Purpose:To study the three-dimensional morphological features of retinal arteriovenous crossings with optical coherence tomography (OCT) and elucidate the vascular changes associated with crossing phenomena as seen on fundus photographs. Methods: We examined 150 consecutive eyes with no ocular disease. In each eye, fundus photographs were taken, and one randomly selected arteriovenous crossing was examined by OCT. The OCT analysis was performed using sequential thin sections along and perpendicular to the retinal vessels. Results:OCT analysis of these arteriovenous crossings showed that the veins abruptly changed their directions to pass the artery and frequently displayed focal luminal narrowing with no ...

Purpose To investigate the choroidal thickness/volume of eyes with reticular pseudodrusen using high-penetration swept-source optical coherence tomography (SS-OCT) and to evaluate the choroidal vasculature changes using en face images. Design Prospective cross sectional study. Methods Thirty-eight eyes with reticular pseudodrusen and 14 normal eyes were studied with prototype SS-OCT. Eyes with reticular pseudodrusen were classified into 3 subgroups: eyes without late age-related macular degeneration (AMD) (group1), eyes with neovascular AMD (group2), and eyes with geographic atrophy (group3). Mean regional choroidal thickness/volume measurements were obtained by three-dimensional (3D) raster scanning. The choroidal vascular area was measured using en face ...

Purpose To study retrospectively the characteristics of residual indocyanine green (ICG) fluorescence after ICG-assisted vitrectomy and the association with spectral-domain optical coherence tomography (SD-OCT) findings in diabetic macular oedema (DMO). Methods Thirteen consecutive eyes of 12 patients for whom fundus near-infrared fluorescence and 20° retinal sectional images were obtained using HRA2 and Spectralis OCT, respectively, 5 days after vitrectomy combined with ICG-assisted inner limiting membrane peeling for DMO. The relationship between the characteristics of the ICG hyperfluorescence and the cystoid spaces in the outer plexiform layer (OPL) on SD-OCT images was evaluated. Results A total of 390 well-demarcated areas of ...

Purpose: To visualize changes in deep optic nerve head (ONH) structures following glaucoma surgery using (3-dimensional (3D)) swept-source optical coherence tomography (SS-OCT) and to determine the clinical and structural factors associated with postoperative lamina cribrosa (LC) and prelaminar neural tissue (PLT) changes. Methods: In this prospective observational case series, SS-OCT thin-sliced datasets of the ONH covering a 3×3-mm area comprised of 256 B-scans (interval between scans = ∼12µm) were obtained before and 3 months after the surgery and evaluated in 73 eyes of 73 patients with glaucoma. Bruch's membrane opening (BMO) and anterior LC boundary were manually delineated ...

PURPOSE: To study morphological changes of the retinal vasculature in eyes with central retinal vein occlusion (CRVO) through the use of optical coherence tomography (OCT). METHODS: Major retinal vessels in eyes from 35 consecutive patients (35 eyes) with acute CRVO were prospectively and longitudinally examined with sequential thin sectioning and circumpapillary scanning. Anteroposterior venous tortuosity associated with CRVO was quantified on longitudinal OCT images of a randomly selected major temporal vein. On OCT sections of a given vein, we identified the innermost and the outermost points of the vessel wall. The degree of anteroposterior venous tortuosity was defined as the ...

Purpose. To visualize lamina cribrosa defects using three-dimensional (3D) swept-source optical coherence tomography (SS-OCT), and to determine the factors associated with this feature. Methods. All subjects were examined using an SS-OCT prototype system, which uses a tunable laser as a light source, operated at 100,000 Hz A-scan repetition rate in the 1050-nm wavelength. A 3D raster scan protocol consisting of 256 × 256 A-scans was acquired over a square area of 3 mm × 3 mm centered on the optic disc. En face sectioned volume and serial en face images and orthogonal (horizontal and vertical) serial B-scans were evaluated. Results. A ...

Purpose: To visualize and analyze focal lamina cribrosa defects using 3-dimensional (3D) swept-source optical coherence tomography (SS-OCT). Methods: All the subjects were examined using an SS-OCT prototype system, which employs a tunable laser as a light source operated at 100,000 Hz A-scan repetition rate in the 1,050 nm wavelength. Three-dimensional raster scan protocol comprising 256 × 256 A-scans was acquired over a square area of 3 mm × 3 mm centered at the optic disc. En face sectioned volume and serial en face images, which were reconstructed from the 3D data set, and orthogonal (horizontal and vertical) serial B-scan were ...

PURPOSE. To study diagnostic performances of circle and grid-wise analyses of peripapillary retinal nerve fiber layer thickness (RNFLT) using spectral domain optical coherence tomography (SD-OCT) in early stage glaucoma. METHODS. Eighty-nine open-angle glaucoma (OAG) eyes (mean deviation, -2.5 ± 1.8 dB) and 89 age-matched normal eyes were studied. Peripapillary RNFLT was analyzed using SD-OCT raster scan in a 6.0 × 6.0 mm area. Averaged RNFLT was calculated over 0.1 × 0.1, 0.21 × 0.21, or 0.42 × 0.42 mm grids in the peripapillary area (grid method), or arcuate sector areas between 2.8 and 4 ...

Purpose. To evaluate the inter-visit reproducibility of spectral-domain optical coherence tomography (SD-OCT) measurement of the macular retinal nerve fiber layer thickness (mRNFLT), combined ganglion cell layer and inner plexiform layer (GCL+IPL) thickness, and ganglion cell complex (GCC) thicknesses (sum of mRNFLT and GCL+IPL thicknesses) compared with that of circumpapillary RNFLT (cpRNFLT) and the effect of ocular rotation on reproducibility. Methods. SD-OCT imaging was performed twice on different days in one eye of 58 normal subjects and 73 glaucoma patients. The reproducibility was evaluated for the entire 4.8 mm x 4.8 mm macular area and sub-areas (upper ...