1. Molly Brewer

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    1. Mentioned In 15 Articles

    2. Correlating optical coherence elastography based strain measurements with collagen content of the human ovarian tissue

      Correlating optical coherence elastography based strain measurements with collagen content of the human ovarian tissue
      In this manuscript, the initial feasibility of a catheter based phase stabilized swept source optical coherence tomography (OCT) system was studied for characterization of the strain inside different human ovarian tissue groups. The ovarian tissue samples were periodically compressed with 500 Hz square wave signal along the axial direction between the surface of an unfocused transducer and a glass cover slide. The displacement and corresponding strain were calculated during loading ...
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    3. Optical and Photoacoustic Imaging for Ovarian Cancer Detection (Thesis)

      Optical and Photoacoustic Imaging for Ovarian Cancer Detection (Thesis)
      Ovarian cancer is the fifth most common cancer among women and has the highest mortality rate of all gynecologic cancers. Current clinical imaging modalities are limited by poor sensitivity and specificity. Therefore, there is an urgent need to develop effective tools to detect ovarian cancer. In this dissertation, two imaging modalities, optical coherence tomography (OCT) and photoacoustic imaging have been investigated for ovarian cancer detection and characterization. In the first ...
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    4. Quantitative analysis of angle-resolved scattering properties of ovarian tissue using optical coherence tomography

      Quantitative analysis of angle-resolved scattering properties of ovarian tissue using optical coherence tomography
      Angle-resolved optical scattering properties of ovarian tissue, on different optical coherence tomography (OCT) imaging planes, were quantitatively measured by fitting the compounded OCT A-lines into a single scattering model. Higher cross correlation value of angle-resolved scattering coefficients between different OCT imaging planes was found in normal ovaries than was present in malignant ovaries. The mean cross correlation coefficient (MCC) was introduced in this pilot study to characterize and differentiate normal ...
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    5. Assessment of collagen changes in ovarian tissue by extracting optical scattering coefficient from OCT images

      Assessment of collagen changes in ovarian tissue by extracting optical scattering coefficient from OCT images
      Optical scattering coefficient from ex-vivo unfixed normal and malignant ovarian tissue was quantitatively extracted by fitting optical coherence tomography (OCT) A-line signals to a single scattering model. 1097 average A-line measurements at a wavelength of 1310nm were performed at 108 sites obtained from 18 ovaries. The average scattering coefficient obtained from normal group consisted of 833 measurements from 88 sites was 2.41 mm-1 (±0.59), while the average coefficient ...
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    6. Feature Of The Week 10/23/11: Hybrid Intraoperative Probe Based on OCT and Positron Detection for Ovarian Cancer Detection

      Feature Of The Week 10/23/11: Hybrid Intraoperative Probe Based on OCT and Positron Detection for Ovarian Cancer Detection
      Multi-modality imaging involving OCT and one or more additional imaging technologies continues to show very promising results for increasing the diagnostic and interventional guidance capability of biomedical imaging probes. These synergistic effects have been published in numerous papers over the past year. This includes OCT in combination with fluorescence, Raman, NIR, ultrasound, and other technologies. Such approaches have the obvious disadvantage of increasing the cost and complexity of the imaging ...
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    7. Potential role of a hybrid intraoperative probe based on OCT and positron detection for ovarian cancer detection and characterization

      Potential role of a hybrid intraoperative probe based on OCT and positron detection for ovarian cancer detection and characterization
      ...Nrusingh C. Biswal, Tianheng Wang, Patrick D. Kumavor, Mozafareddin Karimeddini, John Vento, Melinda Sanders, Molly Brewer, and Quing Zhu, "Potential role of a hybrid intraoperative probe based on OCT and positron detect...
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    8. Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis

      Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis
      Determining if an ovarian mass is benign or malignant is an ongoing clinical challenge. The development of reliable animal models provides means to evaluate new diagnostic tools to more accurately determine if an ovary has benign or malignant features. Although sex cord-stromal tumors (SCST) account for 0.1-0.5% of ovarian malignancies, they have similar appearances to more aggressive epithelial cancers and can serve as a prototype for developing better ...
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    9. Feature Of The Week 6/21/09: Laparoscopic optical coherence tomography imaging of human ovarian cancer

      Feature Of The Week 6/21/09: Laparoscopic optical coherence tomography imaging of human ovarian cancer
      Feature Of The Week 6/21/09: Ovarian cancer is the fourth leading cause of cancer-related death among women in the US, largely attributed to late detection due to unreliable symptomology and screening tools without adequate resolution and specificity. As a result, ovarian cancer is often diagnosed at advanced stages, after invasion of adjacent structures or metastasis to a distant site. Women with regional and distant disease have a 5-year ...
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    10. Laparoscopic optical coherence tomography imaging of human ovarian cancer

      Objectives Ovarian cancer is the fourth leading cause of cancer-related death among women in the US largely due to late detection secondary to unreliable symptomology and screening tools without adequate resolution. Optical coherence tomography (OCT) is a recently emerging imaging modality with promise in ovarian cancer diagnostics, providing non-destructive subsurface imaging at imaging depths up to 2 mm with near-histological grade resolution (10–20 μm). In this study, we developed ...
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    11. Laparoscopic optical coherence tomographic imaging of human ovarian cancer

      Ovarian cancer is the fourth leading cause of cancer-related death among women in the United States. If diagnosed at an early stage, the 5-year survival rate is 94%, but drops to 68% for regional disease and 29% for distant metastasis; only 19% of all cases are diagnosed at the early, localized stag ... [Proc. SPIE Int. Soc. Opt. Eng. 6851, 685107 (2008)] published Tue Feb 5, 2008.
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  2. About Molly Brewer

    Molly Brewer

    Molly Brewer, MD, is a physician in the Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center. Dr. Brewer is a nationally recognized gynecologic oncologist. She offers highly personalized care for women with gynecologic malignancies, such as ovarian, uterine and cervical cancer. Dr. Brewer also provides consultations about cancer prevention, particularly ovarian cancer, through the Women’s Cancer Prevention Program.