1. Michiko Watanabe

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    1. Mentioned In 20 Articles

    2. Folic acid prevents functional and structural heart defects induced by prenatal ethanol exposur

      Folic acid prevents functional and structural heart defects induced by prenatal ethanol exposur
      Increased regurgitant blood flow has been linked to endocardial cushion defects and resultant congenital heart diseases (CHDs). Prenatal alcohol exposure (PAE) has been shown to alter early blood flow resulting in abnormal endocardial cushions and CHDs. Compounds, including folic acid (FA), mitigate PAE effects and prevent CHDs, but few studies have assessed their effects on blood flow. We modeled binge drinking in quail embryos at gastrulation. Embryos were exposed to ...
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    3. SLIME: robust, high-speed 3D microvascular mapping

      SLIME: robust, high-speed 3D microvascular mapping
      Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while maintaining a simple and low cost approach that does not require in-depth OCT knowledge. The new method enables fast 3D microvascular mapping in large tissue volumes ...
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    4. Using optical coherence tomography to detect disturbances in coronary microvascular in a model of fetal alcohol syndrome

      Using optical coherence tomography to detect disturbances in coronary microvascular in a model of fetal alcohol syndrome
      Congenital coronary anomalies can result in severe consequences such as arrhythmias and sudden death. However, the etiology of abnormal embryonic coronary microvasculature development is understudied. Using a novel contrast-agent-based optical coherence tomography (OCT) technique, scatter labeled imaging of microvasculature in excised tissue (SLIME), we compared diseased and normal embryonic quail coronary microvasculature in 3D. Congenital heart defects associated with fetal alcohol syndrome (FAS) were induced in a quail model by ...
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    5. Thin-cap fibroatheroma and large calcification at the proximal stent edge correlate with a high proportion of uncovered stent struts in the chronic phase

      Thin-cap fibroatheroma and large calcification at the proximal stent edge correlate with a high proportion of uncovered stent struts in the chronic phase
      Objective: A high proportion of uncovered stent struts is associated with late stent thrombosis after drug-eluting stent (DES) implantation, which frequently results in myocardial infarction or death. However, the predictors of uncovered stent struts remain unknown. Here, using optical coherence tomography (OCT), we studied the baseline tissue characteristics of the target coronary segment and evaluated their influence on the neointimal coverage of the strut in the chronic phase. Methods: We ...
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    6. Feature Of The Week 02/22/15: Case Western Reserve University Demostrates Using OCT to Rapidly Phenotype and Quantify Congenital Heart Defects Associated with Prenatal Alcohol Exposure

      Feature Of The Week 02/22/15:  Case Western Reserve University Demostrates Using OCT to Rapidly Phenotype and Quantify Congenital Heart Defects Associated with Prenatal Alcohol Exposure
      The most commonly used method to analyze congenital heart defects involves serial sectioning and histology. However, this is often a time-consuming process where the quantification of cardiac defects can be difficult due to problems with accurate section registration. Here we demonstrate the advantages of using optical coherence tomography, a comparatively new and rising technology, to phenotype avian embryo hearts in a model of Fetal Alcohol Syndrome where a binge-like quantity ...
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    7. Using optical coherence tomography to rapidly phenotype and quantify congenital heart defects associated with prenatal alcohol exposure

      Using optical coherence tomography to rapidly phenotype and quantify congenital heart defects associated with prenatal alcohol exposure
      Background : The most commonly used method to analyze congenital heart defects involves serial sectioning and histology. However, this is often a time-consuming process where the quantification of cardiac defects can be difficult due to problems with accurate section registration. Here we demonstrate the advantages of using optical coherence tomography, a comparatively new and rising technology, to phenotype avian embryo hearts in a model of Fetal Alcohol Syndrome where a binge-like ...
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    8. Three-dimensional correction of conduction velocity in the embryonic heart using integrated optical mapping and optical coherence tomography

      Three-dimensional correction of conduction velocity in the embryonic heart using integrated optical mapping and optical coherence tomography
      ...lectrophysiology, thereby improving our understanding of heart development. Pei Ma ; Yves T. Wang ; Shi Gu ; Michiko Watanabe ; Michael W. Jenkins, et al. "Three-dimensional correction of conduction velocity in the emb...
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    9. Ethanol exposure alters early cardiac function in the looping heart: a mechanism for congenital heart defects?

      Ethanol exposure alters early cardiac function in the looping heart: a mechanism for congenital heart defects?
      ...n , Lindsy Peterson , Katherine Mai , Quinn McHale , Michael W Jenkins , Kersti K Linask , Andrew M Rollins , Michiko Watanabe American Journal of Physiology - Heart and Circulatory PhysiologyPublished 22 November 2013Vo...
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    10. 4D shear stress maps of the developing heart using Doppler optical coherence tomography

      4D shear stress maps of the developing heart using Doppler optical coherence tomography
      Accurate imaging and measurement of hemodynamic forces is vital for investigating how physical forces acting on the embryonic heart are transduced and influence developmental pathways. Of particular importance is blood flow-induced shear stress, which influences gene expression by endothelial cells and potentially leads to congenital heart defects through abnormal heart looping, septation, and valvulogenesis. However no imaging tool has been available to measure shear stress on the endocardium volumetrically and ...
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    11. Longitudinal Imaging of Heart Development With Optical Coherence Tomography

      Longitudinal Imaging of Heart Development With Optical Coherence Tomography
      Optical coherence tomography (OCT) has great potential for deciphering the role of mechanics in normal and abnormal heart development. OCT images tissue microstructure and blood flow deep into the tissue (1-2 mm) at high spatiotemporal resolutions allowing unprecedented images of the developing heart. Here, we review the advancement of OCT technology to image heart development and report some of our recent findings utilizing OCT imaging under environmental control for longitudinal ...
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    12. Optical coherence tomography captures rapid hemodynamic responses to acute hypoxia of the embryonic cardiovascular system of Early Embryos

      Optical coherence tomography captures rapid hemodynamic responses to acute hypoxia of the embryonic cardiovascular system of Early Embryos
      ...4106 Department of Pediatrics, School of Medicine, Case Western Reserve University, OH 44106 *Correspondence: Michiko Watanabe, RB&C Hospital, 11100 Euclid Avenue, Cleveland, Ohio, United States, 44106 Hypoxia; Congenita...
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    13. Feature Of The Week 4/17/11: Researchers Study Fundamental Aspects of Embryonic Heart Development Using OCT

      Feature Of The Week 4/17/11: Researchers Study Fundamental Aspects of Embryonic Heart Development Using OCT
      Feature Of The Week 4/17/11: Researchers from the University of South Florida, Western Reserve University , and the Massachusetts Institute of Technology use 4-D OCT to study fundamental aspects of embryonic heart development during the morphogenesis of a single chamber heart to a four chamber heart. Below, courtesy of Dr. Kersti Linask, is a visual, audio, and text summary of that work. Please click "full screen" and also click ...
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  2. About Michiko Watanabe

    Michiko Watanabe is a professor at Case Western Reserve University.