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    1. Mentioned In 109 Articles

    2. Postdoctoral Position in Triangulated Optical Coherence Tomography at National Research Council Canada

      Postdoctoral Position in Triangulated Optical Coherence Tomography at National Research Council Canada
      Location : Ottawa, ON and Boucherville, QC Optical coherence tomography (OCT) is an imaging technique that captures volumetric images of a scattering medium. Because of its interferometric nature, it is robust to local variations of light intensities and only requires a direct line of sight. Triangulation-based 3D imaging (laser scanning or structured-light systems), on the other hand, can perform fast surface measurements on large working volumes but requires two lines of ...
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    3. External amplification of OCT swept-sources for challenging applications: from 10 mW to more than 120 mW

      External amplification of OCT swept-sources for challenging applications: from 10 mW to more than 120 mW
      For bioimaging applications, commercial swept-sources currently provide enough power (tens of milliwatts) insuring good imaging condition without damaging the tissues. For industrial applications, more power is needed since the amount of light collected can be very low due to challenging measurement conditions or due to poor sample reflectivity. To address this challenge, we explore three different setups to externally amplify the output of a commercial swept-source: a booster semiconductor optical ...
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    4. Validating Intravascular Imaging with Serial Optical Coherence Tomography and Confocal Fluorescence Microscopy

      Validating Intravascular Imaging with Serial Optical Coherence Tomography and Confocal Fluorescence Microscopy
      Atherosclerotic cardiovascular diseases are characterized by the formation of a plaque in the arterial wall. Intravascular ultrasound (IVUS) provides high-resolution images allowing delineation of atherosclerotic plaques. When combined with near infrared fluorescence (NIRF), the plaque can also be studied at a molecular level with a large variety of biomarkers. In this work, we present a system enabling automated volumetric histology imaging of excised aortas that can spatially correlate results with ...
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    5. Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks

      Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks
      Analysis of intravascular optical coherence tomography (IVOCT) data has potential for real-time in vivo plaque classification. We developed a processing pipeline on a three-dimensional local region of support for estimation of optical properties of atherosclerotic plaques from coronary artery, IVOCT pullbacks. Using realistic coronary artery disease phantoms, we determined insignificant differences in mean and standard deviation estimates between our pullback analyses and more conventional processing of stationary acquisitions with frame ...
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    6. Nanometer resolution optical coherence tomography using broad bandwidth XUV and soft x-ray radiation

      Nanometer resolution optical coherence tomography using broad bandwidth XUV and soft x-ray radiation
      Optical coherence tomography (OCT) is a non-invasive technique for cross-sectional imaging. It is particularly advantageous for applications where conventional microscopy is not able to image deeper layers of samples in a reasonable time, e.g. in fast moving, deeper lying structures. However, at infrared and optical wavelengths, which are commonly used, the axial resolution of OCT is limited to about 1 m, even if the bandwidth of the light covers ...
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    7. IMPROVED ARTERIAL TISSUE DIFFERENTIATION BY SPECTROSCOPIC OPTICAL COHERENCE TOMOGRAPHY

      IMPROVED ARTERIAL TISSUE DIFFERENTIATION BY SPECTROSCOPIC OPTICAL COHERENCE TOMOGRAPHY
      Optical coherence tomography (OCT) is a relatively new imaging modality similar with ultrasound where the sound waves are replaced by ballistic photons. OCT provides images at high spatial resolution which allow for the identification of micron size morphological tissue structures. A high impact application is visualization of arterial wall and atherosclerotic plaques. Despite high spatial resolution to complete the transfer of this imaging modality into clinical environment there is a ...
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    8. Detection of Atherosclerotic Plaque from Optical Coherence Tomography Images Using Texture-Based Segmentation

      Detection of Atherosclerotic Plaque from Optical Coherence Tomography Images Using Texture-Based Segmentation
      Detection of atherosclerotic plaque from optical coherence tomography (OCT) images by visual inspection is difficult. We developed a texture based segmentation method to identify atherosclerotic plaque automatically from OCT images without any reliance on visual inspection. Our method involves extraction of texture statistical features (spatial gray level dependence matrix method), application of an unsupervised clustering algorithm (K-means) on these features, and mapping of the clustered regions: background, plaque, vascular tissue ...
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    9. National Research Council of Canada Receives NIH Grant for Validating OCT and Raman Spectrosopy for Assessment of Tooth De/Remineralization

