1. National University of Singapore

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    1. Mentioned In 189 Articles

    2. Associations between thinner retinal neuronal layers and suboptimal brain structural integrity: Are the eyes a window to the brain?

      Explore bioRxiv.org Neurology , Ophthalmology
      Associations between thinner retinal neuronal layers and suboptimal brain structural integrity: Are the eyes a window to the brain?
      We investigated the extent to which measures of retinal neuronal thickness capture variability in the structural integrity of the brain in a large population-based cohort followed from birth to midlife. Using data from the Dunedin Multidisciplinary Health and Development Study (n=1037; analytic n=828, aged 45 years), we specifically tested for associations between optical coherence tomography-measured retinal neuronal layers and MRI-measured structural brain integrity. We found that Study members ...
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      Mentions: Duke University Singapore Eye Research Institute National University of Singapore

    3. Evaluation of Generative Adversarial Networks for High-Resolution Synthetic Image Generation of Circumpapillary Optical Coherence Tomography Images for Glaucoma

      Explore The JAMA Network Ophthalmology
      Evaluation of Generative Adversarial Networks for High-Resolution Synthetic Image Generation of Circumpapillary Optical Coherence Tomography Images for Glaucoma
      Importance: Deep learning (DL) networks require large data sets for training, which can be challenging to collect clinically. Generative models could be used to generate large numbers of synthetic optical coherence tomography (OCT) images to train such DL networks for glaucoma detection. Objective: To assess whether generative models can synthesize circumpapillary optic nerve head OCT images of normal and glaucomatous eyes and determine the usability of synthetic images for training ...
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      Mentions: Medical University of Vienna Singapore Eye Research Institute National University of Singapore

    4. Intraoperative optical coherence tomography guided iris stromal cyst treatment with absolute alcohol injection

      Explore ScienceDirect Ophthalmology
      Intraoperative optical coherence tomography guided iris stromal cyst treatment with absolute alcohol injection
      Purpose To report on the utility of intraoperative optical coherence tomography (iOCT) in the treatment of a traumatic iris cyst with aspiration and alcohol injection. Observations A 61-year-old male, with a past ocular history of a left corneoscleral laceration in 1982, presented with gradual onset of blurring of vision in 2021. Examination revealed a large iris stromal cyst. He subsequently underwent iOCT guided iris stromal cyst aspiration and absolute alcohol ...
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      Mentions: Singapore Eye Research Institute National University of Singapore

    5. Three-Dimensional Multi-Task Deep Learning Model to Detect Glaucomatous Optic Neuropathy and Myopic Features From Optical Coherence Tomography Scans: A Retrospective Multi-Centre Study

      Explore Frontiers Ophthalmology
      Three-Dimensional Multi-Task Deep Learning Model to Detect Glaucomatous Optic Neuropathy and Myopic Features From Optical Coherence Tomography Scans: A Retrospective Multi-Centre Study
      Purpose: We aim to develop a multi-task three-dimensional (3D) deep learning (DL) model to detect glaucomatous optic neuropathy (GON) and myopic features (MF) simultaneously from spectral-domain optical coherence tomography (SDOCT) volumetric scans. Methods: Each volumetric scan was labelled as GON according to the criteria of retinal nerve fibre layer (RNFL) thinning, with a structural defect that correlated in position with the visual field defect (i.e., reference standard). MF were ...
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      Mentions: Stanford University National University of Singapore The Chinese University of Hong Kong

    6. Advances in OCT Imaging in Myopia and Pathologic Myopia

      Explore MDPI Open Access Journals Platform Ophthalmology
      Advances in OCT Imaging in Myopia and Pathologic Myopia
      Advances in imaging with optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) technology, including the development of swept source OCT/OCTA, widefield or ultra-widefield systems, have greatly improved the understanding, diagnosis, and treatment of myopia and myopia-related complications. Anterior segment OCT is useful for imaging the anterior segment of myopes, providing the basis for implantable collamer lens optimization, or detecting intraocular lens decentration in high myopic patients. OCT ...
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      Mentions: Columbia University National University of Singapore

    7. Normative data and associations of Optical Coherence Tomography Angiography measurements of the macula: The Singapore Malay Eye Study

      Explore ScienceDirect Ophthalmology
      Normative data and associations of Optical Coherence Tomography Angiography measurements of the macula: The Singapore Malay Eye Study
      Objective: To describe the normative quantitative parameters of macular retinal vasculature and their systemic and ocular associations, using optical coherence tomography angiography (OCTA). Design: Population based cross sectional study SUBJECTS: Adults above 50 years old were recruited from the third examination of the population-based Singapore Malay Eye Study. Methods: All participants underwent standardized comprehensive examination and Spectral domain-OCTA (Optovue, USA) of the macula. OCTA scans with pre-existing retinal disease, macular ...
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      Mentions: Visionix Singapore Eye Research Institute National University of Singapore

