1. National Taiwan University

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    1. Mentioned In 129 Articles

    2. Clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography

      Clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography
      This study highlights the clinical features and treatment response of polypoidal choroidal vasculopathy (PCV) among three different branching vascular network (BVN) morphologies in optical coherence tomography angiography (OCTA), and further correlates the BVN features with those under fluorescent angiography (FA) and indocyanine green angiography (ICGA). In total, we reviewed 70 eyes with PCV followed up for 12 months. OCTA, ICGA and FA images were obtained at baseline and post-treatments. BVN ...
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    3. The structure-function correlation analysed by OCT and full field ERG in typical and pericentral subtypes of retinitis pigmentosa

      The structure-function correlation analysed by OCT and full field ERG in typical and pericentral subtypes of retinitis pigmentosa
      To investigate the structure-function correlation analysed by full-field electroretinography (ffERG) and optical coherence tomography (OCT) in typical and pericentral subtypes of retinitis pigmentosa (RP). A retrospective, cross-sectional, observational study of right eyes was conducted. The primary analysis used ffERG data to compare the RP subtypes. The subgroup analysis was used to correlate the structure, analysed by OCT, and function, determined by ffERG. Linear regressions explored the relationship between best-corrected visual ...
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    4. Rapid pseudo-H&E imaging using a fluorescence-inbuilt optical coherence microscopic imaging system

      Rapid pseudo-H&E imaging using a fluorescence-inbuilt optical coherence microscopic imaging system
      A technique using Linnik-based optical coherence microscopy (OCM), with built-in fluorescence microscopy (FM), is demonstrated here to describe cellular-level morphology for fresh porcine and biobank tissue specimens. The proposed method utilizes color-coding to generate digital pseudo-HE (p-HE) images. Using the same camera, colocalized FM images are merged with corresponding morphological OCM images using a 24-bit RGB composition process to generate position-matched p-HE images. From receipt of dissected fresh tissue piece ...
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    5. Macular Ischemia Quantification Using Deep-Learning Denoised Optical Coherence Tomography Angiography in Branch Retinal Vein Occlusion

      Macular Ischemia Quantification Using Deep-Learning Denoised Optical Coherence Tomography Angiography in Branch Retinal Vein Occlusion
      Purpose: To examine whether deep-learning denoised optical coherence tomography angiography (OCTA) images could enhance automated macular ischemia quantification in branch retinal vein occlusion (BRVO). Methods: This retrospective, single-center, cross-sectional study enrolled 74 patients with BRVO and 46 age-matched healthy subjects. The severity of macular ischemia was graded as mild, moderate, or severe. Denoised OCTA images were produced using a neural network model. Quantitative parameters derived from denoised images, including vessel ...
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    6. Combined Quantitative and Qualitative Optical Coherence Tomography Angiography Biomarkers for Predicting Active Neovascular Age-related Macular Degeneration

      Combined Quantitative and Qualitative Optical Coherence Tomography Angiography Biomarkers for Predicting Active Neovascular Age-related Macular Degeneration
      Purpose: To investigate choroidal neovascularization (CNV) activity after anti-vascular endothelial growth factor (anti-VEGF) therapy in patients with neovascular age-related macular degeneration (nAMD) by optical coherence tomography angiography (OCTA) and to determine whether combined qualitative and quantitative biomarkers can achieve high predictive accuracy to guide treatment decisions. Methods: Patients diagnosed with type 1 or type 2 CNV via multimodal imaging who had received anti-VEGF treatmentwere retrospectively reviewed. Qualitative and quantitative CNV ...
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    7. Mirau-type full-field optical coherence tomography with switchable partially spatially coherent illumination modes

      Mirau-type full-field optical coherence tomography with switchable partially spatially coherent illumination modes
      A crystalline-fiber-based Mirau-type full-field optical coherence tomography (FF-OCT) system utilizing two partially coherent illumination modes is presented. Using a diode-pumped Ti:sapphire crystalline fiber with a high numerical aperture, spatially-incoherent broadband emission can be generated with high radiance. With two modes of different spatial coherence settings, either deeper penetration depth or higher B-scan rate can be achieved. In a wide-field illumination mode, the system functions like FF-OCT with partially coherent ...
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    8. Generation of Augmented Capillary Network Optical Coherence Tomography Image Data of Human Skin for Deep Learning and Capillary Segmentation

      Generation of Augmented Capillary Network Optical Coherence Tomography Image Data of Human Skin for Deep Learning and Capillary Segmentation
      The segmentation of capillaries in human skin in full-field optical coherence tomography (FF-OCT) images plays a vital role in clinical applications. Recent advances in deep learning techniques have demonstrated a state-of-the-art level of accuracy for the task of automatic medical image segmentation. However, a gigantic amount of annotated data is required for the successful training of deep learning models, which demands a great deal of effort and is costly. To ...
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    9. Quantitative spectroscopic comparison of the optical properties of mouse cochlea microstructures using optical coherence tomography at 1.06 µm and 1.3 µm wavelengths

