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2. Full Range Swept-Source Optical Coherence Tomography with Ultra Small Fiber Probes for Biomedical Imaging (Book Chapter)
  
  Explore intechopen.com Jan 11 2019 Textbooks
  
  Biomedical imaging is becoming an indispensable branch within bioengineering. This research field has recently expanded due to the requirement of high-level medical diagnostics and rapid development of interdisciplinary modern technologies. This book is designed to present the most recent advances in instrumentation, methods, and image processing as well as clinical applications in important areas of biomedical imaging. It provides broad coverage of the field of biomedical imaging, with particular attention ...
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  Mentions: Shoude Chang Youxin Mao Costel Flueraru
3. Preclinical quantitative in-vivo assessment of skin tissue vascularity in radiation-induced fibrosis with optical coherence tomography
  
  Explore SPIE Digital Library Oct 16 2018 Dermatology
  
  Radiation therapy (RT) is widely and effectively used for cancer treatment but can also cause deleterious side effects, such as a late-toxicity complication called radiation-induced fibrosis (RIF). Accurate diagnosis of RIF requires analysis of histological sections to assess extracellular matrix infiltration. This is invasive, prone to sampling limitations, and thus rarely used; instead, current practice relies on subjective clinical surrogates, including visual observation, palpation, and patient symptomatology questionnaires. This preclinical ...
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  Mentions: University of Toronto I. Alex Vitkin Costel Flueraru
4. Postdoctoral Position in Triangulated Optical Coherence Tomography at National Research Council Canada
  
  Explore Optical Coherence Tomography News Apr 9 2017 Jobs & Studentships
  
  Location : Ottawa, ON and Boucherville, QC Optical coherence tomography (OCT) is an imaging technique that captures volumetric images of a scattering medium. Because of its interferometric nature, it is robust to local variations of light intensities and only requires a direct line of sight. Triangulation-based 3D imaging (laser scanning or structured-light systems), on the other hand, can perform fast surface measurements on large working volumes but requires two lines of ...
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  Mentions: Guy Lamouche National Research Council Canada
5. External amplification of OCT swept-sources for challenging applications: from 10 mW to more than 120 mW
  
  Explore Conference Proceedings Apr 1 2017
  
  For bioimaging applications, commercial swept-sources currently provide enough power (tens of milliwatts) insuring good imaging condition without damaging the tissues. For industrial applications, more power is needed since the amount of light collected can be very low due to challenging measurement conditions or due to poor sample reflectivity. To address this challenge, we explore three different setups to externally amplify the output of a commercial swept-source: a booster semiconductor optical ...
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  Mentions: Guy Lamouche National Research Council Canada
6. Validating Intravascular Imaging with Serial Optical Coherence Tomography and Confocal Fluorescence Microscopy
  
  Explore MDPI Open Access Journals Platform Dec 15 2016 Cardiology
  
  Atherosclerotic cardiovascular diseases are characterized by the formation of a plaque in the arterial wall. Intravascular ultrasound (IVUS) provides high-resolution images allowing delineation of atherosclerotic plaques. When combined with near infrared fluorescence (NIRF), the plaque can also be studied at a molecular level with a large variety of biomarkers. In this work, we present a system enabling automated volumetric histology imaging of excised aortas that can spatially correlate results with ...
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  Mentions: University of Montreal Polytechnique Montreal National Research Council Canada
7. Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks
  
  Explore SPIE | Journal May 15 2016 Cardiology
  
  Analysis of intravascular optical coherence tomography (IVOCT) data has potential for real-time in vivo plaque classification. We developed a processing pipeline on a three-dimensional local region of support for estimation of optical properties of atherosclerotic plaques from coronary artery, IVOCT pullbacks. Using realistic coronary artery disease phantoms, we determined insignificant differences in mean and standard deviation estimates between our pullback analyses and more conventional processing of stationary acquisitions with frame ...
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  Mentions: Andrew M. Rollins Case Western Reserve University Guy Lamouche
8. Nanometer resolution optical coherence tomography using broad bandwidth XUV and soft x-ray radiation
  
  Explore Nature Publishing Group Feb 11 2016
  
  Optical coherence tomography (OCT) is a non-invasive technique for cross-sectional imaging. It is particularly advantageous for applications where conventional microscopy is not able to image deeper layers of samples in a reasonable time, e.g. in fast moving, deeper lying structures. However, at infrared and optical wavelengths, which are commonly used, the axial resolution of OCT is limited to about 1 m, even if the bandwidth of the light covers ...
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  Mentions: National Research Council Canada
9. IMPROVED ARTERIAL TISSUE DIFFERENTIATION BY SPECTROSCOPIC OPTICAL COHERENCE TOMOGRAPHY
  
