1. Mount Sinai School of Medicine

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    1. Mentioned In 64 Articles

    2. Mount Sinai Launches First and Only Eye Stroke Service in New York City to Rapidly Diagnose and Treat Blinding Condition

      Mount Sinai Launches First and Only Eye Stroke Service in New York City to Rapidly Diagnose and Treat Blinding Condition
      Mount Sinai Health System has launched the first eye stroke service in New York City to expedite the diagnosis and treatment of patients who arrive at the emergency room with eye strokea medical emergency that must be addressed as quickly as possible to prevent irreversible vision loss. Four emergency departments in the Mount Sinai Health System are now the only sites in New York City equipped with advanced high-resolution imaging ...
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    3. Evaluating Onychomycosis Outcomes 2 Months into an 11-month-long Efinaconazole Regimen: The Role of Optical Coherence Tomography

      Evaluating Onychomycosis Outcomes 2 Months into an 11-month-long Efinaconazole Regimen: The Role of Optical Coherence Tomography
      Background. Onychomycosis affects 43 million people in the United States and Europe. Topical therapies can be effective but require lengthy and costly regimens without an established method for predicting the treatment outcome. Objective. We studied the role of optical coherence tomography (OCT), a noninvasive imaging device approved by the United States Food and Drug Administration, in evaluating onychomycosis treatment outcomes. Methods. This investigator-initiated prospective clinical study recruited subjects from two ...
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    4. Optical Coherence Tomography of Plaque Vulnerability and Rupture: JACC Focus Seminar Part 1/3

      Optical Coherence Tomography of Plaque Vulnerability and Rupture: JACC Focus Seminar Part 1/3
      Plaque rupture is the most common cause of acute coronary syndromes and sudden cardiac death. Characteristics and pathobiology of vulnerable plaques prone to plaque rupture have been studied extensively over 2 decades in humans using optical coherence tomography (OCT), an intravascular imaging technique with micron scale resolution. OCT studies have identified key features of plaque vulnerability and described the in vivo characteristics and spatial distribution of thin cap fibroatheromas as ...
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    5. Optical Coherence Tomography of Plaque Erosion: JACC Focus Seminar Part 2/3

      Optical Coherence Tomography of Plaque Erosion: JACC Focus Seminar Part 2/3
      Plaque erosion, a distinct histopathological and clinical entity, accounts for over 30% of acute coronary syndromes (ACS). Optical coherence tomography allows in vivo diagnosis of plaque erosion. Local flow perturbation with activation of Toll-like receptor 2 and CD8 + T cells and subsequent desquamation of endothelium and neutrophil extracellular trap formation contribute to mechanisms of plaque erosion. Compared with ACS patients with plaque rupture, those with plaque erosion are younger, have ...
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    6. Optical Coherence Tomography of Coronary Plaque Progression and Destabilization: JACC Focus Seminar Part 3/3

      Optical Coherence Tomography of Coronary Plaque Progression and Destabilization: JACC Focus Seminar Part 3/3
      The development of optical coherence tomography (OCT) has revolutionized our understanding of coronary artery disease. In vivo OCT research has paralleled with advances in computational fluid dynamics, providing additional insights in the various hemodynamic factors influencing plaque growth and stability. Recent OCT studies introduced a new concept of plaque healing in relation to clinical presentation. In addition to known mechanisms of acute coronary syndromes such as plaque rupture and plaque ...
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    7. Combining Nd:YAG laser with optical coherence tomography for nonsurgical treatment of basal cell carcinoma

      Combining Nd:YAG laser with optical coherence tomography for nonsurgical treatment of basal cell carcinoma
      Background: Effective and aesthetically appealing management options are needed for basal cell carcinoma (BCC), the most common skin cancer. The Nd:YAG laser shows promise, but most studies use biopsy to demonstrate tumor clearance. Optical coherence tomography (OCT) could allow good tumor margin control while enabling recurrence monitoring. Objective: Determine the efficacy of the Nd:YAG laser to treat BCCs while controlling for tumor margin with OCT. Methods: A 1064-nm ...
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    8. Confocal Microscopy and Anterior Segment Optical Coherence Tomography Imaging of the Ocular Surface and Bleb Morphology in Medically and Surgically Treated Glaucoma Patients: A Review

      Confocal Microscopy and Anterior Segment Optical Coherence Tomography Imaging of the Ocular Surface and Bleb Morphology in Medically and Surgically Treated Glaucoma Patients: A Review
      Glaucoma patients often suffer from ocular surface disease (OSD) caused by the chronic administration of topical anti-glaucoma medications, especially in cases of long-term therapy with preserved or multiple drugs. Additionally, glaucoma surgery may determine ocular surface changes related to the formation and location of the filtering bleb, the application of anti-mitotic agents, and the post-operative wound-healing processes within the conjunctiva. Recently, several studies have evaluated the role of advanced diagnostic ...
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    9. Three dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility

