1. Nanyang Technological University

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    1. Mentioned In 61 Articles

    2. Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia

      Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia
      We report the design and fabrication of a flexible, longitudinally scanning high-resolution micro-optical coherence tomography (OCT) endobronchial probe, optimized for micro-anatomical imaging in airways. The 2.4 mm diameter and flexibility of the probe allows it to be inserted into the instrument channel of a standard bronchoscope, enabling real-time video guidance of probe placement. To generate a depth-of-focus enhancing annular beam, we utilized a new fabrication method, whereby a hollow ...
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    3. Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy

      Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy
      Purpose To characterise vascular changes in eyes with acute non-arteritic anterior ischaemic optic neuropathy (NAION), using optical coherence tomography angiography (OCT-A) imaging. Methods This hospital-based observational case-control study included included five patients with acute NAION (6 eyes), within 7 days after onset of symptoms and 19 age-matched healthy controls (19 eyes). OCT-A (RTVue XR 100; Optovue, Fremont, California, USA), covering a 4.54.5 mm scan area, was used to ...
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    4. Multifiber angular compounding optical coherence tomography for speckle reduction

      Multifiber angular compounding optical coherence tomography for speckle reduction
      We report on an integrated fiber optic design to implement multifiber angular compounding optical coherence tomography, which enables angular compounding for speckle reduction. A multi-facet fiber array delivers three light beams to the sample with different incident angles. Back-reflective/back-scattered signals from these channels were simultaneously detected by a three-channel spectrometer. The axial and lateral resolution was measured to be 3 3 and 3.5 m 3.5m , respectively, in ...
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    5. Effects of spacer orientations on the cake formation during membrane fouling: Quantitative analysis based on 3D OCT imaging

      Effects of spacer orientations on the cake formation during membrane fouling: Quantitative analysis based on 3D OCT imaging
      Spacer design plays an important role in improving the performance of membrane processes for water/wastewater treatment. This work focused on a fundamental issue of spacer design, i.e., investigating the effects of spacer orientations on the fouling behavior during a membrane process. A series of fouling experiments with different spacer orientation were carried out to in situ characterize the formation of a cake layer in a spacer unit cell ...
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    6. Quantitative optical coherence microscopy for the in situ investigation of the biofilm

      Quantitative optical coherence microscopy for the in situ investigation of the biofilm
      his paper explores the potential of optical coherence microscopy (OCM) for the in situ monitoring of biofilm growth. The quantitative imaging of the early developmental biology of a representative biofilm, Klebsiella pneumonia (KP-1), was performed using a swept source-based Fourier domain OCM system. The growth dynamics of the KP-1 biofilms and their transient response under perturbation was investigated using the enface visualization of microcolonies and their spatial localization. Furthermore, the ...
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    7. Contrast Enhanced Subsurface Fingerprint Detection using High-speed Optical Coherence Tomography

      Contrast Enhanced Subsurface Fingerprint Detection using High-speed Optical Coherence Tomography
      Spectral-domain optical coherence tomography (SDOCT) has been demonstrated to be a viable tool in forensic science for fingerprint detection, yet it still suffers from certain practical issues, e.g., the limited scanning speed and low image contrast. In this letter, we report a high-speed SD-OCT together with an image contrast enhancement mechanism for reliable subsurface fingerprint detection. The constructed SDOCT system achieves a scanning rate up to 60K A-lines/s ...
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    8. Spectral domain optical coherence tomography with extended depth-of-focus by aperture synthesis

      Spectral domain optical coherence tomography with extended depth-of-focus by aperture synthesis
      We developed a spectral domain optical coherence tomography (SD-OCT) with an extended depth-of-focus (DOF) by synthetizing aperture. For a designated Gaussian-shape light source, the lateral resolution was determined by the numerical aperture (NA) of the objective lens and can be approximately maintained over the confocal parameter, which was defined as twice the Rayleigh range. However, the DOF was proportional to the square of the lateral resolution. Consequently, a trade-off existed ...
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    9. Spectral phase-based automatic calibration scheme for swept source-based optical coherence tomography systems

