1. National University of Singapore

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    1. Mentioned In 123 Articles

    2. A Deep Learning Approach to Digitally Stain Optical Coherence Tomography Images of the Optic Nerve Head

      A Deep Learning Approach to Digitally Stain Optical Coherence Tomography Images of the Optic Nerve Head
      Purpose. To develop a deep learning approach to digitally-stain optical coherence tomography (OCT) images of the optic nerve head (ONH). Methods. A horizontal B-scan was acquired through the center of the ONH using OCT (Spectralis) for 1 eye of each of 100 subjects (40 normal 60 glaucoma). All images were enhanced using adaptive compensation. A custom deep learning network was then designed and trained with the compensated images to digitally ...
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    3. Repeatability and Reproducibility of Retinal Neuronal and Axonal Measures on Spectral-domain Optical Coherence Tomography in Patients with Cognitive Impairment

      Repeatability and Reproducibility of Retinal Neuronal and Axonal Measures on Spectral-domain Optical Coherence Tomography in Patients with Cognitive Impairment
      Background: With increasing interest in determining if measurement of retinal neuronal structure with spectral-domain optical coherence tomography (SD-OCT) is useful in accessing neurodegenerative process in cognitive decline and development of dementia, it is important to evaluate whether the SD-OCT measurements are repeatable and reproducible in patients with Alzheimers disease (AD) or mild cognitive impairment (MCI). Methods: This is a retrospective cohort study. Patients with AD or MCI with no change ...
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    4. Macular Ganglion Cell and Retinal Nerve Fiber Layer Thickness in Children With Refractive Errors—An Optical Coherence Tomography Study

      Macular Ganglion Cell and Retinal Nerve Fiber Layer Thickness in Children With Refractive Errors—An Optical Coherence Tomography Study
      Purpose: To study the distribution of macular ganglion cell-inner plexiform layer (GC-IPL) thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in children with refractive errors. Materials and Methods: Two hundred forty-three healthy eyes from 139 children with refractive error ranging from 10.00 to +5.00 D were recruited from the National University Hospital Eye Surgery outpatient clinic. After a comprehensive ocular examination, refraction, and axial length (AL) measurement ...
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    5. Feature Of The Week 05/28/2017: In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements

      Feature Of The Week 05/28/2017: In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements
      ...ic neuropathies. For more information see recent Article . Courtesy Xiaofei Wang and Michal J. A. Girard from National University of Singapore . Glaucoma is characterized by an irreversible damage of retinal ganglion cel...
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    6. A Digital Staining Algorithm for Optical Coherence Tomography Images of the Optic Nerve Head

      A Digital Staining Algorithm for Optical Coherence Tomography Images of the Optic Nerve Head
      Purpose : To digitally stain spectral-domain optical coherence tomography (OCT) images of the optic nerve head (ONH), and highlight either connective or neural tissues. Methods : OCT volumes of the ONH were acquired from one eye of 10 healthy subjects. We processed all volumes with adaptive compensation to remove shadows and enhance deep tissue visibility. For each ONH, we identified the four most dissimilar pixel-intensity histograms, each of which was assumed to ...
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    7. Investigation of the variability of anterior chamber scan protocol with Cirrus high definition optical coherence tomography

      Investigation of the variability of anterior chamber scan protocol with Cirrus high definition optical coherence tomography
      Importance The evaluation of anterior chamber scan (ACS) of Cirrus optical coherence tomography (OCT) for routine clinical use Background To assess the variability of anterior chamber angle (ACA) measurements using the ACS Design Cross-sectional observational study Participants Forty subjects aged 40-80 years Methods One randomly selected eye from 40 subjects was imaged with Cirrus OCT (model 5000, Carl Zeiss Meditec, Dublin, CA) by two different operators (expert vs non-expert) with ...
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    8. Evaluation of the Anterior Segment Angle-to-Angle Scan of Cirrus High-Definition Optical Coherence Tomography and Comparison With Gonioscopy and With the Visante OCT

      Evaluation of the Anterior Segment Angle-to-Angle Scan of Cirrus High-Definition Optical Coherence Tomography and Comparison With Gonioscopy and With the Visante OCT
      Purpose : To evaluate the diagnostic performance of the anterior segment angle-to-angle scan of the Cirrus high-definition optical coherence tomography (HD-OCT) in detecting eyes with closed angles. Methods : All subjects underwent dark-room gonioscopy by an ophthalmologist. A technician performed anterior segment imaging with Cirrus ( n = 202) and Visante OCT ( n = 85) under dark-room conditions. All eyes were categorized by two masked graders as per number of closed quadrants. Each quadrant of ...
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    9. Artificial Intelligence With Deep Learning Technology Looks Into Diabetic Retinopathy Screening

