1. National University of Singapore

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    1. Mentioned In 164 Articles

    2. Diabetic Macular Ischemia: Influence of Optical Coherence Tomography Angiography Parameters on Changes in Functional Outcomes Over One Year

      Explore IOVS Journal Ophthalmology
      Diabetic Macular Ischemia: Influence of Optical Coherence Tomography Angiography Parameters on Changes in Functional Outcomes Over One Year
      Purpose : To prospectively evaluate whether diabetic macular ischemia detected with coherence tomography angiography (OCTA) is associated with change in functional outcomes over a period of one year. Methods : This is a one-year prospective, observational study that included 56 eyes with varying levels of diabetic retinopathy. All participants underwent best corrected visual acuity evaluation, swept-source OCTA and microperimetry at baseline and repeated at one year. Parafoveal vessel densities (VD) and foveal ...
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      Mentions: Singapore Eye Research Institute National University of Singapore

    3. Effect of vessel enhancement filters on the repeatability of measurements obtained from widefield swept-source optical coherence tomography angiography

      Explore Nature Publishing Group Ophthalmology
      Effect of vessel enhancement filters on the repeatability of measurements obtained from widefield swept-source optical coherence tomography angiography
      We assessed the inter-visit repeatability of 15 9-mm 2 swept-source OCTA (SS-OCTA; PLEX Elite 9000, Carl Zeiss Meditec) metrics in 14 healthy participants. We analysed the perfusion density (PD) of large vessels, superficial capillary plexus (SCP), and deep capillary plexus (DCP) as well as choriocapillaris flow voids in 2 different regions: the macular region and peripheral region. Also, retinal plexus metrics were processed further using different filters (Hessian, Gabor and ...
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      Mentions: Medical University of Vienna Carl Zeiss Meditec National University of Singapore

    4. Optical coherence tomography angiography measured area of retinal neovascularization is predictive of treatment response and progression of disease in patients with proliferative diabetic retinopathy

      Explore journalretinavitreous.biomedcentral.com Ophthalmology
      Optical coherence tomography angiography measured area of retinal neovascularization is predictive of treatment response and progression of disease in patients with proliferative diabetic retinopathy
      Background The purpose of this study was to evaluate the area of retinal neovascularization in patients with treatment-nave proliferative diabetic retinopathy (PDR) as measured by optical coherence tomography angiography (OCT-A) as a marker of subsequent treatment response after panretinal photocoagulation (PRP), and to examine if this area correlated with area of retinal neovascularization as measured by fluorescein angiography (FA). Methods En face OCT-A scans (4.5 4.5 mm) of ...
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      Mentions: National University of Singapore Optos Queen's University Belfast

    5. Deep learning algorithms to isolate and quantify the structures of the anterior segment in optical coherence tomography images

      Explore BJO Online Ophthalmology
      Deep learning algorithms to isolate and quantify the structures of the anterior segment in optical coherence tomography images
      Background/Aims Accurate isolation and quantification of intraocular dimensions in the anterior segment (AS) of the eye using optical coherence tomography (OCT) images is important in the diagnosis and treatment of many eye diseases, especially angle-closure glaucoma. Method In this study, we developed a deep convolutional neural network (DCNN) for the localisation of the scleral spur; moreover, we introduced an information-rich segmentation approach for this localisation problem. An ensemble of ...
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      Mentions: Cardiff University Singapore Eye Research Institute National University of Singapore

    6. Detection of features associated with neovascular age-related macular degeneration in ethnically distinct data sets by an optical coherence tomography: trained deep learning algorithm

      Explore BJO Online Ophthalmology
      Detection of features associated with neovascular age-related macular degeneration in ethnically distinct data sets by an optical coherence tomography: trained deep learning algorithm
      Background The ability of deep learning (DL) algorithms to identify eyes with neovascular age-related macular degeneration (nAMD) from optical coherence tomography (OCT) scans has been previously established. We herewith evaluate the ability of a DL model, showing excellent performance on a Korean data set, to generalse onto an American data set despite ethnic differences. In addition, expert graders were surveyed to verify if the DL model was appropriately identifying lesions ...
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      Mentions: Singapore Eye Research Institute University of Washington National University of Singapore

