1. National Research Council Canada

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    1. Mentioned In 118 Articles

    2. Calibration procedure for enhanced mirror artifact removal in full-range optical coherence tomography using passive quadrature demultiplexing

      Calibration procedure for enhanced mirror artifact removal in full-range optical coherence tomography using passive quadrature demultiplexing
      Significance Passive quadrature demultiplexing allows full-range optical coherence tomography (FR-OCT). However, imperfections in the wavelength- and frequency-response of the demodulation circuits can cause residual mirror artifacts, which hinder high-quality imaging on both sides of zero delay. Aim We aim at achieving high mirror artifact extinction by calibrated postprocessing of the FR-OCT signal. Approach We propose a mathematical framework for the origin of the residual mirror peaks as well as a ...
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    3. Binary dose level classification of tumour microvascular response to radiotherapy using artificial intelligence analysis of optical coherence tomography images

      Binary dose level classification of tumour microvascular response to radiotherapy using artificial intelligence analysis of optical coherence tomography images
      The dominant consequence of irradiating biological systems is cellular damage, yet microvascular damage begins to assume an increasingly important role as the radiation dose levels increase. This is currently becoming more relevant in radiation medicine with its pivot towards higher-dose-per-fraction/fewer fractions treatment paradigm (e.g., stereotactic body radiotherapy (SBRT)). We have thus developed a 3D preclinical imaging platform based on speckle-variance optical coherence tomography (svOCT) for longitudinal monitoring of ...
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    4. Longitudinal in-vivo quantification of tumour microvasculature heterogeneity via optical coherence tomography (OCT) angiography in a pre-clinical model of radiation therapy

      Longitudinal in-vivo quantification of tumour microvasculature heterogeneity via optical coherence tomography (OCT) angiography in a pre-clinical model of radiation therapy
      Stereotactic body radiotherapy (SBRT) is an emerging cancer treatment due to its logistical and potential therapeutic benefits as compared to conventional radiotherapy. However, its mechanism of action is yet to be fully understood, likely involving the ablation of tumour microvasculature by higher doses per fraction used in SBRT. In this study, we hypothesized that longitudinal imaging and quantification of the vascular architecture may elucidate the relationship between the microvasculature and ...
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    5. Analysis of low-scattering regions in optical coherence tomography: applications to neurography and lymphangiography

      Analysis of low-scattering regions in optical coherence tomography: applications to neurography and lymphangiography
      Analysis of semi-transparent low scattering biological structures in optical coherence tomography (OCT) has been actively pursued in the context of lymphatic imaging, with most approaches relying on the relative absence of signal as a means of detection. Here we present an alternate methodology based on spatial speckle statistics, utilizing the similarity of a distribution of given voxel intensities to the power distribution function of pure noise, to visualize the low-scattering ...
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    6. Analysis of low-scattering regions in optical coherence tomography

      Analysis of low-scattering regions in optical coherence tomography
      Analysis of semi-transparent low scattering biological structures in optical coherence tomography (OCT) has been actively pursued in the context of lymphatic imaging, with most approaches relying on the relative absence of signal as a means of detection. Here we present an alternate methodology based on spatial speckle statistics, utilizing the similarity of a distribution of given voxel intensities to the power distribution function of pure noise, to visualize the low-scattering ...
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    7. Comparison of laser triangulation, phase shift triangulation and swept source optical coherence Tomography for nondestructive inspection of objects with micrometric accuracy

      Comparison of laser triangulation, phase shift triangulation and swept source optical coherence Tomography for nondestructive inspection of objects with micrometric accuracy
      We compare the performance of laser triangulation, phase shift triangulation and swept source optical coherence tomography (SSOCT) for quantitative nondestructive inspection. Measurement accuracies of these three optical 3D imaging techniques can be reduced to a few tens of micrometers or less, making it possible to locate and geometrically characterize defects at the micrometric scale. We consider surfaces with different optical properties and we discuss the ability of these techniques to ...
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    8. Full Range Swept-Source Optical Coherence Tomography with Ultra Small Fiber Probes for Biomedical Imaging (Book Chapter)

      Full Range Swept-Source Optical Coherence Tomography with Ultra Small Fiber Probes for Biomedical Imaging (Book Chapter)
      Biomedical imaging is becoming an indispensable branch within bioengineering. This research field has recently expanded due to the requirement of high-level medical diagnostics and rapid development of interdisciplinary modern technologies. This book is designed to present the most recent advances in instrumentation, methods, and image processing as well as clinical applications in important areas of biomedical imaging. It provides broad coverage of the field of biomedical imaging, with particular attention ...
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    9. Preclinical quantitative in-vivo assessment of skin tissue vascularity in radiation-induced fibrosis with optical coherence tomography

