1. Nanjing University of Science and Technology

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    1. Mentioned In 61 Articles

    2. Effects of orientation deviation of a beam splitter and a reference mirror on the stability of a two-interferometer-based handheld FFOCT imaging probe

      Effects of orientation deviation of a beam splitter and a reference mirror on the stability of a two-interferometer-based handheld FFOCT imaging probe
      In this work, we present a handheld full-field optical coherence tomography (FFOCT) system based on a series connection of two interferometers: the Michelson interferometer is used as a compensation part and the Fizeau interferometer is used as a detection part. Owing to the common-path arrangement of the Fizeau interferometer, this handheld FFOCT system has a compact detection arm and is insensitive to the external disturbance. A high-output halogen lamp and ...
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    3. RetFluidNet: Retinal Fluid Segmentation for SD-OCT Images Using Convolutional Neural Network

      RetFluidNet: Retinal Fluid Segmentation for SD-OCT Images Using Convolutional Neural Network
      Age-related macular degeneration (AMD) is one of the leading causes of irreversible blindness and is characterized by fluid-related accumulations such as intra-retinal fluid (IRF), subretinal fluid (SRF), and pigment epithelial detachment (PED). Spectral-domain optical coherence tomography (SD-OCT) is the primary modality used to diagnose AMD, yet it does not have algorithms that directly detect and quantify the fluid. This work presents an improved convolutional neural network (CNN)-based architecture called ...
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    4. Differentiation of breast tissue types for surgical margin assessment using machine learning and polarization-sensitive optical coherence tomography

      Differentiation of breast tissue types for surgical margin assessment using machine learning and polarization-sensitive optical coherence tomography
      We report an automated differentiation model for classifying malignant tumor, fibro-adipose, and stroma in human breast tissues based on polarization-sensitive optical coherence tomography (PS-OCT). A total of 720 PS-OCT images from 72 sites of 41 patients with HE histology-confirmed diagnoses as the gold standard were employed in this study. The differentiation model is trained by the features extracted from both one standard OCT-based metric (i.e., intensity) and four PS-OCT-based ...
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    5. Noise Reduction for SD-OCT Using a Structure-Preserving Domain Transfer Approach

      Noise Reduction for SD-OCT Using a Structure-Preserving Domain Transfer Approach
      Spectral-domain optical coherence tomography (SD-OCT) images inevitably suffer from multiplicative speckle noise caused by random interference. This study proposes an unsupervised domain adaptation approach for noise reduction by translating the SD-OCT to the corresponding high-quality enhanced depth imaging (EDI)-OCT. We propose a structure-persevered cycle-consistent generative adversarial network for unpaired image-to-image translation, which can be applied to imbalanced unpaired data, and can effectively preserve retinal details based on a structure-specific ...
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    6. CT texture analysis of vulnerable plaques on optical coherence tomography

      CT texture analysis of vulnerable plaques on optical coherence tomography
      Purpose: To explore whether CT texture analysis can identify thin-cap fibroatheroma (TCFA) determined by optical coherence tomography (OCT). Methods: Thirty-three patients with 43 lesions who underwent both CCTA and OCT within 3 months were retrospectively included. 12 conventional CT-derived plaque features, fat attenuation index (FAI) and 1691 plaque radiomics features were extracted to discriminate TCFA lesions and non-TCFA lesions determined by OCT. Minimum redundancy and maximum relevance (mRMR) method was ...
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    7. An optimized segmentation and quantification approach in microvascular imaging for OCTA-based neovascular regression monitoring

      An optimized segmentation and quantification approach in microvascular imaging for OCTA-based neovascular regression monitoring
      Background: Quantification of neovascularization changes in terms of neovascular complex (NVC) acquired from the optical coherence tomography angiography (OCTA) imaging is extremely important for diagnosis and treatment monitoring of proliferative diabetic retinopathy (PDR). However, only few vessel extraction methods have so far been reported to quantify neovascular changes in NVC with proliferative diabetic retinopathy PDR based on OCTA images. Methods: Here we propose an optimized approach to segment blood vessels ...
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    8. Image Projection Network: 3D to 2D Image Segmentation in OCTA Images

      Image Projection Network: 3D to 2D Image Segmentation in OCTA Images
      We present an image projection network (IPN), which is a novel end-to-end architecture and can achieve 3D-to-2D image segmentation in optical coherence tomography angiography (OCTA) images. Our key insight is to build a projection learning module (PLM) which uses a unidirectional pooling layer to conduct effective features selection and dimension reduction concurrently. By combining multiple PLMs, the proposed network can input 3D OCTA data, and output 2D segmentation results such ...
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    9. Superficial Calcification With Rotund Shape Is Associated With Carotid Plaque Rupture: An Optical Coherence Tomography Study