      Spectral phase-based automatic calibration scheme for swept source-based optical coherence tomography systems
      The automatic calibration in Fourier-domain optical coherence tomography (FD-OCT) systems allows for high resolution imaging with precise depth ranging functionality in many complex imaging scenarios, such as microsurgery. However, the accuracy and speed of the existing automatic schemes are limited due to the functional approximations and iterative operations used in their procedures. In this paper, we present a new real-time automatic calibration scheme for swept source-based optical coherence tomography (SS-OCT ...
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    10. Gold nanorods with higher aspect ratio as potential contrast agent in optical coherence tomography and for photothermal applications around 1300 nm imaging window

      Gold nanorods with higher aspect ratio as potential contrast agent in optical coherence tomography and for photothermal applications around 1300 nm imaging window
      Over the past few years, plasmon-resonant nanorods of gold (AuNRs) have been used as the contrast agent in optical imaging and for photothermal applications. However, most of these studies were limited to AuNRs whose spectral peaks fall below 1000 nm. Recently, optical coherence tomography (OCT) imaging around 1300 nm has become one of the niche research areas due to its potential for many diagnostics imaging applications. In this paper, we ...
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    11. Evaluation of a Micro-Optical Coherence Tomography for the Corneal Endothelium in an Animal Model

      Evaluation of a Micro-Optical Coherence Tomography for the Corneal Endothelium in an Animal Model
      Recent developments in optical coherence tomography (OCT) systems for the cornea have limited resolution or acquisition speed. In this study we aim to evaluate the use of a micro-OCT (OCT ~1m axial resolution) compared to existing imaging modalities using animal models of corneal endothelial disease. We used established cryoinjury and bullous keratopathy models in Sprague Dawley rats comparing ex vivo OCT imaging in normal and diseased eyes to (1) histology ...
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    12. Toward High-Speed Imaging of Cellular Structures in Rat Colon Using Micro-optical Coherence Tomography

      Toward High-Speed Imaging of Cellular Structures in Rat Colon Using Micro-optical Coherence Tomography
      The mucosal microanatomy of the large intestine is characterized by the presence of crypts of Lieberkhn, which is associated predominantly with goblet cells. Such cellular-level intestinal microstructures undergo morphological changes during the progression of bowel diseases, such as colon cancer or ulcerative colitis. As an indicator of gastric cancers, intestinal metaplasia in the large intestine is characterized by the appearance of goblet cells in gastric epithelium, and therefore, visualization of ...
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    13. Complex wavelet based quality assessment for AS-OCT images with application to Angle Closure Glaucoma diagnosis

      Complex wavelet based quality assessment for AS-OCT images with application to Angle Closure Glaucoma diagnosis
      Background and objectives Angle closure disease in the eye can be detected using time-domain Anterior Segment Optical Coherence Tomography (AS-OCT). The Anterior Chamber (AC) characteristics can be quantified from AS-OCT image, which is dependent on the image quality at the image acquisition stage. To date, to the best of our knowledge there are no objective or automated subjective measurements to assess the quality of AS-OCT images. Methods To address AS-OCT ...
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    14. Automated anterior segment OCT image analysis for Angle Closure Glaucoma mechanisms classification

      Automated anterior segment OCT image analysis for Angle Closure Glaucoma mechanisms classification
      Background and objectives Angle closure glaucoma (ACG) is an eye disease prevalent throughout the world. ACG is caused by four major mechanisms: exaggerated lens vault, pupil block, thick peripheral iris roll, and plateau iris. Identifying the specific mechanism in a given patient is important because each mechanism requires a specific medication and treatment regimen. Traditional methods of classifying these four mechanisms are based on clinically important parameters measured from anterior ...
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    15. Postdoctoral research fellowship, research associate position, and PhD scholarship (optical coherence tomography) at Nanyang Technological University

      Postdoctoral research fellowship, research associate position, and PhD scholarship (optical coherence tomography) at Nanyang Technological University
      One research fellow position, one research associate position, and one PhD scholarship is available at School of Electrical Electronic Engineering. The successful candidates will join a multidisciplinary team of 10 research staff and 10 PhD students and work on collaborative research projects with a focus on microscopic/endoscopic technology development and translational studies. These positions are supported by multiple active grants (Funding amount: $10M; Funding period: 2015-2020) for developing ultrahigh ...
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  2. About Nanyang Technological University

    Nanyang Technological University

    Nanyang Technological University (NTU is an internationally reputed research-intensive tertiary institution. Our broad-based education covers science and technology, business and the arts, entrepreneurial and leadership skills to prepare students for the global working world.