1. National University of Singapore

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    1. Mentioned In 138 Articles

    2. New Concepts in Polypoidal Choroidal Vasculopathy Imaging: A Focus on Optical Coherence Tomography and Optical Coherence Tomography Angiography

      Explore Asia-Pacific Academy of Ophthalmology Ophthalmology
      New Concepts in Polypoidal Choroidal Vasculopathy Imaging: A Focus on Optical Coherence Tomography and Optical Coherence Tomography Angiography
      Polypoidal choroidal vasculopathy (PCV) is a variant of neovascular age-related macular degeneration. It is characterized by polypoidal dilatations at the terminus of branching vascular network located beneath the retinal pigment epithelium. These polypoidal lesions are best visualized on indocyanine green angiography. With recent advances in ocular imaging, optical coherence tomography (OCT) and OCT angiography (OCTA) have been increasingly used to aid in the diagnosis and monitoring of treatment responses in ...
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      Mentions: National University of Singapore

    4. Imaging in myopia: potential biomarkers, current challenges and future developments

      Explore BJO Online Ophthalmology
      Imaging in myopia: potential biomarkers, current challenges and future developments
      Myopia is rapidly increasing in Asia and around the world, while it is recognised that complications from high myopia may cause significant visual impairment. Thus, imaging the myopic eye is important for the diagnosis of sight-threatening complications, monitoring of disease progression and evaluation of treatments. For example, recent advances in high-resolution imaging using optical coherence tomography may delineate early myopic macula pathology, optical coherence tomography angiography may aid early choroidal ...
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      Mentions: Columbia University Medical University of Vienna Singapore Eye Research Institute

    5. Quantitative analysis of choriocapillaris in non-human primates using swept-source optical coherence tomography angiography (SS-OCTA)

      Explore OSA | OSA Publishing Ophthalmology
      Quantitative analysis of choriocapillaris in non-human primates using swept-source optical coherence tomography angiography (SS-OCTA)
      The choriocapillaris is a unique vascular plexus located posterior to the retinal pigment epithelium. In recent years, there is an increasing interest in the examination of the interrelationship between the choriocapillaris and eye diseases. We used several techniques to study choroidal perfusion, including laser Doppler flowmetry, laser speckle flowgraphy, and optical coherence tomography angiography (OCTA), but with the latter no standardized algorithm for quantitative analysis has been provided. We analyzed ...
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      Mentions: Medical University of Vienna Carl Zeiss Meditec Nanyang Technological University

    6. Artificial intelligence and deep learning in ophthalmology

      Explore BJO Online Ophthalmology
      Artificial intelligence and deep learning in ophthalmology
      Artificial intelligence (AI) based on deep learning (DL) has sparked tremendous global interest in recent years. DL has been widely adopted in image recognition, speech recognition and natural language processing, but is only beginning to impact on healthcare. In ophthalmology, DL has been applied to fundus photographs, optical coherence tomography and visual fields, achieving robust classification performance in the detection of diabetic retinopathy and retinopathy of prematurity, the glaucoma-like disc ...
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      Mentions: University College London Medical University of Vienna Oregon Health & Science University

    7. Comparison Of Optical Coherence Tomography Angiographic Changes After Anti–Vascular Endothelial Growth Factor Therapy Alone Or In Combination With Photodynamic Therapy In Polypoidal Choroidal Vasculopathy

      Explore LWW Online Ophthalmology
      Comparison Of Optical Coherence Tomography Angiographic Changes After Anti–Vascular Endothelial Growth Factor Therapy Alone Or In Combination With Photodynamic Therapy In Polypoidal Choroidal Vasculopathy
      Purpose: To compare changes in optical coherence tomography angiography in eyes with polypoidal choroidal vasculopathy after treatment with antivascular endothelial growth factor monotherapy or combined with photodynamic therapy . Methods: This is a longitudinal case-controlled study. The authors performed optical coherence tomography angiography at baseline and Month 3 in patients with treatment-naive polypoidal choroidal vasculopathy undergoing monotherapy (n = 10) or combination therapy (n = 13). We analyzed flow signal within the outer ...
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      Mentions: Singapore Eye Research Institute National University of Singapore Tien Yin Wong

    8. Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis

      Explore ScienceDirect Neurology , Ophthalmology
      Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis
      Topic Optical coherence tomography (OCT) is a non-invasive tool to measure specific retinal layers in the eye. The relationship of retinal spectral domain-OCT (SD-OCT) measurements with Alzheimers Disease (AD) and mild cognitive impairment (MCI) remains unclear. Hence, we conducted a systematic review and meta-analysis to examine the SD-OCT measurements in AD and MCI. Clinical Relevance Current methods of diagnosing early AD are expensive and invasive. Retinal measurements of SD-OCT, which ...
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      Mentions: Singapore Eye Research Institute National University of Singapore The Chinese University of Hong Kong

    9. DRUNET: a dilated-residual U-Net deep learning network to segment optic nerve head tissues in optical coherence tomography images

      Explore OSA | OSA Publishing Ophthalmology
      DRUNET: a dilated-residual U-Net deep learning network to segment optic nerve head tissues in optical coherence tomography images
      Given that the neural and connective tissues of the optic nerve head (ONH) exhibit complex morphological changes with the development and progression of glaucoma, their simultaneous isolation from optical coherence tomography (OCT) images may be of great interest for the clinical diagnosis and management of this pathology. A deep learning algorithm (custom U-NET) was designed and trained to segment 6 ONH tissue layers by capturing both the local (tissue texture ...
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      Mentions: University College London Singapore Eye Research Institute National University of Singapore

