1. Narendran Sudheendran

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    1. Mentioned In 19 Articles

    2. Rotational imaging optical coherence tomography for full-body mouse embryonic imaging

      Rotational imaging optical coherence tomography for full-body mouse embryonic imaging
      Optical coherence tomography (OCT) has been widely used to study mammalian embryonic development with the advantages of high spatial and temporal resolutions and without the need for any contrast enhancement probes. However, the limited imaging depth of traditional OCT might prohibit visualization of the full embryonic body. To overcome this limitation, we have developed a new methodology to enhance the imaging range of OCT in embryonic day (E) 9.5 ...
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    3. En face projection imaging of the human choroidal layers with tracking SLO and swept source OCT angiography methods

      En face projection imaging of the human choroidal layers with tracking SLO and swept source OCT angiography methods
      We tested and compared the capability of multiple optical coherence tomography (OCT) angiography methods: phase variance, amplitude decorrelation and speckle variance, with application of the split spectrum technique, to image the choroiretinal complex of the human eye. To test the possibility of OCT imaging stability improvement we utilized a real-time tracking scanning laser ophthalmoscopy (TSLO) system combined with a swept source OCT setup. In addition, we implemented a post- processing ...
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    4. Quantification of Mouse Embryonic Eye Development with Optical Coherence Tomography In Utero

      Quantification	of	Mouse	Embryonic	Eye	Development	with	 Optical	Coherence	Tomography	In	Utero
      Mouse models are commonly used as research tools to understand regulatory pathways affected by human diseases and disorders. Live imaging tools for visualization of mouse embryonic ocular tissues would be beneficial in research associated with developmental ocular defects. In this study, in utero quantitative assessment of ocular structures in mouse embryos was performed with a swept-source optical coherence tomography (SSOCT). To define developmental changes in eye morphology in live embryos ...
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    5. Algorithms for improved 3-D reconstruction of live mammalian embryo vasculature from optical coherence tomography data

      Algorithms for improved 3-D reconstruction of live mammalian embryo vasculature from optical coherence tomography data
      ...om optical coherence tomography data Prathamesh M. Kulkarni^1, Nicolas Rey-Villamizar^1, Amine Merouane^1, Narendran Sudheendran^2, Shang Wang^3, Monica Garcia^3, Irina V. Larina^3, Badrinath Roysam^1, Kirill V. Larin...
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    6. Line-scan Raman microscopy complements optical coherence tomography for tumor boundary detection

      Line-scan Raman microscopy complements optical coherence tomography for tumor boundary detection
      Current technique for tumor resection requires biopsy of the tumor region and histological confirmation before the surgeon can be certain that the entire tumor has been resected. This confirmation process is time consuming both for the surgeon and the patient and also requires sacrifice of healthy tissue, motivating the development of novel technologies which can enable real-time detection of tumor-healthy tissue boundary for faster and more efficient surgeries. In this ...
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    7. Comparative assessments of the effects of alcohol exposure on fetal brain development using optical coherence tomography and ultrasound imaging

      Comparative assessments of the effects of alcohol exposure on fetal brain development using optical coherence tomography and ultrasound imaging
      The developing fetal brain is vulnerable to a variety of environmental agents including maternal ethanol consumption. Preclinical studies on the development and amelioration of fetal teratology would be significantly facilitated by the application of high resolution imaging technologies like optical coherence tomography (OCT) and high-frequency ultrasound (US). This study investigates the ability of these imaging technologies to measure the effects of maternal ethanol exposure on brain development, ex vivo , in ...
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    8. Optical coherence tomography for live phenotypic analysis of embryonic ocular structures in mouse models

      Optical coherence tomography for live phenotypic analysis of embryonic ocular structures in mouse models
      Mouse models of ocular diseases provide a powerful resource for exploration of molecular regulation of eye development and pre-clinical studies. Availability of a live high-resolution imaging method for mouse embryonic eyes would significantly enhance longitudinal analyses and high-throughput morphological screening. We demonstrate that optical coherence tomography (OCT) can be used for live embryonic ocular imaging throughout gestation. At all studied stages, the whole eye is within the imaging distance of ...
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  2. About Narendran Sudheendran

    Narendran Sudheendran

    Narendran Sudheendran is a Ph.D. student in the Electrical and Computer Engineering at the University of Houston. His focus is quantification of blood flow in tissues using Speckle in Optical Coherence Tomography.