1. Natalia D. Gladkova

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    1. Mentioned In 42 Articles

    2. Depth-resolved approach for the attenuation coefficient calculation from the Optical Coherence Tomography data and its application for the brain imaging

      Depth-resolved approach for the attenuation coefficient calculation from the Optical Coherence Tomography data and its application for the brain imaging
      Optical coherence tomography (OCT) is a promising tool for intraoperative tissue morphology determination. Several studies suggest that the attenuation coefficient, derived from the OCT images can differentiate between normal and tumorous tissues, as well as between gray and white brain matter. The methods used for attenuation coefficient derivation in these studies follow the assumption that the optical properties of the specimen are uniform within the OCT imaging depth range. Although ...
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    3. Histological validation of in vivo assessment of cancer tissue inhomogeneity and automated morphological segmentation enabled by Optical Coherence Elastography

      Histological validation of in vivo assessment of cancer tissue inhomogeneity and automated morphological segmentation enabled by Optical Coherence Elastography
      We present a non-invasive (albeit contact) method based on Optical Coherence Elastography (OCE) enabling the in vivo segmentation of morphological tissue constituents, in particular, monitoring of morphological alterations during both tumor development and its response to therapies. The method uses compressional OCE to reconstruct tissue stiffness map as the first step. Then the OCE-image is divided into regions, for which the Youngs modulus (stiffness) falls in specific ranges corresponding to ...
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    4. TRANS-SEROSAL MULTIMODAL OPTICAL COHERENCE TOMOGRAPHY FOR VISUALIZATION OF MICROSTRUCTURE AND BLOOD CIRCULATION OF THE SMALL INTESTINE WALL

      TRANS-SEROSAL MULTIMODAL OPTICAL COHERENCE TOMOGRAPHY FOR VISUALIZATION OF MICROSTRUCTURE AND BLOOD CIRCULATION OF THE SMALL INTESTINE WALL
      The aim of the study was to evaluate the performance of trans-serosal multimodal OCT (MM OCT) in in vivo detecting of changes in microstructure and blood circulation of the small intestine wall caused by arteriovenous ischemia resulted from intestine strangulation. Materials and Methods. In experiments on Wistar rats (n=22), we examined the small intestine wall in vivo using MM OCT; the access to the intestine was reached through laparotomy ...
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    5. Multimodal Optical Coherence Tomography: Imaging of Blood and Lymphatic Vessels of the Vulva

      Multimodal Optical Coherence Tomography: Imaging of Blood and Lymphatic Vessels of the Vulva
      The aim of the study was to test the method of optical coherence tomography (OCT) for its ability to obtain images of blood and lymphatic vessels of the vulva. Materials and Methods. The study was performed using a multimodal optical coherence tomography device developed in the Institute of Applied Physics of the Russian Academy of Sciences (Nizhny Novgorod). In this setup, 3D images of 3.43.41.25 mm are ...
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    6. Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study

      Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study
      Microvascular networks of human basal cell carcinomas (BCC) and surrounding skin were assessed with optical coherence angiography (OCA) in conjunction with photodynamic therapy (PDT). OCA images were collected and analyzed in 31 lesions pre-treatment, and immediately/24hours/312 months post-treatment. Pre-treatment OCA enabled differentiation between prevalent subtypes of BCC (nodular and superficial) and nodular-with-necrotic-core BCC subtypes with a diagnostic accuracy of 78%; this can facilitate more accurate biopsy reducing sampling ...
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    7. Optical coefficients as tools for increasing the optical coherence tomography contrast for normal brain visualization and glioblastoma detection

      Optical coefficients as tools for increasing the optical coherence tomography contrast for normal brain visualization and glioblastoma detection
      The methods used for digital processing of optical coherence tomography (OCT) and crosspolarization (CP) OCT images are focused on improving the contrast ratio of native structural OCT images. Such advances are particularly important for the intraoperative detection of glioma margins where the visual assessment of OCT images can be difficult and lead to errors. The aim of the study was to investigate the application of optical coefficients obtained from CP ...
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    8. Cross-polarization optical coherence tomography for brain tumor imaging

      Cross-polarization optical coherence tomography for brain tumor imaging
      This paper considers valuable visual assessment criteria for distinguishing between tumorous and non-tumorous tissues, intraoperatively, using cross-polarization OCT (CP OCT) OCT with a functional extension, that enables detection of the polarization properties of the tissues in addition to their conventional light scattering. Materials and methods. The study was performed on 176 ex vivo human specimens obtained from 30 glioma patients. To measure the degree to which the typical parameters of ...
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    9. Time-related ex vivo changes in the optical properties of normal brain tissues

      Time-related ex vivo changes in the optical properties of normal brain tissues
      The aim of the study was to observe time-related changes in the optical properties of normal brain tissues as measured using cross-polarization optical coherence tomography (CP OCT). 32 ex vivo tissue samples from 16 animals (rats) were monitored under different external conditions, over a period of 1 hour after excision, to measure time-related optical changes. It was found that the optical properties of white matter were quite stable over the ...
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    10. Optical coherence angiography without motion correction preprocessing