  Explore Журнал СТМ Apr 27 2015 Cardiology
  
  Optical coherence tomography (OCT) is a relatively new imaging modality similar with ultrasound where the sound waves are replaced by ballistic photons. OCT provides images at high spatial resolution which allow for the identification of micron size morphological tissue structures. A high impact application is visualization of arterial wall and atherosclerotic plaques. Despite high spatial resolution to complete the transfer of this imaging modality into clinical environment there is a ...
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  Mentions: University of Toronto Shoude Chang Youxin Mao
10. Detection of Atherosclerotic Plaque from Optical Coherence Tomography Images Using Texture-Based Segmentation
  
  Explore Журнал СТМ Apr 27 2015 Cardiology
  
  Detection of atherosclerotic plaque from optical coherence tomography (OCT) images by visual inspection is difficult. We developed a texture based segmentation method to identify atherosclerotic plaque automatically from OCT images without any reliance on visual inspection. Our method involves extraction of texture statistical features (spatial gray level dependence matrix method), application of an unsupervised clustering algorithm (K-means) on these features, and mapping of the clustered regions: background, plaque, vascular tissue ...
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  Mentions: Sherif S. Sherif Michael G. Sowa Mark D. Hewko
11. National Research Council of Canada Receives NIH Grant for Validating OCT and Raman Spectrosopy for Assessment of Tooth De/Remineralization
  
  Explore Optical Coherence Tomography News Apr 14 2015 Dentistry , Funding
  
  ...ram in which an oral health objective is to reduce caries and untreated decay among children and adolescents. National Research Council of Canada Received a 2015 NIH Grant for $208,382 for Validating OCT and Raman Spectr...
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  Mentions: National Institutes of Health Michael G. Sowa National Research Council Canada
12. Multilayered tissue phantoms, fabrication methods, and use
  
  Explore uspto.gov Nov 18 2014 Patents
  
  A method for producing a multilayer tissue phantom involves successively forming at least two layers, each layer formed by depositing a viscous flowable material over a supporting element or over a previously formed layer of the phantom supported by the supporting element, selectively redistributing the material while material is solidifying to control a thickness distribution of the layer, and allowing the material to solidify sufficiently to apply a next layer ...
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  Mentions: Guy Lamouche Marc L. Dufour National Research Council Canada
13. Exact Surface Registration of Retinal Surfaces From 3D Optical Coherence Tomography Images
  
  Explore IEEE Xplore Oct 15 2014 Ophthalmology
  
  Nonrigid registration of optical coherence tomography (OCT) images is an important problem in studying eye diseases, evaluating the effect of pharmaceuticals in treating vision loss, and performing group-wise cross-sectional analysis. High dimensional nonrigid registration algorithms required for cross-sectional and longitudinal analysis are still being developed for accurate registration of OCT image volumes, with the speckle noise in images presenting a challenge for registration. Development of algorithms for segmentation of OCT ...
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  Mentions: Marinko V. Sarunic National Research Council Canada Simon Fraser University
14. Characterization of Optical Coherence Tomography Images Acquired at Large Distances With Large-Diameter Beams
  
  Explore IEEE Xplore May 20 2014 Dermatology
  
  We tested the imaging capabilities for variants of a 1550-nm swept-source fiber-based optical coherence tomography system with a telecentric system incorporated at the end of its sample arm. The system was designed for in vivo imaging of burns; therefore, we acquired images from samples located at distances greater than 24 cm from the exit of the telecentric system. Each system variation had a specific combination of diameters for the reference ...
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  Mentions: Michael G. Sowa National Research Council Canada Dan P. Popescu
15. Artery phantoms for intravascular optical coherence tomography: diseased arteries
  
  Explore SPIE | Journal Sep 15 2013 Cardiology
  
  We propose and test various strategies for the creation of artery phantoms mimicking different kinds of diseased arteries when imaged by intravascular optical coherence tomography (IVOCT). We first review the method for making healthy artery phantoms. We then describe the procedure to fabricate diseased artery phantoms with intima thickening, lipid pool, thin-capped fibroatheroma, calcification, and restenosis (homogeneous and layered) after stent apposition. For each case, a phantom is fabricated, an ...
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  Mentions: Guy Lamouche National Research Council Canada Charles-Étienne Bisaillon
16. Texture based segmentation method to detect atherosclerotic plaque from optical tomography images
  
  Explore Conference Proceedings Jun 23 2013 Cardiology
  
  Optical coherence tomography (OCT) imaging has been widely employed in assessing cardiovascular disease. Atherosclerosis is one of the major cause cardio vascular diseases. However visual detection of atherosclerotic plaque from OCT images is often limited and further complicated by high frame rates. We developed a texture based segmentation method to automatically detect plaque and non plaque regions from OCT images. To verify our results we compared them to photographs of ...
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  Mentions: Sherif S. Sherif Michael G. Sowa Mark D. Hewko
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