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    1. Mentioned In 83 Articles

    2. Comparison of Optical Coherence Tomography Angiography to Indocyanine Green Angiography and Slit Lamp Photography for Corneal Vascularization in an Animal Model

      Comparison of Optical Coherence Tomography Angiography to Indocyanine Green Angiography and Slit Lamp Photography for Corneal Vascularization in an Animal Model
      Corneal neovascularization (CoNV) could be treated by novel anti-angiogenic therapies, though reliable and objective imaging tools to evaluate corneal vasculature and treatment efficacy is still lacking. Optical coherence tomography angiography (OCTA) currently designed as a retinal vascular imaging system has been recently adapted for anterior-segment and showed good potential for successful imaging of CoNV. However, further development requires an animal model where parameters can be studied more carefully with histological ...
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    3. Novel application of In Vivo Micro-Optical Coherence Tomography to assess Cornea scarring in an Animal Model

      Novel application of In Vivo Micro-Optical Coherence Tomography to assess Cornea scarring in an Animal Model
      This pilot study uses a micro-optical coherence tomography (micro-OCT) system with ~1m axial resolution specifically to image the cornea and corneal scars in vivo . We used an established murine corneal scar model by irregular phototherapeutic keratectomy in ten C57BL/6 mice, with serial imaging using the micro-OCT and compared to anterior segment (AS-OCT) (RTvue, Optovue, Fremont, CA) before and after scar induction. Main outcome was agreement between the AS-OCT and ...
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    4. Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design

      Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design
      We report a dual-focus fiber-optic probe designed to extend depth of focus (DOF) in high-resolution endoscopic optical coherence tomography. We exploited the broad spectral bandwidth of a supercontinuum source and, in the fiber probe, the foci of the 7501000 nm and 11001450 nm inputs were axially chromatically shifted. The interference signals from the two spectral bands were measured with a Si camera-based spectrometer and an InGaAs camera-based spectrometer, respectively. We ...
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    5. Postdoctoral Research Fellow Position in the Ocular Imaging Program at the Singapore Eye Research Institute

      Postdoctoral Research Fellow Position in the Ocular Imaging Program at the Singapore Eye Research Institute
      ... research programmes for eye diseases. Recently SERI has established an ocular imaging program together with Nanyang Technological University (NTU) under the directorship of Prof. Leopold Schmetterer. SERI is seeking a ...
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    6. Multiscale skin imaging in vivo using optical coherence tomography

      Multiscale skin imaging in vivo using optical coherence tomography
      Optical coherence tomography (OCT) is a noninvasive high-resolution diagnostic imaging modality that plays an increasingly important role in dermatology. Diagnosis of skin diseases using OCT requires both cellular-level high resolution and large area skin coverage. In practice, however, there exists a trade-off between the achievable spatial resolutions and the transverse scanning range. In this study, we report a Micro-OCT ( OCT) system that is capable of providing three-dimensional images of the ...
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    7. Evaluating micro-optical coherence tomography (μOCT) as a feasible imaging tool for pancreatic disease diagnosis

      Evaluating micro-optical coherence tomography (μOCT) as a feasible imaging tool for pancreatic disease diagnosis
      Pancreatic cancer is one of the leading causes of cancer mortality worldwide due to the lack of reliable tools for early diagnosis of this cancer. In this study, we evaluated the feasibility of micro-optical coherence tomography (OCT) as an imaging tool for the diagnosis of pancreatic cancers. Specifically, we constructed a OCT device that achieves a resolution of 1.67 m and 1.79 m in axial and lateral directions ...
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    8. Extending axial focus of optical coherence tomography using parallel multiple aperture synthesis

      Extending axial focus of optical coherence tomography using parallel multiple aperture synthesis
      Compromising the inherent trade-off between transverse resolution and depth of focus (DOF) remains a long-standing issue in optical coherence tomography (OCT). In this work, we report a novel techniqueparallel multiple aperture synthesis (pMAS) to simultaneously generate multiple optical apertures in an OCT sample arm by employing a two-surface coated mirror. In the proposed pMAS, the DOF is extended by a factor of 16.49 without sacrificing the transverse resolution for ...
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    9. Tunable optical coherence tomography in the infrared range using visible photons

