1. Nanyang Technological University

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    1. Mentioned In 165 Articles

    2. Interferometric imaging of thermal expansion for temperature control in retinal laser therapy

      Interferometric imaging of thermal expansion for temperature control in retinal laser therapy
      Precise control of the temperature rise is a prerequisite for proper photothermal therapy. In retinal laser therapy, the heat deposition is primarily governed by the melanin concentration, which can significantly vary across the retina and from patient to patient. In this work, we present a method for determining the optical and thermal properties of layered materials, directly applicable to the retina, using low-energy laser heating and phase-resolved optical coherence tomography ...
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    3. Subsurface detection of hair follicles in alopecia areata using optical coherence tomography

      Subsurface detection of hair follicles in alopecia areata using optical coherence tomography
      Dear Editors, Alopecia areata (AA) is an autoimmune skin disorder that affects any hair-bearing areas and results in localized nonscarring hair loss. It can occur in individuals at any age regardless of ethnicity with a lifetime risk of 12%. 1 The loss of hair is caused by perifollicular inflammation, which is associated with cytokines and chemokines released by T cells. 2 , 3 Although spontaneous regrowth is possible in 80% of ...
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    4. Multi-task learning approach for volumetric segmentation and reconstruction in 3D OCT images

      Multi-task learning approach for volumetric segmentation and reconstruction in 3D OCT images
      The choroid is the vascular layer of the eye that supplies photoreceptors with oxygen. Changes in the choroid are associated with many pathologies including myopia where the choroid progressively thins due to axial elongation. To quantize these changes, there is a need to automatically and accurately segment the choroidal layer from optical coherence tomography (OCT) images. In this paper, we propose a multi-task learning approach to segment the choroid from ...
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    5. Combining OCT and OCTA for Focal Structure-Function Modeling in Early Primary Open-Angle Glaucoma

      Combining OCT and OCTA for Focal Structure-Function Modeling in Early Primary Open-Angle Glaucoma
      Purpose: To investigate modeling of the focal visual field (VF) loss by combining structural measurements and vascular measurements in eyes with early primary open-angle glaucoma (POAG). Methods: In this cross-sectional study, subjects with early glaucoma (VF mean deviation, -6 dB) underwent optical coherence tomography (OCT) imaging, optical coherence tomography angiography (OCTA) imaging, and Humphrey 24-2 VF tests. Capillary perfusion densities (CPDs) were calculated after the removal of large vessels in ...
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    6. Semi-automated quantitative analysis of the middle limiting membrane in tubercular serpiginous-like choroiditis using swept-source optical coherence tomography

      Semi-automated quantitative analysis of the middle limiting membrane in tubercular serpiginous-like choroiditis using swept-source optical coherence tomography
      o analyze the longitudinal changes in the outer plexiform layer (OPL) in patients with tubercular serpiginous-like choroiditis (TB SLC) and compare it to the healthy control population. Clinical and imaging data of subjects with TB SLC (minimum 6-month follow-up) and healthy control subjects were reviewed. Optical coherence tomography (OCT) imaging obtained using swept-source device (DRI Triton, Topcon, Japan) from three visits (baseline, 3 months, and 6 months) were analyzed. Three ...
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    7. Aberration Mitigation in High-resolution Optical Coherence Tomography Implementing Elliptical Beam Design

      Aberration Mitigation in High-resolution Optical Coherence Tomography Implementing Elliptical Beam Design
      We report an elliptical beam design for aberration mitigation in high-resolution optical coherence tomography (OCT). We polished a large angle on the fiber terminal facet in the sample arm to make a non-rotational symmetric beam with different numerical apertures (NA) for the two axes vertical to the optical axis. By sacrificing the resolution in the out-of-plane transverse direction, the elliptical beam mitigated the aberration introduced by the focusing optics in ...
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    8. Spectrally Extended Line Field Optical Coherence Tomography Angiography

      Spectrally Extended Line Field Optical Coherence Tomography Angiography
      Optical coherence tomography angiography (OCTA) has been established as a powerful tool for investigating vascular diseases and is expected to become a standard of care technology. However, its widespread clinical usage is hindered by technical gaps such as limited field of view (FOV), lack of quantitative flow information, and suboptimal motion correction. Here we report a new imaging platform, termed spectrally extended line field (SELF) OCTA that provides advanced solutions ...
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    9. Ultrawide field, distortion-corrected ocular shape estimation with MHz optical coherence tomography (OCT)

