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    1. Mentioned In 65 Articles

    2. Endomicroscopic optical coherence tomography for cellular resolution imaging of gastrointestinal tracts

      Explore Wiley Online Library Gastroenterology
      Endomicroscopic optical coherence tomography for cellular resolution imaging of gastrointestinal tracts
      Our ability to detect neoplastic changes in gastrointestinal (GI) tracts is limited by the lack of an endomicroscopic imaging tool that provides cellular-level structural details of GI mucosa over a large tissue area. In this paper, we report a fiber-optic based micro-optical coherence tomography (OCT) system and demonstrate its capability to acquire cellular-level details of GI tissue through circumferential scanning. The system achieves an axial resolution of 2.48m in ...
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      Mentions: Nanyang Technological University Linbo Liu

    3. Polarization management to mitigate misalignment-induced fringe fading in fiber-based optical coherence tomography

      Explore OSA | OSA Publishing
      Polarization management to mitigate misalignment-induced fringe fading in fiber-based optical coherence tomography
      In fiber-based optical coherence tomography (OCT), the interference fringes suffer from the fading effect due to misalignment of the light polarization states between the reference and sample arms, resulting in sensitivity degradation and image intensity variation. We theoretically and experimentally analyzed the relation between the misalignment and the fading coefficient. Assuming that the variation of the light polarization in single-mode fiber (SMF) was a random process, we statistically quantified the ...
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      Mentions: Nanyang Technological University Linbo Liu

    5. Depth-of-focus extension in optical coherence tomography via multiple aperture synthesis

      Explore OSA | OSA Publishing
      Depth-of-focus extension in optical coherence tomography via multiple aperture synthesis
      In this paper, we report what we believe is a novel technique to overcome the depth-of-focus (DOF) limitation in optical coherence tomography (OCT). Using confocal optics on a sample arm, we scanned the illumination beam across the under-filled objective lens pupil plane by steering the beam at the pinhole using a microcylindrical lens. The detected interferometric signals from multiple distinctive apertures were digitally refocused, which is analogous to synthetic aperture ...
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      Mentions: Nanyang Technological University Linbo Liu

    6. Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia

      Explore OSA | OSA Publishing Pulmonology , Probes
      Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia
      We report the design and fabrication of a flexible, longitudinally scanning high-resolution micro-optical coherence tomography (OCT) endobronchial probe, optimized for micro-anatomical imaging in airways. The 2.4 mm diameter and flexibility of the probe allows it to be inserted into the instrument channel of a standard bronchoscope, enabling real-time video guidance of probe placement. To generate a depth-of-focus enhancing annular beam, we utilized a new fabrication method, whereby a hollow ...
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      Mentions: Guillermo J. Tearney Massachusetts General Hospital University of Alabama

    8. Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy

      Explore BJO Online Ophthalmology
      Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy
      Purpose To characterise vascular changes in eyes with acute non-arteritic anterior ischaemic optic neuropathy (NAION), using optical coherence tomography angiography (OCT-A) imaging. Methods This hospital-based observational case-control study included included five patients with acute NAION (6 eyes), within 7 days after onset of symptoms and 19 age-matched healthy controls (19 eyes). OCT-A (RTVue XR 100; Optovue, Fremont, California, USA), covering a 4.54.5 mm scan area, was used to ...
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      Mentions: Optovue Duke University Medical University of Vienna

    9. Multifiber angular compounding optical coherence tomography for speckle reduction

      Explore OSA | OSA Publishing
      Multifiber angular compounding optical coherence tomography for speckle reduction
      We report on an integrated fiber optic design to implement multifiber angular compounding optical coherence tomography, which enables angular compounding for speckle reduction. A multi-facet fiber array delivers three light beams to the sample with different incident angles. Back-reflective/back-scattered signals from these channels were simultaneously detected by a three-channel spectrometer. The axial and lateral resolution was measured to be 3 3 and 3.5 m 3.5m , respectively, in ...
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      Mentions: Nanyang Technological University Linbo Liu

    10. Effects of spacer orientations on the cake formation during membrane fouling: Quantitative analysis based on 3D OCT imaging

      Explore ScienceDirect NDE/NDT , Other Non-Medical
      Effects of spacer orientations on the cake formation during membrane fouling: Quantitative analysis based on 3D OCT imaging
      Spacer design plays an important role in improving the performance of membrane processes for water/wastewater treatment. This work focused on a fundamental issue of spacer design, i.e., investigating the effects of spacer orientations on the fouling behavior during a membrane process. A series of fouling experiments with different spacer orientation were carried out to in situ characterize the formation of a cake layer in a spacer unit cell ...
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      Mentions: Nanyang Technological University