      Tunable optical coherence tomography in the infrared range using visible photons
      Optical coherence tomography (OCT) is an appealing technique for bio-imaging, medicine, and material analysis. For many applications, OCT in mid- and far-infrared (IR) leads to significantly more accurate results. Reported mid-IR OCT systems require light sources and photodetectors which operate in mid-IR range. These devices are expensive and need cryogenic cooling. Here, we report a proof-of-concept demonstration of a wavelength tunable IR OCT technique with detection of only visible range ...
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    10. Pixel-Reassigned Spectral-Domain Optical Coherence Tomography

      Pixel-Reassigned Spectral-Domain Optical Coherence Tomography
      A novel method of pixel reassignment (PRA) is proposed to achieve transverse superresolution in the confocal microscopy. Inspired by it, for the first time, we report a pixel-reassigned spectral-domain optical coherence tomography (OCT) with 1.5 times transverse resolution improvement both in numerical simulations and imaging experiments. PRA is implemented by transversely shifting the detection fiber from the on-axis position to five off-axis positions, capturing cross-sectional images at each shifting ...
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    11. PhD Student Opening in Functional Optical Imaging Employing Contrast Agents at the Medical University of Vienna

      PhD Student Opening in Functional Optical Imaging Employing Contrast Agents at the Medical University of Vienna
      ...ding for 3 years. The student will work for two years at the Medical University of Vienna and one year at the Nanyang Technological University in Singapore. A Master’s degree in veterinary medicine, biology, biochemistry...
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    12. Multiple aperture synthetic optical coherence tomography for biological tissue imaging

      Multiple aperture synthetic optical coherence tomography for biological tissue imaging
      An inherent compromise must be made between transverse resolution and depth of focus (DOF) in spectral domain optical coherence tomography (SD-OCT). Thus far, OCT has not been capable of providing a sufficient DOF to stably acquire cellular-resolution images. We previously reported a novel technique named multiple aperture synthesis (MAS) to extend the DOF in high-resolution OCT [Optica4, 701 (2017)]. In this technique, the illumination beam is scanned across the objective ...
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    13. Optical coherence tomography angiography: a review of current and future clinical applications

      Optical coherence tomography angiography: a review of current and future clinical applications
      Optical coherence tomography angiography is a non-invasive imaging technique that now allows for simultaneous in vivo imaging of the morphology as well as the vasculature in the eye. In this review, we provide an update on the existing clinical applications of optical coherence tomography angiography technology from the anterior to posterior segment of the eye. We also discuss the limitations of optical coherence tomography angiography technology, as well as the ...
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    14. Analyzing external and internal membrane fouling by oil emulsions via 3D optical coherence tomography

      Analyzing external and internal membrane fouling by oil emulsions via 3D optical coherence tomography
      Membrane-based filtration is an emerging technique for processing oily wastewater. Improving the efficiency of oil-water separation via membranes entails novel techniques for studying the complex interactions between the oil droplets and membrane underlying fouling. This paper presents the first study that applies optical coherence tomography (OCT) to the characterization of membrane fouling by oil emulsions. A series of dead-end filtration experiments was performed to characterize the rejection of oil droplets ...
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    15. Tunable Optical Coherence Tomography in the Infrared Range Using Visible Photons

      Tunable Optical Coherence Tomography in the Infrared Range Using Visible Photons
      We report a proof-of-concept demonstration of a tunable infrared (IR) optical coherence tomography (OCT) technique with detection of only visible range photons. Our method is based on the nonclassical interference of frequency correlated photon pairs. The nonlinear crystal, introduced in the Michelson-type interferometer, generates photon pairs with one photon in the visible and another in the IR range. The intensity of detected visible photons depends on the phase and loss ...
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  2. About Nanyang Technological University

    Nanyang Technological University

    Nanyang Technological University (NTU is an internationally reputed research-intensive tertiary institution. Our broad-based education covers science and technology, business and the arts, entrepreneurial and leadership skills to prepare students for the global working world.