    8. The New Era of Retinal Imaging in Hypertensive Patients

      Explore LWW Online Ophthalmology
      The New Era of Retinal Imaging in Hypertensive Patients
      Structural and functional alterations in the microcirculation by systemic hypertension can cause significant organ damage at the eye, heart, brain, and kidneys. As the retina is the only tissue in the body that allows direct imaging of small vessels, the relationship of hypertensive retinopathy signs with development of disease states in other organs have been extensively studied; large-scale epidemiological studies using fundus photography and advanced semi-automated analysis software have reported ...
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      Mentions: Medical University of Vienna Nanyang Technological University National University of Singapore

    9. Application of Intraoperative Optical Coherence Tomography Technology in Anterior Segment Surgery

      Explore Hindawi Publishing Corporation Ophthalmology
      Application of Intraoperative Optical Coherence Tomography Technology in Anterior Segment Surgery
      The use of optical coherence tomography (OCT) technology in anterior segment diseases allows for precise assessment of the changes following anterior segment surgery. Advances in microscope-integrated OCT systems have allowed the utilization of intraoperative OCT (iOCT) in anterior segment surgeries, i.e., cornea, cataract, and refractive surgery. iOCT has enabled real-time precise visualization of anterior segment tissues as well as interactions between surgical instruments and ocular tissue; thus, the device ...
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      Mentions: Singapore Eye Research Institute Carl Zeiss Meditec National University of Singapore

    10. A multi-regression framework to improve diagnostic ability of optical coherence tomography retinal biomarkers to discriminate mild cognitive impairment and Alzheimer’s disease

      Explore Alzheimer's Research & Therapy Neurology , Ophthalmology
      A multi-regression framework to improve diagnostic ability of optical coherence tomography retinal biomarkers to discriminate mild cognitive impairment and Alzheimer’s disease
      Background Diagnostic performance of optical coherence tomography (OCT) to detect Alzheimers disease (AD) and mild cognitive impairment (MCI) remains limited. We assessed whether compensating the circumpapillary retinal nerve fiber layer (cpRNFL) thickness for multiple demographic and anatomical factors as well as the combination of macular layers improves the detection of MCI and AD. Methods This cross-sectional study of 62 AD ( n =92 eyes), 108 MCI ( n =158 eyes), and 55 ...
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      Mentions: Medical University of Vienna Singapore Eye Research Institute Nanyang Technological University

    11. A multi-regression framework to improve diagnostic ability of optical coherence tomography retinal biomarkers to discriminate mild cognitive impairment and Alzheimer’s disease

      Explore Alzheimer's Research & Therapy Neurology , Ophthalmology
      A multi-regression framework to improve diagnostic ability of optical coherence tomography retinal biomarkers to discriminate mild cognitive impairment and Alzheimer’s disease
      Background: Diagnostic performance of optical coherence tomography (OCT) to detect Alzheimer's disease (AD) and mild cognitive impairment (MCI) remains limited. We assessed whether compensating the circumpapillary retinal nerve fiber layer (cpRNFL) thickness for multiple demographic and anatomical factors as well as the combination of macular layers improves the detection of MCI and AD. Methods: This cross-sectional study of 62 AD (n = 92 eyes), 108 MCI (n = 158 eyes), and ...
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      Mentions: Medical University of Vienna Nanyang Technological University National University of Singapore

    12. Angle closure extent, anterior segment dimensions and intraocular pressure

      Explore BJO Online Ophthalmology
      Angle closure extent, anterior segment dimensions and intraocular pressure
      Aim To investigate the association between the extent of iridotrabecular contact and other quantitative anterior segment dimensions measured by swept-source optical coherence tomography (SS-OCT; CASIA SS-1000, Tomey, Nagoya, Japan) with intraocular pressure (IOP). Methods Cross-sectional study. All subjects who were 50 years with no history of glaucoma, ocular surgery or trauma, underwent SS-OCT imaging (eight equally spaced radial scans), Goldman applanation tonometry and gonioscopy on the same day. We measured ...
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      Mentions: Singapore Eye Research Institute National University of Singapore Tomey Corporation

    13. Outcome Measures for Disease Monitoring in Intraocular Inflammatory and Infectious Diseases (OCTOMERIA): Understanding the Choroid in Uveitis with Optical Coherence Tomography (OCT)