      Artificial Intelligence With Deep Learning Technology Looks Into Diabetic Retinopathy Screening
      D iabetic retinopathy is a leading cause of vision loss in the United States and globally, particularly among working-aged individuals. Diabetic retinopathy meets all the criteria for screening: first, the condition (diabetic retinopathy) is an important public health care problem; second, the epidemiology and natural history of the condition, including development from asymptomatic latent to severe disease, are adequately understood; third, the screening test (retinal photography) is simple, safe, validated ...
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    10. A method to study the hemodynamics of chicken embryo's aortic arches using optical coherence tomography

      A method to study the hemodynamics of chicken embryo's aortic arches using optical coherence tomography
      Congenital cardiovascular defects are the leading cause of birth defect related death. It has been hypothesized that fluid mechanical forces of embryonic blood flow affect cardiovascular development and play a role in congenital malformations. Studies in small animal embryos can improve our understanding of congenital malformations and can lead to better treatment. We present a feasibility study in which high-resolution optical coherence tomography (OCT) and computational fluid dynamics (CFD) are ...
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    11. In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements

      In Vivo 3-Dimensional Strain Mapping Confirms Large Optic Nerve Head Deformations Following Horizontal Eye Movements
      Purpose : To measure lamina cribrosa (LC) strains (deformations) following abduction and adduction in healthy subjects and to compare them with those resulting from a relatively high acute intraocular pressure (IOP) elevation. Methods : A total of 16 eyes from 8 healthy subjects were included. Among the 16 eyes, 11 had peripapillary atrophy (PPA). For each subject, both optic nerve heads (ONHs) were imaged using optical coherence tomography (OCT) at baseline (twice ...
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    12. Enhancement of Corneal Visibility in Optical Coherence Tomography Images with Corneal Opacification

      Enhancement of Corneal Visibility in Optical Coherence Tomography Images with Corneal Opacification
      Purpose : To establish and to rank the performance of a corneal adaptive compensation (CAC) algorithm in enhancing corneal images with scars acquired from three commercially available anterior segment optical coherence tomography (ASOCT) devices. Methods : Horizontal B-scans of the cornea were acquired from 10 patients using three ASOCT devices (Spectralis, RTVue, and Cirrus). We compared ASOCT image quality (with and without CAC) by computing the intralayer contrast (a measure of shadow ...
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    13. Posterior Eye Shape Measurement With Retinal OCT Compared to MRI

      Posterior Eye Shape Measurement With Retinal OCT Compared to MRI
      Purpose : Posterior eye shape assessment by magnetic resonance imaging (MRI) is used to study myopia. We tested the hypothesis that optical coherence tomography (OCT), as an alternative, could measure posterior eye shape similarly to MRI. Methods : Macular spectral-domain OCT and brain MRI images previously acquired as part of the Singapore Epidemiology of Eye Diseases study were analyzed. The right eye in the MRI and OCT images was automatically segmented. Optical ...
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    14. Development of a hybrid Raman spectroscopy and optical coherence tomography technique for real-time in vivo tissue measurements

      Development of a hybrid Raman spectroscopy and optical coherence tomography technique for real-time in vivo tissue measurements
      We report on the development of a unique sideview handheld hybrid Raman spectroscopy (RS) and optical coherence tomography (OCT) technique for real-time in vivo tissue measurements. A sideview handheld RS-OCT optical probe is designed to coalign the optical paths of RS and OCT sampling arms, whereby a compact long-pass dichroic mirror (LPDM) is utilized to transmit the OCT signal through a gradient index rod lens and a reflection mirror, whereas ...
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    15. Complex wavelet based quality assessment for AS-OCT images with application to Angle Closure Glaucoma diagnosis

      Complex wavelet based quality assessment for AS-OCT images with application to Angle Closure Glaucoma diagnosis
      Background and objectives Angle closure disease in the eye can be detected using time-domain Anterior Segment Optical Coherence Tomography (AS-OCT). The Anterior Chamber (AC) characteristics can be quantified from AS-OCT image, which is dependent on the image quality at the image acquisition stage. To date, to the best of our knowledge there are no objective or automated subjective measurements to assess the quality of AS-OCT images. Methods To address AS-OCT ...
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    16. Automated anterior segment OCT image analysis for Angle Closure Glaucoma mechanisms classification

      Automated anterior segment OCT image analysis for Angle Closure Glaucoma mechanisms classification
      Background and objectives Angle closure glaucoma (ACG) is an eye disease prevalent throughout the world. ACG is caused by four major mechanisms: exaggerated lens vault, pupil block, thick peripheral iris roll, and plateau iris. Identifying the specific mechanism in a given patient is important because each mechanism requires a specific medication and treatment regimen. Traditional methods of classifying these four mechanisms are based on clinically important parameters measured from anterior ...
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  2. About National University of Singapore

    National University of Singapore

    National University of Singapore (NUS) is Singapore's oldest university. It is the largest university in the country in terms of student enrollment and curriculum offered. National University Health System (NUHS) was incorporated in January 2008, to bring the National University Hospital (NUH), and the National University of Singapore's (NUS) Yong Loo Lin School of Medicine and the Faculty of Dentistry under a common governance structure and develop academic medicine in Singapore. NUH is on the campus of NUS.