1. National University of Singapore

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    1. Mentioned In 143 Articles

    2. Automatic fibroatheroma identification in intravascular optical coherence tomography volumes

      Automatic fibroatheroma identification in intravascular optical coherence tomography volumes
      Coronary heart disease is the most common type of heart disease that leads to heart attacks. The identification of vulnerable plaques, especially the thin-cap fibroatheroma (TCFA), is crucial to the diagnosis of coronary artery disease. Intravascular optical coherence tomography (IVOCT), an emerging imaging modality, has been proven to be useful for the identification of vulnerable plaques. In this work, we propose an approach to identify the volumes with fibroatheroma frames ...
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    3. DeshadowGAN: A Deep Learning Approach to Remove Shadows from Optical Coherence Tomography Images

      DeshadowGAN: A Deep Learning Approach to Remove Shadows from Optical Coherence Tomography Images
      Purpose: To remove retinal shadows from optical coherence tomography (OCT) images of the optic nerve head (ONH). Methods: 2328 OCT images acquired through the center of the ONH using a Spectralis OCT machine for both eyes of 13 subjects were used to train a generative adversarial network (GAN) using a custom loss function.Image quality was assessed qualitatively (for artifacts) and quantitatively using the intralayer contrast € a measure of shadow ...
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    4. Optical coherence tomography angiography for the assessment of choroidal vasculature in high myopia

      Optical coherence tomography angiography for the assessment of choroidal vasculature in high myopia
      Aims To assess specific layers of the choroid in highly myopic young adults and to examine their associations with levels of myopia. Methods We recruited 51 young myopes (n=91 eyes) from the Singapore Cohort of Risk Factors for Myopia cohort. We performed standardised optical coherence tomography (OCT) and OCT angiography imaging and developed a novel segmentation technique assessing choroidal layers thickness (overall choroidal thickness (CT), medium-vessel choroidal layer (MVCL ...
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    5. A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head

      A Deep Learning Approach to Denoise Optical Coherence Tomography Images of the Optic Nerve Head
      Optical coherence tomography (OCT) has become an established clinical routine for the in vivo imaging of the optic nerve head (ONH) tissues, that is crucial in the diagnosis and management of various ocular and neuro-ocular pathologies. However, the presence of speckle noise affects the quality of OCT images and its interpretation. Although recent frame-averaging techniques have shown to enhance OCT image quality, they require longer scanning durations, resulting in patient ...
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    6. Anterior Segment Optical Coherence Tomography Is there a Clinical Role in Management of Primary Angle Closure Disease?

      Anterior Segment Optical Coherence Tomography Is there a Clinical Role in Management of Primary Angle Closure Disease?
      Primary angle-closure disease (PACD) covers a spectrum that includes primary angle-closure suspect (PACS), primary angle-closure (PAC), primary angle-closure glaucoma (PACG), as well as acute primary angle closure (APAC). Accumulating evidence suggests that the pathogenesis of PACD is complex, with multiple contributory factors including variations in the anatomical or biometric characteristics of the angle segment structures. Advances in anterior segment optical coherence tomography (ASOCT) technology have further enhanced our understanding of ...
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    7. New Concepts in Polypoidal Choroidal Vasculopathy Imaging: A Focus on Optical Coherence Tomography and Optical Coherence Tomography Angiography

      New Concepts in Polypoidal Choroidal Vasculopathy Imaging: A Focus on Optical Coherence Tomography and Optical Coherence Tomography Angiography
      Polypoidal choroidal vasculopathy (PCV) is a variant of neovascular age-related macular degeneration. It is characterized by polypoidal dilatations at the terminus of branching vascular network located beneath the retinal pigment epithelium. These polypoidal lesions are best visualized on indocyanine green angiography. With recent advances in ocular imaging, optical coherence tomography (OCT) and OCT angiography (OCTA) have been increasingly used to aid in the diagnosis and monitoring of treatment responses in ...
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    8. Imaging in myopia: potential biomarkers, current challenges and future developments

      Imaging in myopia: potential biomarkers, current challenges and future developments
      Myopia is rapidly increasing in Asia and around the world, while it is recognised that complications from high myopia may cause significant visual impairment. Thus, imaging the myopic eye is important for the diagnosis of sight-threatening complications, monitoring of disease progression and evaluation of treatments. For example, recent advances in high-resolution imaging using optical coherence tomography may delineate early myopic macula pathology, optical coherence tomography angiography may aid early choroidal ...
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    9. Quantitative analysis of choriocapillaris in non-human primates using swept-source optical coherence tomography angiography (SS-OCTA)