      Quantitative spectroscopic comparison of the optical properties of mouse cochlea microstructures using optical coherence tomography at 1.06 µm and 1.3 µm wavelengths
      Currently, the cochlear implantation procedure mainly relies on using a hand lens or surgical microscope, where the success rate and surgery time strongly depend on the surgeons experience. Therefore, a real-time image guidance tool may facilitate the implantation procedure. In this study, we performed a systematic and quantitative analysis on the optical characterization of ex vivo mouse cochlear samples using two swept-source optical coherence tomography (OCT) systems operating at the ...
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    10. Effect of A-scan rate and interscan interval on optical coherence angiography

      Effect of A-scan rate and interscan interval on optical coherence angiography
      Optical coherence tomography angiography (OCTA) can provide rapid, volumetric, and noninvasive imaging of tissue microvasculature without the requirement of exogenous contrast agents. To investigate how A-scan rate and interscan time affected the contrast and dynamic range of OCTA, we developed a 1.06-m swept-source OCT system enabling 100-kHz or 200-kHz OCT using two light sources. After system settings were carefully adjusted, almost the same detection sensitivity was achieved between the ...
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    11. Spectral-Domain Optical Coherence Tomography For Evaluating Palisades of Vogt in Ocular Surface Disorders With Limbal Involvement

      Spectral-Domain Optical Coherence Tomography For Evaluating Palisades of Vogt in Ocular Surface Disorders With Limbal Involvement
      Spectral-domain optical coherence tomography (SD-OCT) has been used to observe the morphology and epithelial thickness of the palisades of Vogt (POV) with satisfactory resolutions. In this study, we used SD-OCT to examine the microstructure of the POV in ocular surface disorders with limbal involvement and to detect subclinical limbal pathologies based on five parameters. Eighteen eyes of 10 patients (2 men and 8 women; mean age, 48.7 14.0 ...
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    12. Submicron spatial resolution optical coherence tomography for visualising the 3D structures of cells cultivated in complex culture systems

      Submicron spatial resolution optical coherence tomography for visualising the 3D structures of cells cultivated in complex culture systems
      Three-dimensional (3D) configuration of in vitro cultivated cells has been recognised as a valuable tool in developing stem cell and cancer cell therapy. However, currently available imaging approaches for live cells have drawbacks, including unsatisfactory resolution, lack of cross-sectional and 3D images, and poor penetration of multi-layered cell products, especially when cells are cultivated on semitransparent carriers. Herein, we report a prototype of a full-field optical coherence tomography (FF-OCT) system ...
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    13. Correlation between Visual Acuity and Optical Coherence Tomography Angiography Parameters in Unilateral Idiopathic Epiretinal Membrane

      Correlation between Visual Acuity and Optical Coherence Tomography Angiography Parameters in Unilateral Idiopathic Epiretinal Membrane
      Background: The tangential traction by idiopathic epiretinal membrane (iERM) may alter the hemodynamics of the macula. We investigated the correlation between visual acuity and the optical coherence tomography angiography (OCTA) parameters in unilateral iERM. Methods: We included 61 eyes of 61 consecutive patients with unilateral iERM between January 2018 and December 2018. The flow area of the retinal superficial capillary plexus (SCP), deep capillary plexus (DCP), and choroidal capillary plexus ...
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    14. Broadband Coupler Manipulation through Particle Swarm Optimization for Arrayed Waveguide Grating based Optical Coherence Tomography

      Broadband Coupler Manipulation through Particle Swarm Optimization for Arrayed Waveguide Grating based Optical Coherence Tomography
      The state-of-the-art optical coherence technology (OCT) has its limitation, such as bulky and quite expensive. Miniaturization and integration of the OCT system are promising to get a compact, less costly, and more stable device. In this paper, we report the influence of optical power splitting on the sensitivity and axial resolution in spectral-domain OCT (SD-OCT) on silicon chip using tandem Mach-Zehnder directional coupler (MZDC) based broadband coupler through particle swarm ...
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    15. Dermal Epidermal Junction Detection for Full-Field Optical Coherence Tomography Data of Human Skin by Deep Learning

      Dermal Epidermal Junction Detection for Full-Field Optical Coherence Tomography Data of Human Skin by Deep Learning
      Full-field optical coherence tomography (FF-OCT) has been developed to obtain three-dimensional (3D) OCT data of human skin for early diagnosis of skin cancer. Detection of dermal epidermal junction (DEJ), where melanomas and basal cell carcinomas originate, is an essential step for skin cancer diagnosis. However, most existing DEJ detection methods consider each cross-sectional frame of the 3D OCT data independently, leaving the relationship between neighboring frames unexplored. In this paper ...
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  2. About National Taiwan University

    National Taiwan University

    National Taiwan University main campus is set upon 1,086,167 square meters in Taipei's Daan District. In addition, the university has 6 other campuses in Taiwan, occupying a total of 345,830,000 square meters. NTU is the top ranking University by scientific paper performance in Taiwan and ranked the 102nd in the world. Currently the University consists of 11 colleges, 54 departments, 96 graduate institutes and 4 research centers and offers diplomas in over 100 fields of study. NTU was founded in 1928 by the Japanese during the Japanese colonial era and was then known as the Taihoku (Taipei) Imperial University. After World War II and Taiwan's retrocession to Chinese sovereignty, the Taiwan government resumed the admnistration of Taihoku University and reorganized and renamed it National Taiwan University on November 15, 1945.