1. National Taiwan University

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    1. Mentioned In 120 Articles

    2. Spectral-Domain Optical Coherence Tomography For Evaluating Palisades of Vogt in Ocular Surface Disorders With Limbal Involvement

      Spectral-Domain Optical Coherence Tomography For Evaluating Palisades of Vogt in Ocular Surface Disorders With Limbal Involvement
      Spectral-domain optical coherence tomography (SD-OCT) has been used to observe the morphology and epithelial thickness of the palisades of Vogt (POV) with satisfactory resolutions. In this study, we used SD-OCT to examine the microstructure of the POV in ocular surface disorders with limbal involvement and to detect subclinical limbal pathologies based on five parameters. Eighteen eyes of 10 patients (2 men and 8 women; mean age, 48.7 14.0 ...
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    3. Submicron spatial resolution optical coherence tomography for visualising the 3D structures of cells cultivated in complex culture systems

      Submicron spatial resolution optical coherence tomography for visualising the 3D structures of cells cultivated in complex culture systems
      Three-dimensional (3D) configuration of in vitro cultivated cells has been recognised as a valuable tool in developing stem cell and cancer cell therapy. However, currently available imaging approaches for live cells have drawbacks, including unsatisfactory resolution, lack of cross-sectional and 3D images, and poor penetration of multi-layered cell products, especially when cells are cultivated on semitransparent carriers. Herein, we report a prototype of a full-field optical coherence tomography (FF-OCT) system ...
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    4. Correlation between Visual Acuity and Optical Coherence Tomography Angiography Parameters in Unilateral Idiopathic Epiretinal Membrane

      Correlation between Visual Acuity and Optical Coherence Tomography Angiography Parameters in Unilateral Idiopathic Epiretinal Membrane
      Background: The tangential traction by idiopathic epiretinal membrane (iERM) may alter the hemodynamics of the macula. We investigated the correlation between visual acuity and the optical coherence tomography angiography (OCTA) parameters in unilateral iERM. Methods: We included 61 eyes of 61 consecutive patients with unilateral iERM between January 2018 and December 2018. The flow area of the retinal superficial capillary plexus (SCP), deep capillary plexus (DCP), and choroidal capillary plexus ...
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    5. Broadband Coupler Manipulation through Particle Swarm Optimization for Arrayed Waveguide Grating based Optical Coherence Tomography

      Broadband Coupler Manipulation through Particle Swarm Optimization for Arrayed Waveguide Grating based Optical Coherence Tomography
      The state-of-the-art optical coherence technology (OCT) has its limitation, such as bulky and quite expensive. Miniaturization and integration of the OCT system are promising to get a compact, less costly, and more stable device. In this paper, we report the influence of optical power splitting on the sensitivity and axial resolution in spectral-domain OCT (SD-OCT) on silicon chip using tandem Mach-Zehnder directional coupler (MZDC) based broadband coupler through particle swarm ...
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    6. Dermal Epidermal Junction Detection for Full-Field Optical Coherence Tomography Data of Human Skin by Deep Learning

      Dermal Epidermal Junction Detection for Full-Field Optical Coherence Tomography Data of Human Skin by Deep Learning
      Full-field optical coherence tomography (FF-OCT) has been developed to obtain three-dimensional (3D) OCT data of human skin for early diagnosis of skin cancer. Detection of dermal epidermal junction (DEJ), where melanomas and basal cell carcinomas originate, is an essential step for skin cancer diagnosis. However, most existing DEJ detection methods consider each cross-sectional frame of the 3D OCT data independently, leaving the relationship between neighboring frames unexplored. In this paper ...
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    7. A Generic Framework for Fourier-Domain Optical Coherence Tomography Imaging: Software Architecture and Hardware Implementations

      A Generic Framework for Fourier-Domain Optical Coherence Tomography Imaging: Software Architecture and Hardware Implementations
      Fourier-domain optical coherence tomography (FD-OCT), including spectral-domain OCT (SD-OCT) and swept-source OCT (SS-OCT), allows the volumetric imaging of the tissue architecture with a faster speed and higher detection sensitivity than does time-domain OCT. Although the hardware implementations of SD-OCT and SS-OCT are different, these technologies share very similar signal processing steps for image reconstruction. In this study, we developed hardware implementations and software architectures to design a generic framework for ...
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    8. Asymmetry analysis of optical coherence tomography angiography macular perfusion density measurements in preperimetric and perimetric glaucoma

      Asymmetry analysis of optical coherence tomography angiography macular perfusion density measurements in preperimetric and perimetric glaucoma
      Macular retinal layer thickness asymmetry indices, particularly for the ganglion cell layer, are promising early indicators of glaucomatous damage. We evaluated macular perfusion density asymmetry (MPDA) among normal, preperimetric glaucoma (PPG), and perimetric glaucoma (PG) eyes, and we tested the performance of MPDA in differentiating between control and glaucoma eyes with or without visual field (VF) defects. In this study, 116 eyes (39 normal, 27 PPG, and 50 PG eyes ...
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    9. Detecting Mouse Squamous Cell Carcinoma from Submicron FF‐OCT Images by Deep Learning