    10. Clinical Use of Optical Coherence Tomography Angiography in Diabetic Retinopathy Treatment Ready for Showtime?

      Explore The JAMA Network Ophthalmology
      Clinical Use of Optical Coherence Tomography Angiography in Diabetic Retinopathy Treatment Ready for Showtime?
      Diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) are the 2 advanced stages of diabetic retinopathy (DR) that are the main causes for visual loss in patients with diabetes. Both DME and PDR can be readily diagnosed with clinical examination and, increasingly, by the noninvasive use of optical coherence tomography. However, another, less commonly recognized cause of visual loss in patients with diabetes is diabetic macular ischemia (DMI) in ...
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      Mentions: Duke University Singapore Eye Research Institute National University of Singapore

    11. DRUNET: A Dilated-Residual U-Net Deep Learning Network to Digitally Stain Optic Nerve Head Tissues in Optical Coherence Tomography Images

      Explore arxiv.org Ophthalmology
      DRUNET: A Dilated-Residual U-Net Deep Learning Network to Digitally Stain Optic Nerve Head Tissues in Optical Coherence Tomography Images
      Given that the neural and connective tissues of the optic nerve head (ONH) exhibit complex morphological changes with the development and progression of glaucoma, their simultaneous isolation from optical coherence tomography (OCT) images may be of great interest for the clinical diagnosis and management of this pathology. A deep learning algorithm was designed and trained to digitally stain (i.e. highlight) 6 ONH tissue layers by capturing both the local ...
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      Mentions: University College London Singapore Eye Research Institute National University of Singapore

    12. Imaging of the lamina cribrosa and its role in glaucoma: a review

      Explore Wiley Online Library Ophthalmology
      Imaging of the lamina cribrosa and its role in glaucoma: a review
      The lamina cribrosa of the optic nerve head serves two contrasting roles; it must be porous to allow retinal ganglion cell axons to pass through, and yet at the same time, it must also provide adequate structural support to withstand the stresses and strains across it. Improvements in imaging such as optical coherence tomography image capture and image processing have allowed detailed in vivo studies of lamina cribrosa macro- and ...
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      Mentions: Singapore Eye Research Institute National University of Singapore Michaël J. A. Girard

    13. Plateau Iris Distribution Across Anterior Segment Optical Coherence Tomography Defined Subgroups of Subjects With Primary Angle Closure Glaucoma

      Explore IOVS Journal Ophthalmology
      Plateau Iris Distribution Across Anterior Segment Optical Coherence Tomography Defined Subgroups of Subjects With Primary Angle Closure Glaucoma
      Purpose : We previously identified three distinct subgroups of patients with primary angle closure glaucoma (PACG) based on anterior segment optical coherence tomography (ASOCT) imaging. Group 1 was characterized by a large iris area with deepest anterior chambers, group 2 by a large lens vault (LV) and shallow anterior chamber depth (ACD), and group 3 displayed intermediate values across iris area, LV, and ACD. The purpose of the present study was ...
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      Mentions: Singapore Eye Research Institute National University of Singapore Tin Aung

    14. Comparison of anterior segment optical coherence tomography angiography systems for corneal vascularisation

      Explore BJO Online Ophthalmology
      Comparison of anterior segment optical coherence tomography angiography systems for corneal vascularisation
      Aim To newly describe a spectral-domain (SD) optical coherence tomography angiography (OCTA) for the cornea and directly compare two OCTA system scans of the same eyes with corneal vascularisation. Methods Cross-sectional, observational, comparative case series. We performed sequential OCTA scans (10 eyes of 10 subjects with corneal vascularisation,4 scans each eye) repeated using split-spectrum amplitude decorrelation algorithm angiography system (SSADA, AngioVue; Optovue Inc, USA) and SD OCTA (Angioscan; Nidek ...
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      Mentions: Optovue Nidek Medical University of Vienna

    15. Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography

      Explore BJO Online Ophthalmology
      Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography
      Purpose Optical coherence tomography angiography (OCT-A) potentially allows for rapid and non-invasive quantification of retinal capillary plexus density in various disease states. This study aims to identify the key features that influenced the repeatability of OCT-A measurements. Methods We obtained OCT-A images on two separate visits in 44 healthy eyes from 44 subjects, each imaged with using the Topcon DRI OCT Triton imaging system. The parafoveal vessel density within a ...
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      Mentions: Topcon Medical Systems Singapore Eye Research Institute National University of Singapore

    16. Segmentation and Quantification for Angle-Closure Glaucoma Assessment in Anterior Segment OCT

      Explore IEEE Xplore Ophthalmology
      Segmentation and Quantification for Angle-Closure Glaucoma Assessment in Anterior Segment OCT
      Angle-closure glaucoma is a major cause of irreversible visual impairment and can be identified by measuring the anterior chamber angle (ACA) of the eye. The ACA can be viewed clearly through anterior segment optical coherence tomography (AS-OCT), but the imaging characteristics and the shapes and locations of major ocular structures can vary significantly among different AS-OCT modalities, thus complicating image analysis. To address this problem, we propose a data-driven approach ...
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      Mentions: Singapore Eye Research Institute National University of Singapore Mani Baskaran
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  4. About National University of Singapore

    National University of Singapore

    National University of Singapore (NUS) is Singapore's oldest university. It is the largest university in the country in terms of student enrollment and curriculum offered. National University Health System (NUHS) was incorporated in January 2008, to bring the National University Hospital (NUH), and the National University of Singapore's (NUS) Yong Loo Lin School of Medicine and the Faculty of Dentistry under a common governance structure and develop academic medicine in Singapore. NUH is on the campus of NUS.

  5. Related Topics

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    3. Screening for Narrow Angles in the Singapore Population: Evaluation of New Noncontact Screening Methods
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    4. Shadow removal and contrast enhancement in optical coherence tomography images of the human optic nerve head
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