      National Research Council of Canada Receives NIH Grant for Validating OCT and Raman Spectrosopy for Assessment of Tooth De/Remineralization
      ...ram in which an oral health objective is to reduce caries and untreated decay among children and adolescents. National Research Council of Canada Received a 2015 NIH Grant for $208,382 for Validating OCT and Raman Spectr...
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    10. Multilayered tissue phantoms, fabrication methods, and use

      Multilayered tissue phantoms, fabrication methods, and use
      A method for producing a multilayer tissue phantom involves successively forming at least two layers, each layer formed by depositing a viscous flowable material over a supporting element or over a previously formed layer of the phantom supported by the supporting element, selectively redistributing the material while material is solidifying to control a thickness distribution of the layer, and allowing the material to solidify sufficiently to apply a next layer ...
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    11. Exact Surface Registration of Retinal Surfaces From 3D Optical Coherence Tomography Images

      Exact Surface Registration of Retinal Surfaces From 3D Optical Coherence Tomography Images
      Nonrigid registration of optical coherence tomography (OCT) images is an important problem in studying eye diseases, evaluating the effect of pharmaceuticals in treating vision loss, and performing group-wise cross-sectional analysis. High dimensional nonrigid registration algorithms required for cross-sectional and longitudinal analysis are still being developed for accurate registration of OCT image volumes, with the speckle noise in images presenting a challenge for registration. Development of algorithms for segmentation of OCT ...
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    12. Characterization of Optical Coherence Tomography Images Acquired at Large Distances With Large-Diameter Beams

      Characterization of Optical Coherence Tomography Images Acquired at Large Distances With Large-Diameter Beams
      We tested the imaging capabilities for variants of a 1550-nm swept-source fiber-based optical coherence tomography system with a telecentric system incorporated at the end of its sample arm. The system was designed for in vivo imaging of burns; therefore, we acquired images from samples located at distances greater than 24 cm from the exit of the telecentric system. Each system variation had a specific combination of diameters for the reference ...
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    13. Artery phantoms for intravascular optical coherence tomography: diseased arteries

      Artery phantoms for intravascular optical coherence tomography: diseased arteries
      We propose and test various strategies for the creation of artery phantoms mimicking different kinds of diseased arteries when imaged by intravascular optical coherence tomography (IVOCT). We first review the method for making healthy artery phantoms. We then describe the procedure to fabricate diseased artery phantoms with intima thickening, lipid pool, thin-capped fibroatheroma, calcification, and restenosis (homogeneous and layered) after stent apposition. For each case, a phantom is fabricated, an ...
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    14. Texture based segmentation method to detect atherosclerotic plaque from optical tomography images

      Texture based segmentation method to detect atherosclerotic plaque from optical tomography images
      Optical coherence tomography (OCT) imaging has been widely employed in assessing cardiovascular disease. Atherosclerosis is one of the major cause cardio vascular diseases. However visual detection of atherosclerotic plaque from OCT images is often limited and further complicated by high frame rates. We developed a texture based segmentation method to automatically detect plaque and non plaque regions from OCT images. To verify our results we compared them to photographs of ...
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    15. Feature Of The Week 4/21/13: University of Toronto Investigates Analysis of OCT Speckle to Differentiate Tissue Disease State

      Feature Of The Week 4/21/13: University of Toronto Investigates Analysis of OCT Speckle to Differentiate Tissue Disease State
      ... are submicrometer in size. Recently researchers at the University of Toronto, University Health Network, and National Research Council Canada published some interesting results investigating speckle which is highly corr...
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    16. National Research Council Canada Receives a 2013 NIH Grant for Validating OCT and Raman Spectroscopy for Assessment of Tooth De/Remineralization

      National Research Council Canada Receives a 2013 NIH Grant for Validating OCT and Raman Spectroscopy for Assessment of Tooth De/Remineralization
      ...ram in which an oral health objective is to reduce caries and untreated decay among children and adolescents. National Research Council Canada Receives a 2013 NIH Grant for $245,305 for Validating OCT and Raman Spectrosc...
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  2. About National Research Council Canada

    National Research Council Canada

    The National Research Council (NRC) is the Government of Canada's premier organization for research and development. We have been active since 1916.