    7. Longitudinal assessment of optic nerve head changes using optical coherence tomography in a primate microbead model of ocular hypertension

      Explore Nature Publishing Group Ophthalmology
      Longitudinal assessment of optic nerve head changes using optical coherence tomography in a primate microbead model of ocular hypertension
      In humans, the longitudinal characterisation of early optic nerve head (ONH) damage in ocular hypertension (OHT) is difficult as patients with glaucoma usually have structural ONH damage at the time of diagnosis. Previous studies assessed glaucomatous ONH cupping by measuring the anterior lamina cribrosa depth (LCD) and minimal rim width (MRW) using optical coherence tomography (OCT). In this study, we induced OHT by repeated intracameral microbead injections in 16 cynomolgus ...
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      Mentions: Singapore Eye Research Institute National University of Singapore Tin Aung

    8. Objective Imaging Diagnostics for Dry Eye Disease

      Explore Hindawi Publishing Corporation Ophthalmology
      Objective Imaging Diagnostics for Dry Eye Disease
      Traditional diagnostic tests for dry eye disease (DED), such as fluorescein tear film break-up time and the Schirmer test, are often associated with poor reproducibility and reliability, which make the diagnosis, follow-up, and management of the disease challenging. Advances in ocular imaging technology enables objective and reproducible measurement of changes in the ocular surface, tear film, and optical quality associated with DED. In this review, the authors will discuss the ...
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      Mentions: Singapore Eye Research Institute National University of Singapore Jodhbir S. Mehta

    9. Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide‐field optical coherence tomography in Singapore adults with high myopia

      Explore Wiley Online Library Ophthalmology
      Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide‐field optical coherence tomography in Singapore adults with high myopia
      Purpose To investigate the prevalence and risk factors of posterior staphyloma using wide‐field optical coherence tomography (WF‐OCT) in adults with high myopia in Singapore. Design Population‐based cross‐sectional study. Methods Adults with spherical equivalent (SE) 5D in either eye at the first visit of Singapore Epidemiology of Eye Diseases study and Singapore Prospective Study Program study were recruited. Posterior staphyloma was diagnosed using WF‐OCT (PLEX Elite9000 ...
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      Mentions: Duke University Columbia University Topcon Medical Systems

    10. Agreement in Measures of Macular Perfusion between Optical Coherence Tomography Angiography Machines

      Explore Nature Publishing Group Ophthalmology
      Agreement in Measures of Macular Perfusion between Optical Coherence Tomography Angiography Machines
      We evaluated the agreements in foveal avascular zone (FAZ) area and vessel density (VD) parameters (within the superficial capillary plexus region), between two widely used optical coherence tomography angiography machines. Participants who attended the Singapore Malay Eye Study III between 29th March and 6th August 2018, were enrolled in this study. Participants underwent fovea-centered 66-mm macular cube scan, using both AngioVue and Cirrus HDOCT machines. Scans were analyzed automatically using ...
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      Mentions: Optovue Carl Zeiss Meditec National University of Singapore

    11. Association between Macular Thickness Profiles and Visual Function in Healthy Eyes: The Singapore Epidemiology of Eye Diseases (SEED) Study

      Explore Nature Publishing Group Ophthalmology
      Association between Macular Thickness Profiles and Visual Function in Healthy Eyes: The Singapore Epidemiology of Eye Diseases (SEED) Study
      This study aimed to evaluate the association between optical coherence tomography (OCT)-measured retinal layer thickness parameters with clinical and patient-centred visual outcomes in healthy eyes. Participants aged 40 and above were recruited from the Singapore Epidemiology of Eye Diseases Study, a multi-ethnic population-based study. Average macular, ganglion cell-inner plexiform layer (GCIPL), and outer retinal thickness parameters were obtained using the Cirrus High Definition-OCT. Measurements of best-corrected visual acuity (BCVA ...
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      Mentions: Singapore Eye Research Institute National University of Singapore

    12. Effect of Pharmacological Pupil Dilatation on Angle Configuration in Untreated Primary Angle Closure Suspects: A Swept Source Anterior Segment Optical Coherence Tomography Study