      Ultrawide field, distortion-corrected ocular shape estimation with MHz optical coherence tomography (OCT)
      Ocular deformation may be associated with biomechanical alterations in the structures of the eye, especially the cornea and sclera in conditions such as keratoconus, congenital glaucoma, and pathological myopia. Here, we propose a method to estimate ocular shape using an ultra-wide field MHz swept-source optical coherence tomography (SS-OCT) with a Fourier Domain Mode-Locked (FDML) laser and distortion correction of the images. The ocular biometrics for distortion correction was collected by ...
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    10. Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury: a pilot animal model study

      Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury: a pilot animal model study
      To examine the use of anterior segment-optical coherence tomography angiography (AS-OCTA) in the assessment of limbal ischemia in an animal model chemical ocular injury. We conducted a prospective study using an established chemical ocular injury model in 6 rabbits (12 eyes), dividing the cornea limbus into 4 quadrants. Chemical injury grade was induced based on extent of limbal injury (0 to 360 degrees) and all eyes underwent serial slit-lamp with ...
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    11. Developing a normative database for retinal perfusion using optical coherence tomography angiography

      Developing a normative database for retinal perfusion using optical coherence tomography angiography
      Visualizing and characterizing microvascular abnormalities with optical coherence tomography angiography (OCTA) has deepened our understanding of ocular diseases, such as glaucoma, diabetic retinopathy, and age-related macular degeneration. Two types of microvascular defects can be detected by OCTA: focal decrease because of localized absence and collapse of retinal capillaries, which is referred to as the non-perfusion area in OCTA, and diffuse perfusion decrease usually detected by comparing with healthy case-control groups ...
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    12. Framework for quantitative three-dimensional choroidal vasculature analysis using optical coherence tomography

      Framework for quantitative three-dimensional choroidal vasculature analysis using optical coherence tomography
      Choroidal vasculature plays an important role in the pathogenesis of retinal diseases, such as myopic maculopathy, age-related macular degeneration, diabetic retinopathy, central serous chorioretinopathy, and ocular inflammatory diseases. Current optical coherence tomography (OCT) technology provides three-dimensional visualization of the choroidal angioarchitecture; however, quantitative measures remain challenging. Here, we propose and validate a framework to segment and quantify the choroidal vasculature from a prototype swept-source OCT (PLEX Elite 9000, Carl Zeiss ...
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    13. Anterior Segment Optical Coherence Tomography Angiography Assessment of Corneal Vascularisation After Combined Fine-Needle Diathermy with Subconjunctival Ranibizumab: A Pilot Study

      Anterior Segment Optical Coherence Tomography Angiography Assessment of Corneal Vascularisation After Combined Fine-Needle Diathermy with Subconjunctival Ranibizumab: A Pilot Study
      Introduction: To describe anterior segment optical coherence tomography angiography (AS-OCTA) imaging to monitor corneal vascularisation (CoNV) and scar reduction after combined fine-needle diathermy (FND) with subconjunctival ranibizumab. Methods: Prospective clinical study of six eyes from six subjects with corneal scar and CoNV which underwent combined FND with subconjunctival ranibizumab. All eyes were imaged using slit-lamp photography (SLP) and AS-OCTA (Optovue, Inc., Fremont, CA, wavelength: 840 nm) before and after the ...
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    14. Inspection of Intraocular Lens with Dual-side View Optical Coherence Tomography

      Inspection of Intraocular Lens with Dual-side View Optical Coherence Tomography
      Intraocular lens (IOL) is widely used for cataract treatment. Its optical properties are crucial to obtain a good treatment efficacy and thus need to be evaluated and controlled. In this study, we propose a novel method based on optical coherence tomography (OCT) for noncontact and accurate in vitro measurement of thickness, refractive index and dioptric power of IOL implants. The OCT setup is specially designed to create two sampling optics ...
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    15. 1-15 of 165 1 2 3 4 ... 9 10 11 »
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  2. About Nanyang Technological University

    Nanyang Technological University

    Nanyang Technological University (NTU is an internationally reputed research-intensive tertiary institution. Our broad-based education covers science and technology, business and the arts, entrepreneurial and leadership skills to prepare students for the global working world.