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1. Mentioned In 101 Articles
2. Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies
  
  Explore Science Translational Medicine Aug 8 2019 Pulmonology
  
  Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Although impairment of mucociliary clearance contributes to severe morbidity and mortality in people with CF, a clear understanding of the pathophysiology is lacking. This is, in part, due to the absence of clinical imaging techniques capable of capturing CFTR-dependent functional metrics at the cellular level. Here, we report the clinical translation of ...
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  Mentions: Guillermo J. Tearney Massachusetts General Hospital University of Alabama
3. Innovative tool gives researchers new look at the nasal airway in CF patients
  
  Explore uab.edu Aug 7 2019 Pulmonology
  
  ... Fibrosis Research Center; Hui Zheng of Harvard Medical School and MGH’s Biostatistics Center; Dongyao Cui of Nanyang Technological University in Singapore; and Lael M. Yonker and Bryan P. Hurley of MGH’s Mucosal Immunol...
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  Mentions: Guillermo J. Tearney Massachusetts General Hospital University of Alabama
4. Rapid, High-Resolution, Label-Free, and 3-Dimensional Imaging to Differentiate Colorectal Adenomas and Non-Neoplastic Polyps With Micro-Optical Coherence Tomography
  
  Explore insights.ovid.com Jun 24 2019 Gastroenterology
  
  INTRODUCTION: Resectanddiscard paradigmisoneofthemainstrategiestodealwithcolorectaldiminutivepolyps after optical diagnosis. However, there are risks that unrecognized potentially malignant lesions are discarded without accurate diagnosis. The purpose of this study is to validate the potential of micro- optical coherence tomography ( m OCT) to improve the diagnostic accuracy of colorectal lesions and help endoscopists make better clinical decision without additional pathology costs. METHODS: RESULTS: DISCUSSION: Fresh tissue samples were obtained from patients with colorectal polyps or ...
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  Mentions: Jun Zhang Nanyang Technological University Linbo Liu
5. Automatic evaluation of stratum basale and dermal papillae using ultrahigh resolution optical coherence tomography
  
  Explore ScienceDirect Jun 24 2019
  
  Diagnosis of many skin conditions requires evaluation of dermal papillae and stratum basale, such as vitiligo. In clinical practice, imaging dermal papillae structures relies on excisional biopsy followed by histological processing and analysis. As biopsy is invasive and associated with complications, a noninvasive imaging method such as optical coherence tomography (OCT) can complement the existing method by enabling large area scanning. However, because OCT image analysis requires training and it ...
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  Mentions: Nanyang Technological University Linbo Liu
6. Intelligent Detection of Glaucoma Using Ballistic Optical Imaging
  
  Explore ResearchGate May 11 2019 Ophthalmology
  
  Immense imaging strategies have been adept in sprouting investigative supports for glaucoma discovery. Ballistic optical imaging such as optical coherence tomography have been inspected for estimating the key constraints for glaucoma estimation such as disc area, cup area, cup volume, disc and rim area, cup to disc ratio and thickness of the retinal nerve fibre layer. This paper presents a scheme for glaucoma detection by ballistic optical imaging and machine ...
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  Mentions: Stanford University Harvard University Nanyang Technological University
7. Are nuclei in stratified squamous epithelium high scattering or low scattering?
  
  Explore arxiv.org Mar 23 2019
  
  Imaging nuclei of keratinocytes in the stratified squamous epithelium has been a subject of intense research since nucleus associated cellular atypia is the key criteria for the screening and diagnosis of epithelial cancers and their precursors. However, keratinocyte nuclei have been reported to be either low scattering or high scattering, so that these inconsistent reports might have led to misinterpretations of optical images, and more importantly, hindered the establishment of ...
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  Mentions: Nanyang Technological University Linbo Liu
8. Single input state polarization-sensitive optical coherence tomography with high resolution and polarization distortion correction
  
  Explore OSA | OSA Publishing Feb 28 2019
  
  Abstract: In single input state polarization-sensitive optical coherence tomography (PS-OCT) with high resolution, the imperfections of quarter-wave plate (QWP) and the sensitivity roll-off mismatch between the two detection channels cause unpredictable polarization distortion. We present a correction method based on the Jones matrix modeling of the system. In a single input PS-OCT system working at 840 nm with an axial resolution of ~2.3 m, the method yielded better estimation ...
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  Mentions: Nanyang Technological University Linbo Liu
9. Optical coherence tomography with gapped spectrum
  