      Three dimensional reconstruction of coronary artery stents from optical coherence tomography: experimental validation and clinical feasibility
      The structural morphology of coronary stents (e.g. stent expansion, lumen scaffolding, strut apposition, tissue protrusion, side branch jailing, strut fracture), and the local hemodynamic environment after stent deployment are key determinants of procedural success and subsequent clinical outcomes. High-resolution intracoronary imaging has the potential to enable the geometrically accurate three-dimensional (3D) reconstruction of coronary stents. The aim of this work was to present a novel algorithm for 3D stent ...
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    10. Relationship between high shear stress and OCT-verified thin-cap fibroatheroma in patients with coronary artery disease

      Relationship between high shear stress and OCT-verified thin-cap fibroatheroma in patients with coronary artery disease
      High-risk coronary plaques have been considered predictive of adverse cardiac events. Both wall shear stress (WSS) in patients with hemodynamically significant lesions and optical coherence tomography (OCT) -verified thin-cap fibroatheroma (TCFA) are associated with plaque rupture, the most common underlying mechanism of acute coronary syndrome. The aim of the study was to test the hypothesis that invasive coronary angiography-based high WSS is associated with the presence of TCFA detected by ...
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    11. Three Mount Sinai Ophthalmologists Receive Prestigious Achievement Awards

      Three Mount Sinai Ophthalmologists Receive Prestigious Achievement Awards
      Three of the largest and most respected ophthalmology organizations in the world have named members of Mount Sinai Health Systems Department of Ophthalmology as recipients of some of their most prestigious awards of 2020. These honors recognize the researchers outstanding leadership and advancements in ophthalmic research and education. Richard Rosen, MD, Vice Chair and Director of Ophthalmology Research at New York Eye and Ear Infirmary of Mount Sinai (NYEE), earned ...
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    12. OPtical Coherence Tomography Guided Coronary Stent IMplantation Compared to Angiography: A Multicenter Randomized TriaL in PCI

      OPtical Coherence Tomography Guided Coronary Stent IMplantation Compared to Angiography: A Multicenter Randomized TriaL in PCI
      AIMS: Randomized trials have demonstrated improvement in clinical outcomes with intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) compared with angiography-guided PCI. The ILUMIEN III trial demonstrated non-inferiority of an optical coherence tomography (OCT)- versus IVUS-guided PCI strategy in achieving similar post-PCI lumen dimensions. ILUMIEN IV is a large-scale, multicenter, randomized trial designed to demonstrate the superiority of OCT- versus angiography-guided stent implantation in patients with high-risk clinical characteristics (diabetes ...
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    13. OCT angiography shows acute IOP changes after intravitreal injections

      OCT angiography shows acute IOP changes after intravitreal injections
      Repeated intravitreal injections may result in glaucomatous damage, according to research done at New York Eye and Ear Infirmary of Mount Sinai. In a retrospective observational clinical study of 40 eyes of 39 patients, Richard B. Rosen, MD, and colleagues used OCT angiography to demonstrate the acute changes in IOP that result from reduced macular and peripapillary perfusion density after intravitreal injection. These injections cause eye pressure to temporarily go ...
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    14. Optic nerve head diurnal vessel density variations in glaucoma and ocular hypertension measured by optical coherence tomography angiography

      Optic nerve head diurnal vessel density variations in glaucoma and ocular hypertension measured by optical coherence tomography angiography
      Background/aims To evaluate diurnal variations in optic nerve head (ONH) vessel density assessed by optical coherence tomography angiography (OCT-A) in healthy subjects, ocular hypertension (OHT), and open-angle glaucoma (OAG) patients. Methods Forty subjects (OAG, 21; OHT, 6; healthy, 13) were assessed for vessel density percentage (VD%) and flow index in the ONH (NH VD%, NH index), and in the radial peripapillary capillary layer (RPC VD%, RPC index) at 9 ...
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    15. Procedural and one-year outcomes of patients treated with orbital and rotational atherectomy with mechanistic insights from optical coherence tomography

      Procedural and one-year outcomes of patients treated with orbital and rotational atherectomy with mechanistic insights from optical coherence tomography
      Aims: We sought to evaluate procedural complications and one-year clinical outcomes for patients who underwent percutaneous coronary intervention (PCI) with orbital (OA) and rotational atherectomy (RA). Methods and results: From a total of 13,467 patients who underwent PCI in our hospital between January 2013 and June 2016, 1,149 consecutive patients were treated with atherectomy for moderately-severely calcified lesions (184 with OA, 965 with RA). Procedural complications were similarly ...
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  2. About Mount Sinai School of Medicine

    Mount Sinai School of Medicine

    Mount Sinai School of Medicine is a medical school found in the borough of Manhattan in New York City. The official name is Mount Sinai School of Medicine of New York University due to its academic affiliation with New York University (NYU). However, Mount Sinai School of Medicine (MSSM) is independent of NYU; that is, MSSM has its own facilities, board of trustees, administration, student body, faculty, admissions offices, tuition fees, and endowment. MSSM also raises its own funds.