      Superficial Calcification With Rotund Shape Is Associated With Carotid Plaque Rupture: An Optical Coherence Tomography Study
      Background: Plaque rupture is an important etiology for symptomatic carotid stenosis. The role of calcification in the plaque vulnerability has been controversial. We aimed to detect the geometric features of calcifications in carotid plaque and to examine its association with plaque rupture. Methods: Optical coherence tomography assessment of carotid plaque was performed in 88 patients. Calcification shape was evaluated through quantitative measurements of the long and short axis, area size ...
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    10. A theoretical model for the micron resolution spectral domain optical coherence tomography

      A theoretical model for the micron resolution spectral domain optical coherence tomography
      The resolution and effective imaging depth (EID) of spectral domain optical coherence tomography (OCT) are of great importance for visualizing the fine details of biological tissues. To this end, a theoretical model for the micron resolution spectral domain OCT was proposed with both the temporal coherence and the longitudinal spatial coherence considered. Based on the model, the parameters that influence the axial resolution, the signal intensity and the EID can ...
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    11. Fast and Automated Hyperreflective Foci Segmentation Based on Image Enhancement and Improved 3D U-Net in SD-OCT Volumes with Diabetic Retinopathy

      Fast and Automated Hyperreflective Foci Segmentation Based on Image Enhancement and Improved 3D U-Net in SD-OCT Volumes with Diabetic Retinopathy
      Purpose : To design a robust and automated hyperreflective foci (HRF) segmentation framework for spectral-domain optical coherence tomography (SD-OCT) volumes, especially volumes with low HRF-background contrast. Methods : HRF in retinal SD-OCT volumes appear with low-contrast characteristics that results in the difficulty of HRF segmentation. Therefore to effectively segment the HRF we proposed a fully automated method for HRF segmentation in SD-OCT volumes with diabetic retinopathy (DR). First, we generated the enhanced ...
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    12. Point spread function degradation model of a polarization imaging system for wide-field subwavelength nanoparticles

      Point spread function degradation model of a polarization imaging system for wide-field subwavelength nanoparticles
      We propose a comprehensive point spread function (PSF) degradation model, which considers multiple factors consisting of degradation of specimen retardant sampling and polarization angularly anamorphic sampling, to indicate the image degradation characteristics of polarization imaging systems. First, a one-layer optical coherence tomography (OCT) model was established to express the retardancy of medium-loading specimens. Then, a PSF degradation model of angularly anamorphic polarization sampling was deduced through the retrieval of Stokes ...
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    13. Cooperative low-rank models for removing stripe noise from OCTA images

      Cooperative low-rank models for removing stripe noise from OCTA images
      Optical coherence tomography angiography (OCTA) is an emerging non-invasive imaging technique for imaging the microvasculature of the eye based on phase variance or amplitude decorrelation derived from repeated OCT images of the same tissue area. Stripe noise occurs during the OCTA acquisition process due to the involuntary movement of the eye. To remove the stripe noise (or 'destriping') effectively, we propose two novel image decomposition models to simultaneously destripe all ...
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    14. Measurement of optic axis orientation with single-mode fiber-based polarization-sensitive optical coherence tomography

      Measurement of optic axis orientation with single-mode fiber-based polarization-sensitive optical coherence tomography
      An algorithm is presented that can be used to obtain accurate optic axis orientation of birefringent tissue samples. A single-mode fiber (SMF)-based polarization-sensitive optical coherence tomography with a single linearly polarized incident light was used in the measurements in which the light reflected from the sample and detected by the spectrometer is linearly polarized light at 45 deg with respect to the experimental horizontal axis. By employing polarization controllers ...
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    15. Ticagrelor versus clopidogrel for prevention of subclinical stent thrombosis detected by optical coherence tomography in patients with drug-eluting stent implantation—a multicenter and randomized study

      Ticagrelor versus clopidogrel for prevention of subclinical stent thrombosis detected by optical coherence tomography in patients with drug-eluting stent implantation—a multicenter and randomized study
      Introduction : This prospective, multicenter, randomized study was designed to analyze the benefits of ticagrelor over clopidogrel in reducing subclinical stent thrombosis (ST) in patients with coronary artery disease who underwent implantation of a second-generation drug-eluting stent (DES). Methods : About 352 patients with single de novo coronary stenosis were randomly assigne`d to either clopidogrel group (aspirin plus clopidogrel) or ticagrelor group (aspirin plus ticagrelor) after DES implantation for 1 year ...
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  2. About Nanjing University of Science and Technology

    Nanjing University of Science and Technology

    Nanjing University of Science and Technology (NUST) is one of the national key universities under the guidance of the Ministry of Industry and Information Technology. The university has more than sixty years' experience in providing inspiring and broadened-horizon education. It has become a multi-disciplinary university comprising academic fields including: science, engineering, liberal arts, economics, business, management, law and education. In addition, NUST encompasses a wide array of centers, institutes, programs, and administrative support offices.