  Explore IEEE Xplore Feb 19 2019
  
  The axial resolution of optical coherence tomography (OCT) is determined by the spectral shape and bandwidth of the detected light, which are limited by the gaps in the wavelength range of illumination, transmission, and detection. In this work, we demonstrate that the axial resolution deteriorated by gaps in OCT spectra can be restored by adopting the gapped amplitude and phase estimation (GAPES) method. GAPES estimates the missing parts between separated ...
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  Mentions: Nanyang Technological University Linbo Liu
10. Nondestructive Measurement of Conformal Coating Thickness on Printed Circuit Board with Ultra-high Resolution Optical Coherence Tomography
  
  Explore IEEE Xplore Feb 5 2019 NDE/NDT
  
  Conformal coating (CC) is widely used to protect printed circuit board (PCB) from corrosion, mould growth and electrical failures. To ensure an effective protection, the thickness of the conformal coating layer needs to be well controlled. However, to date, the coating thickness is usually measured in a destructive way under microscopes. In this study, we proposed to use optical coherence tomography (OCT) to measure the CC thickness nondestructively. Specifically, to ...
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  Mentions: Nanyang Technological University University of Iowa Linbo Liu
11. Cake formation of bidisperse suspensions in dead-end microfiltration
  
  Explore ScienceDirect Feb 3 2019 NDE/NDT
  
  The evolution of the cake during dead-end microfiltration of different compositions of bidisperse feeds was investigated using network modeling and three-dimensional (3D) optical coherence tomography (OCT) imaging. The foulant particles were latex of two different sizes (namely, 3 and 5 m) and the membrane was polycarbonate track-etched with nominal diameter of 2 m. The results from the network model indicate that (i) the deposition of the smaller particles on the ...
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  Mentions: Nanyang Technological University
12. Cellular resolution corneal imaging with extended imaging range
  
  Explore OSA | OSA Publishing Jan 31 2019 Ophthalmology
  
  Current optical coherence tomography (OCT) technology, which is used for imaging the eyes anterior segment, has been established as a clinical gold standard for the diagnosis of corneal diseases. However, the cellular resolution level information that is critical for many clinical applications is still not available. The major technical challenges toward cellular resolution OCT imaging are the limited ranging depth and depth of focus (DOF). In this work, we present ...
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  Mentions: Nanyang Technological University Linbo Liu
13. Development of cellular resolution optical coherence tomography (Thesis)
  
  Explore DR-NTU HOME Jan 28 2019 Student Theses
  
  Diagnosis of most mucosal diseases including epithelial cancers relies on white-light endoscopy/visual inspection followed by random biopsy and histologic examination. These current standard-of-care tools are associated with many issues such as sampling errors, tissue destruction, and processing artifacts. In addition, it is too traumatic to take a biopsy from tissues like eyes and coronary arteries. Being high resolution, high speed, and non-invasive, optical coherence tomography (OCT) has emerged as ...
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  Mentions: Nanyang Technological University
14. Imaging in myopia: potential biomarkers, current challenges and future developments
  
  Explore BJO Online Jan 12 2019 Ophthalmology
  
  Myopia is rapidly increasing in Asia and around the world, while it is recognised that complications from high myopia may cause significant visual impairment. Thus, imaging the myopic eye is important for the diagnosis of sight-threatening complications, monitoring of disease progression and evaluation of treatments. For example, recent advances in high-resolution imaging using optical coherence tomography may delineate early myopic macula pathology, optical coherence tomography angiography may aid early choroidal ...
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  Mentions: Columbia University Medical University of Vienna Singapore Eye Research Institute
15. Quantitative analysis of choriocapillaris in non-human primates using swept-source optical coherence tomography angiography (SS-OCTA)
  
  Explore OSA | OSA Publishing Dec 26 2018 Ophthalmology
  
  The choriocapillaris is a unique vascular plexus located posterior to the retinal pigment epithelium. In recent years, there is an increasing interest in the examination of the interrelationship between the choriocapillaris and eye diseases. We used several techniques to study choroidal perfusion, including laser Doppler flowmetry, laser speckle flowgraphy, and optical coherence tomography angiography (OCTA), but with the latter no standardized algorithm for quantitative analysis has been provided. We analyzed ...
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  Mentions: Medical University of Vienna Carl Zeiss Meditec Nanyang Technological University
16. Estimation of refractive index for biological tissue using micro-optical coherence tomography
  
  Explore IEEE Xplore Dec 12 2018
  
  $Estimation of refractive index for biological tissue using micro-optical coherence tomography$
  The refractive index of biological tissue is required for investigating the tissue's optical properties. Efforts have been made to characterize refractive indices of biological tissues at a single wavelength, but it is more convenient to know the Cauchy's coefficients, which provide refractive index over a wide range of wavelengths. We demonstrate a method to noninvasively provide the Cauchy's dispersion coefficients of biological tissues using micro-optical coherence tomography ...
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  Mentions: Nanyang Technological University Linbo Liu
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