      Explore LWW Online Ophthalmology
      Effect of Pharmacological Pupil Dilatation on Angle Configuration in Untreated Primary Angle Closure Suspects: A Swept Source Anterior Segment Optical Coherence Tomography Study
      Precis: Angle closure worsens with pharmacological dilatation in about 50.0% of the subjects diagnosed as primary angle closure suspects. Purpose: To evaluate the changes in angle configuration with swept source anterior segment optical coherence tomography before and after pharmacological pupil dilatation in untreated primary angle closure suspects. Patients Methods: 106 subjects over the age of 50 years and diagnosed as primary angle closure suspects were included in this cross-sectional ...
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      Mentions: Singapore Eye Research Institute National University of Singapore Tomey Corporation

    13. Evaluation of meridional scans for angle closure assessment with anterior segment swept-source optical coherence tomography

      Explore BJO Online Ophthalmology
      Evaluation of meridional scans for angle closure assessment with anterior segment swept-source optical coherence tomography
      Background/aims As swept-source optical coherence tomography (SS-OCT) simultaneously obtains 128 meridional scans, it is important to identify which scans are playing the main role in classifying gonioscopic angle closure to simplify the analysis. We aimed to evaluate the diagnostic performance of every meridional scan in its ability to detect gonioscopic angle closure. Methods Observational study with 2027 phakic subjects consecutively recruited from a community polyclinic. Gonioscopy and SS-OCT were ...
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      Mentions: Singapore Eye Research Institute Harvard University National University of Singapore

    14. Towards Label-Free 3D Segmentation of Optical Coherence Tomography Images of the Optic Nerve Head Using Deep Learning

      Explore arxiv.org Ophthalmology
      Towards Label-Free 3D Segmentation of Optical Coherence Tomography Images of the Optic Nerve Head Using Deep Learning
      Since the introduction of optical coherence tomography (OCT), it has been possible to study the complex 3D morphological changes of the optic nerve head (ONH) tissues that occur along with the progression of glaucoma. Although several deep learning (DL) techniques have been recently proposed for the automated extraction (segmentation) and quantification of these morphological changes, the device-specific nature and the difficulty in preparing manual segmentations (training data) limit their clinical ...
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      Mentions: Duke University Medical University of Vienna Singapore Eye Research Institute

    15. Deep learning segmentation for optical coherence tomography measurements of the lower tear meniscus

      Explore OSA | OSA Publishing Ophthalmology
      Deep learning segmentation for optical coherence tomography measurements of the lower tear meniscus
      The tear meniscus contains most of the tear fluid and therefore is a good indicator for the state of the tear film. Previously, we used a custom-built optical coherence tomography (OCT) system to study the lower tear meniscus by automatically segmenting the image data with a thresholding-based segmentation algorithm (TBSA). In this report, we investigate whether the results of this image segmentation algorithm are suitable to train a neural network ...
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      Mentions: Duke University Medical University of Vienna Singapore Eye Research Institute

    16. Methodological Challenges of Deep Learning in Optical Coherence Tomography for Retinal Diseases: A Review

      Explore TVST Journal Ophthalmology
      Methodological Challenges of Deep Learning in Optical Coherence Tomography for Retinal Diseases: A Review
      Artificial intelligence (AI)-based automated classification and segmentation of optical coherence tomography (OCT) features have become increasingly popular. However, its 3-dimensional volumetric nature has made developing an algorithm that generalizes across all patient populations and OCT devices challenging. Several recent studies have reported high diagnostic performances of AI models; however, significant methodological challenges still exist in applying these models in real-world clinical practice. Lack of large-image datasets from multiple OCT ...
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      Mentions: University of Washington National University of Singapore
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  4. About National University of Singapore

    National University of Singapore

    National University of Singapore (NUS) is Singapore's oldest university. It is the largest university in the country in terms of student enrollment and curriculum offered. National University Health System (NUHS) was incorporated in January 2008, to bring the National University Hospital (NUH), and the National University of Singapore's (NUS) Yong Loo Lin School of Medicine and the Faculty of Dentistry under a common governance structure and develop academic medicine in Singapore. NUH is on the campus of NUS.

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