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    1. Mentioned In 132 Articles

    2. Optical Coherence Tomography Angiography in Diabetes and Diabetic Retinopathy

      Optical Coherence Tomography Angiography in Diabetes and Diabetic Retinopathy
      Diabetic retinopathy (DR) is a common complication of diabetes mellitus that disrupts the retinal microvasculature and is a leading cause of vision loss globally. Recently, optical coherence tomography angiography (OCTA) has been developed to image the retinal microvasculature, by generating 3-dimensional images based on the motion contrast of circulating blood cells. OCTA offers numerous benefits over traditional fluorescein angiography in visualizing the retinal vasculature in that it is non-invasive and ...
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    3. Comparison of retinal vessel diameter measurements from swept-source OCT angiography and adaptive optics ophthalmoscope

      Comparison of retinal vessel diameter measurements from swept-source OCT angiography and adaptive optics ophthalmoscope
      Background/ims To compare the retinal vessel diameter measurements obtained from the swept-source optical coherence tomography angiography (OCTA; Plex Elite 9000, Carl Zeiss Meditec, USA) and adaptive optics ophthalmoscope (AOO; RTX1, Imagine Eyes, France). Methods Fifteen healthy subjects, 67% women, mean age (SD) 30.87 (6.19) years, were imaged using OCTA and AOO by a single experienced operator on the same day. Each eye was scanned using two OCTA ...
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    4. Towards Indicating Human Skin State In Vivo Using Geometry-Dependent Spectroscopic Contrast Imaging

      Towards Indicating Human Skin State In Vivo Using Geometry-Dependent Spectroscopic Contrast Imaging
      Skin plays a significant role in human body function and its collagen states change during the human skin ageing process, which affects skin function. We previously reported on geometry-dependent spectroscopic contrast achieved by spectroscopic micro-optical coherence tomography ( S OCT), which discovered that transversely oriented and regularly arranged nano-cylinders selectively backscatter the long-wavelength lights and generate spectral centroid (SC) shifts towards the long wavelengths within a spectral window of 700 950 ...
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    5. Real-time en-face Gabor optical coherence tomographic angiography on human skin using CUDA GPU

      Real-time en-face Gabor optical coherence tomographic angiography on human skin using CUDA GPU
      We recently proposed an optical coherence tomographic angiography (OCTA) algorithm, Gabor optical coherence tomographic angiography (GOCTA), which can extract microvascular signals from a spectral domain directly with lower computational complexity compared to other algorithms. In this manuscript, we combine a programmable swept source, an OCT complex signal detecting unit, and graphics process units (GPU) to achieve a real-time en-face GOCTA system for human skin microvascular imaging. The programmable swept source ...
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    6. Automatic differentiation of nonkeratinized stratified squamous epithelia and columnar epithelia through feature structure extraction using OCT

      Automatic differentiation of nonkeratinized stratified squamous epithelia and columnar epithelia through feature structure extraction using OCT
      As a type of precancerous lesion, metaplasia is usually considered to be associated with developing cancer. In clinical practice, surveillance of metaplastic cases usually relies on excisional biopsy followed by histological processing and analysis. As it is an invasive method accompanied by other complications, non-invasive imaging methods such as optical coherence tomography (OCT) can complement the existing method by enabling large area scanning. However, because it takes time to review ...
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    7. Postdoctoral Research Fellow In Ocular Imaging Program at the Singapore Eye Research Institute

      Postdoctoral Research Fellow In Ocular Imaging Program at the Singapore Eye Research Institute
      ... research programmes for eye diseases. Recently SERI has established an ocular imaging program together with Nanyang Technological University (NTU) under the directorship of Prof. Leopold Schmetterer. SERI is seeking a ...
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    8. Extending depth range of optical coherence tomography (Thesis)

      Extending depth range of optical coherence tomography (Thesis)
      Optical coherence tomography (OCT) is a noninvasive diagnostic imaging tool that has been established in various clinical fields. One of the most cited issue of OCT in clinical practices is the shortage of image depth range. This thesis proposes four novel techniques to significantly extend the depth range without compromising other imaging performances. The OCT depth range is fundamentally limited by two main factors, which are the axial field of ...
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    9. Resolution enhancement and realistic speckle recovery with generative adversarial modeling of micro-optical coherence tomography