      Detecting Mouse Squamous Cell Carcinoma from Submicron FF‐OCT Images by Deep Learning
      The standard medical practice for cancer diagnosis requires histopathology, which is an invasive and time‐consuming procedure. Optical coherence tomography (OCT) is an alternative that is relatively fast, non‐invasive, and able to capture three‐dimensional structures of epithelial tissue. Unlike most previous OCT systems, which cannot capture crucial cellular‐level information for squamous cell carcinoma (SCC) diagnosis, the full‐field OCT (FF‐OCT) technology used in this paper is ...
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    10. Transfer Learning for Automated OCTA Detection of Diabetic Retinopathy

      Transfer Learning for Automated OCTA Detection of Diabetic Retinopathy
      Purpose : To test the feasibility of using deep learning for optical coherence tomography angiography (OCTA) detection of diabetic retinopathy. Methods : A deep-learning convolutional neural network (CNN) architecture, VGG16, was employed for this study. A transfer learning process was implemented to retrain the CNN for robust OCTA classification. One dataset, consisting of images of 32 healthy eyes, 75 eyes with diabetic retinopathy (DR), and 24 eyes with diabetes but no DR ...
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    11. Segmentation boosting with compensation methods in optical coherence tomography angiography ...

      Segmentation boosting with compensation methods in optical coherence tomography angiography ...
      Optical coherence tomography angiography is a noninvasive imaging modality to establish the diagnosis of retinal vascular diseases. However, angiography images are significantly interfered if patients jitter or blink. In this study, a novel retinal image analysis method to accurately detect blood vessels and compensate the effect of interference was proposed. We call this the patch U-Net compensation (PUC) system, which is based on the famous U-Net. Several techniques, including a ...
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    12. Comparison of different morphologies of choroidal neovascularization evaluated by optical coherence tomography angiography in age‐related macular degeneration

      Comparison of different morphologies of choroidal neovascularization evaluated by optical coherence tomography angiography in age‐related macular degeneration
      Importance The clinical implications of different morphologies of choroidal neovascularization (CNV), as evaluated by optical coherence tomography angiography (OCTA) in neovascular age‐related macular degeneration (nAMD), are lacking. Background To describe the morphology of CNV in nAMD using OCTA, and to compare the visual prognosis and other structural OCT biomarkers between different morphologic patterns. Design Retrospective cohort study. Participants 140 eyes with nAMD treated with anti‐vascular endothelial growth factor ...
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    13. Optical coherence tomography/angiography-guided tumor ablation with a continuous-wave laser diode

      Optical coherence tomography/angiography-guided tumor ablation with a continuous-wave laser diode
      Laser ablation can be an effective modality for treatment, but it is complicated to apply continuous-wave (CW) light sources for laser ablation because of the unpredictable photothermal damage. In this study, an integrated theranostic system combining a low-cost CW laser diode with optical coherence tomography (OCT)/angiography (OCTA) was utilized for the in vivo ablation of tumor tissues. To examine the effect of laser exposure on tissue scattering characteristics, the ...
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    14. Tandem Mach Zehnder Directional Coupler Design and Simulation on Silicon Platform for Optical Coherence Tomography Applications

      Tandem Mach Zehnder Directional Coupler Design and Simulation on Silicon Platform for Optical Coherence Tomography Applications
      We design and compare the splitting ratio wavelength flatness of directional coupler (DC), Mach-Zehnder directional coupler (MZDC), and tandem MZDC. All coupler responses are analyzed, and tandem MZDC performance is the best in the wavelength insensitivity compared with the other two. An MZDC with any coupling ratio could be utilized to match the maximum flatness in a 40-nm wavelength range. To extend a broad flatness range, the tandem MZDC is ...
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    15. Early detection of enamel demineralization by optical coherence tomography

      Early detection of enamel demineralization by optical coherence tomography
      Enamel is the outermost layer of the tooth that protects it from invasion. In general, an acidic environment accelerates tooth demineralization, leading to the formation of cavities. Scanning electron microscopy (SEM) is conventionally used as an in vitro tool for the observation of tooth morphology changes with acid attacks. Yet, SEM has intrinsic limitations for the potential application of in vivo detection in the early demineralization process. In this study ...
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  2. About National Taiwan University

    National Taiwan University

    National Taiwan University main campus is set upon 1,086,167 square meters in Taipei's Daan District. In addition, the university has 6 other campuses in Taiwan, occupying a total of 345,830,000 square meters. NTU is the top ranking University by scientific paper performance in Taiwan and ranked the 102nd in the world. Currently the University consists of 11 colleges, 54 departments, 96 graduate institutes and 4 research centers and offers diplomas in over 100 fields of study. NTU was founded in 1928 by the Japanese during the Japanese colonial era and was then known as the Taihoku (Taipei) Imperial University. After World War II and Taiwan's retrocession to Chinese sovereignty, the Taiwan government resumed the admnistration of Taihoku University and reorganized and renamed it National Taiwan University on November 15, 1945.