1. National Taiwan University

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    1. Mentioned In 114 Articles

    2. A Generic Framework for Fourier-Domain Optical Coherence Tomography Imaging: Software Architecture and Hardware Implementations

      A Generic Framework for Fourier-Domain Optical Coherence Tomography Imaging: Software Architecture and Hardware Implementations
      Fourier-domain optical coherence tomography (FD-OCT), including spectral-domain OCT (SD-OCT) and swept-source OCT (SS-OCT), allows the volumetric imaging of the tissue architecture with a faster speed and higher detection sensitivity than does time-domain OCT. Although the hardware implementations of SD-OCT and SS-OCT are different, these technologies share very similar signal processing steps for image reconstruction. In this study, we developed hardware implementations and software architectures to design a generic framework for ...
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    3. Asymmetry analysis of optical coherence tomography angiography macular perfusion density measurements in preperimetric and perimetric glaucoma

      Asymmetry analysis of optical coherence tomography angiography macular perfusion density measurements in preperimetric and perimetric glaucoma
      Macular retinal layer thickness asymmetry indices, particularly for the ganglion cell layer, are promising early indicators of glaucomatous damage. We evaluated macular perfusion density asymmetry (MPDA) among normal, preperimetric glaucoma (PPG), and perimetric glaucoma (PG) eyes, and we tested the performance of MPDA in differentiating between control and glaucoma eyes with or without visual field (VF) defects. In this study, 116 eyes (39 normal, 27 PPG, and 50 PG eyes ...
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    4. Detecting Mouse Squamous Cell Carcinoma from Submicron FF‐OCT Images by Deep Learning

      Detecting Mouse Squamous Cell Carcinoma from Submicron FF‐OCT Images by Deep Learning
      The standard medical practice for cancer diagnosis requires histopathology, which is an invasive and time‐consuming procedure. Optical coherence tomography (OCT) is an alternative that is relatively fast, non‐invasive, and able to capture three‐dimensional structures of epithelial tissue. Unlike most previous OCT systems, which cannot capture crucial cellular‐level information for squamous cell carcinoma (SCC) diagnosis, the full‐field OCT (FF‐OCT) technology used in this paper is ...
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    5. Transfer Learning for Automated OCTA Detection of Diabetic Retinopathy

      Transfer Learning for Automated OCTA Detection of Diabetic Retinopathy
      Purpose : To test the feasibility of using deep learning for optical coherence tomography angiography (OCTA) detection of diabetic retinopathy. Methods : A deep-learning convolutional neural network (CNN) architecture, VGG16, was employed for this study. A transfer learning process was implemented to retrain the CNN for robust OCTA classification. One dataset, consisting of images of 32 healthy eyes, 75 eyes with diabetic retinopathy (DR), and 24 eyes with diabetes but no DR ...
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    6. Segmentation boosting with compensation methods in optical coherence tomography angiography ...

      Segmentation boosting with compensation methods in optical coherence tomography angiography ...
      Optical coherence tomography angiography is a noninvasive imaging modality to establish the diagnosis of retinal vascular diseases. However, angiography images are significantly interfered if patients jitter or blink. In this study, a novel retinal image analysis method to accurately detect blood vessels and compensate the effect of interference was proposed. We call this the patch U-Net compensation (PUC) system, which is based on the famous U-Net. Several techniques, including a ...
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    7. Comparison of different morphologies of choroidal neovascularization evaluated by optical coherence tomography angiography in age‐related macular degeneration

      Comparison of different morphologies of choroidal neovascularization evaluated by optical coherence tomography angiography in age‐related macular degeneration
      Importance The clinical implications of different morphologies of choroidal neovascularization (CNV), as evaluated by optical coherence tomography angiography (OCTA) in neovascular age‐related macular degeneration (nAMD), are lacking. Background To describe the morphology of CNV in nAMD using OCTA, and to compare the visual prognosis and other structural OCT biomarkers between different morphologic patterns. Design Retrospective cohort study. Participants 140 eyes with nAMD treated with anti‐vascular endothelial growth factor ...
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    8. Optical coherence tomography/angiography-guided tumor ablation with a continuous-wave laser diode

      Optical coherence tomography/angiography-guided tumor ablation with a continuous-wave laser diode
      Laser ablation can be an effective modality for treatment, but it is complicated to apply continuous-wave (CW) light sources for laser ablation because of the unpredictable photothermal damage. In this study, an integrated theranostic system combining a low-cost CW laser diode with optical coherence tomography (OCT)/angiography (OCTA) was utilized for the in vivo ablation of tumor tissues. To examine the effect of laser exposure on tissue scattering characteristics, the ...
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    9. Tandem Mach Zehnder Directional Coupler Design and Simulation on Silicon Platform for Optical Coherence Tomography Applications