    11. Quantitative optical coherence microscopy for the in situ investigation of the biofilm

      Explore SPIE | Journal
      Quantitative optical coherence microscopy for the in situ investigation of the biofilm
      his paper explores the potential of optical coherence microscopy (OCM) for the in situ monitoring of biofilm growth. The quantitative imaging of the early developmental biology of a representative biofilm, Klebsiella pneumonia (KP-1), was performed using a swept source-based Fourier domain OCM system. The growth dynamics of the KP-1 biofilms and their transient response under perturbation was investigated using the enface visualization of microcolonies and their spatial localization. Furthermore, the ...
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      Mentions: Nanyang Technological University

    12. Contrast Enhanced Subsurface Fingerprint Detection using High-speed Optical Coherence Tomography

      Explore IEEE Xplore Dermatology , Other Non-Medical
      Contrast Enhanced Subsurface Fingerprint Detection using High-speed Optical Coherence Tomography
      Spectral-domain optical coherence tomography (SDOCT) has been demonstrated to be a viable tool in forensic science for fingerprint detection, yet it still suffers from certain practical issues, e.g., the limited scanning speed and low image contrast. In this letter, we report a high-speed SD-OCT together with an image contrast enhancement mechanism for reliable subsurface fingerprint detection. The constructed SDOCT system achieves a scanning rate up to 60K A-lines/s ...
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      Mentions: Nanyang Technological University Linbo Liu

    13. Spectral domain optical coherence tomography with extended depth-of-focus by aperture synthesis

      Explore Conference Proceedings
      Spectral domain optical coherence tomography with extended depth-of-focus by aperture synthesis
      We developed a spectral domain optical coherence tomography (SD-OCT) with an extended depth-of-focus (DOF) by synthetizing aperture. For a designated Gaussian-shape light source, the lateral resolution was determined by the numerical aperture (NA) of the objective lens and can be approximately maintained over the confocal parameter, which was defined as twice the Rayleigh range. However, the DOF was proportional to the square of the lateral resolution. Consequently, a trade-off existed ...
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      Mentions: Nanyang Technological University Linbo Liu

    14. Spectral phase-based automatic calibration scheme for swept source-based optical coherence tomography systems

      Explore IOPscience
      Spectral phase-based automatic calibration scheme for swept source-based optical coherence tomography systems
      The automatic calibration in Fourier-domain optical coherence tomography (FD-OCT) systems allows for high resolution imaging with precise depth ranging functionality in many complex imaging scenarios, such as microsurgery. However, the accuracy and speed of the existing automatic schemes are limited due to the functional approximations and iterative operations used in their procedures. In this paper, we present a new real-time automatic calibration scheme for swept source-based optical coherence tomography (SS-OCT ...
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      Mentions: Nanyang Technological University

    15. Gold nanorods with higher aspect ratio as potential contrast agent in optical coherence tomography and for photothermal applications around 1300 nm imaging window

      Explore IOPscience
      Gold nanorods with higher aspect ratio as potential contrast agent in optical coherence tomography and for photothermal applications around 1300 nm imaging window
      Over the past few years, plasmon-resonant nanorods of gold (AuNRs) have been used as the contrast agent in optical imaging and for photothermal applications. However, most of these studies were limited to AuNRs whose spectral peaks fall below 1000 nm. Recently, optical coherence tomography (OCT) imaging around 1300 nm has become one of the niche research areas due to its potential for many diagnostics imaging applications. In this paper, we ...
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      Mentions: Nanyang Technological University

    16. Evaluation of a Micro-Optical Coherence Tomography for the Corneal Endothelium in an Animal Model

      Explore Nature Publishing Group
      Evaluation of a Micro-Optical Coherence Tomography for the Corneal Endothelium in an Animal Model
      Recent developments in optical coherence tomography (OCT) systems for the cornea have limited resolution or acquisition speed. In this study we aim to evaluate the use of a micro-OCT (OCT ~1m axial resolution) compared to existing imaging modalities using animal models of corneal endothelial disease. We used established cryoinjury and bullous keratopathy models in Sprague Dawley rats comparing ex vivo OCT imaging in normal and diseased eyes to (1) histology ...
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      Mentions: Duke University Singapore Eye Research Institute Nanyang Technological University
    17. 1-15 of 65 1 2 3 4 5 »
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  4. About Nanyang Technological University

    Nanyang Technological University

    Nanyang Technological University (NTU is an internationally reputed research-intensive tertiary institution. Our broad-based education covers science and technology, business and the arts, entrepreneurial and leadership skills to prepare students for the global working world.

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