      Quantitative analysis of choriocapillaris in non-human primates using swept-source optical coherence tomography angiography (SS-OCTA)
      The choriocapillaris is a unique vascular plexus located posterior to the retinal pigment epithelium. In recent years, there is an increasing interest in the examination of the interrelationship between the choriocapillaris and eye diseases. We used several techniques to study choroidal perfusion, including laser Doppler flowmetry, laser speckle flowgraphy, and optical coherence tomography angiography (OCTA), but with the latter no standardized algorithm for quantitative analysis has been provided. We analyzed ...
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    10. Artificial intelligence and deep learning in ophthalmology

      Artificial intelligence and deep learning in ophthalmology
      Artificial intelligence (AI) based on deep learning (DL) has sparked tremendous global interest in recent years. DL has been widely adopted in image recognition, speech recognition and natural language processing, but is only beginning to impact on healthcare. In ophthalmology, DL has been applied to fundus photographs, optical coherence tomography and visual fields, achieving robust classification performance in the detection of diabetic retinopathy and retinopathy of prematurity, the glaucoma-like disc ...
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    11. Comparison Of Optical Coherence Tomography Angiographic Changes After Anti–Vascular Endothelial Growth Factor Therapy Alone Or In Combination With Photodynamic Therapy In Polypoidal Choroidal Vasculopathy

      Comparison Of Optical Coherence Tomography Angiographic Changes After Anti–Vascular Endothelial Growth Factor Therapy Alone Or In Combination With Photodynamic Therapy In Polypoidal Choroidal Vasculopathy
      Purpose: To compare changes in optical coherence tomography angiography in eyes with polypoidal choroidal vasculopathy after treatment with antivascular endothelial growth factor monotherapy or combined with photodynamic therapy . Methods: This is a longitudinal case-controlled study. The authors performed optical coherence tomography angiography at baseline and Month 3 in patients with treatment-naive polypoidal choroidal vasculopathy undergoing monotherapy (n = 10) or combination therapy (n = 13). We analyzed flow signal within the outer ...
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    12. Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis

      Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis
      Topic Optical coherence tomography (OCT) is a non-invasive tool to measure specific retinal layers in the eye. The relationship of retinal spectral domain-OCT (SD-OCT) measurements with Alzheimers Disease (AD) and mild cognitive impairment (MCI) remains unclear. Hence, we conducted a systematic review and meta-analysis to examine the SD-OCT measurements in AD and MCI. Clinical Relevance Current methods of diagnosing early AD are expensive and invasive. Retinal measurements of SD-OCT, which ...
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    13. DRUNET: a dilated-residual U-Net deep learning network to segment optic nerve head tissues in optical coherence tomography images

      DRUNET: a dilated-residual U-Net deep learning network to segment optic nerve head tissues in optical coherence tomography images
      Given that the neural and connective tissues of the optic nerve head (ONH) exhibit complex morphological changes with the development and progression of glaucoma, their simultaneous isolation from optical coherence tomography (OCT) images may be of great interest for the clinical diagnosis and management of this pathology. A deep learning algorithm (custom U-NET) was designed and trained to segment 6 ONH tissue layers by capturing both the local (tissue texture ...
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    14. Clinical Use of Optical Coherence Tomography Angiography in Diabetic Retinopathy Treatment Ready for Showtime?

      Clinical Use of Optical Coherence Tomography Angiography in Diabetic Retinopathy Treatment Ready for Showtime?
      Diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) are the 2 advanced stages of diabetic retinopathy (DR) that are the main causes for visual loss in patients with diabetes. Both DME and PDR can be readily diagnosed with clinical examination and, increasingly, by the noninvasive use of optical coherence tomography. However, another, less commonly recognized cause of visual loss in patients with diabetes is diabetic macular ischemia (DMI) in ...
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    15. DRUNET: A Dilated-Residual U-Net Deep Learning Network to Digitally Stain Optic Nerve Head Tissues in Optical Coherence Tomography Images

      DRUNET: A Dilated-Residual U-Net Deep Learning Network to Digitally Stain Optic Nerve Head Tissues in Optical Coherence Tomography Images
      Given that the neural and connective tissues of the optic nerve head (ONH) exhibit complex morphological changes with the development and progression of glaucoma, their simultaneous isolation from optical coherence tomography (OCT) images may be of great interest for the clinical diagnosis and management of this pathology. A deep learning algorithm was designed and trained to digitally stain (i.e. highlight) 6 ONH tissue layers by capturing both the local ...
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  2. About National University of Singapore

    National University of Singapore

    National University of Singapore (NUS) is Singapore's oldest university. It is the largest university in the country in terms of student enrollment and curriculum offered. National University Health System (NUHS) was incorporated in January 2008, to bring the National University Hospital (NUH), and the National University of Singapore's (NUS) Yong Loo Lin School of Medicine and the Faculty of Dentistry under a common governance structure and develop academic medicine in Singapore. NUH is on the campus of NUS.