Purpose. To evaluate the inter-visit reproducibility of spectral-domain optical coherence tomography (SD-OCT) measurement of the macular retinal nerve fiber layer thickness (mRNFLT), combined ganglion cell layer and inner plexiform layer (GCL+IPL) thickness, and ganglion cell complex (GCC) thicknesses (sum of mRNFLT and GCL+IPL thicknesses) compared with that of circumpapillary RNFLT (cpRNFLT) and the effect of ocular rotation on reproducibility. Methods. SD-OCT imaging was performed twice on different days in one eye of 58 normal subjects and 73 glaucoma patients. The reproducibility was evaluated for the entire 4.8 mm x 4.8 mm macular area and sub-areas (upper ...

Purpose. To determine the retinal features associated with a dissociated optic nerve fiber layer (DONFL) appearance after successful macular hole surgery with internal limiting membrane (ILM) peeling. Methods. Forty-seven eyes of 47 patients that underwent pars plana vitrectomy with ILM peeling were examined by spectral-domain optical coherence tomography (SD-OCT). Results. A DONFL appearance was found in 31 (66.0%) eyes on color fundus photography. The postoperative best-corrected visual acuity and its improvements were not significantly different between eyes with and without this appearance. The SD-OCT images showed small inner retinal defects corresponding to each arcuate stria in all eyes with ...

Purpose To detect pathologic changes in retinal nerve fiber bundles in glaucomatous eyes seen on images obtained by adaptive optics (AO) scanning laser ophthalmoscopy (AO SLO). Design Prospective cross-sectional study. Methods Twenty-eight eyes of 28 patients with open-angle glaucoma and 21 normal eyes of 21 volunteer subjects underwent a full ophthalmologic examination, visual field testing using a Humphrey Field Analyzer, fundus photography, red-free SLO imaging, spectral-domain optical coherence tomography, and imaging with an original prototype AO SLO system. Results The AO SLO images showed many hyperreflective bundles suggesting nerve fiber bundles. In glaucomatous eyes, the nerve fiber bundles were narrower ...

A three-beam spectral domain optical coherence tomography system (OCT) whose center wavelength is 840 nm was developed. The three beams focus on fundus 3.1 mm apart from each other and are detected by a single line sensor. The distance between the beams is fixed and the beams scan a total area of 10 × 10     mm 2 while keeping this separation during three-dimensional (3-D) measurement. The line rate of the sensor is 70 kHz, therefore the total speed is equivalent to 210k A-scans per second in this system. A 1000 ( x ) × 500 ( z ) × 250 ( y ) voxel volumetric 3D OCT data ...

PURPOSE: To study the choroidal thickness in eyes with inferior posterior ‎staphyloma (IPS) and to elucidate their role in the development of macular ‎complications.‎ METHODS: The macular area of 42 eyes of 32 patients with IPS was studied ‎prospectively with swept source optical coherence tomography at 1,050 nm. Using a ‎raster scan protocol with 512 × 128 A-scans, we produced a macular choroidal ‎thickness map (6 × 6-mm2).‎ RESULTS: Eyes with IPS showed relatively well-preserved choroid outside of the ‎staphyloma but the inferior-nasal choroid within the staphyloma was thinned ‎substantially. In addition, eyes with IPS often had a belt-shaped area with ...

Purpose. To measure the inner and outer retinal thicknesses on spectral-domain optical coherence tomography (SD-OCT) and evaluate their association with logMAR after vitrectomy for diabetic macular edema (DME). Methods. In this retrospective case series, there were 55 consecutive eyes with DME for which vitrectomy was performed. The total retinal thickness, the inner thickness (from the innermost of the retina to the inner nuclear layer), and the outer thickness (from the outer plexiform layer to the retinal pigment epithelium) in the parafoveal subfields were measured manually, and the association with logMAR was evaluated. Results. The total retinal thicknesses in the central ...

Purpose: To test the glaucoma-discriminating ability of a new method for detecting local ganglion cell loss using spectral-domain optical coherence tomography (SD-OCT). Methods: This study included 58 eyes from glaucomatous patients and 48 healthy eyes from volunteers. The combined thickness of the ganglion cell layer and inner plexus layer (GCIPL) was measured on a macular cube scan (200 × 200) in Cirrus HD-OCT. GCIPL thicknesses on 360 spokes extending from the inner to the outer radius of a macular elliptical annulus were calculated. The lowest value (minimum GCIPL) was compared to the average GCIPL thickness within the elliptical annulus in the ...

Purpose: To determine whether measurement of ganglion cell complex (GCC) thickness over a wide area (8-mm diameter) can improve the glaucoma-discriminating ability of spectral-domain optical coherence tomography (SD-OCT) compared to that in the standard macular area (6-mm diameter). Methods: Ninety-three subjects were enrolled, including 46 healthy eyes of 46 volunteers and 47 eyes of 47 glaucoma patients (23 eyes with preperimetric glaucoma [PPG] and 24 eyes with early glaucoma [EG]). All patients underwent SD-OCT raster scanning over a 9 mm × 9 mm square area centered on the fovea. Areas under the receiver operating characteristic curves (AROCs) were compared between wide ...