Hospital, Renai Bran...
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    13. Photothermal optical coherence tomography based on the localized surface plasmon resonance of Au nanoring

      Photothermal optical coherence tomography based on the localized surface plasmon resonance of Au nanoring
      The conventional optical coherence tomography (OCT) images based on enhanced scattering and the photothermal (PT) images based on enhanced absorption of the localized surface plasmon (LSP) resonance of Au nanorings (NRIs) in a bio-tissue sample are demonstrated with the scans of an OCT system (1310-nm system), in which the spectral range covers the LSP resonance peak wavelength, and another OCT system (1060-nm system), in which the spectral range is away ...
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    14. 1-15 of 27 1 2 »
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  2. About National Yang-Ming University

    National Yang-Ming University

    National Yang Ming University. It is known for its medical studies. The university was founded in 1975 as The National Yang-Ming Medical College to cultivate first-class medical professionals and biomedical scientists. In 1994 it was granted university status by the Ministry of Education and became the first university in Taiwan dedicated to biomedical education and research. Along with its original mission, the University now is devoted to excelling in biomedical research, and to promoting intercollegiate and international collaboration. In the 30 years since its founding, Yang-Ming has enjoyed a robust growth. By the end of the 2005 academic year, Yang-Ming became a medium-sized university with 5 schools - Medicine, Dentistry, Medical Technology and Biomedical Engineering, Life Sciences and Nursing, and a Center for General Education. Additionally, the Veterans General Hospitals, three leading medical centers with a total of more than 5,500 beds and more than 1,600 physicians , serve as the teaching hospitals for medical and paramedical students. Yang-Ming also established 15 research centers with a wide spectrum of emphases including Genomic Medicine, Brain Research, Cognitive Neuroscience, Immunology, Cellular and Molecular Biology, Biomedical Engineering, Medical Imaging, Biophoptonics, Bioinformatics, Health Informatics, AIDS, Community Medicine, and Community Nursing. The University currently has 7 departments and 28 graduate institutes with 1853 undergraduate students, 1736 graduate students, 296 full-time faculty members, and 1066 adjunct faculty members.