      Resolution enhancement and realistic speckle recovery with generative adversarial modeling of micro-optical coherence tomography
      A resolution enhancement technique for optical coherence tomography (OCT), based on Generative Adversarial Networks (GANs), was developed and investigated. GANs have been previously used for resolution enhancement of photography and optical microscopy images. We have adapted and improved this technique for OCT image generation. Conditional GANs (cGANs) were trained on a novel set of ultrahigh resolution spectral domain OCT volumes, termed micro-OCT, as the high-resolution ground truth (1 m isotropic ...
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    10. Cutaneous optical coherence tomography for longitudinal volumetric assessment of intradermal volumes in a mouse model

      Cutaneous optical coherence tomography for longitudinal volumetric assessment of intradermal volumes in a mouse model
      Clinical evaluation of skin lesions requires precise and reproducible technologies for their qualitative and quantitative assessment. In this study, we investigate the applicability of a custom-built dermatologic OCT system for longitudinal assessment of intradermal volumes in a mouse model. The OCT, based on an akinetic swept laser working at 1310nm was employed for visualization and quantification of intradermal deposits of three different hyaluronic acid-based hydrogel formulations one commercial and two ...
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    11. Towards Label-Free 3D Segmentation of Optical Coherence Tomography Images of the Optic Nerve Head Using Deep Learning

      Towards Label-Free 3D Segmentation of Optical Coherence Tomography Images of the Optic Nerve Head Using Deep Learning
      Since the introduction of optical coherence tomography (OCT), it has been possible to study the complex 3D morphological changes of the optic nerve head (ONH) tissues that occur along with the progression of glaucoma. Although several deep learning (DL) techniques have been recently proposed for the automated extraction (segmentation) and quantification of these morphological changes, the device-specific nature and the difficulty in preparing manual segmentations (training data) limit their clinical ...
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    12. Changes in Retinal Blood Flow in Response to an Experimental Increase in IOP in Healthy Participants as Assessed With Doppler Optical Coherence Tomography

      Changes in Retinal Blood Flow in Response to an Experimental Increase in IOP in Healthy Participants as Assessed With Doppler Optical Coherence Tomography
      Purpose : Blood flow autoregulation is an intrinsic mechanism of the healthy retinal vasculature to keep blood flow constant when ocular perfusion pressure (OPP) is changed. In the present study, we set out to investigate retinal blood flow in response to an experimental decrease in OPP in healthy participants using Doppler optical coherence tomography. Methods : Fifteen healthy participants aged between 22 and 31 years (mean, 27 3 years) were included in ...
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    13. Deep learning segmentation for optical coherence tomography measurements of the lower tear meniscus

      Deep learning segmentation for optical coherence tomography measurements of the lower tear meniscus
      The tear meniscus contains most of the tear fluid and therefore is a good indicator for the state of the tear film. Previously, we used a custom-built optical coherence tomography (OCT) system to study the lower tear meniscus by automatically segmenting the image data with a thresholding-based segmentation algorithm (TBSA). In this report, we investigate whether the results of this image segmentation algorithm are suitable to train a neural network ...
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    14. Dual-side view optical coherence tomography for thickness measurement on opaque materials

      Dual-side view optical coherence tomography for thickness measurement on opaque materials
      Optical coherence tomography (OCT), as an optical interferometric imaging technique, has found wide applications in various fields. In principle, OCT is well suited for imaging layered structures, and thus, one of the typical applications is thickness measurement. However, due to the limited imaging depth resulting from light attenuation, thickness measurement by OCT is limited to non-opaque materials. In this study, we developed a novel (to the best of our knowledge ...
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    15. Beyond Fourier transform: break the axial resolution limit in optical coherence tomography

      Beyond Fourier transform: break the axial resolution limit in optical coherence tomography
      Optical coherence tomography (OCT) is a volumetric imaging modality that empowers the clinicians and scientists to noninvasively visualize and examine the microscopic cross-sectional architectures of biological samples. By taking advantages of the coherence gating, OCT could achieve micrometer-level axial sectioning with high sensitivity. In the past decade, substantial efforts have been made to push the axial resolution of Fourier-domain OCT (FD-OCT) further into the sub-micron regime via physically extending the ...
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    16. 1-15 of 132 1 2 3 4 5 6 7 8 9 »
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  2. About Nanyang Technological University

    Nanyang Technological University

    Nanyang Technological University (NTU is an internationally reputed research-intensive tertiary institution. Our broad-based education covers science and technology, business and the arts, entrepreneurial and leadership skills to prepare students for the global working world.