      Optical coherence angiography without motion correction preprocessing
      The method for vessel visualization from optical coherence tomography (OCT) data is presented. The method is based on high-frequency filtration of the normalized absolute values of the scattered field measured with OCT. It is shown that in contrast with optical coherence angiography based on the processing of complex values of a scattered field, the proposed processing does not require motion correction preprocessing while providing resulting angiographic images of comparable quality.
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    11. Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

      Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography
      Optical coherence tomography (OCT) is a promising method for detecting cancer margins during tumor resection. This study focused on differentiating tumorous from nontumorous tissues in human brain tissues using cross-polarization OCT (CP OCT). The study was performed on fresh ex vivo human brain tissues from 30 patients with high- and low-grade gliomas. Different tissue types that neurosurgeons should clearly distinguish during surgery, such as the cortex, white matter, necrosis and ...
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    12. Optical coherence tomography‐based angiography device with real‐time angiography B‐scans visualization and hand‐held probe for everyday clinical use

      Optical coherence tomography‐based angiography device with real‐time angiography B‐scans visualization and hand‐held probe for everyday clinical use
      This work is dedicated to the development of the OCT system with angiography for everyday clinical use. Two major problems were solved during the development: compensation of specific natural tissue displacements, induced by contact scanning mode and physiological motion of patients (eg, respiratory and cardiac motions) and online visualization of vessel cross‐sections to provide feedback for the system operator.
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    13. Quantitative Cross-Polarization Optical Coherence Tomography Detection of Infiltrative Tumor Margin in a Rat Glioma Model: a Pilot Study

      Quantitative Cross-Polarization Optical Coherence Tomography Detection of Infiltrative Tumor Margin in a Rat Glioma Model: a Pilot Study
      Determining boundaries of infiltrative glial tumors remains a challenging problem in neurooncology. Optical coherence tomography (OCT) with cross-polarization (CP) visualization is a promising technique as a surgical guidance tool. However, the outcome of the procedures performed under OCT guidance strongly depends on the surgeons qualification. Thus, a quantitative method for assessing resection margins with OCT is required. The aim of this study was to develop a robust quantitative approach for ...
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    14. Cross-Polarization Optical Coherence Tomography in Comparative in vivo and ex vivo Studies of the Optical Properties of Normal and Tumorous Brain Tissues

      Cross-Polarization Optical Coherence Tomography in Comparative in vivo and ex vivo Studies of the Optical Properties of Normal and Tumorous Brain Tissues
      The aim of the study was to provide visual and quantitative evaluation of tumorous and normal brain tissue images obtained by cross-polarization optical coherence tomography (CP OCT) in a comparative in vivo and ex vivo study. Materials and Methods. The CP OCT as a non-damaging noninvasive optical method for tissue structure imaging was used in the study. It enables obtaining volumetric images of 2.42.41.25 mm 3 in ...
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    15. In-vivo longitudinal imaging of microvascular changes in irradiated oral mucosa of radiotherapy cancer patients using optical coherence tomography

      In-vivo longitudinal imaging of microvascular changes in irradiated oral mucosa of radiotherapy cancer patients using optical coherence tomography
      Mucositis is the limiting toxicity of radio(chemo)therapy of head and neck cancer. Diagnostics, prophylaxis and correction of this condition demand new accurate and objective approaches. Here we report on an in vivo longitudinal monitoring of the oral mucosa dynamics in 25 patients during the course of radiotherapy of oropharyngeal and nasopharyngeal cancer using multifunctional optical coherence tomography (OCT). A spectral domain OCT system with a specially-designed oral imaging ...
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    16. Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography

      Pixel classification method in optical coherence tomography for tumor segmentation and its complementary usage with OCT microangiography
      A novel machine-learning method to distinguish between tumor and normal tissue in optical coherence tomography (OCT) has been developed. Pre-clinical murine ear model implanted with mouse colon carcinoma CT-26 was used. Structural-image-based feature sets were defined for each pixel and machine learning classifiers were trained using ground truth OCT images manually segmented by comparison with histology. The accuracy of the OCT tumour segmentation method was then quantified by comparing with ...
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    17. 1-15 of 42 1 2 3 »
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  2. About Natalia D. Gladkova

    Natalia D. Gladkova

    Natalia D. Gladkova, graduated from the Nizhny Novgorod State Medical Academy in 1973. She received her PhD in 1983, her Dr. of Sciences in 1997, professorship in 2005, and the State Prize in Science and Technology for research on OCT in 1999. She is working as the Head of Optical Coherence Tomography (OCT) research group at the Research Institute of Applied and Fundamental Medicine and a senior researcher of the Department of Nonlinear Dynamics and Optics at the Institute of Applied Physics of the Russian Academy of Science. Author of more than 200 research publications on OCT in endoscopy, oncology, stomatology, and dermatology. Author of 12 patents of the Russian Federation and of their 7 international analogs. Professor Natalia Gladkova is an internationally recognized expert in the field of OCT medical applications. Scientific interests: optical diagnostics, imaging of biotissue structure and interaction of high intensity laser radiation with biotissues.