      Tandem Mach Zehnder Directional Coupler Design and Simulation on Silicon Platform for Optical Coherence Tomography Applications
      We design and compare the splitting ratio wavelength flatness of directional coupler (DC), Mach-Zehnder directional coupler (MZDC), and tandem MZDC. All coupler responses are analyzed, and tandem MZDC performance is the best in the wavelength insensitivity compared with the other two. An MZDC with any coupling ratio could be utilized to match the maximum flatness in a 40-nm wavelength range. To extend a broad flatness range, the tandem MZDC is ...
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    10. Early detection of enamel demineralization by optical coherence tomography

      Early detection of enamel demineralization by optical coherence tomography
      Enamel is the outermost layer of the tooth that protects it from invasion. In general, an acidic environment accelerates tooth demineralization, leading to the formation of cavities. Scanning electron microscopy (SEM) is conventionally used as an in vitro tool for the observation of tooth morphology changes with acid attacks. Yet, SEM has intrinsic limitations for the potential application of in vivo detection in the early demineralization process. In this study ...
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    11. Ultrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser

      Ultrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser
      In this study, a Q-switch pumped supercontinuum laser (QS-SCL) is used as a light source for in vivo imaging via ultrahigh-resolution optical coherence tomography and angiography (UHR-OCT/OCTA). For this purpose, an OCT system based on a spectral-domain detection scheme is constructed, and a spectrometer with a spectral range of 635875 nm is designed. The effective full-width at half maximum of spectrum covers 150 nm, and the corresponding axial and ...
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    12. OCT-Based Tooth Scan and Reconstruction

      OCT-Based Tooth Scan and Reconstruction
      Digital dental reconstruction can be a more efficient and effective mechanism for artificial crown construction and period inspection. However, optical methods cannot reconstruct those portions under gums, and X-ray-based methods have high radiation to limit their applied frequency. Optical coherence tomography (OCT) can harmlessly penetrate gums using low-coherence infrared rays, and thus, this work designs an OCT-based framework for dental reconstruction using optical rectification, fast Fourier transform, volumetric boundary detection ...
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    13. Correlations between visual acuity and macular microvasculature quantified with optical coherence tomography angiography in diabetic macular oedema

      Correlations between visual acuity and macular microvasculature quantified with optical coherence tomography angiography in diabetic macular oedema
      Purpose To explore the impact of macular ischaemia on vision in diabetic macular oedema (DMO) by analysing the correlations between visual acuity and macular microvascular parameters using optical coherence tomography angiography (OCTA). Methods OCTA was performed in 81 eyes of 48 patients with DMO, and 33-mm 2 en face OCTA images of the superficial capillary plexus and deep capillary plexus in the central macula were retrospectively collected. Microvascular parameters including ...
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    14. Myopic traction maculopathy biomarkers on optical coherence tomography angiography—An overlooked mechanism of visual acuity correction in myopic eyes

      Myopic traction maculopathy biomarkers on optical coherence tomography angiography—An overlooked mechanism of visual acuity correction in myopic eyes
      Background/objectives Myopic traction maculopathy of the retinoschisis type is a unique entity that has been frequently overlooked in refraction correction in daily practice in myopic eyes. The objective of this study was to describe the imaging characteristics of myopic traction maculopathy (MTM) seen on optical coherence tomography angiography (OCTA) and to detect biomarkers of the associated functional changes. Subjects/methods We performed OCTA on eyes with MTM and retinoschisis ...
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    15. Biomarkers of optical coherence tomography in evaluating the treatment outcomes of neovascular age-related macular degeneration: a real-world study

      Biomarkers of optical coherence tomography in evaluating the treatment outcomes of neovascular age-related macular degeneration: a real-world study
      This study evaluated the characteristic changes in optical coherence tomography (OCT) biomarkers in neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial growth factor drugs and their relationship with visual outcomes at 1-year follow-up in a real-world setting. We retrospectively reviewed the medical records of 126 eyes with nAMD treated with either intravitreal ranibizumab or aflibercept, including ophthalmologic examinations and spectral-domain OCT at baseline and months 3, 6, and 12 ...
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  2. About National Taiwan University

    National Taiwan University

    National Taiwan University main campus is set upon 1,086,167 square meters in Taipei's Daan District. In addition, the university has 6 other campuses in Taiwan, occupying a total of 345,830,000 square meters. NTU is the top ranking University by scientific paper performance in Taiwan and ranked the 102nd in the world. Currently the University consists of 11 colleges, 54 departments, 96 graduate institutes and 4 research centers and offers diplomas in over 100 fields of study. NTU was founded in 1928 by the Japanese during the Japanese colonial era and was then known as the Taihoku (Taipei) Imperial University. After World War II and Taiwan's retrocession to Chinese sovereignty, the Taiwan government resumed the admnistration of Taihoku University and reorganized and renamed it National Taiwan University on November 15, 1945.