      Preclinical quantitative in-vivo assessment of skin tissue vascularity in radiation-induced fibrosis with optical coherence tomography
      Radiation therapy (RT) is widely and effectively used for cancer treatment but can also cause deleterious side effects, such as a late-toxicity complication called radiation-induced fibrosis (RIF). Accurate diagnosis of RIF requires analysis of histological sections to assess extracellular matrix infiltration. This is invasive, prone to sampling limitations, and thus rarely used; instead, current practice relies on subjective clinical surrogates, including visual observation, palpation, and patient symptomatology questionnaires. This preclinical ...
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    10. Postdoctoral Position in Triangulated Optical Coherence Tomography at National Research Council Canada

      Postdoctoral Position in Triangulated Optical Coherence Tomography at National Research Council Canada
      Location : Ottawa, ON and Boucherville, QC Optical coherence tomography (OCT) is an imaging technique that captures volumetric images of a scattering medium. Because of its interferometric nature, it is robust to local variations of light intensities and only requires a direct line of sight. Triangulation-based 3D imaging (laser scanning or structured-light systems), on the other hand, can perform fast surface measurements on large working volumes but requires two lines of ...
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    11. External amplification of OCT swept-sources for challenging applications: from 10 mW to more than 120 mW

      External amplification of OCT swept-sources for challenging applications: from 10 mW to more than 120 mW
      For bioimaging applications, commercial swept-sources currently provide enough power (tens of milliwatts) insuring good imaging condition without damaging the tissues. For industrial applications, more power is needed since the amount of light collected can be very low due to challenging measurement conditions or due to poor sample reflectivity. To address this challenge, we explore three different setups to externally amplify the output of a commercial swept-source: a booster semiconductor optical ...
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    12. Validating Intravascular Imaging with Serial Optical Coherence Tomography and Confocal Fluorescence Microscopy

      Validating Intravascular Imaging with Serial Optical Coherence Tomography and Confocal Fluorescence Microscopy
      Atherosclerotic cardiovascular diseases are characterized by the formation of a plaque in the arterial wall. Intravascular ultrasound (IVUS) provides high-resolution images allowing delineation of atherosclerotic plaques. When combined with near infrared fluorescence (NIRF), the plaque can also be studied at a molecular level with a large variety of biomarkers. In this work, we present a system enabling automated volumetric histology imaging of excised aortas that can spatially correlate results with ...
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    13. Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks

      Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks
      Analysis of intravascular optical coherence tomography (IVOCT) data has potential for real-time in vivo plaque classification. We developed a processing pipeline on a three-dimensional local region of support for estimation of optical properties of atherosclerotic plaques from coronary artery, IVOCT pullbacks. Using realistic coronary artery disease phantoms, we determined insignificant differences in mean and standard deviation estimates between our pullback analyses and more conventional processing of stationary acquisitions with frame ...
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    14. Nanometer resolution optical coherence tomography using broad bandwidth XUV and soft x-ray radiation

      Nanometer resolution optical coherence tomography using broad bandwidth XUV and soft x-ray radiation
      Optical coherence tomography (OCT) is a non-invasive technique for cross-sectional imaging. It is particularly advantageous for applications where conventional microscopy is not able to image deeper layers of samples in a reasonable time, e.g. in fast moving, deeper lying structures. However, at infrared and optical wavelengths, which are commonly used, the axial resolution of OCT is limited to about 1 m, even if the bandwidth of the light covers ...
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    15. IMPROVED ARTERIAL TISSUE DIFFERENTIATION BY SPECTROSCOPIC OPTICAL COHERENCE TOMOGRAPHY

      IMPROVED ARTERIAL TISSUE DIFFERENTIATION BY SPECTROSCOPIC OPTICAL COHERENCE TOMOGRAPHY
      Optical coherence tomography (OCT) is a relatively new imaging modality similar with ultrasound where the sound waves are replaced by ballistic photons. OCT provides images at high spatial resolution which allow for the identification of micron size morphological tissue structures. A high impact application is visualization of arterial wall and atherosclerotic plaques. Despite high spatial resolution to complete the transfer of this imaging modality into clinical environment there is a ...
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  2. About National Research Council Canada

    National Research Council Canada

    The National Research Council (NRC) is the Government of Canada's premier organization for research and development. We have been active since 1916.