      Explore Taylor & Francis Online Ophthalmology
      Outcome Measures for Disease Monitoring in Intraocular Inflammatory and Infectious Diseases (OCTOMERIA): Understanding the Choroid in Uveitis with Optical Coherence Tomography (OCT)
      Purpose: To compare imaging modalities for the choroid of the eye, and evaluate various choroidal changes in uveitides entities. Methods: A comprehensive systematic literature review was conducted looking at current imaging modalities available to assess choroid architecture and commonly used parameters available to qualify and quantify choroidal changes, before looking at specific uveitides entities with choroidal involvement which have been broadly separated into non-infectious and infectious in etiology. Results: We ...
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      Mentions: National University of Singapore

    14. Non-optical coherence tomography modalities for assessment of angle closure

      Explore Taiwan Journal of Ophthalmology Ophthalmology
      Non-optical coherence tomography modalities for assessment of angle closure
      Primary angle closure glaucoma is a leading cause of irreversible blindness, particularly in Asia. Its pathophysiology is based in the closure of the anterior chamber angle (ACA). In addition to gonioscopy (current reference standard), in the past decade, anterior segment optical coherence tomography (AS-OCT) has been incorporated in routine ophthalmic practice to help assess the configuration of the ACA. Especially in nonspecialist ophthalmology practice, gonioscopy may be less frequently performed ...
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      Mentions: Nidek Singapore Eye Research Institute National University of Singapore

    15. The Application of Optical Coherence Tomography Angiography in Systemic Hypertension: A Meta-Analysis

      Explore Frontiers Ophthalmology
      The Application of Optical Coherence Tomography Angiography in Systemic Hypertension: A Meta-Analysis
      Objective: Multiple studies have compared various optical coherence tomography angiography (OCTA) parameters in participants with systemic hypertension vs. controls and have presented discordant findings. We conducted a meta-analysis to pool together data from different studies to generate an overall effect size and find out whether OCTA parameter(s) significantly differed in participants with systemic hypertension as compared to controls. Methods: We conducted a literature search through a search of electronic ...
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      Mentions: Medical University of Vienna Singapore Eye Research Institute National University of Singapore

    16. OPTICAL COHERENCE TOMOGRAPHY FEATURES OF POLYPOIDAL LESION CLOSURE IN POLYPOIDAL CHOROIDAL VASCULOPATHY TREATED WITH AFLIBERCEPT

      Explore LWW Online Ophthalmology
      OPTICAL COHERENCE TOMOGRAPHY FEATURES OF POLYPOIDAL LESION CLOSURE IN POLYPOIDAL CHOROIDAL VASCULOPATHY TREATED WITH AFLIBERCEPT
      Purpose: To evaluate whether optical coherence tomography (OCT) can determine polypoidal lesion (PL) perfusion in polypoidal choroidal vasculopathy (PCV) eyes following 12-months of aflibercept monotherapy. PL perfusion status, assessed by indocyanine green angiography (ICGA), is an important anatomical outcome in PCV management. Methods: Post-hoc data from a prospective randomised, open-label, study in eyes with PCV undergoing monotherapy with aflibercept evaluated PL perfusion status based on ICGA (gold standard) and OCT ...
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      Mentions: National University of Singapore Queen's University Belfast
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  4. About National University of Singapore

    National University of Singapore

    National University of Singapore (NUS) is Singapore's oldest university. It is the largest university in the country in terms of student enrollment and curriculum offered. National University Health System (NUHS) was incorporated in January 2008, to bring the National University Hospital (NUH), and the National University of Singapore's (NUS) Yong Loo Lin School of Medicine and the Faculty of Dentistry under a common governance structure and develop academic medicine in Singapore. NUH is on the campus of NUS.

  5. Related Topics

    1. Changes in anterior segment morphology in response to illumination and after laser iridotomy in Asian eyes: an anterior segment OCT study
      115 articles also mentioned Singapore Eye Research Institute
    2. Corneal Imaging with Anterior Segment Optical Coherence Tomography for Lamellar Keratoplasty Procedures
      37 articles also mentioned Carl Zeiss Meditec
    3. Imaging Systems of Human Eye: A Review
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    4. Comparison of anterior segment optical coherence tomography angiography systems for corneal vascularisation
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    5. Variation of Angle Parameters in Asians: An Anterior Segment Optical Coherence Tomography Study in a Population of Singapore Malays
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    6. Determinants of Quantitative Optic Nerve Measurements using Spectral Domain Optical Coherence Tomography in a Population-based Sample of Non-glaucomatous Subjects
      12 articles also mentioned The Chinese University of Hong Kong